Oncotarget

Research Papers:

Prognostic factors associated with locally advanced gastric cancer patients treated with neoadjuvant chemotherapy followed by surgical resection

Yongkun Sun, Lin Yang _, Chengfeng Wang, Dongbing Zhao, Jianqiang Cai, Wenbin Li, Wen Zhang, Jing Huang and Aiping Zhou

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Oncotarget. 2017; 8:75186-75194. https://doi.org/10.18632/oncotarget.20660

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Abstract

Yongkun Sun1, Lin Yang1, Chengfeng Wang1, Dongbing Zhao1, Jianqiang Cai1, Wenbin Li1, Wen Zhang1, Jing Huang1 and Aiping Zhou1

1National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

Correspondence to:

Lin Yang, email: lyang69@sina.com

Keywords: prognostic factors, locally advanced gastric cancer, neoadjuvant chemotherapy, gastrectomy

Received: February 07, 2017     Accepted: July 25, 2017     Published: September 06, 2017

ABSTRACT

In this retrospective study, we analyzed prognostic factors associated with survival outcomes in 73 locally advanced gastric cancer patients treated with neoadjuvant chemotherapy (NAC) followed by surgical resection. Median disease-free survival (DFS) for 64 patients that received R0 resection was 685 days, whereas median overall survival (OS) for 73 patients was 930 days. Multivariate analysis demonstrated that post-treatment nodal stages (P = 0.002), nervous invasion (P = 0.0492) and serum CA199 levels (P = 0.0398) were independent prognostic factors for DFS. Nodal stages (P = 0.0007), presence of nervous invasion (P = 0.0259) and non-radical resection (P = 0.0165) were independent prognostic factors for OS. These results indicate that post-treatment nodal stages, neural invasion and serum CA199 levels are all associated with poor DFS. Moreover, post-treatment nodal stage, resection type and neural invasion status are independent prognostic factors for OS.


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