Editorial

Recent developments in vertical transmission of ZIKA virus	Recent developments in vertical transmission of ZIKA virus
https://doi.org/10.18632/oncotarget.11619 Peter S. Silverstein, Nour A. Aljouda, and Anil Kumar
62797-62798

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Priority Research Papers

γsecretase inhibitor I inhibits neuroblastoma cells with NOTCH and the proteasome among its targets	γsecretase inhibitor I inhibits neuroblastoma cells with NOTCH and the proteasome among its targets
https://doi.org/10.18632/oncotarget.11715 Carmen Dorneburg, Annika V. Goß, Matthias Fischer, Frederik Roels, Thomas F.E. Barth, Frank Berthold, Roland Kappler, Franz Oswald, Jens T. Siveke, Jan J. Molenaar, Klaus-Michael Debatin, and Christian Beltinger
62799-62813

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Acquisition of an oncogenic fusion protein serves as an initial driving mutation by inducing aneuploidy and overriding proliferative defects	Acquisition of an oncogenic fusion protein serves as an initial driving mutation by inducing aneuploidy and overriding proliferative defects
https://doi.org/10.18632/oncotarget.11716 Jacob M. Loupe, Patrick J. Miller, Benjamin P. Bonner, Elaine C. Maggi, Jyothi Vijayaraghavan, Jovanny Zabaleta, Christopher M. Taylor, Fern Tsien, Judy S. Crabtree, and Andrew D. Hollenbach
62814-62835

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Research Papers: Gerotarget (Focus on Aging)

A steroid like phytochemical Antcin M is an antiaging reagent that eliminates hyperglycemiaaccelerated premature senescence in dermal fibroblasts by direct activation of Nrf2 and SIRT1	A steroid like phytochemical Antcin M is an antiaging reagent that eliminates hyperglycemiaaccelerated premature senescence in dermal fibroblasts by direct activation of Nrf2 and SIRT1
https://doi.org/10.18632/oncotarget.11229 Kumar K.J. Senthil, Vani M. Gokila, Jeng-Leun Mau, Chin-Chung Lin, Fang-Hua Chu, Chia-Cheng Wei, Vivian Hsiu-Chuan Liao, and Sheng-Yang Wang
62836-62861

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Blunted dynamics of adenosine A2A receptors is associated with increased susceptibility to Candida albicans infection in the elderly	Blunted dynamics of adenosine A2A receptors is associated with increased susceptibility to Candida albicans infection in the elderly
https://doi.org/10.18632/oncotarget.11760 Lisa Rodrigues, Isabel M. Miranda, Geanne M. Andrade, Marta Mota, Luísa Cortes, Acácio G. Rodrigues, Rodrigo A. Cunha, and Teresa Gonçalves
62862-62872

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Transfection of the IHH gene into rabbit BMSCs in a simulated microgravity environment promotes chondrogenic differentiation and inhibits cartilage aging	Transfection of the IHH gene into rabbit BMSCs in a simulated microgravity environment promotes chondrogenic differentiation and inhibits cartilage aging
https://doi.org/10.18632/oncotarget.11871 Peng-Cheng Liu, Kuan Liu, Jun-Feng Liu, Kuo Xia, Li-Yang Chen, and Xing Wu
62873-62885

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Research Papers: Pathology

Long noncoding RNA PVT1 activates hepatic stellate cells through competitively binding microRNA152	Long noncoding RNA PVT1 activates hepatic stellate cells through competitively binding microRNA152
https://doi.org/10.18632/oncotarget.11709 Jianjian Zheng, Fujun Yu, Peihong Dong, Limei Wu, Yuan Zhang, Yanwei Hu, and Lei Zheng
62886-62897

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Research Papers: Immunology

Racerelated differences in antibody responses to the inactivated influenza vaccine are linked to distinct prevaccination gene expression profiles in blood	Racerelated differences in antibody responses to the inactivated influenza vaccine are linked to distinct prevaccination gene expression profiles in blood
https://doi.org/10.18632/oncotarget.11704 Raj Kurupati, Andrew Kossenkov, Larissa Haut, Senthil Kannan, Zhiquan Xiang, Yan Li, Susan Doyle, Qin Liu, Kenneth Schmader, Louise Showe, and Hildegund Ertl
62898-62911

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Research Papers: Autophagy and Cell Death

A potential molecular model for studying apoptosis enhanced by the interaction of BCLG with JAB1 in swine	A potential molecular model for studying apoptosis enhanced by the interaction of BCLG with JAB1 in swine
https://doi.org/10.18632/oncotarget.11230 Pengfei Jiang, Xingye Wang, Xiaolin Chen, Yaping Wang, Zhanzhan Kang, Jingna Wang, and Deli Zhang
62912-62924

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Research Papers

Targeting FXYD2 by cardiac glycosides potently blocks tumor growth in ovarian clear cell carcinoma	Targeting FXYD2 by cardiac glycosides potently blocks tumor growth in ovarian clear cell carcinoma
https://doi.org/10.18632/oncotarget.7497 I-Ling Hsu, Cheng-Yang Chou, Yi-Ying Wu, Jia-En Wu, Chen-Hsien Liang, Yao- Tsung Tsai, Jhen-Yu Ke, Yuh-Ling Chen, Keng-Fu Hsu, and Tse-Ming Hong
62925-62938

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Systematic analysis of tumour cellextracellular matrix adhesion identifies independent prognostic factors in breast cancer	Systematic analysis of tumour cellextracellular matrix adhesion identifies independent prognostic factors in breast cancer
https://doi.org/10.18632/oncotarget.11307 Jason R. Todd, Karen A. Ryall, Simon Vyse, Jocelyn P. Wong, Rachael C. Natrajan, Yinyin Yuan, Aik-Choon Tan, and Paul H. Huang
62939-62953

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Two common functional catalase gene polymorphisms rs1001179 and rs794316 and cancer susceptibility: evidence from 14942 cancer cases and 43285 controls	Two common functional catalase gene polymorphisms rs1001179 and rs794316 and cancer susceptibility: evidence from 14942 cancer cases and 43285 controls
https://doi.org/10.18632/oncotarget.10617 Kang Liu, Xinghan Liu, Meng Wang, Xijing Wang, Huafeng Kang, Shuai Lin, Pengtao Yang, Cong Dai, Peng Xu, Shanli Li, and Zhijun Dai
62954-62965

