Interview with Dr. Robert Hsu from the Department of Internal Medicine, Division of Medical Oncology, Norris Comprehensive Cancer Center and Hospital, University of Southern California
Correspondence to - Jorge J. Nieva, email: jorge.nieva@med.usc.edu
Keywords: lung cancer, tumor microenvironment, diagnostic biomarkers, biomarkers for immunotherapy, cancer testis antigen
Interview with Dr. Alexander Pohlman from Rush University Medical Center, Chicago, IL
Correspondence to - Jeffrey A. Borgia, email: jeffrey_a_borgia@rush.edu
Keywords: IGF, lung cancer, biomarkers, screening, prognostication
Interview with Franco Cortese from the Biogerontology Research Foundation, London, UK
Correspondence to - Ivan V. Ozerov, email: ivan@insilicomedicine.com, Morten Scheibye-Knudsen, email: mscheibye@sund.ku.dk, and Alex Zhavoronkov, email: alex@insilico.com
Keywords: radioresistance, space exploration, longevity, DNA damage, Mars mission
Interview with Dr. Dae Joon Kim and Liza Morales from the Department of Biomedical Sciences, School of Medicine, University of Texas Rio Grande Valley
Correspondence to - Dae Joon Kim, email: dae.kim@utrgv.edu
Keywords: TC-PTP, nuclear translocation, AKT, 14-3-3α, keratinocytes
Interview with Dr. Bishal Gyawali from the Institute of Cancer Policy, London and Department of Clinical Oncology and Chemotherapy, Nagoya University Hospital
Correspondence to - Bishal Gyawali, email: bg.bishalgyawali@gmail.com
Keywords: value, affordability, global oncology, drug prices, cancer
Interview with Dr. Derrick Haslem and Dr. Lincoln Nadauld from the Precision Genomics Program, Intermountain Healthcare, Saint George, UT
Correspondence to - Lincoln D. Nadauld, email: lincoln.nadauld@imail.org
Keywords: precision medicine, oncology, outcomes, costs, overall survival
Interview with Dr. Nerymar Ortiz-Otero from the Meinig School of Biomedical Engineering, Cornell University
Correspondence to - Michael R. King, email: mike.king@vanderbilt.edu
Keywords: metastasis, cancer associated fibroblasts, circulating tumor cells, cytoprotection, collective migration
Interview with Dr. Sandip Pravin Patel, Dr. Karen Yun and Dr. Karen Mccowen from the University of California San Diego
Correspondence to - Sandip Pravin Patel, email: patel@ucsd.edu
Keywords: type 1 diabetes, diabetic ketoacidosis (DKA), immune-related adverse event (irAE), immunotherapy, PD-1 inhibitors
Interview with Dr. Sridhar Mani from Medicine and Genetics of the Albert Einstein College of Medicine
Correspondence to - Sridhar Mani, email: sridhar.mani@einsteinmed.org
Keywords: microbial metabolites, inflammation, IBD, mimicry, drugs
Interview with Dr. J. Kimble Frazer and Dr. Gilseung Park from University of Oklahoma Health Sciences Center and Clay Foster from the University of North Carolina
Correspondence to - J. Kimble Frazer, email: Kimble-Frazer@ouhsc.edu
Keywords: acute lymphoblastic leukemia, ALL, zebrafish, lymphocyte, MYC
Interview with Dr. Mobin Karimi from SUNY Upstate Medical University
Correspondence to - Mobin Karimi, email: karimim@upstate.edu
Keywords: graft-versus-host disease, CrkL, T cell, migration, inflammation
Interview with Dr. Jennifer Sheng from Johns Hopkins Cancer Center
Correspondence to - Jennifer Y. Sheng, email: jsheng7@jhmi.edu
Keywords: breast cancer, obesity, lifestyle interventions
Interview with Dr. Gina Abdelaal and Dr. Stephany Veuger from Northumbria University
Correspondence to - Gina Abdelaal, email: gina.abdelaal@northumbria.ac.uk
Keywords: iron chelator, oncogenesis, selective cytotoxicity, hallmarks of cancer, NDRG1
Interview with Dr. Sivanesan Dakshanamurthy from Georgetown University Medical Center and Dr. Qiyi Tang and Dr. Hemayet Ullah from Howard University College of Medicine
