Potential application of the oxidative nucleic acid damage biomarkers in detection of diseases

Cheng Guo _, Peili Ding, Cong Xie, Chenyang Ye, Minfeng Ye, Chi Pan, Xiaoji Cao, Suzhan Zhang and Shu Zheng

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Oncotarget. 2017; 8:75767-75777. https://doi.org/10.18632/oncotarget.20801

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Cheng Guo1,*, Peili Ding1,*, Cong Xie1,2, Chenyang Ye1, Minfeng Ye1,3, Chi Pan1, Xiaoji Cao2, Suzhan Zhang1,4 and Shu Zheng1,4

1Cancer Institute, Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China

2College of Chemical Engineering, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, China

3Department of Gastrointestinal Surgery, Shaoxing People’s Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing, Zhejiang 312000, China

4Research Center for Air Pollution and Health, Zhejiang University, Hangzhou, Zhejiang 310009, China

*These authors contributed equally to this work

Correspondence to:

Cheng Guo, email: [email protected]

Xiaoji Cao, email: [email protected]

Suzhan Zhang, email: [email protected]

Keywords: oxidative DNA damage, oxidative RNA damage, ROS, biomarker, cancer

Received: July 15, 2017     Accepted: August 27, 2017     Published: September 08, 2017


Reactive oxygen species (ROS) are generated after exposure to harmful environmental factors and during normal cellular metabolic processes. The balance of the generating and scavenging of ROS plays a significant role in living cells. The accumulation of ROS will lead to oxidative damage to biomolecules including nucleic acid. Although many types of oxidative nucleic acid damage products have been identified, 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-oxodG) and 8-oxo-7,8-dihydroguanosine (8-oxoG) has been commonly chosen as the biomarkers of oxidative damage to DNA and RNA, respectively. It has been demonstrated that oxidative damage to nucleic acid is an initiator in pathogenesis of numerous diseases. Thus, oxidative nucleic acid damage biomarkers have the potential to be utilized for detection of diseases. Herein, we reviewed the relationship of oxidative nucleic acid damage and development of various diseases including cancers (colorectal cancer, gastrointestinal cancer, breast cancer, lung cancer, epithelial ovarian carcinoma, esophageal squamous cell carcinoma), neurodegenerative disorders and chronic diseases (diabetes and its complications, cardiovascular diseases). The potential of oxidative nucleic acid damage biomarkers for detection of diseases and drug development were described. Moreover, the approaches for detection of these biomarkers were also summarized.

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