Vol 8, No 43

PD-L1/PD-1: new kid on the “immune metabolic” block

KLF4 represses MAP2K7 signaling in T-ALL

Mannan binding lectin triggers mobilization of hematopoietic stem cells

Aspirin in the era of immunotherapy

Screening of cancer tissue arrays identifies CXCR4 on adrenocortical carcinoma: correlates with expression and quantification on metastases using ⁶⁴Cu-plerixafor PET

Sulforaphane reduces YAP/∆Np63α signaling to reduce cancer stem cell survival and tumor formation

Protein expression of TTF1 and cMYC define distinct molecular subgroups of small cell lung cancer with unique vulnerabilities to aurora kinase inhibition, DLL3 targeting, and other targeted therapies

Central role of mTORC1 downstream of YAP/TAZ in hepatoblastoma development

The downregulation of putative anticancer target BORIS/CTCFL in an addicted myeloid cancer cell line modulates the expression of multiple protein coding and ncRNA genes

Enhanced immunotherapy by combining a vaccine with a novel murine GITR ligand fusion protein

Dysfunctional transcripts are formed by alternative polyadenylation in OPMD

Hydrogen sulfide ameliorates subarachnoid hemorrhage-induced neuronal apoptosis via the ROS-MST1 pathway

Effect of osteoporosis induced by ovariectomy on vertebral bone defect/fracture in rat

Gender difference of metabolic syndrome and its association with dietary diversity at different ages

Transcriptome-wide analysis of immune-responsive microRNAs against poly (I:C) challenge in Branchiostoma belcheri by deep sequencing and bioinformatics

ABO blood type is associated with renal outcomes in patients with IgA nephropathy

Inflexibility of AMPK-mediated metabolic reprogramming in mitochondrial disease

Active evolution of memory B-cells specific to viral gH/gL/pUL128/130/131 pentameric complex in healthy subjects with silent human cytomegalovirus infection

Long-term administration of ketamine induces erectile dysfunction by decreasing neuronal nitric oxide synthase on cavernous nerve and increasing corporal smooth muscle cell apoptosis in rats

Post-pancreaticoduodenectomy hemorrhage: DSA diagnosis and endovascular treatment

Mesenchymal stem cells in inflammatory microenvironment potently promote metastatic growth of cholangiocarcinoma via activating Akt/NF-κB signaling by paracrine CCL5

Prolonged mitotic arrest induced by Wee1 inhibition sensitizes breast cancer cells to paclitaxel

Chondroitin sulfate proteoglycan serglycin influences protein cargo loading and functions of tumor-derived exosomes

Hsp-27 levels and thrombus burden relate to clinical outcomes in patients with ST-segment elevation myocardial infarction

Reciprocal expression of INSM1 and YAP1 defines subgroups in small cell lung cancer

Dietary fat/cholesterol-sensitive PKCβ-RB signaling: Potential role in NASH/HCC axis

In vitro and in vivo anti-tumor activity of alectinib in tumor cells with NCOA4-RET

Significance of B10 cell in patients with thymoma complicated with myasthenia gravis

Increased breast tissue receptor activator of nuclear factor- κB ligand (RANKL) gene expression is associated with higher mammographic density in premenopausal women

Cystatin C deficiency suppresses tumor growth in a breast cancer model through decreased proliferation of tumor cells

H. pylori attenuates TNBS-induced colitis via increasing mucosal Th2 cells in mice

Increased CCL19 expression is associated with progression in cervical cancer

Identification and validation of a prognostic 9-genes expression signature for gastric cancer

Phylogenic analysis and forensic genetic characterization of Chinese Uyghur group via autosomal multi STR markers

The zebrafish miR-125c is induced under hypoxic stress via hypoxia-inducible factor 1α and functions in cellular adaptations and embryogenesis

CyclinD1 and p57^kip2 as biomarkers in differentiation, metastasis and prognosis of gastric cardia adenocarcinoma

Activation of TRKA receptor elicits mastocytosis in mice and is involved in the development of resistance to KIT-targeted therapy

MiR-302a sensitizes leukemia cells to etoposide by targeting Rad52

Suppression of hypoxia-induced excessive angiogenesis by metformin via elevating tumor blood perfusion

trans-4,4’-Dihydroxystilbene (DHS) inhibits human neuroblastoma tumor growth and induces mitochondrial and lysosomal damages in neuroblastoma cell lines