Keywords: host targeted antiviral (HTA), herpes simplex virus (HSV), receptor for activated C kinase 1 (RACK1), RACK1 inhibitor, internal ribosomal entry site (IRES)
Interview with Dr. Jean-François Laes from OncoDNA SA
Correspondence to - Jean-François, email: jf.laes@oncodna.com
Keywords: molecular profiling, solid tumour, precision medicine, next-generation sequencing, therapeutic decision making in oncology
Interview with Dr. Michael H. Roehrl from Memorial Sloan Kettering Cancer Center
Correspondence to - Michael H. Roehrl , email: roehrlm@mskcc.org
Keywords: P4HA1, colorectal cancer, biomarker, prognosis, pathology
Interview with Brian A. Van Tine and Dr. Charles Schutt from the Division of Medical Oncology, Washington University
Correspondence to - Brian A. Van Tine, email: bvantine@wustl.edu
Keywords: head and neck squamous cell carcinoma, neoantigens, mutational evolution, tumor relapse, immune cell infiltration
Interview with Dr. Katherine M. Bever from the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Correspondence to - Dung T. Le, email: dle@jhmi.edu
Keywords: pancreatic cancer, mTOR inhibition, maintenance therapy, metformin
Interview with Susan E. Erdman from Massachusetts Institute of Technology
Correspondence to - Susan E. Erdman, email: serdman@mit.edu
Keywords: body weight, mouse, exotoxin subunit B, CLS, inflammation
Interview with Dr. Richard C. Schwartz from Michigan State University
Correspondence to - Richard C. Schwartz, email: schwart9@msu.edu
Keywords: oxybenzone, benzophenone-3, mammary tumorigenesis, dietary animal fat, breast cancer
Interview with Dr. Yves C. Chabu from the Division of Biological Sciences, University of Missouri
Correspondence to - Yves C. Chabu, email: chabuc@missouri.edu
Keywords: salmonella, cancer targeting, prostate cancer, immunotherapy, TRAMP
Interview with Dr. Tapasree Roy Sarkar from the Department of Translational Molecular Pathology, the University of Texas MD Anderson Cancer Center and the Department of Biology, Texas A&M University
Correspondence to - Tapasree Roy Sarkar, email: tsarkar@bio.tamu.edu
Keywords: angiogenesis, endothelial transdifferentiation, epithelial-mesenchymal transition, vasculogenic mimicry, FOXC2
Interview with Dr. Wafik S. El-Deiry from the Cancer Center at Brown University and Warren Alpert Medical School, and Marie D. Ralff from Temple University
Correspondence to - Wafik S. El-Deiry, email: wafik@brown.edu
Keywords: ONC201, TRAIL, breast cancer, death receptors, apoptosis
Interview with Dr. Vladimir N. Anisimov from the N.N. Petrov National Medical Research Center of Oncology
Correspondence to - Vladimir N. Anisimov, email: aging@mail.ru
Keywords: prostate cancer, overall survival, poor prognosis, melatonin
Interview with Dr. Hua Li and Dr. Shashwat Sharad from Uniformed Services University of the Health Sciences and the Walter Reed National Military Medical and Center and Henry Jackson Foundation for the Advancement of Military Medicine
Correspondence to - Hua Li, email: hli@cpdr.org and Shashwat Sharad, email: ssharad@cpdr.org
Keywords: prostate cancer, PMEPA1, gene isoform, splice variant, TGF-β
Interview with Dr. Beatrice Aramini and Dr. Valentina Masciale from the Division of Thoracic Surgery, Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia
Correspondence to - Beatrice Aramini, email: beatrice.aramini@unimore.it
Keywords: cancer stem cells, macrophages, future perspectives, cancer, target treatments
Interview with Dr. Benjamin Purow from the Department of Neurology, University of Virginia
Correspondence to - Benjamin Purow, email: bwp5g@virginia.edu