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Clinicopathological and prognostic significance of metastasisassociated in colon cancer1 MACC1 overexpression in colorectal cancer: a metaanalysis	Clinicopathological and prognostic significance of metastasisassociated in colon cancer1 MACC1 overexpression in colorectal cancer: a metaanalysis
https://doi.org/10.18632/oncotarget.11287 Yang Zhao, Cong Dai, Meng Wang, Huafeng Kang, Shuai Lin, Pengtao Yang, Xinghan Liu, Kang Liu, Peng Xu, Yi Zheng, Shanli Li, and Zhijun Dai
62966-62975

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The effect of epigenetic silencing and TP53 mutation on the expression of DLL4 in human cancer stem disorder	The effect of epigenetic silencing and TP53 mutation on the expression of DLL4 in human cancer stem disorder
https://doi.org/10.18632/oncotarget.11316 Zhixing Yao, and Zaki A. Sherif
62976-62988

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Molecular dissection of the valproic acid effects on glioma cells	Molecular dissection of the valproic acid effects on glioma cells
https://doi.org/10.18632/oncotarget.11379 Sabine Hoja, Markus Schulze, Michael Rehli, Martin Proescholdt, Christel Herold-Mende, Peter Hau, and Markus J. Riemenschneider
62989-63002

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Gene expression signature based screening identifies ribonucleotide reductase as a candidate therapeutic target in Ewing sarcoma	Gene expression signature based screening identifies ribonucleotide reductase as a candidate therapeutic target in Ewing sarcoma
https://doi.org/10.18632/oncotarget.11416 Kelli L. Goss, and David J. Gordon
63003-63019

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Reversibility of glioma stem cells’ phenotypes explains their complex in vitro and in vivo behavior: Discovery of a novel neurospherespecific enzyme cGMPdependent protein kinase 1 using the genomic landscape of human glioma stem cells as a discovery tool	Reversibility of glioma stem cells’ phenotypes explains their complex in vitro and in vivo behavior: Discovery of a novel neurospherespecific enzyme cGMPdependent protein kinase 1 using the genomic landscape of human glioma stem cells as a discovery tool
https://doi.org/10.18632/oncotarget.11589 Thomas J. Wilson, Daniel B. Zamler, Robert Doherty, Maria G. Castro, and Pedro R. Lowenstein
63020-63041

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Prognostic impact of the expression of Wntsignaling proteins in cervical carcinoma FIGO stage IIV treated with radiotherapy or chemoradiotherapy	Prognostic impact of the expression of Wntsignaling proteins in cervical carcinoma FIGO stage IIV treated with radiotherapy or chemoradiotherapy
https://doi.org/10.18632/oncotarget.11642 Louise Bohr Mordhorst, Cecilia Ahlin, and Bengt Sorbe
63042-63053

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Effect of epidermal growth factor receptor gene polymorphisms on prognosis in glioma patients	Effect of epidermal growth factor receptor gene polymorphisms on prognosis in glioma patients
https://doi.org/10.18632/oncotarget.10666 Bin Li, Wenhui Zhao, Jingjie Li, Mengdan Yan, Zhilan Xie, Yuanyuan Zhu, Chao Chen, and Tianbo Jin
63054-63064

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Targeted suppression of ARV7 using PIP5K1α inhibitor overcomes enzalutamide resistance in prostate cancer cells	Targeted suppression of ARV7 using PIP5K1α inhibitor overcomes enzalutamide resistance in prostate cancer cells
https://doi.org/10.18632/oncotarget.11757 Martuza Sarwar, Julius Semenas, Regina Miftakhova, Athanasios Simoulis, Brian Robinson, Anette Gjörloff Wingren, Nigel P. Mongan, David M. Heery, Heather Johnsson, Per-Anders Abrahamsson, Nishtman Dizeyi, Jun Luo, and Jenny L. Persson
63065-63081

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Clues toward precision medicine in oral squamous cell carcinoma: utility of nextgeneration sequencing for the prognostic stratification of highrisk patients harboring neck lymph node extracapsular extension	Clues toward precision medicine in oral squamous cell carcinoma: utility of nextgeneration sequencing for the prognostic stratification of highrisk patients harboring neck lymph node extracapsular extension
https://doi.org/10.18632/oncotarget.11762 Hung-Ming Wang, Chun-Ta Liao, Tzu-Chen Yen, Shu-Jen Chen, Li-Yu Lee, Chia-Hsun Hsieh, Chien-Yu Lin, and Shu-Hang Ng
63082-63092

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Visceral fat adipocytes from obese and colorectal cancer subjects exhibit distinct secretory and ω6 polyunsaturated fatty acid profiles and deliver immunosuppressive signals to innate immunity cells	Visceral fat adipocytes from obese and colorectal cancer subjects exhibit distinct secretory and ω6 polyunsaturated fatty acid profiles and deliver immunosuppressive signals to innate immunity cells
https://doi.org/10.18632/oncotarget.10998 Manuela Del Cornò, Massimo D’Archivio, Lucia Conti, Beatrice Scazzocchio, Rosaria Varì, Gloria Donninelli, Barbara Varano, Stefania Giammarioli, Simone De Meo, Gianfranco Silecchia, Francesco Pennestrì, Roberto Persiani, Roberta Masella, and Sandra Gessani
63093-63105

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Phosphatidylinositide 3kinase PI3K and PI3Krelated kinase PIKK activity contributes to radioresistance in thyroid carcinomas	Phosphatidylinositide 3kinase PI3K and PI3Krelated kinase PIKK activity contributes to radioresistance in thyroid carcinomas
https://doi.org/10.18632/oncotarget.11056 Natalie Burrows, Joseph Williams, Brian A Telfer, Julia Resch, Helen R Valentine, Richard J Fitzmaurice, Amanda Eustace, Joely Irlam, Emily J Rowling, Cuong Hoang-Vu, Catharine M West, Georg Brabant, and Kaye J Williams
63106-63123

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DDA suppresses angiogenesis and tumor growth of colorectal cancer in vivo through decreasing VEGFR2 signaling	DDA suppresses angiogenesis and tumor growth of colorectal cancer in vivo through decreasing VEGFR2 signaling
https://doi.org/10.18632/oncotarget.11152 Shiu-Wen Huang, Jin-Cherng Lien, Sheng-Chu Kuo, and Tur-Fu Huang
63124-63137