Identification of a novel ATM inhibitor with cancer cell specific radiosensitization activity

MicroRNA-378 enhances inhibitory effect of curcumin on glioblastoma

Combined inhibition of AKT and HSF1 suppresses breast cancer stem cells and tumor growth

The shortening of leukocyte telomere length relates to DNA hypermethylation of LINE-1 in type 2 diabetes mellitus

The impact of pathologic differentiation (well/poorly) and the degree of Ki-67 index in patients with metastatic WHO grade 3 GEP-NECs

Newcastle disease virus-induced autophagy mediates antiapoptotic signaling responses in vitro and in vivo

Overexpression of centromere protein K (CENP-K) gene in hepatocellular carcinoma promote cell proliferation by activating AKT/TP53 signal pathway

CBP501 inhibits EGF-dependent cell migration, invasion and epithelial-to–mesenchymal transition of non-small cell lung cancer cells by blocking KRas to calmodulin binding

Neuropilin-1 is a glial cell line-derived neurotrophic factor receptor in glioblastoma

Promoter hypomethylation of NY-ESO-1, association with clinicopathological features and PD-L1 expression in non-small cell lung cancer

Patient-specific molecular alterations are associated with metastatic clear cell renal cell cancer progressing under tyrosine kinase inhibitor therapy

Preclinical data on the combination of cisplatin and anti-CD70 therapy in non-small cell lung cancer as an excellent match in the era of combination therapy

Regulation of human glioblastoma cell death by combined treatment of cannabidiol, γ-radiation and small molecule inhibitors of cell signaling pathways

Correlation analysis between molecular subtypes and Nottingham Prognostic Index in breast cancer

ERG overexpression plus SLC45A3 (prostein) and PTEN expression loss: Strong association of the triple hit phenotype with an aggressive pathway of prostate cancer progression

Vitamin D receptor-binding site variants affect prostate cancer progression

Correlation of thyroid stimulating hormone receptor mRNA expression levels in peripheral blood with undesirable clinicopathological features in papillary thyroid carcinoma patients

RNA-sequencing investigation identifies an effective risk score generated by three novel lncRNAs for the survival of papillary thyroid cancer patients

⁶⁴Cu-PSMA-617: A novel PSMA-targeted radio-tracer for PET imaging in gastric adenocarcinoma xenografted mice model

Expression differences of programmed death ligand 1 in de-novo and recurrent glioblastoma multiforme

Overexpression of CHD1L is associated with poor survival and aggressive tumor biology in esophageal carcinoma

Release of HER2 repression of trefoil factor 3 (TFF3) expression mediates trastuzumab resistance in HER2+/ER+ mammary carcinoma

The additive effects of the TM6SF2 E167K and PNPLA3 I148M polymorphisms on lipid metabolism

A novel pan-Nox inhibitor, APX-115, protects kidney injury in streptozotocin-induced diabetic mice: possible role of peroxisomal and mitochondrial biogenesis

BRCA1 and BRCA2 founder mutations account for 78% of germline carriers among hereditary breast cancer families in Chile

A peptidomimetic with a chiral switch is an inhibitor of epidermal growth factor receptor heterodimerization

Annexin A5 suppresses cyclooxygenase-2 expression by downregulating the protein kinase C-ζ–nuclear factor-κB signaling pathway in prostate cancer cells

miR-146a promotes growth of osteosarcoma cells by targeting ZNRF3/GSK-3β/β-catenin signaling pathway

Clinicopathological characteristics and survival outcomes of invasive lobular carcinoma in different races

Effect of p53 on pancreatic cancer-glucose tolerance abnormalities by regulating transglutaminase 2 in resistance to glucose metabolic stress

Rs7911488 modified the efficacy of capecitabine-based therapy in colon cancer through altering miR-1307-3p and TYMS expression

Melatonin attenuated the brain damage and cognitive impairment partially through MT2 melatonin receptor in mice with chronic cerebral hypoperfusion

Generation of DKK1 transgenic Tibet minipigs by somatic cell nuclear transfer (SCNT)

