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About The Cover

The cover for issue 25 of Oncotarget features Figure 7A, "In silico prediction of the binding of PR5-LL-CM01 and EPZ015666 to PRMT5," from Prabhu, et al.

Table of Contents

Editorial

Shaping chromatin with DICER

https://doi.org/10.18632/oncotarget.17773

Shalaka Chitale, and Holger Richly
39937-39938
Abstract  |  PDF  |  How to cite

Metformin induces protein acetylation in cancer cells

https://doi.org/10.18632/oncotarget.17829

Ales Vancura, and Ivana Vancurova
39939-39940
Abstract  |  PDF  |  How to cite

APOE genotype and Alzheimer’s immunotherapy

https://doi.org/10.18632/oncotarget.17990

Joanna E. Pankiewicz, and Martin J. Sadowski
39941-39942
Abstract  |  PDF  |  How to cite

Abnormal protein oligomers for neurodegeneration

https://doi.org/10.18632/oncotarget.18030

Eiichi Tokuda, and Yoshiaki Furukawa
39943-39944
Abstract  |  PDF  |  How to cite

Priority Research Papers

BRCA2 EGFR and NTRK mutations in mismatch repairdeficient colorectal cancers with MSH2 or MLH1 mutations

https://doi.org/10.18632/oncotarget.18098

Safoora Deihimi, Avital Lev, Michael Slifker, Elena Shagisultanova, Qifang Xu, Kyungsuk Jung, Namrata Vijayvergia, Eric A. Ross, Joanne Xiu, Jeffrey Swensen, Zoran Gatalica, Mark Andrake, Roland L. Dunbrack, and Wafik S. El-Deiry
39945-39962
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Adapting AlphaLISA high throughput screen to discover a novel smallmolecule inhibitor targeting protein arginine methyltransferase 5 in pancreatic and colorectal cancers

https://doi.org/10.18632/oncotarget.18102

Lakshmi Prabhu, Han Wei, Lan Chen, Özlem Demir, George Sandusky, Emily Sun, John Wang, Jessica Mo, Lifan Zeng, Melissa Fishel, Ahmad Safa, Rommie Amaro, Murray Korc, Zhong-Yin Zhang, and Tao Lu
39963-39977
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Peretinoin an acyclic retinoid suppresses steatohepatitis and tumorigenesis by activating autophagy in mice fed an atherogenic highfat diet

https://doi.org/10.18632/oncotarget.18116

Hikari Okada, Riuta Takabatake, Masao Honda, Kai Takegoshi, Taro Yamashita, Mikiko Nakamura, Takayoshi Shirasaki, Yoshio Sakai, Tetsuro Shimakami, Naoto Nagata, Toshinari Takamura, Takuji Tanaka, and Shuichi Kaneko
39978-39993
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

An AML1ETO/miR29b1 regulatory circuit modulates phenotypic properties of acute myeloid leukemia cells

https://doi.org/10.18632/oncotarget.18127

Sayyed K. Zaidi, Andrew W. Perez, Elizabeth S. White, Jane B. Lian, Janet L. Stein, and Gary S. Stein
39994-40005
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Research Papers: Gerotarget (Focus on Aging)

Dry agerelated macular degeneration like pathology in aged 5XFAD mice: Ultrastructure and microarray analysis

https://doi.org/10.18632/oncotarget.16967

Sung Wook Park, Sora Im, Hyoung Oh Jun, Kihwang Lee, Young-Jun Park, Jin Hyoung Kim, Woo Jin Park, Young-Hoon Lee, and Jeong Hun Kim
40006-40018
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Research Papers: Pathology

Chaperonemediated autophagy compensates for impaired macroautophagy in the cirrhotic liver to promote hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.16685

Srinivas Chava, Christine Lee, Yucel Aydin, Partha K. Chandra, Asha Dash, Milad Chedid, Swan N. Thung, Krzysztof Moroz, Tong Wu, Nabeen C. Nayak, and Srikanta Dash
40019-40036
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Research Papers: Immunology

Lysosomal lipid hydrolysis provides substrates for lipid mediator synthesis in murine macrophages

https://doi.org/10.18632/oncotarget.16673

Stefanie Schlager, Nemanja Vujic, Melanie Korbelius, Madalina Duta-Mare, Juliane Dorow, Christina Leopold, Silvia Rainer, Martin Wegscheider, Helga Reicher, Uta Ceglarek, Wolfgang Sattler, Branislav Radovic, and Dagmar Kratky
40037-40051
Abstract  |  PDF  |  Full Text  |  How to cite

Characterization of a secreted macrophage migration inhibitory factor homologue of the parasitic nematode Haemonchus Contortus acting at the parasitehost cell interface

https://doi.org/10.18632/oncotarget.16675

Yujian Wang, MingMin Lu, Shuai Wang, Muhammad Ehsan, RuoFeng Yan, XiaoKai Song, LiXin Xu, and XiangRui Li
40052-40064
Abstract  |  PDF  |  Full Text  |  How to cite

Neuroprotection by IFNγ via astrocytesecreted IL6 in acute neuroinflammation

https://doi.org/10.18632/oncotarget.16990

Lijie Sun, Yan Li, Xiuzhi Jia, Qi Wang, Yue Li, Minghui Hu, Linlu Tian, Jinfeng Yang, Wenjing Xing, Weihua Zhang, Jingtao Wang, Hongwei Xu, Lihua Wang, Dekai Zhang, and Huan Ren
40065-40078
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Research Papers: Chromosome

The IGH locus relocalizes to a “recombination compartment” in the perinucleolar region of differentiating Blymphocytes

https://doi.org/10.18632/oncotarget.16941

Andrey Pichugin, Olga V. Iarovaia, Alexey Gavrilov, Ilya Sklyar, Natalja Barinova, Aleksandr Barinov, Evgeny Ivashkin, Gersende Caron, Said Aoufouchi, Sergey V. Razin, Thierry Fest, Marc Lipinski, and Yegor S. Vassetzky
40079-40089
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Estimating the effects of transcription factors binding and histone modifications on gene expression levels in human cells

https://doi.org/10.18632/oncotarget.16988

Lu-Qiang Zhang, and Qian-Zhong Li
40090-40103
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Research Papers

Caveolin1 scaffolding domain peptides enhance antiinflammatory effect of heme oxygenase1 through interrupting its interact with caveolin1

https://doi.org/10.18632/oncotarget.16676

Ping Weng, Xiao-Tong Zhang, Qiong Sheng, Wen-Fang Tian, Jun-Liang Chen, Jia-Jia Yuan, Ji-Ru Zhang, and Qing-Feng Pang
40104-40114
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Role of Deltalike 4 in Jagged1induced tumour angiogenesis and tumour growth

https://doi.org/10.18632/oncotarget.16969

Chern Ein Oon, Esther Bridges, Helen Sheldon, Richard C.A. Sainson, Adrian Jubb, Helen Turley, Russell Leek, Francesca Buffa, Adrian L. Harris, and Ji-Liang Li
40115-40131
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Telomere erosion in NF1 tumorigenesis

https://doi.org/10.18632/oncotarget.16981

Rhiannon E. Jones, Julia W. Grimstead, Ashni Sedani, Duncan Baird, and Meena Upadhyaya
40132-40139
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Locallyapplied 5fluorouracilloaded slowrelease patch prevents pancreatic cancer growth in an orthotopic mouse model

https://doi.org/10.18632/oncotarget.17370

In Kyong Shim, Hye-Jin Yi, Hee-Gyeong Yi, Chan Mi Lee, Yu Na Lee, Yeong-Jin Choi, Seong-Yun Jeong, Eunsung Jun, Robert M. Hoffman, Dong-Woo Cho, and Song Cheol Kim
40140-40151
Abstract  |  PDF  |  Full Text  |  How to cite