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Hypoxia enhances the malignant nature of bladder cancer cells and concomitantly antagonizes protein Oglycosylation extension	Hypoxia enhances the malignant nature of bladder cancer cells and concomitantly antagonizes protein Oglycosylation extension
https://doi.org/10.18632/oncotarget.11257 Andreia Peixoto, Elisabete Fernandes, Cristiana Gaiteiro, Luís Lima, Rita Azevedo, Janine Soares, Sofia Cotton, Beatriz Parreira, Manuel Neves, Teresina Amaro, Ana Tavares, Filipe Teixeira, Carlos Palmeira, Maria Rangel, André M.N. Silva, Celso A. Reis, Lúcio Lara Santos, Maria José Oliveira, and José Alexandre Ferreira
63138-63157

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Altered phosphatidylcholines expression in sputum for diagnosis of nonsmall cell lung cancer	Altered phosphatidylcholines expression in sputum for diagnosis of nonsmall cell lung cancer
https://doi.org/10.18632/oncotarget.11283 Jianyong Zhang, Jianjun Xu, Haiyan Lu, Jianhua Ding, Dongliang Yu, Penghui Li, Jianwen Xiong, Xingxing Liu, Huanwen Chen, and Yiping Wei
63158-63165

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Landscape of RNAs in human lumbar disc degeneration	Landscape of RNAs in human lumbar disc degeneration
https://doi.org/10.18632/oncotarget.11334 Ping-Heng Lan, Zhi-Heng Liu, Yan-Jun Pei, Zhi-Gang Wu, Yang Yu, Yong-Feng Yang, Xu Liu, Lu Che, Chi-Jiao Ma, Yan-Ke Xie, Qing-Jie Hu, Zhong-Yuan Wan, and Hai-Qiang Wang
63166-63176

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Distinct mutation profile and prognostic relevance in patients with hypoplastic myelodysplastic syndromes hMDS	Distinct mutation profile and prognostic relevance in patients with hypoplastic myelodysplastic syndromes hMDS
https://doi.org/10.18632/oncotarget.11050 Chi-Yuan Yao, Hsin-An Hou, Tzung-Yi Lin, Chien-Chin Lin, Wen-Chien Chou, Mei-Hsuan Tseng, Ying-Chieh Chiang, Ming-Chih Liu, Chia-Wen Liu, Yuan-Yeh Kuo, Shang-Ju Wu, Xiu-Wen Liao, Chien-Ting Lin, Bor-Shen Ko, Chien-Yuan Chen, Szu-Chun Hsu, Chi-Cheng Li, Shang-Yi Huang, Ming Yao, Jih-Luh Tang, Woei Tsay, Chieh-Yu Liu, and Hwei-Fang Tien
63177-63188

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Validation of a networkbased strategy for the optimization of combinatorial target selection in breast cancer therapy: siRNA knockdown of network targets in MDAMB231 cells as an in vitro model for inhibition of tumor development	Validation of a networkbased strategy for the optimization of combinatorial target selection in breast cancer therapy: siRNA knockdown of network targets in MDAMB231 cells as an in vitro model for inhibition of tumor development
https://doi.org/10.18632/oncotarget.11055 Tatiana M. Tilli, Nicolas Carels, Jack A. Tuszynski, and Manijeh Pasdar
63189-63203

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Immunosuppressive effect of bladder cancer on function of dendritic cells involving of Jak2/STAT3 pathway	Immunosuppressive effect of bladder cancer on function of dendritic cells involving of Jak2/STAT3 pathway
https://doi.org/10.18632/oncotarget.11434 Weigang Xiu, Juan Ma, Ting Lei, Man Zhang, and Shangyan Zhou
63204-63214

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FAM65B controls the proliferation of transformed and primary T cells	FAM65B controls the proliferation of transformed and primary T cells
https://doi.org/10.18632/oncotarget.11438 Jeanne Froehlich, Margaux Versapuech, Laura Megrelis, Quitterie Largeteau, Sylvain Meunier, Corinne Tanchot, Georges Bismuth, Jérôme Delon, and Marianne Mangeney
63215-63225

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Therapeutic dosages of aspirin counteract the IL6 induced protumorigenic effects by slowing down the ribosome biogenesis rate	Therapeutic dosages of aspirin counteract the IL6 induced protumorigenic effects by slowing down the ribosome biogenesis rate
https://doi.org/10.18632/oncotarget.11441 Elisa Brighenti, Ferdinando Antonino Giannone, Francesca Fornari, Carmine Onofrillo, Marzia Govoni, Lorenzo Montanaro, Davide Treré, and Massimo Derenzini
63226-63241

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The double benefit of Spalax p53: surviving underground hypoxia while defying lung cancer cells in vitro via autophagy and caspasedependent cell death	The double benefit of Spalax p53: surviving underground hypoxia while defying lung cancer cells in vitro via autophagy and caspasedependent cell death
https://doi.org/10.18632/oncotarget.11443 Martin Ellis, Orly Stern, and Osnat Ashur-Fabian
63242-63251

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Target sequencing and CRISPR/Cas editing reveal simultaneous loss of UTX and UTY in urothelial bladder cancer	Target sequencing and CRISPR/Cas editing reveal simultaneous loss of UTX and UTY in urothelial bladder cancer
https://doi.org/10.18632/oncotarget.11207 Jinwoo Ahn, Kwang Hyun Kim, Sanghui Park, Young-Ho Ahn, Ha Young Kim, Hana Yoon, Ji Hyun Lee, Duhee Bang, and Dong Hyeon Lee
63252-63260

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RORα and RORγ expression inversely correlates with human melanoma progression	RORα and RORγ expression inversely correlates with human melanoma progression
https://doi.org/10.18632/oncotarget.11211 Anna A. Brożyna, Wojciech Jóźwicki, Cezary Skobowiat, Anton Jetten, and Andrzej T. Slominski
63261-63282

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The accuracy of microRNA210 in diagnosing lung cancer: a systematic review and metaanalysis	The accuracy of microRNA210 in diagnosing lung cancer: a systematic review and metaanalysis
https://doi.org/10.18632/oncotarget.11446 Huqin Yang, Huijuan Wang, Chao Zhang, and Zhaohui Tong
63283-63293

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Decreased TSPAN1 promotes prostate cancer progression and is a marker for early biochemical recurrence after radical prostatectomy	Decreased TSPAN1 promotes prostate cancer progression and is a marker for early biochemical recurrence after radical prostatectomy
https://doi.org/10.18632/oncotarget.11448 Fan Xu, Yujing Gao, Yanqing Wang, Jiahua Pan, Jianjun Sha, Xiaoguang Shao, Xunlei Kang, Jun Qin, M. James You, Yiran Huang, Baijun Dong, and Wei Xue
63294-63305

