Associations between apparent diffusion coefficient (ADC) and KI 67 in different tumors: a meta-analysis. Part 1: ADCmean

Alexey Surov _, Hans Jonas Meyer and Andreas Wienke

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Oncotarget. 2017; 8:75434-75444. https://doi.org/10.18632/oncotarget.20406

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Alexey Surov1,*, Hans Jonas Meyer1,* and Andreas Wienke2,*

1Department of Diagnostic and Interventional Radiology, University of Leipzig, Leipzig, Germany

2Institute of Medical Epidemiology, Biostatistics, and Informatics, Martin Luther University of Halle-Wittenberg, Halle, Germany

*These authors contributed equally to this work

Correspondence to:

Alexey Surov, email: [email protected]

Keywords: diffusion weighted imaging, ADC, ki 67

Received: June 23, 2017     Accepted: August 15, 2017     Published: August 24, 2017


Diffusion weighted imaging (DWI) is a magnetic resonance imaging (MRI) technique based on measure of water diffusion in tissues. This diffusion can be quantified by apparent diffusion coefficient (ADC). Some reports indicated that ADC can reflect tumor proliferation potential. The purpose of this meta-analysis was to provide evident data regarding associations between ADC and KI 67 in different tumors. Studies investigating the relationship between ADC and KI 67 in different tumors were identified.

MEDLINE library was screened for associations between ADC and KI 67 in different tumors up to April 2017. Overall, 42 studies with 2026 patients were identified. The following data were extracted from the literature: authors, year of publication, number of patients, tumor type, and correlation coefficients.

Associations between ADC and KI 67 were analyzed by Spearman's correlation coefficient. The reported Pearson correlation coefficients in some studies were converted into Spearman correlation coefficients.

The pooled correlation coefficient between ADCmean and KI 67 for all included tumors was ρ = −0.44. Furthermore, correlation coefficient for every tumor entity was calculated. The calculated correlation coefficients were as follows: ovarian cancer: ρ = −0.62, urothelial carcinomas: ρ = −0.56, cerebral lymphoma: ρ = −0.55, neuroendocrine tumors: ρ = −0.52, glioma: ρ = −0.51, lung cancer: ρ = −0.50, prostatic cancer: ρ = −0.43, rectal cancer: ρ = −0.42, pituitary adenoma:ρ = −0.44, meningioma, ρ = −0.43, hepatocellular carcinoma: ρ = −0.37, breast cancer: ρ = −0.22.

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