Cumulative defects in DNA repair pathways drive the PARP inhibitor response in highgrade serous epithelial ovarian cancer cell lines

https://doi.org/10.18632/oncotarget.10308

Hubert Fleury, Euridice Carmona, Vincent G. Morin, Liliane Meunier, Jean-Yves Masson, Patricia N. Tonin, Diane Provencher, and Anne-Marie Mes-Masson
40152-40168
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Downregulation of microRNA199b predicts unfavorable prognosis and emerges as a novel therapeutic target which contributes to PP2A inhibition in metastatic colorectal cancer

https://doi.org/10.18632/oncotarget.11174

Ion Cristóbal, Cristina Caramés, Raúl Rincón, Rebeca Manso, Juan Madoz-Gúrpide, Blanca Torrejón, Paula González-Alonso, Federico Rojo, and Jesús García-Foncillas
40169-40180
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Elevated plasma midkine and pleiotrophin levels in patients with systemic lupus erythematosus

https://doi.org/10.18632/oncotarget.13658

Guo-Cui Wu, Hui Yuan, Hai-Feng Pan, and Dong-Qing Ye
40181-40189
Abstract  |  PDF  |  Full Text  |  How to cite

Role of TOPK in lipopolysaccharideinduced breast cancer cell migration and invasion

https://doi.org/10.18632/oncotarget.15360

Min-Ah Seol, Jung-Hwan Park, Ji Heun Jeong, Jungmook Lyu, Seung Yun Han, and Sang-Muk Oh
40190-40203
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

The association between miR423 rs6505162 polymorphism and cancer susceptibility: a systematic review and metaanalysis

https://doi.org/10.18632/oncotarget.16319

Ru Chen, Yonglan Zheng, Lin Zhuo, and Shengfeng Wang
40204-40213
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Prognostic value of circulating vitamin D binding protein total free and bioavailable 25hydroxy vitamin D in patients with colorectal cancer

https://doi.org/10.18632/oncotarget.16597

Lin Yang, Hong Chen, Miao Zhao, and Peng Peng
40214-40221
Abstract  |  PDF  |  Full Text  |  How to cite

BRCA2 mutations should be screened early and routinely as markers of poor prognosis: evidence from 8988 patients with prostate cancer

https://doi.org/10.18632/oncotarget.16712

Ming Cui, Xian-Shu Gao, Xiaobin Gu, Wei Guo, Xiaoying Li, Mingwei Ma, Shangbin Qin, Xin Qi, Mu Xie, Chuan Peng, and Yun Bai
40222-40232
Abstract  |  PDF  |  Full Text  |  How to cite

Cardiac glycosides suppress the maintenance of stemness and malignancy via inhibiting HIF1α in human glioma stem cells

https://doi.org/10.18632/oncotarget.16714

Dae-Hee Lee, Sang Cheul Oh, Amber J. Giles, Jinkyu Jung, Mark R. Gilbert, and Deric M. Park
40233-40245
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Anticancer effect of danshen and dihydroisotanshinone I on prostate cancer: targeting the crosstalk between macrophages and cancer cells via inhibition of the STAT3/CCL2 signaling pathway

https://doi.org/10.18632/oncotarget.14958

Ching-Yuan Wu, Yao-Hsu Yang, Yin-Yin Lin, Feng-Che Kuan, Yu-Shin Lin, Wei-Yu Lin, Ming-Yen Tsai, Jia-Jing Yang, Yu-Ching Cheng, Li-Hsin Shu, Ming-Chu Lu, Yun-Ju Chen, Kuan-Der Lee, and Hong-Yo Kang
40246-40263
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Curcumin enhances the effects of irinotecan on colorectal cancer cells through the generation of reactive oxygen species and activation of the endoplasmic reticulum stress pathway

https://doi.org/10.18632/oncotarget.16828

Yan-Feng Huang, Da-Jian Zhu, Xiao-Wu Chen, Qi-Kang Chen, Zhen-Tao Luo, Chang-Chun Liu, Guo-Xin Wang, Wei-Jie Zhang, and Nv-Zhu Liao
40264-40275
Abstract  |  PDF  |  Full Text  |  How to cite

An injectable nucleus pulposus cellmodified decellularized scaffold: biocompatible material for prevention of disc degeneration

https://doi.org/10.18632/oncotarget.16831

Zhi Shan, Xianfeng Lin, Shengyu Wang, Xuyang Zhang, Yichuan Pang, Shengyun Li, Tianming Yu, Shunwu Fan, and Fengdong Zhao
40276-40288
Abstract  |  PDF  |  Full Text  |  How to cite

Differential sensitivities of bladder cancer cell lines to resveratol are unrelated to its metabolic profile

https://doi.org/10.18632/oncotarget.15041

Yang Yang, Chuangang Li, Hong Li, Moli Wu, Changle Ren, Yuhong Zhen, Xiaochi Ma, Yunpeng Diao, Xiaodong Ma, Sa Deng, Jia Liu, and Xiaohong Shu
40289-40304
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Baicalein decreases uric acid and prevents hyperuricemic nephropathy in mice

https://doi.org/10.18632/oncotarget.16928

Xiaolu Meng, Zhuo Mao, Xin Li, Dandan Zhong, Min Li, Yingli Jia, Jing Wei, Baoxue Yang, and Hong Zhou
40305-40317
Abstract  |  PDF  |  Full Text  |  How to cite

Homoharringtonine targets Smad3 and TGFβ pathway to inhibit the proliferation of acute myeloid leukemia cells

https://doi.org/10.18632/oncotarget.16956

Jian Chen, Qitian Mu, Xia Li, Xiufeng Yin, Mengxia Yu, Jing Jin, Chenying Li, Yile Zhou, Jiani Zhou, Shanshan Suo, Demin Lu, and Jie Jin
40318-40326
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Subchronic arsenisminduced oxidative stress and inflammation contribute to apoptosis through mitochondrial and death receptor dependent pathways in chicken immune organs

https://doi.org/10.18632/oncotarget.16960

Hongjing Zhao, Ying He, Siwen Li, Xiao Sun, Yu Wang, Yizhi Shao, Zhijun Hou, and Mingwei Xing
40327-40344
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Highthroughput detection of clinically targetable alterations using nextgeneration sequencing

https://doi.org/10.18632/oncotarget.15875

Julie A. Vendrell, David Grand, Isabelle Rouquette, Valérie Costes, Samira Icher, Janick Selves, Marion Larrieux, Aurore Barbe, Pierre Brousset, and Jérôme Solassol
40345-40358
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Nonhomologous end joining induced alterations in DNA methylation: A source of permanent epigenetic change

https://doi.org/10.18632/oncotarget.16122

Brittany Allen, Antonio Pezone, Antonio Porcellini, Mark T. Muller, and Michal M. Masternak
40359-40372
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

RMP promotes epithelialmesenchymal transition through NFκB/CSN2/Snail pathway in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.16177

Wei Zhou, Qi Wang, Yi Xu, Jingting Jiang, Jingchun Guo, Huijun Yu, and Wenxiang Wei
40373-40388
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Aspirin as a potential modality for the chemoprevention of breast cancer: A doseresponse metaanalysis of cohort studies from 857831 participants

https://doi.org/10.18632/oncotarget.16315

Liming Lu, Leiyu Shi, Jingchun Zeng, and Zehuai Wen
40389-40401
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Oncogenic histone methyltransferase EZH2: A novel prognostic marker with therapeutic potential in endometrial cancer

https://doi.org/10.18632/oncotarget.16316

Shinya Oki, Kenbun Sone, Katsutoshi Oda, Ryuji Hamamoto, Masako Ikemura, Daichi Maeda, Makoto Takeuchi, Michihiro Tanikawa, Mayuyo Mori-Uchino, Kazunori Nagasaka, Aki Miyasaka, Tomoko Kashiyama, Yuji Ikeda, Takahide Arimoto, Hiroyuki Kuramoto, Osamu Wada-Hiraike, Kei Kawana, Masashi Fukayama, Yutaka Osuga, and Tomoyuki Fujii
40402-40411
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Urinary RKIP/pRKIP is a potential diagnostic and prognostic marker of clear cell renal cell carcinoma

https://doi.org/10.18632/oncotarget.16341

Massimo Papale, Grazia Vocino, Giuseppe Lucarelli, Monica Rutigliano, Margherita Gigante, Maria Teresa Rocchetti, Francesco Pesce, Francesca Sanguedolce, Pantaleo Bufo, Michele Battaglia, Giovanni Stallone, Giuseppe Grandaliano, Giuseppe Carrieri, Loreto Gesualdo, and Elena Ranieri
40412-40424
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Clinicopathological features of small cell carcinoma of the uterine cervix in the surveillance epidemiology and end results database

https://doi.org/10.18632/oncotarget.16390

Juan Zhou, San-Gang Wu, Jia-Yuan Sun, Li-Ying Tang, Huan-Xin Lin, Feng-Yan Li, Qiong-Hua Chen, Xin Jin, and Zhen-Yu He
40425-40433
Abstract  |  PDF  |  Full Text  |  How to cite

