Oncotarget

Research Papers:

Clinicopathological features of small cell carcinoma of the uterine cervix in the surveillance, epidemiology, and end results database

Juan Zhou, San-Gang Wu, Jia-Yuan Sun, Li-Ying Tang, Huan-Xin Lin, Feng-Yan Li, Qiong-Hua Chen, Xin Jin _ and Zhen-Yu He

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Oncotarget. 2017; 8:40425-40433. https://doi.org/10.18632/oncotarget.16390

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Abstract

Juan Zhou1,*, San-Gang Wu2,*, Jia-Yuan Sun3,*, Li-Ying Tang4, Huan-Xin Lin3, Feng-Yan Li3, Qiong-Hua Chen1, Xin Jin5 and Zhen-Yu He3

1Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xiamen University, Xiamen, People’s Republic of China

2Department of Radiation Oncology, Xiamen Cancer Hospital, The First Affiliated Hospital of Xiamen University, Xiamen, People’s Republic of China

3Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, People’s Republic of China

4Eye Institute of Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Medical College of Xiamen University, Xiamen, People’s Republic of China

5Faculty of Basic Medicine, Medical College, Xiamen University, Xiamen, People’s Republic of China

*These authors have contributed equally to this work

Correspondence to:

Xin Jin, email: xinjin@xmu.edu.cn

Zhen-Yu He, email: hezhy@sysucc.org.cn

Keywords: cervical carcinoma, small cell, survival, prognosis

Received: June 06, 2016    Accepted: March 03, 2017    Published: March 21, 2017

ABSTRACT

To investigate the clinicopathological characteristics and survival of small cell carcinoma of the cervix using Surveillance, Epidemiology, and End Results database. Patients with a diagnosis of small cell carcinoma of the cervix were included between 1988 and 2012. Kaplan-Meier method and Cox regression models were used. A total of 487 patients were included. Of the patients with known International Federation of Gynecology and Obstetrics stage and tumor grade, the stage IV disease was diagnosed in 37.9% patients, and 98.5% patients had poorly or undifferentiated histology. The 5-year cause specific survival and overall survival were 33.0% and 29.4%, respectively. In multivariate analysis, increasing age, advanced stage, and treatment by primary radiotherapy were associated with worse survival outcomes. Small cell carcinoma of the cervix is a rare disease with aggressive characteristics and prone to metastasize and is dismal in prognosis. Reduced survival was associated with increasing age, advanced stage, and treatment by primary radiotherapy.


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