Tissue microarray staining reveals PLD1 and Sp1 have a collaborative, pro-tumoral effect in patients with osteosarcomas

Upregulated SLC22A3 has a potential for improving survival of patients with head and neck squamous cell carcinoma receiving cisplatin treatment

Association of sirtuins with clinicopathological parameters and overall survival in gastric cancer

Relevance between GerdQ score and the severity of reflux esophagitis in Uygur and Han Chinese

Cancer testis antigen Sperm Protein 17 as a new target for triple negative breast cancer immunotherapy

Fatty acid synthase expression and its association with clinico-histopathological features in triple-negative breast cancer

Tenascin-C induces migration and invasion through JNK/c-Jun signalling in pancreatic cancer

Altered expression of target genes of spinal cord in different itch models compared with capsaicin assessed by RT-qPCR validation

Lysine-specific demethylase 1 (LSD1) destabilizes p62 and inhibits autophagy in gynecologic malignancies

Targeting transferrin receptor delivery of temozolomide for a potential glioma stem cell-mediated therapy

The significance of lumican expression in ovarian cancer drug-resistant cell lines

FAM83D, a microtubule-associated protein, promotes tumor growth and progression of human gastric cancer

Withaferin A (WFA) inhibits tumor growth and metastasis by targeting ovarian cancer stem cells

CCN3 promotes epithelial-mesenchymal transition in prostate cancer via FAK/Akt/HIF-1α-induced Twist expression

GABARAPL1 acts as a potential marker and promotes tumor proliferation and metastasis in triple negative breast cancer

Maslinic acid promotes autophagy by disrupting the interaction between Bcl2 and Beclin1 in rat pheochromocytoma PC12 cells

High amplification of FGFR1 gene is a delayed poor prognostic factor in early stage ESCC patients

Identification of microRNA differentially expressed in three subtypes of non-small cell lung cancer and in silico functional analysis

The H19-PEG10/IGF2BP3 axis promotes gastric cancer progression in patients with high lymph node ratios

Anti-inflammatory effects of millet bran derived-bound polyphenols in LPS-induced HT-29 cell via ROS/miR-149/Akt/NF-κB signaling pathway

Genetic variants of PDGF signaling pathway genes predict cutaneous melanoma survival

Global gene expression profile of cerebral ischemia-reperfusion injury in rat MCAO model

Downregulation of microRNA-31 inhibits proliferation and induces apoptosis by targeting HIF1AN in human keloid

Hypoxia negates hyperglycaemia-induced chemo-resistance in breast cancer cells: the role of insulin-like growth factor binding protein 2

Fasting inhibits colorectal cancer growth by reducing M2 polarization of tumor-associated macrophages

Radiation-resistant cancer stem-like cell properties are regulated by PTEN through the activity of nuclear β-catenin in nasopharyngeal carcinoma

Metformin inhibits esophageal squamous cell carcinoma-induced angiogenesis by suppressing JAK/STAT3 signaling pathway

CC-115, a dual inhibitor of mTOR Kinase and DNA-PK, blocks DNA damage repair pathways and selectively inhibits ATM-deficient cell growth in vitro

Transcriptome analysis of human colorectal cancer biopsies reveals extensive expression correlations among genes related to cell proliferation, lipid metabolism, immune response and collagen catabolism

Cigarette smoke promotes COPD by activating platelet-activating factor receptor and inducing neutrophil autophagic death in mice

Fascin promotes migration and invasion and is a prognostic marker for oral squamous cell carcinoma

KRAS-driven miR-29b expression is required for tumor suppressor gene silencing

Phosphorylation and degradation of αB-crystallin during enterovirus infection facilitates viral replication and induces viral pathogenesis

Beclin 1 acetylation impairs the anticancer effect of aspirin in colorectal cancer cells

Diallyl trisulfide exerts cardioprotection against myocardial ischemia-reperfusion injury in diabetic state, role of AMPK-mediated AKT/GSK-3β/HIF-1α activation

PTMA, a new identified autoantigen for oral submucous fibrosis, regulates oral submucous fibroblast proliferation and extracellular matrix

Mitochondrial pathway is involved in the protective effects of alpha-ketoglutarate on hydrogen peroxide induced damage to intestinal cells

Let-7d increases ovarian cancer cell sensitivity to a genistein analog by targeting c-Myc

