Oncotarget

Research Papers:

Pulmonary function impairment predicted poor prognosis of patients with hepatocellular carcinoma after hepatectomy

Yanhua Zhao, Shusheng Leng, Dongdong Li, Shu Feng, Zhonghao Wang and Chuanmin Tao _

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Oncotarget. 2017; 8:75326-75335. https://doi.org/10.18632/oncotarget.20850

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Abstract

Yanhua Zhao1, Shusheng Leng2, Dongdong Li1, Shu Feng1, Zhonghao Wang1 and Chuanmin Tao1

1Department of Laboratory Medicine/Clinical Research Center of Laboratory Medicine, West China Hospital of Sichuan University, Chengdu 610041, China

2General Surgery Department, Affiliated Hospital/Clinical Medical College of Chengdu University, Chengdu 610081, China

Correspondence to:

Chuanmin Tao, email: taocm@scu.edu.cn

Shusheng Leng, email: lengshusheng@hotmail.com

Keywords: hepatocellular carcinoma, pulmonary function, hypoxia, prognosis

Received: July 03, 2017    Accepted: August 17, 2017    Published: September 12, 2017

ABSTRACT

Tumor hypoxia can influence the progression and metastasis of various cancers, including hepatocellular carcinoma (HCC). Clinical studies have indicated that hyperbaric oxygen may improve the prognosis and reduce complications in HCC patients; however, whether pulmonary function can influence the prognosis of HCC remains unknown. In this study, we found that pulmonary function was associated with clinicopathological features, including smoking, liver cirrhosis, tumor size Edmondson-Steiner grade, total operative blood loss and perioperative blood transfusion. Through Cox proportional hazard regression analysis, smoking, tumor number, tumor size, liver cirrhosis, total operative blood loss and pulmonary function were independent risk factors for overall survival (OS) and disease-free survival (DFS). In addition, poor pulmonary function was independently associated with shorter survival and increased HCC recurrence in patients. Notably, we also found that HCC with liver cirrhosis predicted worse prognosis. In summary, our study found pulmonary function could influence HCC progression. Improve pulmonary function may enhance the OS and DFS of patients with HCC.


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