Impact of non-alcoholic fatty liver disease and smoking on colorectal polyps
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Qin-Fen Chen1,*, Xiao-Dong Zhou2,*, Dan-Hong Fang3, Yang-Jie Sun1, Qian Zhao1, Jun-Hua Huang1, Yin Jin1 and Jian-Sheng Wu3
1Department of Gastroenterology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China
2Department of Cardiovascular Medicine, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China
3Medical and Health Care Center, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China
Keywords: colorectal polyps, smoking, non-alcoholic fatty liver disease, health check
Received: February 27, 2017 Accepted: July 25, 2017 Published: August 24, 2017
Objectives: Non-alcoholic fatty liver disease (NAFLD) and smoking have similar mechanisms of promoting colorectal polyps. The potential link between NAFLD and smoking in men and colorectal polyps has not been adequately evaluated. The aim is to investigate this association.
Methods: A retrospective cross-sectional study was conducted on 2409 individuals undergoing a health check. Univariate and multivariate logistic regression were performed for analyzing the association between risk factors and colorectal polyps. Individuals were divided into four groups: Q1: NAFLD (-)/smoking (-); Q2: NAFLD (+)/smoking (-); Q3: NAFLD (-)/smoking (+); Q4: NAFLD (+)/smoking (+). Logistic analyses were used to explore associations for the whole study population and stratified groups.
Results: The prevalence of colorectal polyps was 38.8% in males, and that of colorectal polyps in smokers and individuals with NAFLD were 47.0% (428/911) and 42.9% (267/622), respectively. With Q1 as reference, subjects with NAFLD (+) and smoking habits (+) had the highest ORs for colorectal polyps (OR = 2.64, 95% CI: 1.91 - 3.64, P < 0.001), adenomatous polyps (OR = 2.06, 95% CI: 1.38 - 3.05, P < 0.05), non-adenomatous polyps (OR = 1.97, 95% CI: 1.39 - 2.80, P < 0.05), ≥ 3 polyps (OR = 2.05, 95% CI: 1.31 - 3.22, P < 0.05) and proximal polyps (OR = 1.58, 95% CI: 1.02 - 2.45, P < 0.05) after adjusting for confounding variables.
Conclusions: Men with NAFLD and smoking habits have an increasing risk of colorectal polyps.
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