Comprehensive analysis of a novel four-lncRNA signature as a prognostic biomarker for human gastric cancer
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Yan Miao1,*, Jing Sui1,*, Si-Yi Xu1, Ge-Yu Liang1, Yue-Pu Pu1 and Li-Hong Yin1
1Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, Jiangsu 210009, P.R. China
*These authors have contributed equally to this work
Li-Hong Yin, email: [email protected]
Keywords: lncRNA, GC, prognostic biomarker, overall survival, TCGA
Received: June 09, 2017 Accepted: July 26, 2017 Published: August 24, 2017
Emerging evidence indicates that long non-coding RNAs (lncRNAs) play a crucial role in predicting survival for gastric cancer (GC) patients. This study aims to identify a lncRNA-related signature for evaluating the overall survival of 379 GC patients from The Cancer Genome Atlas (TCGA) database. The associations between survival outcome and the expression of lncRNAs were evaluated by the univariate and multivariate Cox proportional hazards regression analyses. Four lncRNAs (LINC01018, LOC553137, MIR4435-2HG, and TTTY14) were identified as significantly correlated with overall survival. These four lncRNAs were gathered as a single prognostic signature. There was a significant positive correlation between GC patients with low-risk scores and overall survival (P = 0.001). Further analysis suggested that the prognostic value of this four-lncRNA signature was independent in clinical features. Gene set enrichment analysis found that these four lncRNAs were correlated with several molecular pathways of the tumor. Our study indicates that this novel lncRNA expression signature may be a useful biomarker of the prognosis for GC patients, based on bioinformatics analysis.
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