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MetAP1 and MetAP2 drive cell selectivity for a potent anticancer agent in synergy by controlling glutathione redox state	MetAP1 and MetAP2 drive cell selectivity for a potent anticancer agent in synergy by controlling glutathione redox state
https://doi.org/10.18632/oncotarget.11216 Frédéric Frottin, Willy V. Bienvenut, Jérôme Bignon, Eric Jacquet, Alvaro Sebastian Vaca Jacome, Alain Van Dorsselaer, Sarah Cianferani, Christine Carapito, Thierry Meinnel, and Carmela Giglione
63306-63323

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Sphingosine1phosphate induced epithelialmesenchymal transition of hepatocellular carcinoma via an MMP7/ syndecan1/TGFβ autocrine loop	Sphingosine1phosphate induced epithelialmesenchymal transition of hepatocellular carcinoma via an MMP7/ syndecan1/TGFβ autocrine loop
https://doi.org/10.18632/oncotarget.11450 Ye Zeng, Xinghong Yao, Li Chen, Zhiping Yan, Jingxia Liu, Yingying Zhang, Tang Feng, Jiang Wu, and Xiaoheng Liu
63324-63337

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Correlation between body mass index BMI and the Gleason score of prostate biopsies in Chinese population	Correlation between body mass index BMI and the Gleason score of prostate biopsies in Chinese population
https://doi.org/10.18632/oncotarget.11453 Feng Zhou, Xi Chen, Jinxian Pu, Jun Ouyang, Gang Li, Jigen Ping, Yong Lu, Jianquan Hou, and Yong Han
63338-63341

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Rab27A mediated by NFκB promotes the stemness of colon cancer cells via upregulation of cytokine secretion	Rab27A mediated by NFκB promotes the stemness of colon cancer cells via upregulation of cytokine secretion
https://doi.org/10.18632/oncotarget.11454 Feixue Feng, Yinghao Jiang, Huanyu Lu, Xiaozhao Lu, Shan Wang, Lifeng Wang, Mengying Wei, Wei Lu, Zhichao Du, Zichen Ye, Guodong Yang, Fang Yuan, Yanxia Ma, Xiaoying Lei, and Zifan Lu
63342-63351

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Mel18 negatively regulates stem celllike properties through downregulation of miR21 in gastric cancer	Mel18 negatively regulates stem celllike properties through downregulation of miR21 in gastric cancer
https://doi.org/10.18632/oncotarget.11221 Xiao-Feng Wang, Xiao-Wei Zhang, Rui-Xi Hua, Yi-Qun Du, Ming-Zhu Huang, Yong Liu, Yu Fang Cheng, and Wei-Jian Guo
63352-63361

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Control of translational activation by PIM kinase in activated Bcell diffuse large Bcell lymphoma confers sensitivity to inhibition by PIM447	Control of translational activation by PIM kinase in activated Bcell diffuse large Bcell lymphoma confers sensitivity to inhibition by PIM447
https://doi.org/10.18632/oncotarget.11457 Tara L. Peters, Lingxiao Li, Ana A. Tula-Sanchez, Praechompoo Pongtornpipat, and Jonathan H. Schatz
63362-63373

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Adrenomedullin blockade suppresses sunitinibresistant renal cell carcinoma growth by targeting the ERK/MAPK pathway	Adrenomedullin blockade suppresses sunitinibresistant renal cell carcinoma growth by targeting the ERK/MAPK pathway
https://doi.org/10.18632/oncotarget.11463 Yongqian Gao, Jinyi Li, Na Qiao, Qingsong Meng, Ming Zhang, Xin Wang, Jianghua Jia, Shuwen Yang, Changbao Qu, Wei Li, and Dongbin Wang
63374-63387

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Identification of tumorigenesisrelated mRNAs associated with RNAbinding protein HuR in thyroid cancer cells	Identification of tumorigenesisrelated mRNAs associated with RNAbinding protein HuR in thyroid cancer cells
https://doi.org/10.18632/oncotarget.11255 Federica Baldan, Catia Mio, Lorenzo Allegri, Ketty Conzatti, Barbara Toffoletto, Cinzia Puppin, Slobodanka Radovic, Carlo Vascotto, Diego Russo, Carla Di Loreto, and Giuseppe Damante
63388-63407

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Altered pH gradient at the plasma membrane of osteosarcoma cells is a key mechanism of drug resistance	Altered pH gradient at the plasma membrane of osteosarcoma cells is a key mechanism of drug resistance
https://doi.org/10.18632/oncotarget.11503 Sofia Avnet, Silvia Lemma, Margherita Cortini, Paola Pellegrini, Francesca Perut, Nicoletta Zini, Katsuyuki Kusuzaki, Tokuhiro Chano, Giulia Grisendi, Massimo Dominici, Angelo De Milito, and Nicola Baldini
63408-63423

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Epigenetic changes in localized gastric cancer: the role of RUNX3 in tumor progression and the immune microenvironment	Epigenetic changes in localized gastric cancer: the role of RUNX3 in tumor progression and the immune microenvironment
https://doi.org/10.18632/oncotarget.11520 Marta Jessica Llorca-Cardeñosa, Tania Fleitas, Maider Ibarrola-Villava, María Peña-Chilet, Cristina Mongort, Carolina Martinez-Ciarpaglini, Lara Navarro, Valentina Gambardella, Josefa Castillo, Susana Roselló, Samuel Navarro, Gloria Ribas, and Andrés Cervantes
63424-63436

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Nontargeted and targeted metabolomics approaches to diagnosing lung cancer and predicting patient prognosis	Nontargeted and targeted metabolomics approaches to diagnosing lung cancer and predicting patient prognosis
https://doi.org/10.18632/oncotarget.11521 Xiaoli Zhang, Xinyue Zhu, Caihong Wang, Haixia Zhang, and Zhiming Cai
63437-63448

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Silencing of cZNF292 circular RNA suppresses human glioma tube formation via the Wnt/βcatenin signaling pathway	Silencing of cZNF292 circular RNA suppresses human glioma tube formation via the Wnt/βcatenin signaling pathway
https://doi.org/10.18632/oncotarget.11523 Ping Yang, Zhijun Qiu, Yuan Jiang, Lei Dong, Wensheng Yang, Chao Gu, Guang Li, and Yu Zhu
63449-63455

