Relationship between rs1801157 polymorphism in stromal cell-derived factor gene and systemic lupus erythematosus risk
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Can Qian1,*, Qinghua Zou1,* and Yong Wang1
1Department of Rheumatology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
*These authors contributed equally to this work
Yong Wang, email: [email protected]
Keywords: SDF-1, polymorphism, SLE, meta-analysis
Received: July 04, 2016 Accepted: April 18, 2017 Published: August 01, 2017
Objective: Present meta-analysis was performed to investigate the role of stromal cell-derived factor (SDF-1) gene rs1801157 polymorphism in systemic lupus erythematosus (SLE).
Results: Five publications with 1,087 cases and 1,181 controls were incorporated in this meta-analysis. Overall, a marginal association between SDF-1 rs1801157 polymorphism and reduced SLE risk was found under GA vs. GG model (OR = 0.84, 95% CI = 0.70–1.00). A similar result was also observed in Asian subgroup under the same comparison after stratification analysis by ethnicity (OR = 0.79, 95% CI = 0.63–1.00).
Materials and Methods: All included studies were retrieved from PubMed, EMBASE, Google Scholar Web and Chinese National Knowledge Infrastructure (CNKI). Odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated to appraise the strength of association between SDF-1 rs1801157 polymorphism and SLE risk. The stratification analysis was also performed according to ethnicity. In addition, heterogeneity was examined with Q test, and sensitivity analysis was used to test the stability of final results. Begg’s funnel plot and Egger’s test were adopted to evaluate publication bias.
Conclusions: SDF-1 rs1801157 polymorphism may not influence the risk of SLE. However, more studies with larger sample sizes involving different populations are needed to further explore this issue.
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