Keywords: statin, glioblastoma, TGF-beta, SMAD3, RhoA/ROCK
Interview with Dr. Bruce M. Boman from the University of Delaware, Helen F. Graham Cancer Center and Research Institute, and Thomas Jefferson University
Correspondence to - Bruce M. Boman, email: brboman@christianacare.org
Keywords: ALDH, retinoic acid, colorectal cancer, stem cell, neuroendocrine cell
Interview with Dr. Lawrence M. Pfeffer and Dr. Debolina Ganguly from the Department of Pathology and Laboratory Medicine, and Center for Cancer Research, University of Tennessee Health Science Center
Correspondence to - Lawrence M. Pfeffer, email: lpfeffer@uthsc.edu
Keywords: STAT3, glioblastoma, phosphorylation, gene expression, tumorigenesis
Interview with Dr. Mariana Perepitchka, Dr. Yekaterina Galat, and Dr. Vasiliy Galat
Correspondence to - Mariana Perepitchka, email: mperepitchka@u.northwestern.edu, Yekaterina Galat, email: ygalat@luriechildrens.org, and Vasiliy Galat, email: v-galat@northwestern.edu
Keywords: down syndrome, iPSC-derived endothelial model, T21 genome-wide Implications, meta-analysis, tumor microenvironment
Interview with Dr. Beatrice Aramini from the University of Modena and Reggio Emilia
Correspondence to - Beatrice Aramini, email: beatrice.aramini@unimore.it
Keywords: immunophenotype, cancer stem cells, cancer stem-like cells, non-small cell lung cancer (NSCLC), target therapy
Interview with Dr. Kelber from the Department of Biology, at the California State University Northridge
Correspondence to - Jonathan A. Kelber, email: jonathan.kelber@csun.edu
Keywords: premetastatic niche, tumor microenvironment, metastasis, breast cancer secretomes, LCN2
Interview with the National Institutes of Health's Dr. Stanley Lipkowitz & Dr. Yoshimi Endo Greer
Correspondence to - Stanley Lipkowitz, email: lipkowis@mail.nih.gov
Keywords: ONC201, breast cancer, mitochondria
Interview with Dr. Arieh Eden from Lady Davis Carmel Medical Center
Correspondence to - Arieh Eden, email: ganyneden@gmail.com
Keywords: sepsis, empty SV40 capsids, RNAseq, signaling, cellular functions
Interview with Dr. Beatrice Aramini from the University of Modena University of Modena and Reggio Emilia
Correspondence to - Beatrice Aramini, email: beatrice.aramini@unimore.it
Keywords: somatic mutations, non-small cell lung cancer (NSCLC), lung cancer treatment, overall survival, target therapy
Interview with Dr. Mary J. Janatpour from Dynavax Technologies
Correspondence to - Mary J. Janatpour, email: mjanatpour@dynavax.com
Keywords: TLR9, SD-101, cyclophosphamide, immune therapy, innate immunity
Interview with Prof. Malka Cohen-Armon from Tel Aviv University
Correspondence to - Malka Cohen-Armon, email: marmon@tauex.tau.ac.il
Keywords: PJ34, pancreas cancer, stroma, PANC1 cancer xenografts
Interview with Dr. Marie Wood from the University of Vermont Cancer Center
Correspondence to - Nicholas H. Farina, email: nicholas.farina@uvm.edu
Marie E. Wood, email: marie.wood@uvm.edu
Keywords: microRNA; high risk breast cancer; liquid biopsy; risk signature; benign breast disease
Interview with Dr. Sameek Roychowdhury & Dr. Hui Zi Chen from Ohio State University
Correspondence to - Sameek Roychowdhury, email: Sameek.Roychowdhury@osumc.edu
Keywords: tumor heterogeneity, research autopsy, hypermutation
Interview with Professor Mohamed El-Tanani from the University of Bradford
Correspondence to - Mohamed El-Tanan, email: M.El-Tanani@bradford.ac.uk
Keywords: pimozide, breast cancer, DSB, apoptosis, xenograft
Interview with Dr. Tanwar from the University of Newcastle
Correspondence to - Pradeep S. Tanwar, email: pradeep.tanwar@newcastle.edu.au
Keywords: Wnt, βcatenin, spermatgonia, testicular cancer, fertility, Gerotarget
