Prognostic analysis of radical resection for intrahepatic cholangiocarcinoma: a retrospective cohort study

Qingqiang Ni; Weifeng Shen; Minfeng Zhang; Cheng Yang; Wenchang Cai; Mengchao Wu; Jiamei Yang

doi:10.18632/oncotarget.18465

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Clinical Research Papers:

Prognostic analysis of radical resection for intrahepatic cholangiocarcinoma: a retrospective cohort study

Qingqiang Ni, Weifeng Shen _, Minfeng Zhang, Cheng Yang, Wenchang Cai, Mengchao Wu and Jiamei Yang

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Oncotarget. 2017; 8:75627-75637. https://doi.org/10.18632/oncotarget.18465

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Abstract

Qingqiang Ni1,2, Weifeng Shen2, Minfeng Zhang2, Cheng Yang2, Wenchang Cai2, Mengchao Wu2 and Jiamei Yang2

1 Medical College of Soochow University, Suzhou, Jiangsu, China

2 Department of Special Treatment and Liver Transplantation, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China

Correspondence to:

Weifeng Shen, email:

Jiamei Yang, email:

Keywords: intrahepatic cholangiocarcinoma, radical resection, disease-free survival, overall survival, retrospective cohort study

Received: June 21, 2016 Accepted: March 09, 2017 Published: June 13, 2017

Abstract

The aim of this study was to investigate the relationship between the clinicopathological characteristics of intrahepatic cholangiocarcinoma (ICC) and both disease-free survival (DFS) and overall survival (OS) in intrahepatic cholangiocarcinoma (ICC) patients who underwent radical resection (R0). We retrospectively analyzed the clinicopathological characteristics of 319 patients who underwent radical resection of ICC between October 1999 and December 2003. The independent adverse prognostic factors that affected DFS after radical resection of ICC were as follows: maximum tumor diameter (HR = 1.330, P = 0.014), complicated bile duct stone (HR = 1.923, P = 0.013), macroscopic tumor thrombus (HR = 1.826, P = 0.009), and lymph node metastasis (Pathology N1) (HR = 2.330, P = 0.005) were independent adverse prognostic factors that affected the DFS after radical resection of ICC. The postoperative median DFS was 6 months. The independent adverse prognostic factors that affected OS after radical resection of ICC were as follows: maximum tumor diameter (HR = 1.326, P = 0.014), complicated bile duct stone (HR = 2.349, P = 0.001), and lymph node metastasis (Pathology N1) (HR = 2.420, P = 0.003). The postoperative median survival time was 22 months, the 3-year survival rate was 33.9%, and the 5-year survival rate was 23.2%. Macroscopic tumor thrombus (OR = 2.991, P = 0.004) was an independent risk factor for death within 1 year after radical resection.

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Clinical Research Papers:

Prognostic analysis of radical resection for intrahepatic cholangiocarcinoma: a retrospective cohort study

Abstract