Oncotarget

Research Papers:

Clinicopathological characteristics and survival outcomes of invasive lobular carcinoma in different races

Li-Yuan Yang, Li-Peng Yang and Biao Zhu _

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Oncotarget. 2017; 8:74287-74298. https://doi.org/10.18632/oncotarget.19396

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Abstract

Li-Yuan Yang1,2,*, Li-Peng Yang3,* and Biao Zhu1

1Department of Intensive Care Unit, Fudan University Shanghai cancer center, Shanghai 200032, China

2Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China

3Department of Pathology, School of Basic Medical Sciences, Fudan University Shanghai 200032, China

*These authors have contributed equally to this work

Correspondence to:

Biao Zhu, email: zhubiaozs@126.com

Keywords: invasive lobular cancer, race, overall survival, breast cancer specific survival, SEER

Received: April 13, 2017    Accepted: June 18, 2017    Published: July 19, 2017

ABSTRACT

To investigate the clinicopathological characteristics and to determine whether there is a differential effect of race and examine survival outcomes according to race, 18,295 breast invasive lobular carcinoma (ILC) patients were identified in the Surveillance, Epidemiology, and End Result (SEER) database, which includes White patients (n=15,936), Black patients (n=1,451) and patients of other races (including American Indians/Alaskan Natives and Asian/Pacific Islanders) (n=908). The Black ILC patients presented a higher rate of advanced histological grades and American Joint Committee on Cancer (AJCC) stages, a higher rate of lymph node (LN) involvement and a lower rate of progesterone receptors (PR)-positivity than the White patients and other races. The five-year overall survival (OS) and five-year breast cancer specific survival (BCSS) were worst in the Black patients among these patients (85.5%, 76.0% and 87.7%, P<0.01; 91.1%, 84.4% and 91.6%, P<0.01). Multivariate regression analyses were performed to determine the risk hazards ratios (HR) of death for patients of the White, Black and other races. Among these patients, the Black patients had the worst survival outcomes in five-year OS and BCSS outcomes (HR=1.35, 95% confidence interval (CI) :1.20-1.51, P<0.01; HR=1.39, 95%CI:1.21-1.61, P<0.01, respectively). After a 1:1:1 matching of the three groups, the Black patients still presented worse survival outcomes in BCSS compared to White patients (HR=1.88, 95%CI: 1.14-3.10, P=0.013), however, there was no difference in OS (HR=1.35, 95%CI: 0.93-1.96, P=0.111). Difference in outcomes may partially explained by difference in histological grades, AJCC stage, LN and PR status among the three groups. In conclusion, this study revealed that the Black patients had worse five-year OS and BCSS than White and other race patients.


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