Interview with Dr. Anutosh Ganguly from the University of Texas Medical School
Correspondence to - Fernando Cabral, email: fernando.r.cabral@uth.tmc.edu
Keywords: tubulin isotypes; microtubules; dynamic instability; motility; drug resistance
Interview with Dr. Francisco Esteva from Perlmutter Cancer Center
Correspondence to - Francisco J. Esteva, email: francisco.esteva@nyumc.org
Aristotelis Tsirigos, email: Aristotelis.Tsirigos@nyumc.org
Keywords: breast cancer; gene expression profiling
Interview with Dr. Gregory J. Riggins from Johns Hopkins University
Correspondence to - Gregory J. Riggins, email: griggin1@jhmi.edu
Paul J. Hergenrother, email: hergenro@illinois.edu
Timothy M. Fan, email: t-fan@illinois.edu
Keywords: PAC-1, procaspase-3 activator, glioblastoma, small molecule therapy
Interview with Dr. Marene Landström & Dr. Reshma Sundar from Umeå University
Correspondence to - Marene Landström, email: Marene.Landstrom@medbio.umu.se
Keywords: signal transduction, tumor biology, Snail1, sumoylation, prostate cancer
Interview with Dr. John R. Hawse from Mayo Clinic
Correspondence to - John R. Hawse, email: hawse.john@mayo.edu
Keywords: TNBC, ERβ, cell cycle, CDK, estrogen
Interview with Dr. Gary Goldberg from Rowan University
Correspondence to - Gary S. Goldberg, email: gary.goldberg@rowan.edu
Keywords: podoplanin, cancer, cell migration, receptor, lectin
Interview with Dr. Neil from the University of Glasgow
Correspondence to - James C. Neil, email: James.Neil@glasgow.ac.uk
Ewan Cameron, email: Ewan.Cameron@glasgow.ac.uk
Keywords: Runx1, lymphoma, myc, oncogene addiction
Interview with Dr. Carmelo Nucera from Harvard Medical School
Correspondence to - Carmelo Nucera, email: cnucera@bidmc.harvard.edu
Keywords: papillary thyroid cancer preclinical model, BRAFV600E, chromosome 5, combined therapy with vemurafenib and palbociclib, drug resistance
Interview with Dr. Whitney Henry from Harvard Medical School
Correspondence to - Alex Toker, email: atoker@bidmc.harvard.edu
John L. Rinn, email: john_rinn@harvard.edu
Keywords: lncRNA, Src, PI3K, breast cancer, LINC00520
Interview with Dr. Field from the University of Miami
Correspondence to - J. William Harbour, email: harbour@miami.edu
Keywords: PRAME, preferentially expressed antigen in melanoma, uveal melanoma, DNA methylation, chromosomal instability
Interview with Dr. Dmitrovsky from the Geisel School of Medicine and the University of Texas
Correspondence to - Ethan Dmitrovsky, email: edmitrovsky@mdanderson.org
Keywords: ISG15, USP18, PTEN, protein stability, and lung cancer
Interview with Dr. Kelber from California State University Northridge
Correspondence to - Jonathan A. Kelber, email: jonathan.kelber@csun.edu
Keywords: FFPE RNA extraction, microHomogenizer™, pancreatic cancer, patient-derived orthotopic xenografts (PDOX) tumor microenvironment, cancer biomarkers
Interview with Dr. Raz from Leiden University Medical Center
Correspondence to - Vered Raz, email: v.raz@lumc.nl
Keywords: shoulder disease, atrophy, fatty infiltration, muscle satellite cells, deep RNA-seq, Gerotarget
Interview with Dr. Hirbe from the Washington University School of Medicine
Correspondence to - David H. Gutmann, email: gutmannd@neuro.wustl.edu
Keywords: Neurofibromatosis Type 1, MPNST, lentivirus, p53, mouse models
Interview with Dr. Larrivée from the University of Montreal
Correspondence to - Bruno Larrivée, email: bruno.larrivee@umontreal.ca
Keywords: age-related macular degeneration, ocular pathologies, angiogenesis, BMP signaling, Gerotarget
Interview with Dr. Hechtman from Memorial Sloan Kettering Cancer Center
Correspondence to - Jaclyn F. Hechtman, email: hechtmaj@mskcc.org