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Subclones in Blymphoma cell lines: isogenic models for the study of gene regulation	Subclones in Blymphoma cell lines: isogenic models for the study of gene regulation
https://doi.org/10.18632/oncotarget.11524 Hilmar Quentmeier, Claudia Pommerenke, Ole Ammerpohl, Robert Geffers, Vivien Hauer, Roderick AF MacLeod, Stefan Nagel, Julia Romani, Emanuela Rosati, Anders Rosén, Cord C Uphoff, Margarete Zaborski, and Hans G Drexler
63456-63465

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Integrin β1 myosin light chain kinase and myosin IIA are required for activation of PI3KAKT signaling following MEK inhibition in metastatic triple negative breast cancer	Integrin β1 myosin light chain kinase and myosin IIA are required for activation of PI3KAKT signaling following MEK inhibition in metastatic triple negative breast cancer
https://doi.org/10.18632/oncotarget.11525 Cheolwon Choi, Junyeob Kwon, Sunyoung Lim, and David M. Helfman
63466-63487

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Construction and immunological characterization of CD40L or GMCSF incorporated Hantaan virus like particle	Construction and immunological characterization of CD40L or GMCSF incorporated Hantaan virus like particle
https://doi.org/10.18632/oncotarget.11329 Qikang Ying, Tiejun Ma, Linfeng Cheng, Xiaoxiao Zhang, Agnieszka D. Truax, Ruixue Ma, Ziyu Liu, Yingfeng Lei, Liang Zhang, Wei Ye, Fanglin Zhang, Zhikai Xu, Lei Shang, Rongrong Liu, Fang Wang, and Xingan Wu
63488-63503

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Differential IgM expression distinguishes two types of pediatric Burkitt lymphoma in mouse and human	Differential IgM expression distinguishes two types of pediatric Burkitt lymphoma in mouse and human
https://doi.org/10.18632/oncotarget.11531 Anthony B. Eason, Sang-Hoon Sin, Carolina Lin, Blossom Damania, Steven Park, Yuri Fedoriw, Carlos E. Bacchi, and Dirk P. Dittmer
63504-63513

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Peptidome analysis of human milk from women delivering macrosomic fetuses reveals multiple means of protection for infants	Peptidome analysis of human milk from women delivering macrosomic fetuses reveals multiple means of protection for infants
https://doi.org/10.18632/oncotarget.11532 Xianwei Cui, Yun Li, Lei Yang, Lianghui You, Xing Wang, Chunmei Shi, Chenbo Ji, and Xirong Guo
63514-63525

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A novel molecular and clinical staging model to predict survival for patients with esophageal squamous cell carcinoma	A novel molecular and clinical staging model to predict survival for patients with esophageal squamous cell carcinoma
https://doi.org/10.18632/oncotarget.11362 Wei Wang, Zhiwei Wang, Jun Zhao, Min Wei, Xinghua Zhu, Qi He, Tianlong Ling, Xiaoyan Chen, Ziang Cao, Yixin Zhang, Lei Liu, and Minxin Shi
63526-63536

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Secretome proteomics reveals candidate noninvasive biomarkers of BRCA1 deficiency in breast cancer	Secretome proteomics reveals candidate noninvasive biomarkers of BRCA1 deficiency in breast cancer
https://doi.org/10.18632/oncotarget.11535 Marc Warmoes, Siu W. Lam, Petra van der Groep, Janneke E. Jaspers, Yvonne H.C.M. Smolders, Leon de Boer, Thang V. Pham, Sander R. Piersma, Sven Rottenberg, Epie Boven, Jos Jonkers, Paul J. van Diest, and Connie R. Jimenez
63537-63548

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Novel synthetic cyclic integrin αvβ3 binding peptide ALOS4: antitumor activity in mouse melanoma models	Novel synthetic cyclic integrin αvβ3 binding peptide ALOS4: antitumor activity in mouse melanoma models
https://doi.org/10.18632/oncotarget.11363 Shiri Yacobovich, Lena Tuchinsky, Michael Kirby, Tetiana Kardash, Oryan Agranyoni, Elimelech Nesher, Boris Redko, Gary Gellerman, Dror Tobi, Katerina Gurova, Igor Koman, Osnat Ashur Fabian, and Albert Pinhasov
63549-63560

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Long noncoding RNA HoxAAS3 interacts with EZH2 to regulate lineage commitment of mesenchymal stem cells	Long noncoding RNA HoxAAS3 interacts with EZH2 to regulate lineage commitment of mesenchymal stem cells
https://doi.org/10.18632/oncotarget.11538 Xin-Xing Zhu, Ya-Wei Yan, Demeng Chen, Chun-Zhi Ai, Xifeng Lu, Shan-Shan Xu, Shan Jiang, Gen-Shen Zhong, Dong-Bao Chen, and Yi-Zhou Jiang
63561-63570

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HER2 amplification level is not a prognostic factor for HER2positive breast cancer with trastuzumabbased adjuvant treatment: a systematic review and metaanalysis	HER2 amplification level is not a prognostic factor for HER2positive breast cancer with trastuzumabbased adjuvant treatment: a systematic review and metaanalysis
https://doi.org/10.18632/oncotarget.11541 Qian-Qian Xu, Bo Pan, Chang-Jun Wang, Yi-Dong Zhou, Feng Mao, Yan Lin, Jing-Hong Guan, Song-Jie Shen, Xiao-Hui Zhang, Ya-Li Xu, Ying Zhong, Xue-Jing Wang, Yan-Na Zhang, and Qiang Sun
63571-63582

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The ω3 polyunsaturated fatty acids prevented colitisassociated carcinogenesis through blocking dissociation of βcatenin complex inhibiting COX2 through repressing NFκB and inducing 15prostaglandin dehydrogenase	The ω3 polyunsaturated fatty acids prevented colitisassociated carcinogenesis through blocking dissociation of βcatenin complex inhibiting COX2 through repressing NFκB and inducing 15prostaglandin dehydrogenase
https://doi.org/10.18632/oncotarget.11544 Young-Min Han, Migyeung Jeong, Jong-Min Park, Mi-Young Kim, Eun-Jin Go, Ji Young Cha, Kyung Jo Kim, and Ki Baik Hahm
63583-63595

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ERMP1 a novel potential oncogene involved in UPR and oxidative stress defense is highly expressed in human cancer	ERMP1 a novel potential oncogene involved in UPR and oxidative stress defense is highly expressed in human cancer
https://doi.org/10.18632/oncotarget.11550 Alberto Grandi, Alice Santi, Susanna Campagnoli, Matteo Parri, Elisa De Camilli, Chaojun Song, Boquan Jin, Aurelien Lacombe, Serenella Castori-Eppenberger, Paolo Sarmientos, Guido Grandi, Giuseppe Viale, Luigi Terracciano, Paola Chiarugi, Piero Pileri, and Renata Grifantini
63596-63610