Molecular profiling identifies prognostic markers of stage IA lung adenocarcinoma

B7-H3 combats apoptosis induced by chemotherapy by delivering signals to pancreatic cancer cells

Exploration and validation of radiomics signature as an independent prognostic biomarker in stage III-IVb nasopharyngeal carcinoma

Obese donor mice splenocytes aggravated the pathogenesis of acute graft-versus-host disease via regulating differentiation of Tregs and CD4⁺ T cell induced-type I inflammation

Immunohistochemistry cannot replace DNA analysis for evaluation of BRAF V600E mutations in papillary thyroid carcinoma

Kinetic change of serum carcinoembryonic antigen can early predict progression in patients with metastatic non-small cell lung cancer during maintenance therapy with bevacizumab plus pemetrexed

A genome-wide association analysis identifies PDE1A|DNAJC10 locus on chromosome 2 associated with idiopathic pulmonary arterial hypertension in a Japanese population

Impact of non-alcoholic fatty liver disease and smoking on colorectal polyps

Common, germline genetic variations in the novel tumor suppressor BAP1 and risk of developing different types of cancer

Sphingosine kinase 1/sphingosine-1-phosphate (S1P)/S1P receptor axis is involved in ovarian cancer angiogenesis

TUFT1 is expressed in breast cancer and involved in cancer cell proliferation and survival

Prognostic role of the neutrophil-to-lymphocyte ratio in patients with primary central nervous system lymphoma

Cabozantinib-induced osteoblast secretome promotes survival and migration of metastatic prostate cancer cells in bone

Comprehensive analysis of a novel four-lncRNA signature as a prognostic biomarker for human gastric cancer

2'-Hydroxyflavanone: A novel strategy for targeting breast cancer

Immethridine, histamine H₃-receptor (H₃R) agonist, alleviated experimental autoimmune encephalomyelitis via inhibiting the function of dendritic cells

Activation of CaMKIIγ potentiates T-cell acute lymphoblastic leukemia leukemogenesis via phosphorylating FOXO3a

Nicotine suppresses apoptosis by regulating α7nAChR/Prx1 axis in oral precancerous lesions

Loss of cadherin related family member 5 (CDHR5) expression in clear cell renal cell carcinoma is a prognostic marker of disease progression

Development of a preprocedure nomogram for predicting contrast-induced acute kidney injury after coronary angiography or percutaneous coronary intervention

Differences in modifiable factors of oral squamous cell carcinoma in the upper and lower of oral fissure

Lasp1 promotes malignant phenotype of non-small-cell lung cancer via inducing phosphorylation of FAK-AKT pathway

Dietary menthol-induced TRPM8 activation enhances WAT “browning” and ameliorates diet-induced obesity

Stabilization of the transcription factors slug and twist by the deubiquitinase dub3 is a key requirement for tumor metastasis

Association of a common genetic variant in RNASEL and prostate cancer susceptibility

Non-response to preoperative chemotherapy is a contraindication to hepatectomy plus radiofrequency ablation in patients with colorectal liver metastases

Preclinical PET imaging of HIP/PAP using 1'-¹⁸F-fluoroethyl-β-D-lactose

Correlation between KLOTHO gene and mild cognitive impairment in the Uygur and Han populations of Xinjiang

Prognostic factors associated with locally advanced gastric cancer patients treated with neoadjuvant chemotherapy followed by surgical resection

Prognostic value of a novel FPR biomarker in patients with surgical stage II and III gastric cancer

Metformin partially reverses the carboplatin-resistance in NSCLC by inhibiting glucose metabolism

Analyses of functions of an anti-PD-L1/TGFβR2 bispecific fusion protein (M7824)

Novel histone deacetylase inhibitor N25 exerts anti-tumor effects and induces autophagy in human glioma cells by inhibiting HDAC3

Decreased TOB1 expression and increased phosphorylation of nuclear TOB1 promotes gastric cancer

Regulation of malonyl-CoA-acyl carrier protein transacylase network in umbilical cord blood affected by intrauterine hyperglycemia

Whole-exome sequencing reveals genetic variants in ERC1 and KCNG4 associated with complete hydatidiform mole in Chinese Han women

Rab27A overexpression promotes bladder cancer proliferation and chemoresistance through regulation of NF-κB signaling