Epigenetic silencing of triple negative breast cancer hallmarks by Withaferin A

https://doi.org/10.18632/oncotarget.17107

Katarzyna Szarc vel Szic, Ken Declerck, René A.J. Crans, Jolien Diddens, David B. Scherf, Clarissa Gerhäuser, and Wim Vanden Berghe
40434-40453
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Targeting PEPT1: a novel strategy to improve the antitumor efficacy of doxorubicin in human hepatocellular carcinoma therapy

https://doi.org/10.18632/oncotarget.17117

Yanxia Gong, Xiang Wu, Tao Wang, Jia Zhao, Xi Liu, Zhi Yao, Qingyu Zhang, and Xu Jian
40454-40468
Abstract  |  PDF  |  Full Text  |  How to cite

IGF2 mRNA binding protein 3 IMP3 promotes glioma cell migration by enhancing the translation of RELA/p65

https://doi.org/10.18632/oncotarget.17118

Shruti Bhargava, Abhirami Visvanathan, Vikas Patil, Anuj Kumar, Santosh Kesari, Saumitra Das, Alangar S. Hegde, Arimappamagan Arivazhagan, Vani Santosh, and Kumaravel Somasundaram
40469-40485
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Indoleamine 23dioxygenase 1 deficiency attenuates CCl4induced fibrosis through Th17 cells downregulation and tryptophan 23dioxygenase compensation

https://doi.org/10.18632/oncotarget.17119

Weichao Zhong, Lei Gao, Zhenting Zhou, Haiyan Lin, Chun Chen, Peng Huang, Weiliang Huang, Chuying Zhou, Shaohui Huang, Linghui Nie, Ye Liu, Youming Chen, Daqiao Zhou, and Zhiping Lv
40486-40500
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

RACK1 promotes lung cancer cell growth via an MCM7/RACK1/Akt signaling complex

https://doi.org/10.18632/oncotarget.17120

Liangru Fei, Yinan Ma, Meiyu Zhang, Xiaofang Liu, Yuan Luo, Congcong Wang, Haiyan Zhang, Wenzhu Zhang, and Yuchen Han
40501-40513
Abstract  |  PDF  |  Full Text  |  How to cite

Quantification of cell cycle kinetics by EdU 5ethynyl2′deoxyuridinecoupledfluorescenceintensity analysis

https://doi.org/10.18632/oncotarget.17121

Pedro D. Pereira, Ana Serra-Caetano, Marisa Cabrita, Evguenia Bekman, José Braga, José Rino, Renè Santus, Paulo L. Filipe, Ana E. Sousa, and João A. Ferreira
40514-40532
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Oncolytic efficacy of thymidine kinasedeleted vaccinia virus strain Guang9

https://doi.org/10.18632/oncotarget.17125

Lili Deng, Jun Fan, Yuedi Ding, Jue Zhang, Bin Zhou, Yi Zhang, and Biao Huang
40533-40543
Abstract  |  PDF  |  Full Text  |  How to cite

The p75 neurotrophin receptor regulates cranial irradiationinduced hippocampusdependent cognitive dysfunction

https://doi.org/10.18632/oncotarget.16492

Xin Ding, Hao-Hao Wu, Sheng-Jun Ji, Shang Cai, Pei-Wen Dai, Mei-Ling Xu, Jun-Jun Zhang, Qi-Xian Zhang, Ye Tian, and Quan-Hong Ma
40544-40557
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Incidence of menopausal symptoms in postmenopausal breast cancer patients treated with aromatase inhibitors

https://doi.org/10.18632/oncotarget.17194

Dongsheng Hong, Ling Bi, Jun Zhou, Yinghui Tong, Qingwei Zhao, Jing Chen, and Xiaoyang Lu
40558-40567
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Glibenclamide a diabetic drug prevents acute radiationinduced liver injury of mice via upregulating intracellular ROS and subsequently activating Akt–NFκB pathway

https://doi.org/10.18632/oncotarget.16501

Hu Liu, Shichao Wang, Zhao Wu, Ziyun Huang, Wei You Chen, Yanyong Yang, Jianguo Cui, Cong Liu, Hainan Zhao, Jiaming Guo, Pei Zhang, Fu Gao, Bailong Li, and Jianming Cai
40568-40582
Abstract  |  PDF  |  Full Text  |  How to cite

YY1 promotes HDAC1 expression and decreases sensitivity of hepatocellular carcinoma cells to HDAC inhibitor

https://doi.org/10.18632/oncotarget.17196

Sheng Dong, Xiang Ma, Zusen Wang, Bing Han, Hao Zou, Zehua Wu, Yunjin Zang, and Likun Zhuang
40583-40593
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Is MPP a good prognostic factor in stage III lung adenocarcinoma with EGFR exon 19 mutation

https://doi.org/10.18632/oncotarget.16505

Tian Zhang, Jing Wang, Yanjun Su, Xi Chen, Qingna Yan, Qi Li, Leina Sun, Yuwen Wang, Puchun Er, Qingsong Pang, and Ping Wang
40594-40605
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

The Gprotein coupled receptor 56 expressed in colonic stem and cancer cells binds progastrin to promote proliferation and carcinogenesis

https://doi.org/10.18632/oncotarget.16506

Guangchun Jin, Kosuke Sakitani, Hongshan Wang, Ying Jin, Alexander Dubeykovskiy, Daniel L. Worthley, Yagnesh Tailor, and Timothy C. Wang
40606-40619
Abstract  |  PDF  |  Full Text  |  How to cite

The prognostic significance of UCA1 for predicting clinical outcome in patients with digestive system malignancies

https://doi.org/10.18632/oncotarget.16534

Fang-Teng Liu, Qing Dong, Hui Gao, and Zheng-Ming Zhu
40620-40632
Abstract  |  PDF  |  Full Text  |  How to cite

Effect on intensity of treadmill running on learning memory and expressions of cell cyclerelated proteins in rats with cerebral ischemia

https://doi.org/10.18632/oncotarget.16537

Ya-Ning Zhao, Jian-Min Li, Chang-Xiang Chen, Shu-Xing Li, and Cheng-Jing Xue
40633-40642
Abstract  |  PDF  |  Full Text  |  How to cite

Detection of oncogenic mutations in resected bronchial margins by nextgeneration sequencing indicates early relapse in stage IA lung adenocarcinoma patients

https://doi.org/10.18632/oncotarget.16539

Tangfeng Lv, Jiawei Zou, Hongbing Liu, Qin Shen, Zhenfeng Lu, XiaoJun Zhou, Xiaonan Wang, and Yong Song
40643-40653
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Motifs in the aminoterminus of CENPA are required for its accumulation within the nucleus and at the centromere

https://doi.org/10.18632/oncotarget.17204

Ruiqi Jing, Jiajie Xi, Ye Leng, Wen Chen, Guiying Wang, Wenwen Jia, Jiuhong Kang, and Songcheng Zhu
40654-40667
Abstract  |  PDF  |  Full Text  |  How to cite