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Numblike NumbL downregulation increases tumorigenicity cancer stem celllike properties and resistance to chemotherapy	Numblike NumbL downregulation increases tumorigenicity cancer stem celllike properties and resistance to chemotherapy
https://doi.org/10.18632/oncotarget.11553 José M. García-Heredia, Eva M. Verdugo Sivianes, Antonio Lucena-Cacace, Sonia Molina-Pinelo, and Amancio Carnero
63611-63628

Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Protein arginine methyltransferase 1 is a novel regulator of MYCN in neuroblastoma	Protein arginine methyltransferase 1 is a novel regulator of MYCN in neuroblastoma
https://doi.org/10.18632/oncotarget.11556 Allison Eberhardt, Jeanne N. Hansen, Jan Koster, Louis T. Lotta Jr, Simeng Wang, Emmett Livingstone, Kun Qian, Linda J. Valentijn, Yujun George Zheng, Nina F. Schor, and Xingguo Li
63629-63639

Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Common genetic variations in cell cycle and DNA repair pathways associated with pediatric brain tumor susceptibility	Common genetic variations in cell cycle and DNA repair pathways associated with pediatric brain tumor susceptibility
https://doi.org/10.18632/oncotarget.11575 Maral Adel Fahmideh, Catharina Lavebratt, Joachim Schüz, Martin Röösli, Tore Tynes, Michael A. Grotzer, Christoffer Johansen, Claudia E Kuehni, Birgitta Lannering, Michaela Prochazka, Lisbeth S Schmidt, and Maria Feychting
63640-63650

Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

NOD2 upregulates TLR2mediated IL23p19 expression via NFκB subunit cRel in Paneth celllike cells	NOD2 upregulates TLR2mediated IL23p19 expression via NFκB subunit cRel in Paneth celllike cells
https://doi.org/10.18632/oncotarget.11467 Gao Tan, Erbo Liang, Kaili Liao, Feihong Deng, Wendi Zhang, Yuqing Chen, Jun Xu, and Fachao Zhi
63651-63660

Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

High CLEC2 expression associates with unfavorable postoperative prognosis of patients with clear cell renal cell carcinoma	High CLEC2 expression associates with unfavorable postoperative prognosis of patients with clear cell renal cell carcinoma
https://doi.org/10.18632/oncotarget.11606 Ying Xiong, Li Liu, Yu Xia, Jiajun Wang, Wei Xi, Qi Bai, Yang Qu, Qilai Long, Jiejie Xu, and Jianming Guo
63661-63668

Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Expression of immune checkpoints in T cells of esophageal cancer patients	Expression of immune checkpoints in T cells of esophageal cancer patients
https://doi.org/10.18632/oncotarget.11611 Jinhua Xie, Ji Wang, Shouliang Cheng, Liangfeng Zheng, Feiyue Ji, Lin Yang, Yan Zhang, and Haoming Ji
63669-63678

Abstract  |  PDF  |  Full Text  |  How to cite

Leucine deprivation inhibits proliferation and induces apoptosis of human breast cancer cells via fatty acid synthase	Leucine deprivation inhibits proliferation and induces apoptosis of human breast cancer cells via fatty acid synthase
https://doi.org/10.18632/oncotarget.11626 Fei Xiao, Chunxia Wang, Hongkun Yin, Junjie Yu, Shanghai Chen, Jing Fang, and Feifan Guo
63679-63689

Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Hypoxia inducible factor1 mediates the expression of the immune checkpoint HLAG in glioma cells through hypoxia response element located in exon 2	Hypoxia inducible factor1 mediates the expression of the immune checkpoint HLAG in glioma cells through hypoxia response element located in exon 2
https://doi.org/10.18632/oncotarget.11628 Layale Yaghi, Isabelle Poras, Renata T. Simoes, Eduardo A. Donadi, Jörg Tost, Antoine Daunay, Bibiana Sgorla de Almeida, Edgardo D. Carosella, and Philippe Moreau
63690-63707

Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

New role of osteopontin in DNA repair and impact on human glioblastoma radiosensitivity	New role of osteopontin in DNA repair and impact on human glioblastoma radiosensitivity
https://doi.org/10.18632/oncotarget.11483 Aurélie Henry, Marie-Julie Nokin, Natacha Leroi, François Lallemand, Jérémy Lambert, Nicolas Goffart, Patrick Roncarati, Elettra Bianchi, Paul Peixoto, Arnaud Blomme, Andrei Turtoi, Olivier Peulen, Yvette Habraken, Félix Scholtes, Philippe Martinive, Philippe Delvenne, Bernard Rogister, Vincent Castronovo, and Akeila Bellahcène
63708-63721

Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Effectiveness of capecitabine with or without docetaxel therapy for the treatment of patients with advanced urothelial carcinoma: a singleinstitution experience	Effectiveness of capecitabine with or without docetaxel therapy for the treatment of patients with advanced urothelial carcinoma: a singleinstitution experience
https://doi.org/10.18632/oncotarget.11641 Cong Xue, Xin An, Ye Cao, Tanhuan Chen, Wei Yang, Yingfei Deng, Hui Han, Xiaoyu Teng, Fangjian Zhou, and Yanxia Shi
63722-63729

Abstract  |  PDF  |  Full Text  |  How to cite

CEACAM1 controls the EMT switch in murine mammary carcinoma in vitro and in vivo	CEACAM1 controls the EMT switch in murine mammary carcinoma in vitro and in vivo
https://doi.org/10.18632/oncotarget.11650 Wegwitz Florian, Eva Lenfert, Daniela Gerstel, Lena von Ehrenstein, Julia Einhoff, Geske Schmidt, Matthew Logsdon, Johanna Brandner, Gisa Tiegs, Nicole Beauchemin, Christoph Wagener, Wolfgang Deppert, and Andrea Kristina Horst
63730-63746

Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

[11C]Choline PET/CT in therapy response assessment of a neoadjuvant therapy in locally advanced and high risk prostate cancer before radical prostatectomy	[11C]Choline PET/CT in therapy response assessment of a neoadjuvant therapy in locally advanced and high risk prostate cancer before radical prostatectomy
https://doi.org/10.18632/oncotarget.11653 Sarah M. Schwarzenböck, Anna Knieling, Michael Souvatzoglou, Jens Kurth, Katja Steiger, Matthias Eiber, Irene Esposito, Margitta Retz, Hubert Kübler, Jürgen E. Gschwend, Markus Schwaiger, Bernd J. Krause, and Mark Thalgott
63747-63757

