Interviews

Correspondence to - Ivan V. Ozerov, email: ivan@insilicomedicine.com, Morten Scheibye-Knudsen, email: mscheibye@sund.ku.dk, and Alex Zhavoronkov, email: alex@insilico.com

Keywords: radioresistance, space exploration, longevity, DNA damage, Mars mission

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Correspondence to - Dae Joon Kim, email: dae.kim@utrgv.edu

Keywords: TC-PTP, nuclear translocation, AKT, 14-3-3α, keratinocytes

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Correspondence to - Bishal Gyawali, email: bg.bishalgyawali@gmail.com

Keywords: value, affordability, global oncology, drug prices, cancer

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Correspondence to - Lincoln D. Nadauld, email: lincoln.nadauld@imail.org

Keywords: precision medicine, oncology, outcomes, costs, overall survival

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Correspondence to - Michael R. King, email: mike.king@vanderbilt.edu

Keywords: metastasis, cancer associated fibroblasts, circulating tumor cells, cytoprotection, collective migration

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Correspondence to - Sandip Pravin Patel, email: patel@ucsd.edu

Keywords: type 1 diabetes, diabetic ketoacidosis (DKA), immune-related adverse event (irAE), immunotherapy, PD-1 inhibitors

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Correspondence to - Sridhar Mani, email: sridhar.mani@einsteinmed.org

Keywords: microbial metabolites, inflammation, IBD, mimicry, drugs

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Correspondence to - J. Kimble Frazer, email: Kimble-Frazer@ouhsc.edu

Keywords: acute lymphoblastic leukemia, ALL, zebrafish, lymphocyte, MYC

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Correspondence to - Mobin Karimi, email: karimim@upstate.edu

Keywords: graft-versus-host disease, CrkL, T cell, migration, inflammation

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Correspondence to - Jennifer Y. Sheng, email: jsheng7@jhmi.edu

Keywords: breast cancer, obesity, lifestyle interventions

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Correspondence to - Gina Abdelaal, email: gina.abdelaal@northumbria.ac.uk

Keywords: iron chelator, oncogenesis, selective cytotoxicity, hallmarks of cancer, NDRG1

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Keywords: host targeted antiviral (HTA), herpes simplex virus (HSV), receptor for activated C kinase 1 (RACK1), RACK1 inhibitor, internal ribosomal entry site (IRES)

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Correspondence to - Jean-François, email: jf.laes@oncodna.com

Keywords: molecular profiling, solid tumour, precision medicine, next-generation sequencing, therapeutic decision making in oncology

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Correspondence to - Michael H. Roehrl , email: roehrlm@mskcc.org

Keywords: P4HA1, colorectal cancer, biomarker, prognosis, pathology

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Correspondence to - Brian A. Van Tine, email: bvantine@wustl.edu

Keywords: head and neck squamous cell carcinoma, neoantigens, mutational evolution, tumor relapse, immune cell infiltration

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Correspondence to - Dung T. Le, email: dle@jhmi.edu

Keywords: pancreatic cancer, mTOR inhibition, maintenance therapy, metformin

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Correspondence to - Susan E. Erdman, email: serdman@mit.edu

Keywords: body weight, mouse, exotoxin subunit B, CLS, inflammation

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Correspondence to - Richard C. Schwartz, email: schwart9@msu.edu

Keywords: oxybenzone, benzophenone-3, mammary tumorigenesis, dietary animal fat, breast cancer

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Correspondence to - Yves C. Chabu, email: chabuc@missouri.edu

Keywords: salmonella, cancer targeting, prostate cancer, immunotherapy, TRAMP

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Correspondence to - Tapasree Roy Sarkar, email: tsarkar@bio.tamu.edu

Keywords: angiogenesis, endothelial transdifferentiation, epithelial-mesenchymal transition, vasculogenic mimicry, FOXC2

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Correspondence to - Wafik S. El-Deiry, email: wafik@brown.edu

Keywords: ONC201, TRAIL, breast cancer, death receptors, apoptosis

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Correspondence to - Vladimir N. Anisimov, email: aging@mail.ru

Keywords: prostate cancer, overall survival, poor prognosis, melatonin

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Correspondence to - Hua Li, email: hli@cpdr.org and Shashwat Sharad, email: ssharad@cpdr.org

Keywords: prostate cancer, PMEPA1, gene isoform, splice variant, TGF-β

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Correspondence to - Beatrice Aramini, email: beatrice.aramini@unimore.it

Keywords: cancer stem cells, macrophages, future perspectives, cancer, target treatments

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Correspondence to - Benjamin Purow, email: bwp5g@virginia.edu

