The relationship between tumor markers and pulmonary embolism in lung cancer
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Wei Xiong1,*, Yunfeng Zhao2,*, Mei Xu3, Jian Guo4,*, Bigyan Pudasaini1, Xueling Wu5 and Jinming Liu1
1Department of Cardio-Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China
2Department of Respiratory Medicine, Punan Hospital, Pudong New District, Shanghai, China
3Department of Respiratory Medicine, Gongli Hospital, Pudong New District, Second Military Medical University, Shanghai, China
4Department of Pulmonary Function Test, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China
5Department of Respiratory Medicine, Renji Hospital, Jiaotong University School of Medicine, Shanghai, China
*Joint first authors
Jinming Liu, email: [email protected]
Keywords: tumor markers, pulmonary embolism, lung cancer, panel of combined tumor markers, CEA
Received: March 06, 2017 Accepted: May 01, 2017 Published: May 17, 2017
Background: Tumor markers (TMs) and D-Dimer are both hallmarks of severity and prognosis of lung cancer. Tumor markers could be related to pulmonary embolism (PE) in lung cancer.
Results: The number of abnormal tumor markers of lung cancer patients with pulmonary embolism (3.9 ± 1.1vs1.6 ± 0.6,P 0.005) was more than that in patients without pulmonary embolism. TMs panel (P trend < 0.001), CEA (R2 0.735, P0.003) and CYFRA21-1 (R2 0.718, P0.005) were positively correlated with D-Dimer in patients with pulmonary embolism. The multivariate logistic regression analysis showed that, for tumor markers, TMs panel (OR5.98, P < 0.001) had the strongest correlation with pulmonary embolism. The AUC (area under curve) of TMs panel and CEA were 0.82 [95%CI (0.71–0.95), P < 0.001] and 0.71 [95%CI (0.62–0.84), P 0.002] by ROC (receiver operating characteristic) curve analysis, respectively.
Materials and Methods: Tumor markers were compared between lung cancer patients complicated with pulmonary embolism and those without pulmonary embolism Then the correlation between each tumor marker as well as panel of combined TMs and D-Dimer as well as pulmonary embolism were analyzed for patients with pulmonary embolism.
Conclusions: There is a relationship between tumor markers and pulmonary embolism in patients with lung cancer. The panel of combined tumor markers is a valuable diagnostic marker for pulmonary embolism in lung cancer.
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