Abstract  |  PDF  |  Full Text  |  How to cite

Gene status and clinicopathologic characteristics of lung adenocarcinomas with mediastinal lymph node metastasis	Gene status and clinicopathologic characteristics of lung adenocarcinomas with mediastinal lymph node metastasis
https://doi.org/10.18632/oncotarget.11494 Shumeng Zhang, Bing Yan, Jing Zheng, Jing Zhao, and Jianying Zhou
63758-63766

Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

RSPOs facilitated HSC activation and promoted hepatic fibrogenesis	RSPOs facilitated HSC activation and promoted hepatic fibrogenesis
https://doi.org/10.18632/oncotarget.11654 Xinguang Yin, Huixing Yi, Linlin Wang, Wanxin Wu, Xiaojun Wu, and Linghua Yu
63767-63778

Abstract  |  PDF  |  Full Text  |  How to cite

RSL3 and Erastin differentially regulate redox signaling to promote Smac mimeticinduced cell death	RSL3 and Erastin differentially regulate redox signaling to promote Smac mimeticinduced cell death
https://doi.org/10.18632/oncotarget.11687 Jasmin Dächert, Hannah Schoeneberger, Katharina Rohde, and Simone Fulda
63779-63792

Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

NKAIN2 functions as a novel tumor suppressor in prostate cancer	NKAIN2 functions as a novel tumor suppressor in prostate cancer
https://doi.org/10.18632/oncotarget.11690 Xueying Mao, Fei Luo, Lara K. Boyd, Bowei Zhou, Yanling Zhang, Elzbieta Stankiewicz, Jacek Marzec, Natasa Vasiljevic, Yongwei Yu, Ninghan Feng, Jia Xu, Attila Lorincz, Yong Jiang, Claude Chelala, Guoping Ren, Daniel M Berney, Shan-Chao Zhao, and Yong-Jie Lu
63793-63803

Abstract  |  PDF  |  Full Text  |  How to cite

Mycobacterium tuberculosis multistage antigens confer comprehensive protection against pre and postexposure infections by driving Th1type T cell immunity	Mycobacterium tuberculosis multistage antigens confer comprehensive protection against pre and postexposure infections by driving Th1type T cell immunity
https://doi.org/10.18632/oncotarget.11542 Jilei Ma, Maopeng Tian, Xionglin Fan, Qi Yu, Yukai Jing, Weihua Wang, Li Li, and Zijie Zhou
63804-63815

Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Essential role of Na+/Ca2+ exchanger 1 in smokinginduced growth and migration of esophageal squamous cell carcinoma	Essential role of Na+/Ca2+ exchanger 1 in smokinginduced growth and migration of esophageal squamous cell carcinoma
https://doi.org/10.18632/oncotarget.11695 Jiexia Wen, Yan Pang, Tao Zhou, Ximing Qi, Min Zhao, Bin Xuan, Xiangcai Meng, Yunsheng Guo, Qingbin Liu, Huagang Liang, Yang Li, Hui Dong, and Yimin Wang
63816-63828

Abstract  |  PDF  |  Full Text  |  How to cite

Differential effects of histone deacetylase inhibitors on cellular drug transporters and their implications for using epigenetic modifiers in combination chemotherapy	Differential effects of histone deacetylase inhibitors on cellular drug transporters and their implications for using epigenetic modifiers in combination chemotherapy
https://doi.org/10.18632/oncotarget.11561 Benigno C. Valdez, Yang Li, David Murray, Jonathan E. Brammer, Yan Liu, Chitra Hosing, Yago Nieto, Richard E. Champlin, and Borje S. Andersson
63829-63838

Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Induction of VEGFA and Snail1 by meningitic Escherichia coli mediates disruption of the bloodbrain barrier	Induction of VEGFA and Snail1 by meningitic Escherichia coli mediates disruption of the bloodbrain barrier
https://doi.org/10.18632/oncotarget.11696 Ruicheng Yang, Wentong Liu, Ling Miao, Xiaopei Yang, Jiyang Fu, Beibei Dou, Aoling Cai, Xin Zong, Chen Tan, Huanchun Chen, and Xiangru Wang
63839-63855

Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Lipid rafts promote liver cancer cell proliferation and migration by upregulation of TLR7 expression	Lipid rafts promote liver cancer cell proliferation and migration by upregulation of TLR7 expression
https://doi.org/10.18632/oncotarget.11697 Yuan Liu, Xiaodong Guo, Liyuan Wu, Mei Yang, Zhiwei Li, Yinjie Gao, Shuhong Liu, Guangde Zhou, and Jingmin Zhao
63856-63869

Abstract  |  PDF  |  Full Text  |  How to cite

Curcumin potentiates antitumor activity of cisplatin in bladder cancer cell lines via ROSmediated activation of ERK1/2	Curcumin potentiates antitumor activity of cisplatin in bladder cancer cell lines via ROSmediated activation of ERK1/2
https://doi.org/10.18632/oncotarget.11563 Bong Hee Park, Joung Eun Lim, Hwang Gyun Jeon, Seong Il Seo, Hyun Moo Lee, Han Yong Choi, Seong Soo Jeon, and Byong Chang Jeong
63870-63886

Abstract  |  PDF  |  Full Text  |  How to cite

FAM122A a new endogenous inhibitor of protein phosphatase 2A	FAM122A a new endogenous inhibitor of protein phosphatase 2A
https://doi.org/10.18632/oncotarget.11698 Li Fan, Man-Hua Liu, Meng Guo, Chuan-Xi Hu, Zhao-Wen Yan, Jing Chen, Guo-Qiang Chen, and Ying Huang
63887-63900

Abstract  |  PDF  |  Full Text  |  How to cite

Long noncoding RNA MALAT1 acts as a competing endogenous RNA to promote malignant melanoma growth and metastasis by sponging miR22	Long noncoding RNA MALAT1 acts as a competing endogenous RNA to promote malignant melanoma growth and metastasis by sponging miR22
https://doi.org/10.18632/oncotarget.11564 Wenkang Luan, Lubo Li, Yan Shi, Xuefeng Bu, Yun Xia, Jinlong Wang, Henry Siaw Djangmah, Xiaohui Liu, Yongping You, and Bin Xu
63901-63912

