Oncotarget

Meta-Analysis:

Association between serum resistin concentration and hypertension: A systematic review and meta-analysis

Yuxiang Zhang, Yixing Li, Lin Yu and Lei Zhou _

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Oncotarget. 2017; 8:41529-41537. https://doi.org/10.18632/oncotarget.17561

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Abstract

Yuxiang Zhang2,3,4,*, Yixing Li1,*, Lin Yu1 and Lei Zhou1

1State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, College of Animal Science and Technology, Guangxi University, Nanning, 530004, P.R. China

2The Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA

3Pharmacology Graduate Program, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA

4Public Health Certificate Program, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA

*These authors contributed equally to this work

Correspondence to:

Lei Zhou, email: [email protected]

Keywords: resistin, hypertension, meta-analysis

Received: March 12, 2017     Accepted: April 19, 2017     Published: May 02, 2017

ABSTRACT

Objectives: Recent studies have suggested the involvement of adipokines in the pathogenesis of cardiovascular diseases, including hypertension. In this study, we evaluated the significance of serum resistin levels in hypertensive patients using a meta-analysis approach.

Materials and Methods: Relevant articles were retrieved by searching the following databases: PubMed, Embase, Ovid Medline, ISI Web of Knowledge. The retrieved studies were subjected to a thorough screening procedure to identify case-control studies that contained the required data. Data were extracted from each study and analyzed by Stata software and Review Manager software. In total, 14 case-control studies, containing 718 hypertensive patients and 645 normotensive controls, were included in this study. The major result of the meta-analysis revealed a statistically significant association between serum resistin concentration and hypertension (SMD = 0.85, 95% CI: [0.15, 1.54]), and the association was more obvious in Asian and Hispanic populations, diabetic population and studies with larger size cohorts. Publication bias was a low probability event for overall comparisons.

Conclusions: Based on our results, we conclude that serum resistin level in hypertensive patients is higher than normotensive controls, indicating resistin might be a risk factor for hypertension.


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