Keywords: statin, glioblastoma, TGF-beta, SMAD3, RhoA/ROCK

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Correspondence to - Bruce M. Boman, email: brboman@christianacare.org

Keywords: ALDH, retinoic acid, colorectal cancer, stem cell, neuroendocrine cell

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Correspondence to - Lawrence M. Pfeffer, email: lpfeffer@uthsc.edu

Keywords: STAT3, glioblastoma, phosphorylation, gene expression, tumorigenesis

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Correspondence to - Mariana Perepitchka, email: mperepitchka@u.northwestern.edu, Yekaterina Galat, email: ygalat@luriechildrens.org, and Vasiliy Galat, email: v-galat@northwestern.edu

Keywords: down syndrome, iPSC-derived endothelial model, T21 genome-wide Implications, meta-analysis, tumor microenvironment

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Correspondence to - Beatrice Aramini, email: beatrice.aramini@unimore.it

Keywords: immunophenotype, cancer stem cells, cancer stem-like cells, non-small cell lung cancer (NSCLC), target therapy

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Correspondence to - Jonathan A. Kelber, email: jonathan.kelber@csun.edu

Keywords: premetastatic niche, tumor microenvironment, metastasis, breast cancer secretomes, LCN2

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Correspondence to - Stanley Lipkowitz, email: lipkowis@mail.nih.gov

Keywords: ONC201, breast cancer, mitochondria

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Correspondence to - Arieh Eden, email: ganyneden@gmail.com

Keywords: sepsis, empty SV40 capsids, RNAseq, signaling, cellular functions

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Correspondence to - Beatrice Aramini, email: beatrice.aramini@unimore.it

Keywords: somatic mutations, non-small cell lung cancer (NSCLC), lung cancer treatment, overall survival, target therapy

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Correspondence to - Mary J. Janatpour, email: mjanatpour@dynavax.com

Keywords: TLR9, SD-101, cyclophosphamide, immune therapy, innate immunity

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Correspondence to - Malka Cohen-Armon, email: marmon@tauex.tau.ac.il

Keywords: PJ34, pancreas cancer, stroma, PANC1 cancer xenografts

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Correspondence to - Nicholas H. Farina, email: nicholas.farina@uvm.edu
Marie E. Wood, email: marie.wood@uvm.edu

Keywords: microRNA; high risk breast cancer; liquid biopsy; risk signature; benign breast disease

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Correspondence to - Sameek Roychowdhury, email: Sameek.Roychowdhury@osumc.edu

Keywords: tumor heterogeneity, research autopsy, hypermutation

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Correspondence to - Mohamed El-Tanan, email: M.El-Tanani@bradford.ac.uk

Keywords: pimozide, breast cancer, DSB, apoptosis, xenograft

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Correspondence to - Pradeep S. Tanwar, email: pradeep.tanwar@newcastle.edu.au

Keywords: Wnt, βcatenin, spermatgonia, testicular cancer, fertility, Gerotarget

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Correspondence to - Fernando Cabral, email: fernando.r.cabral@uth.tmc.edu

Keywords: tubulin isotypes; microtubules; dynamic instability; motility; drug resistance

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Correspondence to - Francisco J. Esteva, email: francisco.esteva@nyumc.org
Aristotelis Tsirigos, email: Aristotelis.Tsirigos@nyumc.org

Keywords: breast cancer; gene expression profiling

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Correspondence to - Gregory J. Riggins, email: griggin1@jhmi.edu
Paul J. Hergenrother, email: hergenro@illinois.edu
Timothy M. Fan, email: t-fan@illinois.edu

Keywords: PAC-1, procaspase-3 activator, glioblastoma, small molecule therapy

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Correspondence to - Marene Landström, email: Marene.Landstrom@medbio.umu.se

Keywords: signal transduction, tumor biology, Snail1, sumoylation, prostate cancer

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Correspondence to - John R. Hawse, email: hawse.john@mayo.edu

Keywords: TNBC, ERβ, cell cycle, CDK, estrogen

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Correspondence to - Gary S. Goldberg, email: gary.goldberg@rowan.edu

Keywords: podoplanin, cancer, cell migration, receptor, lectin

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Correspondence to - James C. Neil, email: James.Neil@glasgow.ac.uk
Ewan Cameron, email: Ewan.Cameron@glasgow.ac.uk

Keywords: Runx1, lymphoma, myc, oncogene addiction

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Correspondence to - Carmelo Nucera, email: cnucera@bidmc.harvard.edu

Keywords: papillary thyroid cancer preclinical model, BRAF^V600E, chromosome 5, combined therapy with vemurafenib and palbociclib, drug resistance

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Correspondence to - Alex Toker, email: atoker@bidmc.harvard.edu
John L. Rinn, email: john_rinn@harvard.edu

