Factor V G1691A is associated with an increased risk of retinal vein occlusion: a meta-analysis

Yuanyuan Zou _, Xi Zhang, Jingyi Zhang, Xiangning Ji and Yuqing Liu

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Oncotarget. 2017; 8:75467-75477. https://doi.org/10.18632/oncotarget.20636

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Yuanyuan Zou1, Xi Zhang1, Jingyi Zhang1, Xiangning Ji1 and Yuqing Liu1

1The Second Department of Ophthalmology, Cangzhou Central Hospital, 061001, Cangzhou, PR China

Correspondence to:

Yuanyuan Zou, email: [email protected]

Keywords: factor V, retinal vein occlusion, polymorphism, meta-analysis

Received: June 27, 2017     Accepted: August 17, 2017     Published: September 04, 2017


We performed a meta-analysis to investigate the association between the Factor V G1691A polymorphism and the risk of retinal vein occlusion (RVO). This analysis included 37 studies involving 2,510 cases and 3,466 controls. Factor V G1691A was associated with an increased risk of RVO in the allele, heterozygote, dominant, and carrier models (PA < 0.001, odds ratios >1), but not the homozygote or recessive models (PA > 0.05). Similar results were observed in a meta-analysis of central retinal vein occlusion (CRVO) and when comparing Caucasian subgroups to population-based controls. These data demonstrate that the G/A genotype of Factor V G1691A is associated with an increased risk of RVO/CRVO in a Caucasian population.

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