Oncotarget

Clinical Research Papers:

Therapeutic effects of atorvastatin and ezetimibe compared with double-dose atorvastatin in very elderly patients with acute coronary syndrome

Zhi Liu, Hengjian Hao, Chunlin Yin, Yanyan Chu, Jing Li and Dong Xu _

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Oncotarget. 2017; 8:41582-41589. https://doi.org/10.18632/oncotarget.15078

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Abstract

Zhi Liu1, Hengjian Hao1, Chunlin Yin1, Yanyan Chu1, Jing Li1 and Dong Xu1

1 Division of Cardiology, Xuanwu Hospital Capital Medical University, Beijing, China

Correspondence to:

Dong Xu, email:

Jing Li, email:

Keywords: elderly; acute coronary syndrome; atorvastatin; ezetimibe; prognosis

Received: October 05, 2016 Accepted: January 08, 2017 Published: February 03, 2017

Abstract

Objective Compared the effect of atorvastatin 10 mg combined ezetimibe 10 mg therapy with atorvastatin 20 mg on the long-term outcomes in very elderly patients with acute coronary syndrome.

Methods A total of 230 octogenarian patients with acute coronary syndrome underwent coronary angiography were randomized to combined therapy group (atorvastatin 10 mg/d and ezetimibe 10 mg/d, n=114) or double-dose atorvastatin group (atorvastatin 20mg/d, n=116). The primary end point was one-year incidence of major adverse cardiovascular events (including cardiac death, spontaneous myocardial infarction, unplanned revascularization).

Result At the end of one year, the percentage of patients with low-density lipoprotein cholesterol level decreased more than 30% or 50% were comparable between the two groups (93.5% vs. 90.1%, p= 0.36; 54.6% vs. 49.6%, p= 0.45). The rate of major adverse cardiovascular events in combined therapy group was similar with double-dose atorvastatin group (23.2% vs. 19.8%, p=0.55). In COX regression model, the risk of major adverse cardiovascular events in combined group isn’t significantly higher than double-dose atorvastatin group (HR [95% CI] 1.12 [0.51 to 2.55], p = 0.74). The patients whose alanine aminotransferase increasing more than upper normal limit in combined group was lower than double-dose atorvastatin group (2.8% vs. 9.0%, p = 0.05).

Conclusions For very elderly patients with acute coronary syndrome, atorvastatin combining ezetimibe induced similar long-term outcomes compared with double-dose atorvastatin but with less liver dysfunction.


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