Keywords: SOX9, colorectal carcinoma, KRAS, TP53, oncogene, Pathology Section
Interview with Dr. Chesler from the Institute of Cancer Research and the Royal Marsden NHS Trust
Correspondence to - Louis Chesler, email: louis.chesler@icr.ac.uk
Keywords: neuroblastoma, mTOR, MYC, MYCN, PI3-kinase
Interview with Dr. Schroeder from the University of Arizona
Correspondence to - Joyce Schroeder, email: joyces@email.arizona.edu
Keywords: polarity, migration, Llgl1, epidermal growth factor receptor, TAZ
Interview with Dr. Bernards & Diede Brunen from the Netherlands Cancer Institute
Correspondence to - René Bernards, email: r.bernards@nki.nl
Keywords: AML, PIM, AZD1208, p38, resistance
Interview with Dr. Karpel-Massler & Dr. Siegelin from Columbia University Medical Center
Correspondence to - Markus D. Siegelin, email: ms4169@cumc.columbia.edu
Keywords: apoptosis, L-asparaginase, ABT263, TRAIL, glioblastoma
Interview with Dr. Ayyadevara & Dr. Shmookler Reis from the Central Arkansas Veterans Healthcare Service and the University of Arkansas
Correspondence to - Robert J. Shmookler Reis, email: rjsr@uams.edu
Srinivas Ayyadevara, email: AyyadevaraSrinivas@uams.edu
Keywords: phosphatidylinositol 3-kinase; phosphatidylinositol 3,4,5-triphosphate (PIP3); longevity; oxidative stress resistance; protein aggregation
Interview with Dr. Neelam and Sudeshna Goswami from the Chicago Medical School
Correspondence to - Neelam Sharma-Walia, email: neelam.sharma-walia@rosalindfranklin.edu
Keywords: osteoprotegerin, NF-kB, COX-2, PGE2, FASN
Interview with Dr. Pastan from the National Cancer Institute
Correspondence to - Ira Pastan, email: pastani@mail.nih.gov
Keywords: epitope, immunogenicity, rational design, mesothelioma, pancreatic cancer
Interview with Dr. Aaronson from the Icahn School of Medicine
Correspondence to - Stuart A. Aaronson, email: Stuart.Aaronson@mssm.edu
Keywords: tankyrase inhibitors, TEAD, YAP, angiomotin, tumor cell proliferation
Interview with Dr. Savaskan from the University Hospital Erlangen and BiMECON ENT.
Correspondence to - Nicolai E. Savaskan, email: savaskan@gmx.net, nic.savaskan@gmail.com
Keywords: glioma, PRG3, Ras, oncogenesis, neuronal plasticity
Interview with Dr. Felsher from Stanford University
Correspondence to - Dean W. Felsher, email: dfelsher@stanford.edu
Keywords: apoptosis, BIM, targeted therapies, oncogene inactivation
Interview with Dr. Bohr from National Institute on Aging
Correspondence to - Vilhelm A. Bohr, email: vbohr@nih.gov
Keywords: breast cancer, Werner syndrome, helicase, camptothecin, topoisomerase I
Interview with Dr. Loeb from Johns Hopkins University
Correspondence to - David M. Loeb, email: loebda@jhmi.edu
Keywords: sarcoma, metastasis, Wnt signaling, DKK-1, mouse model
Interview with Dr. Tanwar from the School of Biomedical Sciences and Pharmacy
Correspondence to - Pradeep S. Tanwar, email: pradeep.tanwar@newcastle.edu.au
Keywords: ovarian aging, rapamycin, mTOR, ovary, OSE, Gerotarget
Interview with Dr. Mancini & Dr. Toker from Harvard Medical School
Correspondence to - Alex Toker, email: atoker@bidmc.harvard.edu
Keywords: Akt, breast cancer, PI 3-kinase, HER2, estrogen receptor
Interview with Dr. Bratslavsky & Dr. Mollapour from SUNY Upstate Medical University
Correspondence to - Mehdi Mollapour, email: mollapom@upstate.edu
Gennady Bratslavsky, email: bratslag@upstate.edu
Keywords: FLCN, Birt-Hogg-Dubé syndrome, renal cell carcinoma, clear cell renal cell carcinoma
Interview with Dr. Slack from Harvard Medical School
Correspondence to - Frank J. Slack, email: fslack@bidmc.harvard.edu
Keywords: KRAS, 3′ UTR, post-transcriptional regulation, microRNAs (miRNAs), miR-185