Research Papers:

Differences in modifiable factors of oral squamous cell carcinoma in the upper and lower of oral fissure

Lingjun Yan, Fa Chen, Fengqiong Liu, Yu Qiu, Jing Wang, Junfeng Wu, Xiaodan Bao, Zhijian Hu, Xiane Peng, Xu Lin, Lin Cai, Lisong Lin _ and Baochang He

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Oncotarget. 2017; 8:75094-75101. https://doi.org/10.18632/oncotarget.20520

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Lingjun Yan1,2,*, Fa Chen1,2,*, Fengqiong Liu1,2,*, Yu Qiu4,5, Jing Wang6, Junfeng Wu1,3, Xiaodan Bao1,3, Zhijian Hu1,2, Xiane Peng1,2, Xu Lin2,3, Lin Cai1, Lisong Lin4,5 and Baochang He1,2

1Department of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fujian, China

2Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fujian, China

3Fujian Key Laboratory of Tumor Microbiology, Fujian Medical University, Fujian, China

4Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Fujian Medical University, Fujian, China

5Laboratory of Facial Plastic and Reconstruction of Fujian Medical University, Fujian, China

6Laboratory Center, The Major Subject of Environment and Health of Fujian Key Universities, School of Public Health, Fujian Medical University, Fujian, China

*These authors have contributed equally to the work

Correspondence to:

Lisong Lin, email: [email protected]

Baochang He, email: [email protected]

Keywords: oral squamous cell carcinoma, oral fissure, modifiable factors, alcohol consumption, case-control study

Received: June 14, 2017    Accepted: August 04, 2017    Published: August 24, 2017


The aim of this study was to explore differences in the effects of modifiable factors on oral squamous cell carcinoma (OSCC) occurring in the lower oral fissure (LOF) and upper oral fissure (UOF). We conducted a case-control study with 697 OSCC patients (119 UOF and 578 LOF) and 1910 frequency-matched controls in Fujian province, China. Data on demographic characteristics and possible modifiable factors was collected using a structured questionnaire. Unconditional logistic regression was utilized to calculate the odds ratios (ORs) and corresponding 95% confidence intervals (CIs). Alcohol drinking was more strongly associated with an increased risk of OSCC-LOF than OSCC-UOF. Tobacco smoking, the number of teeth lost ≥5, wearing denture, and recurrent oral ulceration showed similarly associations with OSCC-LOF and -UOF risk. Similarly, the beneficial effects of tea consumption, tooth-brushing ≥2times per day, high intake of fresh fish, seafood, green-leafy vegetables, other vegetables and fruits were not significantly different on OSCC-LOF and -UOF. Although most of the modifiable factors exert similar effects on both OSCC sites, this study suggests that the sites of oral cavity in LOF may be affected more by alcohol drinking than the sites in UOF. Further studies with larger samples are warranted to confirm our findings.

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