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Impact of perioperative blood transfusion on clinical outcomes in patients with colorectal liver metastasis after hepatectomy: a meta-analysis

Xinghua Lyu, Wenhui Qiao, Debang Li and Yufang Leng _

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Oncotarget. 2017; 8:41740-41748. https://doi.org/10.18632/oncotarget.16771

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Abstract

Xinghua Lyu1, Wenhui Qiao1, Debang Li1 and Yufang Leng1

1 Department of Anaesthesiology, The First Hospital of Lanzhou University, Lanzhou, China

Correspondence to:

Yufang Leng, email:

Keywords: colorectal, liver, oncology, outcomes

Received: November 07, 2016 Accepted: March 09, 2017 Published: March 31, 2017

Abstract

BACKGROUND: Perioperative blood transfusion may be associated with negative clinical outcomes in oncological surgery. A meta-analysis of published studies was conducted to evaluate the impact of blood transfusion on short- and long-term outcomes following liver resection of colorectal liver metastasis (CLM).

MATERIALS AND METHODS: A systematic search was performed to identify relevant articles. Data were pooled for meta-analysis using Review Manager version 5.3.

RESULTS: Twenty-five observational studies containing 10621 patients were subjected to the analysis. Compared with non-transfused patients, transfused patients experienced higher overall morbidity (odds ratio [OR], 1.98; 95% confidence intervals [CI] =1.49-2.33), more major complications (OR, 2.12; 95% CI =1.26-3.58), higher mortality (OR, 4.13; 95% CI =1.96-8.72), and longer length of hospital stay (weighted mean difference, 4.43; 95% CI =1.15-7.69). Transfusion was associated with reduced overall survival (risk ratio [RR], 1.24, 95% CI =1.11-1.38) and disease-free survival (RR, 1.38, 95% CI=1.23-1.56).

CONCLUSION: Perioperative blood transfusion has a detrimental impact on the clinical outcomes of patients undergoing CLM resection.


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