Oncotarget


Oncotarget | Chemoradiation-induced Alteration of Programmed Death-ligand 1, CD8+ Tumor-infiltrating Lymphocytes and Mucin Expression in Rectal Cancer


FOR IMMEDIATE RELEASE
2022-08-02

“In conclusion, our study provides further data on the immunologic impact of nCRT in rectal cancer.”


BUFFALO, NY- August 2, 2022 – A new research paper was published in Oncotarget on July 28, 2022, entitled, “Chemoradiation-induced alteration of programmed death-ligand 1, CD8+ tumor-infiltrating lymphocytes and mucin expression in rectal cancer.”

DNA damage and resulting neoantigen formation is considered a mechanism for synergy between radiotherapy and PD-1/PD-L1 pathway inhibition to induce... continue reading >>


Oncotarget | CUDC907 Promotes Apoptosis of NF2 Schwannoma Cells


FOR IMMEDIATE RELEASE
2022-07-26

“CUDC907 has cytotoxic activity in NF2 schwannoma models and primary VS cells and is a candidate for clinical trials.”



BUFFALO, NY- July 26, 2022 –
A new research paper was published in Oncotarget on July 19, 2022, entitled, “CUDC907, a dual phosphoinositide-3 kinase/histone deacetylase inhibitor, promotes apoptosis of NF2 Schwannoma cells.”

Neurofibromatosis Type 2 (NF2) is a rare tumor disorder caused by pathogenic variants of the merlin tumor suppressor encoded by NF2. Patients develop... continue reading >>


Oncotarget | Predicting Cancer Immunotherapy Response From Gut Microbiomes Using Machine Learning Models


FOR IMMEDIATE RELEASE
2022-07-19

“Findings demonstrate how machine learning models can reveal microbiome-immunotherapy interactions that may ultimately improve cancer patient outcomes.”


BUFFALO, NY- July 19, 2022 –
A new research paper was published in Oncotarget on July 19, 2022, entitled, “Predicting cancer immunotherapy response from gut microbiomes using machine learning models.”

“In the last decade, the use of cancer immunotherapy targeting immune checkpoint inhibitors (ICIs) to boost T cell mediated cancer cell... continue reading >>




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