SMAD7 rs4939827 variant contributes to colorectal cancer risk in Chinese population
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Chunze Zhang1,*, Xichuan Li2,*, Wenzheng Fu1, Yijia Wang3, Tao Wang1, Wenhong Wang4, Shuo Chen1, Hai Qin1 and Xipeng Zhang1
1Department of Colorectal Surgery, Tianjin Union Medical Center, Tianjin 300121, China
2Department of Immunology, Biochemistry and Molecular Biology, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Key Laboratory of Medical Epigenetics, Tianjin Medical University, Tianjin 300070, China
3Department of Pathology, Tianjin Union Medical Center, Tianjin 300121, China
4Department of Imaging, Tianjin Union Medical Center, Tianjin 300121, China
*These authors have contributed equally to this work
Keywords: colorectal cancer, SMAD7, rs4939827, meta-analysis
Received: November 04, 2016 Accepted: March 11, 2017 Published: April 12, 2017
A genome-wide association study identified a common genetic variant rs4939827 at 18q21 in SMAD7 to be related with colorectal cancer (CRC) risk with OR=1.2 and P =7.80E-28. Until recently, several meta-analysis studies have been conducted, and reported significant association between rs4939827 and CRC risk. However none of these studies evaluated the potential association between rs4939827 and CRC risk in Chinese population. In this study, we evaluated this association by a meta-analysis using 12077 samples including 5816 CRC cases and 6261 controls. In the end, we identified the T allele of rs4939827 to be significantly related with an increase CRC risk (P=2.22E-05, OR=1.14, 95% CI 1.07-1.21) in Chinese population.
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