Correlation analysis between molecular subtypes and Nottingham Prognostic Index in breast cancer
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Hongchao Zhen1, Liuting Yang2, Li Li1, Junxian Yu3, Lei Zhao1, Yingying Li4 and Qin Li1
1Department of Oncology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China
2Department of Biochemistry and Molecular Biology, Basic Medical College, Shanxi Medical University, Taiyuan, 030001, China
3Department of Pharmacy, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China
4Department of Pathology and Pathophysiology, Basic Medical College, Capital Medical University, Beijing, 100069, China
Qin Li, email: [email protected]
Keywords: molecular subtypes, Nottingham Prognostic Index, breast cancer, prognosis, correlation analysis
Received: October 29, 2016 Accepted: May 14, 2017 Published: May 27, 2017
Molecular subtypes and Nottingham Prognostic Index (NPI) are both prognostic models for breast cancer patients. We evaluated the association between molecular subtypes and NPI in 1042 breast cancer patients. The molecular subtypes indicating poorer prognosis were positively correlated to higher NPI (r = 0.138, P = 0.001). ER positive expression and PR high expression were positively correlated with NPI (r = 0.142, P = 0.001; r = 0.139, P = 0.001; respectively) and negatively correlated with histological grade (r = −0.233, P < 0.001; r = −0.176, P < 0.001; respectively). Ki67 status was negatively correlated with NPI and positively correlated with histological grade (r = −0.120, P =0.004; r = 0.197, P < 0.001; respectively). The percentages of cases with NPI score 2.00–3.40 were higher in the luminar A, ER+, PR high expression and Ki67 low expression group, and the percentages of cases with NPI > 5.40 were higher in the HER2 overexpression subtype, basal-like subtype, ER-, PR low/negative expression, and Ki67 high expression groups. The excellent consistence was observed between histological grade and molecular subtypes, ER, PR, Ki67. The difference of histological grade between the HER2 positive and negative group was statistically significant. In conclusion, there was closely association between molecular subtypes and NPI in breast cancer. For further comparing the prognostic significance of molecular subtypes and NPI, survival analyses should be performed on the same population in a large-scale prospective study.
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