Keywords: lncRNA, Src, PI3K, breast cancer, LINC00520

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Correspondence to - J. William Harbour, email: harbour@miami.edu

Keywords: PRAME, preferentially expressed antigen in melanoma, uveal melanoma, DNA methylation, chromosomal instability

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Correspondence to - Ethan Dmitrovsky, email: edmitrovsky@mdanderson.org

Keywords: ISG15, USP18, PTEN, protein stability, and lung cancer

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Correspondence to - Jonathan A. Kelber, email: jonathan.kelber@csun.edu

Keywords: FFPE RNA extraction, microHomogenizer™, pancreatic cancer, patient-derived orthotopic xenografts (PDOX) tumor microenvironment, cancer biomarkers

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Correspondence to - Vered Raz, email: v.raz@lumc.nl

Keywords: shoulder disease, atrophy, fatty infiltration, muscle satellite cells, deep RNA-seq, Gerotarget

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Correspondence to - David H. Gutmann, email: gutmannd@neuro.wustl.edu

Keywords: Neurofibromatosis Type 1, MPNST, lentivirus, p53, mouse models

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Correspondence to - Bruno Larrivée, email: bruno.larrivee@umontreal.ca

Keywords: age-related macular degeneration, ocular pathologies, angiogenesis, BMP signaling, Gerotarget

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Correspondence to - Jaclyn F. Hechtman, email: hechtmaj@mskcc.org

Keywords: SOX9, colorectal carcinoma, KRAS, TP53, oncogene, Pathology Section

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Correspondence to - Louis Chesler, email: louis.chesler@icr.ac.uk

Keywords: neuroblastoma, mTOR, MYC, MYCN, PI3-kinase

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Correspondence to - Joyce Schroeder, email: joyces@email.arizona.edu

Keywords: polarity, migration, Llgl1, epidermal growth factor receptor, TAZ

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Correspondence to - René Bernards, email: r.bernards@nki.nl

Keywords: AML, PIM, AZD1208, p38, resistance

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Correspondence to - Markus D. Siegelin, email: ms4169@cumc.columbia.edu

Keywords: apoptosis, L-asparaginase, ABT263, TRAIL, glioblastoma

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Correspondence to - Robert J. Shmookler Reis, email: rjsr@uams.edu
Srinivas Ayyadevara, email: AyyadevaraSrinivas@uams.edu

Keywords: phosphatidylinositol 3-kinase; phosphatidylinositol 3,4,5-triphosphate (PIP3); longevity; oxidative stress resistance; protein aggregation

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Correspondence to - Neelam Sharma-Walia, email: neelam.sharma-walia@rosalindfranklin.edu

Keywords: osteoprotegerin, NF-kB, COX-2, PGE2, FASN

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Correspondence to - Ira Pastan, email: pastani@mail.nih.gov

Keywords: epitope, immunogenicity, rational design, mesothelioma, pancreatic cancer

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Correspondence to - Stuart A. Aaronson, email: Stuart.Aaronson@mssm.edu

Keywords: tankyrase inhibitors, TEAD, YAP, angiomotin, tumor cell proliferation

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Correspondence to - Nicolai E. Savaskan, email: savaskan@gmx.net, nic.savaskan@gmail.com

Keywords: glioma, PRG3, Ras, oncogenesis, neuronal plasticity

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Correspondence to - Dean W. Felsher, email: dfelsher@stanford.edu

Keywords: apoptosis, BIM, targeted therapies, oncogene inactivation

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Correspondence to - Vilhelm A. Bohr, email: vbohr@nih.gov

Keywords: breast cancer, Werner syndrome, helicase, camptothecin, topoisomerase I

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Correspondence to - David M. Loeb, email: loebda@jhmi.edu

Keywords: sarcoma, metastasis, Wnt signaling, DKK-1, mouse model

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Correspondence to - Pradeep S. Tanwar, email: pradeep.tanwar@newcastle.edu.au

Keywords: ovarian aging, rapamycin, mTOR, ovary, OSE, Gerotarget

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Correspondence to - Alex Toker, email: atoker@bidmc.harvard.edu

Keywords: Akt, breast cancer, PI 3-kinase, HER2, estrogen receptor

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Correspondence to - Mehdi Mollapour, email: mollapom@upstate.edu
Gennady Bratslavsky, email: bratslag@upstate.edu

Keywords: FLCN, Birt-Hogg-Dubé syndrome, renal cell carcinoma, clear cell renal cell carcinoma

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Correspondence to - Frank J. Slack, email: fslack@bidmc.harvard.edu

Keywords: KRAS, 3′ UTR, post-transcriptional regulation, microRNAs (miRNAs), miR-185

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