Comparative study of joint bioinformatics analysis of underlying potential of ‘neurimmiR’ miR2123P/miR1323P being involved in epilepsy and its emerging role in human cancer

https://doi.org/10.18632/oncotarget.16541

Lu Xia, Daojiang Li, Changwei Lin, Shuchun Ou, Xiaorong Li, and Songqing Pan
40668-40682
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Targeted next generation sequencing of mucosal melanomas identifies frequent NF1 and RAS mutations

https://doi.org/10.18632/oncotarget.16542

Ioana Cosgarea, Selma Ugurel, Antje Sucker, Elisabeth Livingstone, Lisa Zimmer, Mirjana Ziemer, Jochen Utikal, Peter Mohr, Christiane Pfeiffer, Claudia Pföhler, Uwe Hillen, Susanne Horn, Dirk Schadendorf, Klaus Griewank, and Alexander Roesch
40683-40692
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Transcriptome profiling identifies a recurrent CRYL1IFT88 chimeric transcript in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.17244

Yi Huang, Jiaying Zheng, Dunyan Chen, Feng Li, Wenbing Wu, Xiaoli Huang, Yanan Wu, Yangyang Deng, and Funan Qiu
40693-40704
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Recombinant SjP40 protein enhances p27 promoter expression in hepatic stellate cells via an E2F1dependent mechanism

https://doi.org/10.18632/oncotarget.17248

Yinong Duan, Lei Lyu, Dandan Zhu, Jianxin Wang, Jinling Chen, Liuting Chen, Chunzhao Yang, and Xiaolei Sun
40705-40712
Abstract  |  PDF  |  Full Text  |  How to cite

Targeting neurokinin3 receptor: a novel antiangiogenesis strategy for cancer treatment

https://doi.org/10.18632/oncotarget.17250

Ting Wang, Siwei Chen, Shihui Wang, Liang Shi, Chenggong Wang, Jingxin Zhang, Yanfeng Gao, Guodong Li, Yuanming Qi, Xiuli An, and Lixiang Chen
40713-40723
Abstract  |  PDF  |  Full Text  |  How to cite

Prognostic significance of the red blood cell distribution width in diffuse large Bcell lymphoma patients

https://doi.org/10.18632/oncotarget.16560

Shujuan Zhou, Fang Fang, Huiyao Chen, Wei Zhang, Yang Chen, Yifen Shi, Zhouyi Zheng, Yongyong Ma, Liyuan Tang, Jianhua Feng, Yu Zhang, Lan Sun, Yi Chen, Bin Liang, Kang Yu, and Songfu jiang
40724-40731
Abstract  |  PDF  |  Full Text  |  How to cite

Evaluation of 99mTcHYNICMPG as a novel SPECT radiotracer to detect EGFRactivating mutations in NSCLC

https://doi.org/10.18632/oncotarget.17251

Zunyu Xiao, Yan Song, Wang Kai, Xilin Sun, and Baozhong Shen
40732-40740
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Heat stress induces intestinal injury through lysosome and mitochondriadependent pathway in vivo and in vitro

https://doi.org/10.18632/oncotarget.16580

Gao Yi, Li Li, Meijuan Luo, Xuan He, Zhimin Zou, Zhengtao Gu, and Lei Su
40741-40755
Abstract  |  PDF  |  Full Text  |  How to cite

Intraoperative contrastenhanced ultrasonography for microcirculatory evaluation in rhesus monkey with spinal cord injury

https://doi.org/10.18632/oncotarget.17252

Lin Huang, Keng Chen, Fu-Chao Chen, Hui-Yong Shen, Ji-Chao Ye, Zhao-Peng Cai, and Xi Lin
40756-40764
Abstract  |  PDF  |  Full Text  |  How to cite

Expression of estrogen receptors and androgen receptor and their clinical significance in gastric cancer

https://doi.org/10.18632/oncotarget.16582

Wenbo Tang, Rujiao Liu, Yan Yan, Xiaoli Pan, Minjun Wang, Xiaotian Han, Hui Ren, and Zhe Zhang
40765-40777
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Pancreatic cancer ascites xenograft–an expeditious model mirroring advanced therapeutic resistant disease

https://doi.org/10.18632/oncotarget.17253

Talia Golan, Chani Stossel, Michael Schvimer, Dikla Atias, Sharon Halperin, Ella Buzhor, Maria Raitses-Gurevich, Keren Cohen, Sara Pri-Chen, Julie Wilson, Robert E. Denroche, Ilinca Lungu, John M.S. Bartlett, Faridah Mbabaali, Yosef Yarden, Nishanth Belugali Nataraj, Steven Gallinger, and Raanan Berger
40778-40790
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Enhanced tumor growth inhibition by mesenchymal stem cells derived from iPSCs with targeted integration of interleukin24 into rDNA loci

https://doi.org/10.18632/oncotarget.16584

Bo Liu, Fei Chen, Yong Wu, Xiaolin Wang, Mai Feng, Zhuo Li, Miaojin Zhou, Yanchi Wang, Lingqian Wu, Xionghao Liu, and Desheng Liang
40791-40803
Abstract  |  PDF  |  Full Text  |  How to cite

Inhibiting translesion DNA synthesis as an approach to combat drug resistance to DNA damaging agents

https://doi.org/10.18632/oncotarget.17254

Jung-Suk Choi, Seol Kim, Edward Motea, and Anthony Berdis
40804-40816
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Rapamycin regulates macrophage activation by inhibiting NLRP3 inflammasomep38 MAPKNFκB pathways in autophagy and p62dependent manners

https://doi.org/10.18632/oncotarget.17256

Jung Hwa Ko, Sun-Ok Yoon, Hyun Ju Lee, and Joo Youn Oh
40817-40831
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Cellfree microRNA expression signatures in urine serve as novel noninvasive biomarkers for diagnosis and recurrence prediction of bladder cancer

https://doi.org/10.18632/oncotarget.16586

Lutao Du, Xiumei Jiang, Weili Duan, Rui Wang, lishui Wang, Guixi Zheng, Keqiang Yan, Lili Wang, Juan Li, Xin Zhang, Hongwei Pan, Yongmei Yang, and Chuanxin Wang
40832-40842
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

High glucose induces formation of tau hyperphosphorylation via Cav1mTOR pathway: A potential molecular mechanism for diabetesinduced cognitive dysfunction

https://doi.org/10.18632/oncotarget.17257

Jing Wu, Shan-Lei Zhou, Lin-Hua Pi, Xia-Jie Shi, Ling-Ran Ma, Zi Chen, Min-Li Qu, Xin Li, Sheng-Dan Nie, Duan-Fang Liao, Jin-Jing Pei, and Shan Wang
40843-40856
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Benzene and its metabolite decreases cell proliferation via LncRNAOBFC2Amediated antiproliferation effect involving NOTCH1 and KLF15

https://doi.org/10.18632/oncotarget.16588

Pengling Sun, Jing Wang, Xiaoli Guo, Yujiao Chen, Caihong Xing, and Ai Gao
40857-40871
Abstract  |  PDF  |  Full Text  |  How to cite

αMSH prevents ROSinduced apoptosis by inhibiting Foxo1/mTORC2 in mice adipose tissue

https://doi.org/10.18632/oncotarget.16606

Weina Cao, Meihang Li, Tianjiao Wu, Fei Feng, Tongying Feng, Yang Xu, and Chao Sun
40872-40884
Abstract  |  PDF  |  Full Text  |  How to cite

FHL2 interacts with iASPP and impacts the biological functions of leukemia cells

https://doi.org/10.18632/oncotarget.16617

Wenting Lu, Tengteng Yu, Shuang Liu, Saisai Li, Shouyun Li, Jia Liu, Yingxi Xu, Haiyan Xing, Zheng Tian, Kejing Tang, Qing Rao, Jianxiang Wang, and Min Wang
40885-40895
Abstract  |  PDF  |  Full Text  |  How to cite

