Clinical Research Papers:

Age-sex distribution of patients with high-sensitivity troponin T levels below the 99th percentile

Jie-Yin Liu, Qiao-Wei Jia, Xiao-Ling Zang, Rong-Hu Wang, Chun-Jian Li, Lian-Sheng Wang, Wen-Zhu Ma, Zhi-Jian Yang and En-Zhi Jia _

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Oncotarget. 2017; 8:75638-75645. https://doi.org/10.18632/oncotarget.20328

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Jie-Yin Liu1,*, Qiao-Wei Jia1,*, Xiao-Ling Zang1, Rong-Hu Wang1, Chun-Jian Li1, Lian-Sheng Wang1, Wen-Zhu Ma1, Zhi-Jian Yang1 and En-Zhi Jia1

1First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China

*These authors contributed equally to this work

Correspondence to:

En-Zhi Jia, email: [email protected]

Keywords: high-sensitivity troponin T, the 99th percentile, myoglobin, creatine kinase-MB

Received: May 03, 2017     Accepted: August 06, 2017     Published: August 18, 2017


Background: Recently, very low concentrations of high-sensitivity cardiac troponin T (hs-cTnT), below the 99th percentile, have been used to immediately exclude acute myocardial infarction in certain patients without taking their age and sex into consideration.

Results: The hs-cTnT values below the 99th percentile (≤ 14 ng/L) were higher in men (p = 0.000) and significantly increased with age (p = 0.000) among both men and women. In addition, hs-cTnT was positively associated with age (r = 0.459, p = 0.000), myoglobin (r = 0.392, p = 0.000), and creatine kinase-MB (r = 0.133, p = 0.000). Moreover, males were younger (p = 0.001) and had higher myoglobin (p = 0.000) and creatine kinase-MB (p = 0.000) concentrations than females.

Materials and Methods: A total of 5585 consecutive subjects who presented with non-traumatic chest pain/discomfort to the inpatient, outpatient, or emergency department and who underwent high-sensitivity troponin T, myoglobin and creatine kinase-MB testing at presentation, with hs-cTnT below the 99thpercentile (≤ 14 ng/L), were eligible for enrollment.

Conclusions: We suggest that patients’ age, sex and levels of myocardial injury biomarkers should be taken into consideration when ruling out acute myocardial infarction and/or adverse prognostic implications in patients who have very low hs-cTnT concentrations.

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