The association between miR-423 rs6505162 polymorphism and cancer susceptibility: a systematic review and meta-analysis
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Ru Chen1, Yonglan Zheng2, Lin Zhuo3 and Shengfeng Wang3
1National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
2Department of Medicine, University of Chicago, Chicago, IL, USA
3Department of Epidemiology and Bio-statistics, School of Public Health, Peking University Health Science Center, Beijing, China
Shengfeng Wang, email: [email protected]
Keywords: miR-423, rs6505162, polymorphism, cancer susceptibility, meta-analysis
Received: November 25, 2016 Accepted: February 13, 2017 Published: March 17, 2017
The association between miR-423 polymorphism (C > A) and the risk of different cancers are still controversial. We performed a meta-analysis to clarify its association with multiple cancer risks. PubMed and Embase (as of 10th September, 2016) were searched. A total of 17 studies from 16 articles, consisting of 8,582 cases and 10,291 controls, were finally qualified and enrolled in this meta-analysis. The pooled results showed that the miR-423 AA genotype was associated with decreased cancer risk under the recessive model (odds ratio [OR] = 0.87, 95% confidence interval [CI]: 0.78~0.98, P = 0.020). However, this association became non-significant after excluding the study with the smallest odds ratio. Subgroup analyses revealed a significant decrease in risk of lung cancer (dominant model: OR = 0.73, 95 % CI: 0.60~0.89, P = 0.002; recessive model: OR = 0.59, 95 % CI: 0.37~0.95, P = 0.031). Our study indicates that miR-423 rs6505162 might be associated with a reduced risk of cancers, however, this finding need to be evaluated further in larger samples, especially subgroup analyses. In addition, cancer-specific functional studies are especially needed to reveal the underlying mechanisms between miR-423 and the etiology of cancer.
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