HABP2 pG534E variant in patients with family history of thyroid and breast cancer

https://doi.org/10.18632/oncotarget.16639

Maisa Pinheiro, Sandra Aparecida Drigo, Renata Tonhosolo, Sonia Andrade, Fabio Albuquerque Marchi, Igor Jurisica, Luiz Paulo Kowalski, Maria Isabel Achatz, and Silvia Regina Rogatto
40896-40905
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Ctype natriuretic peptidemodified lipid vesicles: fabrication and use for the treatment of brain glioma

https://doi.org/10.18632/oncotarget.16641

Jia-Shuan Wu, Li-Min Mu, Ying-Zi Bu, Lei Liu, Yan Yan, Ying-Jie Hu, Jing Bai, Jing-Ying Zhang, Weiyue Lu, and Wan-Liang Lu
40906-40921
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Syndecan1 knockdown inhibits glioma cell proliferation and invasion by deregulating a csrc/FAKassociated signaling pathway

https://doi.org/10.18632/oncotarget.16733

Shuang Shi, Dong Zhong, Yao Xiao, Bing Wang, Wentao Wang, Fu'an Zhang, and Haoyang Huang
40922-40934
Abstract  |  PDF  |  Full Text  |  How to cite

Regeneration of cervical reserve celllike cells from human induced pluripotent stem cells iPSCs: A new approach to finding targets for cervical cancer stem cell treatment

https://doi.org/10.18632/oncotarget.16783

Masakazu Sato, Kei Kawana, Katsuyuki Adachi, Asaha Fujimoto, Mitsuyo Yoshida, Hiroe Nakamura, Haruka Nishida, Tomoko Inoue, Ayumi Taguchi, Juri Ogishima, Satoko Eguchi, Aki Yamashita, Kensuke Tomio, Osamu Wada-Hiraike, Katsutoshi Oda, Takeshi Nagamatsu, Yutaka Osuga, and Tomoyuki Fujii
40935-40945
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Identification of serum inflammatory markers as classifiers of lung cancer mortality for stage I adenocarcinoma

https://doi.org/10.18632/oncotarget.16784

Claire L. Meaney, Adriana Zingone, Derek Brown, Yunkai Yu, Liang Cao, and Bríd M. Ryan
40946-40957
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

SET mediates TCEinduced liver cell apoptosis through dephosphorylation and upregulation of nucleolin

https://doi.org/10.18632/oncotarget.16785

Xiaohu Ren, Xinfeng Huang, Xifei Yang, Yungang Liu, Wei Liu, Haiyan Huang, Desheng Wu, Fei Zou, and Jianjun Liu
40958-40966
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

NatBmediated protein Nαterminal acetylation is a potential therapeutic target in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.17332

Leire Neri, Marta Lasa, Alberto Elosegui-Artola, Delia D'Avola, Beatriz Carte, Cristina Gazquez, Sara Alve, Pere Roca-Cusachs, Mercedes Iñarrairaegui, Jose Herrero, Jesús Prieto, Bruno Sangro, and Rafael Aldabe
40967-40981
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Dietary luteolin attenuates chronic liver injury induced by mercuric chloride via the Nrf2/NFκB/P53 signaling pathway in rats

https://doi.org/10.18632/oncotarget.17334

Haili Zhang, Xiao Tan, Daqian Yang, Jingjing Lu, Biying Liu, Ruiqi Baiyun, and Zhigang Zhang
40982-40993
Abstract  |  PDF  |  Full Text  |  How to cite

Timecourse differential lncRNA and mRNA expressions in radioresistant hypopharyngeal cancer cells

https://doi.org/10.18632/oncotarget.17343

Jieyu Zhou, Shengda Cao, Wenming Li, Dongmin Wei, Zhentao Wang, Guojun Li, Xinliang Pan, and Dapeng Lei
40994-41010
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

PDCD1 PD1 promoter methylation predicts outcome in head and neck squamous cell carcinoma patients

https://doi.org/10.18632/oncotarget.17354

Diane Goltz, Heidrun Gevensleben, Joern Dietrich, Friederike Schroeck, Luka de Vos, Freya Droege, Glen Kristiansen, Andreas Schroeck, Jennifer Landsberg, Friedrich Bootz, and Dimo Dietrich
41011-41020
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

A variant in SIRT2 gene 3′UTR is associated with susceptibility to colorectal cancer

https://doi.org/10.18632/oncotarget.17460

Yong Yang, Jie Ding, Zhi-Gang Gao, and Zhen-Jun Wang
41021-41025
Abstract  |  PDF  |  Full Text  |  How to cite

Phosphodiesterase 3A: a new player in development of interstitial cells of Cajal and a prospective target in gastrointestinal stromal tumors GIST

https://doi.org/10.18632/oncotarget.17010

Pierre Vandenberghe, Perrine Hagué, Steven C. Hockman, Vincent C. Manganiello, Pieter Demetter, Christophe Erneux, and Jean-Marie Vanderwinden
41026-41043
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Antiproliferative and antisecretory effects of everolimus on human pancreatic neuroendocrine tumors primary cultures: is there any benefit from combination with somatostatin analogs

https://doi.org/10.18632/oncotarget.17008

Amira Mohamed, David Romano, Alexandru Saveanu, Catherine Roche, Manuela Albertelli, Federica Barbieri, Thierry Brue, Patricia Niccoli, Jean-Robert Delpero, Stephane Garcia, Diego Ferone, Tullio Florio, Vincent Moutardier, Flora Poizat, Anne Barlier, and Corinne Gerard
41044-41063
Abstract  |  PDF  |  Full Text  |  How to cite

Targeting AXL overcomes resistance to docetaxel therapy in advanced prostate cancer

https://doi.org/10.18632/oncotarget.17026

Jian-Zhong Lin, Zeng-Jun Wang, Wei De, Ming Zheng, Wei-Zhang Xu, Hong-Fei Wu, Alex Armstrong, and Jia-Geng Zhu
41064-41077
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

The different pathogenesis of sporadic adenoma and adenocarcinoma in nonampullary lesions of the proximal and distal duodenum

https://doi.org/10.18632/oncotarget.17051

Ayumi Niwa, Seiya Kuwano, Hiroyuki Tomita, Keita Kimura, Yukiya Orihara, Tomohiro Kanayama, Kei Noguchi, Kenji Hisamatsu, Takayuki Nakashima, Yuichiro Hatano, Akihiro Hirata, Tatsuhiko Miyazaki, Kazuhiro Kaneko, Takuji Tanaka, and Akira Hara
41078-41090
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Synergistic inhibition effect of TNIK inhibitor KY05009 and receptor tyrosine kinase inhibitor dovitinib on IL6induced proliferation and Wnt signaling pathway in human multiple myeloma cells

https://doi.org/10.18632/oncotarget.17056

Yura Lee, Jung-Il Jung, Kyeong-Yong Park, Soon Ae Kim, and Jiyeon Kim
41091-41101
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

A prognostic nomogram for overall survival after neoadjuvant radiotherapy or chemoradiotherapy in thoracic esophageal squamous cell carcinoma: a retrospective analysis

https://doi.org/10.18632/oncotarget.17062

Wei Deng, Qifeng Wang, Zefen Xiao, Lijun Tan, Zhao Yang, Zongmei Zhou, Hongxing Zhang, Dongfu Chen, Qinfu Feng, Jun Liang, Yexiong Li, Jie He, Shugeng Gao, Kelin Sun, Guiyu Cheng, Xiangyang Liu, Dekang Fang, Qi Xue, Yousheng Mao, Dali Wang, and and Jian Li
41102-41112
Abstract  |  PDF  |  Full Text  |  How to cite

Evidence of drugresponse heterogeneity rapidly generated from a single cancer cell

https://doi.org/10.18632/oncotarget.17064

Rong Wang, Chengmeng Jin, and Xun Hu
41113-41124
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