LncRNA HSP90AA1-IT1 promotes gliomas by targeting miR-885-5p-CDK2 pathway

IκB-kinase-ε in the tumor microenvironment is essential for the progression of gastric cancer

Metformin treatment after the hypoxia-ischemia attenuates brain injury in newborn rats

Pulmonary function impairment predicted poor prognosis of patients with hepatocellular carcinoma after hepatectomy

Prognostic value of the microRNA-214 in multiple human cancers: a meta-analysis of observational studies

Tumor-infiltrating FoxP3⁺ Tregs predict favorable outcome in colorectal cancer patients: A meta-analysis

Meta-analysis of incidence and risk of severe adverse events and fatal adverse events with crizotinib monotherapy in patients with ALK-positive NSCLC

Prognostic role of systemic immune-inflammation index in solid tumors: a systematic review and meta-analysis

The association between obesity related adipokines and risk of breast cancer: a meta-analysis

Diagnostic accuracy of PCR for detecting ALK gene rearrangement in NSCLC patients: A systematic review and meta-analysis

Statin use and non-melanoma skin cancer risk: a meta-analysis of randomized controlled trials and observational studies

Diagnostic value of contrast-enhanced ultrasound in hepatocellular carcinoma: a meta-analysis with evidence from 1998 to 2016

The prognostic effect of LINC00152 for cancer: a meta-analysis

Associations between apparent diffusion coefficient (ADC) and KI 67 in different tumors: a meta-analysis. Part 1: ADC_mean

Association between C-reactive protein and risk of schizophrenia: An updated meta-analysis

LncRNA PVT1 as an effective biomarker for cancer diagnosis and detection based on transcriptome data and meta-analysis

Factor V G1691A is associated with an increased risk of retinal vein occlusion: a meta-analysis

Clinicopathological impacts of high c-Met expression in renal cell carcinoma: a meta-analysis and review

Association of COL1A1 rs1800012 polymorphism with musculoskeletal degenerative diseases: a meta-analysis

MET inhibitors in advanced non-small-cell lung cancer: a meta-analysis and review

Relationship between rs1801157 polymorphism in stromal cell-derived factor gene and systemic lupus erythematosus risk

TACC3 as an independent prognostic marker for solid tumors: a systematic review and meta-analysis

Prognostic value of HER-2/neu expression in epithelial ovarian cancer: a systematic review and meta-analysis

Concurrent preoperative chemotherapy and three-dimensional conformal radiotherapy followed by surgery for oral squamous cell carcinoma: a retrospective analysis of 104 cases

Cost-utility of stereotactic radiation therapy versus proton beam therapy for inoperable advanced hepatocellular carcinoma

A large-scale retrospective study of the overall survival outcome in nasopharyngeal carcinoma with hypertension in Chinese population

Clinical study of ^99mTc-3P-RGD2 peptide imaging in osteolytic bone metastasis

The value of diffusion kurtosis imaging in assessing pathological complete response to neoadjuvant chemoradiation therapy in rectal cancer: a comparison with conventional diffusion-weighted imaging

Clinical application and outcomes of sentinel node navigation surgery in patients with early gastric cancer

Efficacy of adjuvant chemotherapy with carboplatin for early triple negative breast cancer: a single center experience

Prognostic analysis of radical resection for intrahepatic cholangiocarcinoma: a retrospective cohort study

Age-sex distribution of patients with high-sensitivity troponin T levels below the 99th percentile

Long noncoding RNA CCAT2 as a novel biomaker of metastasis and prognosis in human cancer: a meta-analysis

Overcoming resistance to targeted therapy with immunotherapy and combination therapy for metastatic melanoma

The conundrum of the Epstein-Barr virus-associated gastric carcinoma in the Americas

The application of enhanced recovery after surgery (ERAS)/fast-track surgery in gastrectomy for gastric cancer: a systematic review and meta-analysis

EGFR TKI as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer

Dual roles of yes-associated protein (YAP) in colorectal cancer

Cell-free circulating tumor DNA analysis for breast cancer and its clinical utilization as a biomarker

Stem cells in cancer therapy: opportunities and challenges

Potential application of the oxidative nucleic acid damage biomarkers in detection of diseases