SMAD7 rs4939827 variant contributes to colorectal cancer risk in Chinese population

https://doi.org/10.18632/oncotarget.17065

Chunze Zhang, Xichuan Li, Wenzheng Fu, Yijia Wang, Tao Wang, Wenhong Wang, Shuo Chen, Hai Qin, and Xipeng Zhang
41125-41131
Abstract  |  PDF  |  Full Text  |  How to cite

Metformin and lung cancer risk in patients with type 2 diabetes mellitus

https://doi.org/10.18632/oncotarget.17066

Chin-Hsiao Tseng
41132-41142
Abstract  |  PDF  |  Full Text  |  How to cite

Androgen receptor status predicts development of brain metastases in ovarian cancers

https://doi.org/10.18632/oncotarget.17068

Gloria Mittica, Rebecca Senetta, Giulia Scotto, Massimo Aglietta, Furio Maggiorotto, Eleonora Ghisoni, Sofia Genta, Renzo Boldorini, Claudia Manini, Isabella Morra, Roberta Buosi, Anna Sapino, Paola Cassoni, and Giorgio Valabrega
41143-41153
Abstract  |  PDF  |  Full Text  |  How to cite

The antigenbinding fragment of human gamma immunoglobulin prevents amyloid βpeptide folding into βsheet to form oligomers

https://doi.org/10.18632/oncotarget.17074

Victòria Valls-Comamala, Biuse Guivernau, Jaume Bonet, Marta Puig, Alex Perálvarez-Marín, Ernest Palomer, Xavier Fernàndez-Busquets, Xavier Altafaj, Marta Tajes, Albert Puig-Pijoan, Rubén Vicente, Baldomero Oliva, and Francisco J. Muñoz
41154-41165
Abstract  |  PDF  |  Full Text  |  How to cite

Serum long noncoding RNAs MALAT1 AFAP1AS1 and AL359062 as diagnostic and prognostic biomarkers for nasopharyngeal carcinoma

https://doi.org/10.18632/oncotarget.17083

Baoyu He, Jianchao Zeng, Wei Chao, Xiaoli Chen, Yujie Huang, Kaifeng Deng, Zhizhuo Huang, Jinwan Li, Meiyu Dai, Shaojun Chen, Haixin Huang, and Shengming Dai
41166-41177
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

iRNAm5CPseDNC: identifying RNA 5methylcytosine sites by incorporating physicalchemical properties into pseudo dinucleotide composition

https://doi.org/10.18632/oncotarget.17104

Wang-Ren Qiu, Shi-Yu Jiang, Zhao-Chun Xu, Xuan Xiao, and Kuo-Chen Chou
41178-41188
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

High WAVE3 expression correlates with proliferation migration and invasion in human ovarian cancer

https://doi.org/10.18632/oncotarget.17141

Jin Lu, Su-Li Wang, Ying-Chun Wang, Yi-Nan Wu, Xi Yu, Wan-Zhou Zhao, and Jin-Hua Wang
41189-41201
Abstract  |  PDF  |  Full Text  |  How to cite

Andrographolide ameliorates dgalactosamine/lipopolysaccharideinduced acute liver injury by activating Nrf2 signaling pathway

https://doi.org/10.18632/oncotarget.17149

Chen-wei Pan, Shou-xing Yang, Zhen-zhen Pan, Bo Zheng, Jian-zhang Wang, Guang-rong Lu, Zhan-xiong Xue, and Chang-long Xu
41202-41210
Abstract  |  PDF  |  Full Text  |  How to cite

New tumor suppressor microRNAs target glypican3 in human liver cancer

https://doi.org/10.18632/oncotarget.17162

Flora Cartier, Emilie Indersie, Sarah Lesjean, Justine Charpentier, Katarzyna B. Hooks, Amani Ghousein, Angélique Desplat, Nathalie Dugot-Senant, Véronique Trézéguet, Francis Sagliocco, Martin Hagedorn, and Christophe F. Grosset
41211-41226
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Activation of Akt characterizes estrogen receptor positive human breast cancers which respond to anthracyclines

https://doi.org/10.18632/oncotarget.17167

Synnøve Yndestad, Eilin Austreid, Ida R. Svanberg, Stian Knappskog, Per E. Lønning, and Hans P. Eikesdal
41227-41241
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Radiation improves antitumor effect of immune checkpoint inhibitor in murine hepatocellular carcinoma model

https://doi.org/10.18632/oncotarget.17168

Kyoung-Jin Kim, Ji-Hye Kim, Seo Jin Lee, Eun-Jung Lee, Eui-Cheol Shin, and Jinsil Seong
41242-41255
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Dexmedetomidine plus sufentanil for pediatric flexible bronchoscopy: A retrospective clinical trial

https://doi.org/10.18632/oncotarget.17169

Xiujing Dang, Weidong Hu, Zhendong Yang, and Shiyu Su
41256-41264
Abstract  |  PDF  |  Full Text  |  How to cite

Rewiring carbohydrate catabolism differentially affects survival of pancreatic cancer cell lines with diverse metabolic profiles

https://doi.org/10.18632/oncotarget.17172

Tiziana Tataranni, Francesca Agriesti, Vitalba Ruggieri, Carmela Mazzoccoli, Vittorio Simeon, Ilaria Laurenzana, Rosella Scrima, Valerio Pazienza, Nazzareno Capitanio, and Claudia Piccoli
41265-41281
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Increased levels of LAPTM4B VEGF and survivin are correlated with tumor progression and poor prognosis in breast cancer patients

https://doi.org/10.18632/oncotarget.17176

Sha Li, Lu Wang, Yue Meng, Yanli Chang, Jianjun Xu, and Qingyun Zhang
41282-41293
Abstract  |  PDF  |  Full Text  |  How to cite

Efficacy of an HSP90 inhibitor ganetespib in preclinical thyroid cancer models

https://doi.org/10.18632/oncotarget.17180

Shu-Fu Lin, Jen-Der Lin, Chuen Hsueh, Ting-Chao Chou, Chun-Nan Yeh, Ming-Huang Chen, and Richard J. Wong
41294-41304
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

A nomogram based on serum bilirubin and albumin levels predicts survival in gastric cancer patients

https://doi.org/10.18632/oncotarget.17181

Huiling Sun, Bangshun He, Zhenlin Nie, Yuqin Pan, Kang Lin, Hongxin Peng, Tao Xu, Xiaoxiang Chen, Xiuxiu Hu, Zijuan Wu, Di Wu, and Shukui Wang
41305-41318
Abstract  |  PDF  |  Full Text  |  How to cite

TrkC promotes colorectal cancer growth and metastasis

https://doi.org/10.18632/oncotarget.17289

Min Soo Kim, Kwang Wook Suh, Suntaek Hong, and Wook Jin
41319-41333
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Transcriptional response profiles of paired tumornormal samples offer novel perspectives in pancancer analysis

https://doi.org/10.18632/oncotarget.17295

Shuofeng Hu, Hanyu Yuan, Zongcheng Li, Jian Zhang, Jiaqi Wu, Yaowen Chen, Qiang Shi, Wu Ren, Ningsheng Shao, and Xiaomin Ying
41334-41347
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

EphrinB2/Fc promotes proliferation and migration and suppresses apoptosis in human umbilical vein endothelial cells

https://doi.org/10.18632/oncotarget.17298

Li-Chun Zheng, Xiao-Qing Wang, Kun Lu, Xiao-Ling Deng, Cheng-Wei Zhang, Hong Luo, Xu-Dong Xu, Xiao-Man Chen, Lu Yan, Yi-Qing Wang, and Song-Lin Shi
41348-41363
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Oleateinduced PTX3 promotes head and neck squamous cell carcinoma metastasis through the upregulation of vimentin

https://doi.org/10.18632/oncotarget.17326

Shih-Hung Chan, Jhih-Peng Tsai, Chih-Jie Shen, Yu-Han Liao, and Ben-Kuen Chen
41364-41378
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Elevated serum growth differentiation factor 15 levels are associated with thyroid nodules in type 2 diabetes aged over 60 years

https://doi.org/10.18632/oncotarget.17328

Hongmei Zhang, Weiwei Zhang, Xiaofang Tu, Yixin Niu, Xiaoyong Li, Li Qin, Zhen Yang, and Qing Su
41379-41386
Abstract  |  PDF  |  Full Text  |  How to cite

Induction of immunoglobulin transcription factor 2 and resistance to MEK inhibitor in melanoma cells

https://doi.org/10.18632/oncotarget.17866

Eun-Hye Hur, Bon-Kwan Goo, Juhyun Moon, Yunsuk Choi, Jung Jin Hwang, Choung-Soo Kim, Kyun Seop Bae, Jene Choi, Suk Young Cho, Sang-Hwa Yang, Jeongbeob Seo, Gilnam Lee, and Je-Hwan Lee
41387-41400
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Transscirpusin A showed antitumor effects via autophagy activation and apoptosis induction of colorectal cancer cells

https://doi.org/10.18632/oncotarget.17388

Eun-Hye Hong, Eun-Young Heo, Jae-Hyoung Song, Bo-Eun Kwon, Jae-Young Lee, Yaejeong Park, Jinwoong Kim, Sun-Young Chang, Young-Won Chin, Sang-Min Jeon, and Hyun-Jeong Ko
41401-41411
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

The relationship between tumor markers and pulmonary embolism in lung cancer

https://doi.org/10.18632/oncotarget.17916

Wei Xiong, Yunfeng Zhao, Mei Xu, Jian Guo, Bigyan Pudasaini, Xueling Wu, and Jinming Liu
41412-41421
Abstract  |  PDF  |  Full Text  |  How to cite

P53 suppresses ribonucleotide reductase via inhibiting mTORC1

https://doi.org/10.18632/oncotarget.17440

Zhengfu He, Xing Hu, Weijin Liu, Adrienne Dorrance, Ramiro Garzon, Peter J. Houghton, and Changxian Shen
41422-41431
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Identification of molecular biomarkers for pancreatic cancer with mRMR shortest path method

https://doi.org/10.18632/oncotarget.18186

Shuhua Shen, Tuantuan Gui, and Chengcheng Ma
41432-41439
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Comparative analyses of long noncoding RNA in lean and obese pigs

https://doi.org/10.18632/oncotarget.18269

Lin Yu, Lina Tai, Lifang Zhang, Yi Chu, Yixing Li, and Lei Zhou
41440-41450
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

MicroRNA155 induced by FOXP3 through transcriptional repression of BRCA1 is associated with tumor initiation in human breast cancer

https://doi.org/10.18632/oncotarget.17816

Song Gao, Yicun Wang, Meng Wang, Zhi Li, Zhiying Zhao, Raymond X. Wang, Rong Wu, Zhengwei Yuan, Ranji Cui, Kai Jiao, Lizhong Wang, Ling Ouyang, and Runhua Liu
41451-41464
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Consistency mapping of 16 lymph node stations in gastric cancer by CTbased vesselguided delineation of 255 patients

https://doi.org/10.18632/oncotarget.18407

Shuhang Xu, Lingling Feng, Yongming Chen, Ying Sun, Yao Lu, Shaomin Huang, Yang Fu, Rongqin Zheng, Yujing Zhang, and Rong Zhang
41465-41473
Abstract  |  PDF  |  Full Text  |  How to cite

Meta-Analysis

A systematic review and metaanalysis of individual patient data on the impact of the BIM deletion polymorphism on treatment outcomes in epidermal growth factor receptor mutant lung cancer

https://doi.org/10.18632/oncotarget.17102

Sheila X. Soh, Fahad J. Siddiqui, John C. Allen, Go Woon Kim, Jae Cheol Lee, Yasushi Yatabe, Manabu Soda, Hiroyuki Mano, Ross A. Soo, Tan-Min Chin, Hiromichi Ebi, Seiji Yano, Keitaro Matsuo, Xiaomin Niu, Shun Lu, Kazutoshi Isobe, Jih-Hsiang Lee, James C. Yang, Mingchuan Zhao, Caicun Zhou, June-Koo Lee, Se-Hoon Lee, Ji Yun Lee, Myung-Ju Ahn, Tira J. Tan, Daniel S. Tan, Eng-Huat Tan, S. Tiong Ong, and Wan-Teck Lim
41474-41486
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Efficacy of fibrin glue versus sutures for attaching conjunctival autografts in pterygium surgery: a systematic review with metaanalysis and trial sequential analysis of evidence

https://doi.org/10.18632/oncotarget.17195

Aihua Lan, Feifan Xiao, Yun Wang, Zhen Luo, and Qixin Cao
41487-41497
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Efficacy and safety of decitabine in treatment of elderly patients with acute myeloid leukemia: A systematic review and metaanalysis

https://doi.org/10.18632/oncotarget.17241

Pin-Fang He, Jing-Dong Zhou, Dong-Ming Yao, Ji-Chun Ma, Xiang-Mei Wen, Zhi-Hui Zhang, Xin-Yue Lian, Zi-Jun Xu, Jun Qian, and Jiang Lin
41498-41507
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Statin use and survival outcomes in endocrinerelated gynecologic cancers: A systematic review and metaanalysis

https://doi.org/10.18632/oncotarget.17242

Weimin Xie, Li Ning, Yuenan Huang, Yan Liu, Wen Zhang, Yingchao Hu, Jinghe Lang, and Jiaxin Yang
41508-41517
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Diagnostic value of using 18FFDG PET and PET/CT in immunocompetent patients with primary central nervous system lymphoma: A systematic review and metaanalysis

https://doi.org/10.18632/oncotarget.17456

Yaru Zou, Jianjing Tong, Haiyan Leng, Jingwei Jiang, Meng Pan, and Zi Chen
41518-41528
Abstract  |  PDF  |  Full Text  |  How to cite

Association between serum resistin concentration and hypertension: A systematic review and metaanalysis

https://doi.org/10.18632/oncotarget.17561

Yuxiang Zhang, Yixing Li, Lin Yu, and Lei Zhou
41529-41537
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Clinical Research Papers

A phase I clinical study of autologous dendritic cell therapy in patients with relapsed or refractory multiple myeloma

https://doi.org/10.18632/oncotarget.14582

Sung-Hoon Jung, Hyun-Ju Lee, Youn-Kyung Lee, Deok-Hwan Yang, Hyeoung-Joon Kim, Joon Haeng Rhee, Frank Emmrich, and Je-Jung Lee
41538-41548
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Pathway of peritoneal carcinomatosis maybe hematogenous metastasis rather than peritoneal seeding

https://doi.org/10.18632/oncotarget.14607

Wei Ge, Gang Chen, and Xiang-Shan Fan
41549-41554
Abstract  |  PDF  |  Full Text  |  How to cite

The prevalence of thyroid nodules in northwest China and its correlation with metabolic parameters and uric acid

https://doi.org/10.18632/oncotarget.14720

Yao Liu, Ziwei Lin, Chunjun Sheng, Yikun Zhu, Yun Huang, Ni Zhong, Zhao Jia, and Shen Qu
41555-41562
Abstract  |  PDF  |  Full Text  |  How to cite

Proposed modifications of supraclavicular lymph node metastasis in the esophageal squamous cell carcinoma staging system for improved survival stratification

https://doi.org/10.18632/oncotarget.14892

Yuzhen Zheng, Zhen Wang, Feng Wang, Qingyuan Huang, and Shuoyan Liu
41563-41571
Abstract  |  PDF  |  Full Text  |  How to cite

Combined use of irinotecan with histone deacetylase inhibitor belinostat could cause severe toxicity by inhibiting SN38 glucuronidation via UGT1A1

https://doi.org/10.18632/oncotarget.15017

Lingzhi Wang, Chong En Linus Chan, Andrea Li-Ann Wong, Fang Cheng Wong, Siew Woon Lim, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Lawrence Soon-U Lee, Ross Soo, Wei Peng Yong, Soo Chin Lee, Paul Chi-Lui Ho, Gautam Sethi, and Boon Cher Goh
41572-41581
Abstract  |  PDF  |  Full Text  |  How to cite

Therapeutic effects of atorvastatin and ezetimibe compared with doubledose atorvastatin in very elderly patients with acute coronary syndrome

https://doi.org/10.18632/oncotarget.15078

Zhi Liu, Hengjian Hao, Chunlin Yin, Yanyan Chu, Jing Li, and Dong Xu
41582-41589
Abstract  |  PDF  |  Full Text  |  How to cite

Longterm clinical outcomes of hematopoietic cell transplantation for intermediatetopoorrisk acute myeloid leukemia during first remission according to available donor types

https://doi.org/10.18632/oncotarget.15295

Jae-Ho Yoon, Hee-Je Kim, Sung-Soo Park, Young-Woo Jeon, Sung-Eun Lee, Byung-Sik Cho, Ki-Seong Eom, Yoo-Jin Kim, Seok Lee, Chang-Ki Min, Seok-Goo Cho, Dong-Wook Kim, Jong-Wook Lee, and Woo-Sung Min
41590-41604
Abstract  |  PDF  |  Full Text  |  How to cite

Preoperative serum lipids as prognostic predictors in esophageal squamous cell carcinoma patients with esophagectomy

https://doi.org/10.18632/oncotarget.15651

Pengxiang Chen, Lihui Han, Cong Wang, Yibin Jia, Qingxu Song, Jianbo Wang, Shanghui Guan, Bingxu Tan, Bowen Liu, Wenqiao Jia, Jianfeng Cui, Wei Zhou, and Yufeng Cheng
41605-41619
Abstract  |  PDF  |  Full Text  |  How to cite

Hematology oncology practice in the AsiaPacific APHCON survey results from the 6th international hematologic malignancies conference: bridging the gap 2015 Beijing China

https://doi.org/10.18632/oncotarget.15655

Xiao Jun Huang, Kaiyan Liu, David Ritchie, Borje Andersson, Jin Lu, Jian Hou, Adolfo de la Fuente Burguera, JianXiang Wang, Allen Yeoh, Chenhua Yan, Daobin Zhou, Daryl Tan, Dong Wook Kim, Depei Wu, Elizabeth Shpall, Stephen Kornblau, Sattava Neelapu, Suradej Hongeng, Jianyong Li, Jiong Hu, Lian Sheng Zhang, Michael Wang, Pankaj Malhotra, Qian Jiang, Yazhen Qin, Raymond Wong, Richard Champlin, Frederick Hagemeister, Jason Westin, Swaminathan Iyer, Vikram Mathews, Yu Wang, Yu Hu, Zhijian Xiao, Zonghong Shao, Robert Z. Orlowski, Chor Sang Chim, Stephen Mulligan, Miguel Sanz, Keiya Ozawa, Simrit Parmar, and Surapol Issaragrisil
41620-41630
Abstract  |  PDF  |  Full Text  |  How to cite

Clinical benefit of continuing crizotinib therapy after initial disease progression in Chinese patients with advanced ALKrearranged nonsmallcell lung cancer

https://doi.org/10.18632/oncotarget.15892

Xiangchan Hong, Qi Chen, Lingyu Ding, Ying Liang, Ningning Zhou, Wenfeng Fang, Xinru Chen, and Haiying Wu
41631-41640
Abstract  |  PDF  |  Full Text  |  How to cite

Reviews

Tumor immunotherapy: druginduced neoantigens xenogenization and immune checkpoint inhibitors

https://doi.org/10.18632/oncotarget.16335

Ornella Franzese, Francesco Torino, Maria Pia Fuggetta, Angelo Aquino, Mario Roselli, Enzo Bonmassar, Anna Giuliani, and Stefania D’Atri
41641-41669
Abstract  |  PDF  |  Full Text  |  How to cite

Definitive radiochemotherapy versus surgery within multimodality treatment in stage III nonsmall cell lung cancer NSCLC a cumulative metaanalysis of the randomized evidence

https://doi.org/10.18632/oncotarget.16471

Christoph Pöttgen, Wilfried Eberhardt, Georgios Stamatis, and Martin Stuschke
41670-41678
Abstract  |  PDF  |  Full Text  |  How to cite

Epithelialtomesenchymal transition in the development of endometriosis

https://doi.org/10.18632/oncotarget.16472

Yan-Meng Yang, and Wan-Xi Yang
41679-41689
Abstract  |  PDF  |  Full Text  |  How to cite

Cathepsins in digestive cancers

https://doi.org/10.18632/oncotarget.16677

Siyuan Chen, Hui Dong, Shiming Yang, and Hong Guo
41690-41700
Abstract  |  PDF  |  Full Text  |  How to cite

Distinct functions of dynamin isoforms in tumorigenesis and their potential as therapeutic targets in cancer

https://doi.org/10.18632/oncotarget.16678

Jianghui Meng
41701-41716
Abstract  |  PDF  |  Full Text  |  How to cite

Exosome: emerging biomarker in breast cancer

https://doi.org/10.18632/oncotarget.16684

Yunlu Jia, Yongxia Chen, Qinchuan Wang, Ushani Jayasinghe, Xiao Luo, Qun Wei, Ji Wang, Hanchu Xiong, Cong Chen, Bin Xu, Wenxian Hu, Linbo Wang, Wenhe Zhao, and Jichun Zhou
41717-41733
Abstract  |  PDF  |  Full Text  |  How to cite

Associations of the glutathione Stransferase P1 Ile105Val genetic polymorphism with gynecological cancer susceptibility: a metaanalysis

https://doi.org/10.18632/oncotarget.16764

Erjiang Zhao, Kai Hu, and Yan Zhao
41734-41739
Abstract  |  PDF  |  Full Text  |  How to cite

Impact of perioperative blood transfusion on clinical outcomes in patients with colorectal liver metastasis after hepatectomy: a metaanalysis

https://doi.org/10.18632/oncotarget.16771

Xinghua Lyu, Wenhui Qiao, Debang Li, and Yufang Leng
41740-41748
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

LIM kinases: cofilin and beyond

https://doi.org/10.18632/oncotarget.16978

Chloé Prunier, Renaud Prudent, Reuben Kapur, Karin Sadoul, and Laurence Lafanechère
41749-41763
Abstract  |  PDF  |  Full Text  |  How to cite

The challenge of treating hepatitis C virusassociated cryoglobulinemic vasculitis in the era of antiCD20 monoclonal antibodies and direct antiviral agents

https://doi.org/10.18632/oncotarget.16986

Dario Roccatello, Savino Sciascia, Daniela Rossi, Laura Solfietti, Roberta Fenoglio, Elisa Menegatti, and Simone Baldovino
41764-41777
Abstract  |  PDF  |  Full Text  |  How to cite

Corrections

Correction: Tumor growth suppressive effect of IL4 through p21mediated activation of STAT6 in IL4Rα overexpressed melanoma models

https://doi.org/10.18632/oncotarget.18561

Hye Lim Lee, Mi Hee Park, Ju Kyoung Song, Yu Yeon Jung, Youngsoo Kim, Kyung Bo Kim, Dae Yeon Hwang, Do Young Yoon, Min Jong Song, Sang Bae Han, and Jin Tae Hong
41778-41778
Correction  |  PDF  |  How to cite

Correction: CCR4 promotes metastasis via ERK/NFκB/MMP13 pathway and acts downstream of TNFα in colorectal cancer

https://doi.org/10.18632/oncotarget.18562

Baochi Ou, Jingkun Zhao, Shaopei Guan, Hao Feng, Xiongzhi Wangpu, Congcong Zhu, Yaping Zong, Junjun Ma, Jing Sun, Xiaohui Shen, Minhua Zheng, and Aiguo Lu
41779-41779
Correction  |  PDF  |  How to cite


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