Abstract  |  PDF  |  Full Text  |  How to cite

Autophagy regulates the survival of cells with chromosomal instability	Autophagy regulates the survival of cells with chromosomal instability
https://doi.org/10.18632/oncotarget.11736 Dawei Liu, Zeeshan Shaukat, Tianqi Xu, Donna Denton, Robert Saint, and Stephen Gregory
63913-63923

Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

A novel application of E1A in combination therapy with EGFRTKI treatment in breast cancer	A novel application of E1A in combination therapy with EGFRTKI treatment in breast cancer
https://doi.org/10.18632/oncotarget.11737 Chih-Ming Su, Ting-Yu Chang, Hui-Ping Hsu, Hui-Huang Lai, Jie-Ning Li, Yu-Jhen Lyu, Kuang-Tai Kuo, Ming-Te Huang, Jen-Liang Su, and Pai-Sheng Chen
63924-63936

Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Comparative profiling between primary colorectal carcinomas and metastases identifies heterogeneity on drug resistance	Comparative profiling between primary colorectal carcinomas and metastases identifies heterogeneity on drug resistance
https://doi.org/10.18632/oncotarget.11570 Feng Luo, Jinbang Li, Shigang Wu, Xuefang Wu, Meixiang Chen, Xueyun Zhong, and Kunping Liu
63937-63949

Abstract  |  PDF  |  Full Text  |  How to cite

Transcriptomic and functional pathways analysis of ascorbateinduced cytotoxicity and resistance of Burkitt lymphoma	Transcriptomic and functional pathways analysis of ascorbateinduced cytotoxicity and resistance of Burkitt lymphoma
https://doi.org/10.18632/oncotarget.11740 Zenglin Pei, Xuan Zhang, Chunxia Ji, Song-Mei Liu, and Jin Wang
63950-63959

Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

The LSP1 rs3817198 T > C polymorphism contributes to increased breast cancer risk: a metaanalysis of twelve studies	The LSP1 rs3817198 T > C polymorphism contributes to increased breast cancer risk: a metaanalysis of twelve studies
https://doi.org/10.18632/oncotarget.11741 Jianzhou Tang, Hui Li, Jiashun Luo, Hua Mei, Liang Peng, and Xiaojie Li
63960-63967

Abstract  |  PDF  |  Full Text  |  How to cite

Prognostic value of metabolic parameters on preoperative 18FFluorodeoxyglucose positron emission tomography/ computed tomography in patients with stage III gastric cancer	Prognostic value of metabolic parameters on preoperative 18FFluorodeoxyglucose positron emission tomography/ computed tomography in patients with stage III gastric cancer
https://doi.org/10.18632/oncotarget.11574 Sae Jung Na, Joo Hyun O, Jae Myung Park, Han Hee Lee, Sung Hak Lee, Kyo Young Song, Myung-Gyu Choi, and Cho Hyun Park
63968-63980

Abstract  |  PDF  |  Full Text  |  How to cite

LL202 protects against dextran sulfate sodiuminduced experimental colitis in mice by inhibiting MAPK/AP1 signaling	LL202 protects against dextran sulfate sodiuminduced experimental colitis in mice by inhibiting MAPK/AP1 signaling
https://doi.org/10.18632/oncotarget.11742 Yuan Gao, Yujie Huang, Yue Zhao, Yang Hu, Zhiyu Li, Qinglong Guo, Kai Zhao, and Na Lu
63981-63994

Abstract  |  PDF  |  Full Text  |  How to cite

Modeling of signaling crosstalkmediated drug resistance and its implications on drug combination	Modeling of signaling crosstalkmediated drug resistance and its implications on drug combination
https://doi.org/10.18632/oncotarget.11745 Xiaoqiang Sun, Jiguang Bao, Zhuhong You, Xing Chen, and Jun Cui
63995-64006

Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Gata3 restrains B cell proliferation and cooperates with p18INK4c to repress B cell lymphomagenesis	Gata3 restrains B cell proliferation and cooperates with p18INK4c to repress B cell lymphomagenesis
https://doi.org/10.18632/oncotarget.11746 Shiqin Liu, Ho Lam Chan, Feng Bai, Jinshan Ma, Alexandria Scott, David J. Robbins, Anthony J. Capobianco, Ping Zhu, and Xin-Hai Pei
64007-64020

Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Leptin induces osteocalcin expression in ATDC5 cells through activation of the MAPKERK1/2 signaling pathway	Leptin induces osteocalcin expression in ATDC5 cells through activation of the MAPKERK1/2 signaling pathway
https://doi.org/10.18632/oncotarget.11578 Yingchao Han, Guanghui Xu, Jingjie Zhang, Meijun Yan, Xinhua Li, Bin Ma, Lili Jun, Shan-Jin Wang, and Jun Tan
64021-64029

Abstract  |  PDF  |  Full Text  |  How to cite

Defective CFTR βcatenin interaction promotes NFκB nuclear translocation and intestinal inflammation in cystic fibrosis	Defective CFTR βcatenin interaction promotes NFκB nuclear translocation and intestinal inflammation in cystic fibrosis
https://doi.org/10.18632/oncotarget.11747 Kaisheng Liu, Xiaohu Zhang, Jie Ting Zhang, Lai Ling Tsang, Xiaohua Jiang, and Hsiao Chang Chan
64030-64042

Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Methylation and expression of PTPN22 in esophageal squamous cell carcinoma	Methylation and expression of PTPN22 in esophageal squamous cell carcinoma
https://doi.org/10.18632/oncotarget.11581 Jiaying Deng, Junhua Zhang, Chunyu Wang, Qing Wei, Daizhan Zhou, and Kuaile Zhao
64043-64052

Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Simple and robust diagnosis of early small and AFPnegative primary hepatic carcinomas: an integrative approach of serum fluorescence and conventional blood tests	Simple and robust diagnosis of early small and AFPnegative primary hepatic carcinomas: an integrative approach of serum fluorescence and conventional blood tests
https://doi.org/10.18632/oncotarget.11771 Ting Wang, Kun-He Zhang, Piao-Ping Hu, Zeng-Yong Huang, Pan Zhang, Qin-Si Wan, De-Qiang Huang, and Nong-Hua Lv
64053-64070

Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Deep targeted sequencing in pediatric acute lymphoblastic leukemia unveils distinct mutational patterns between genetic subtypes and novel relapseassociated genes	Deep targeted sequencing in pediatric acute lymphoblastic leukemia unveils distinct mutational patterns between genetic subtypes and novel relapseassociated genes
https://doi.org/10.18632/oncotarget.11773 C. Mårten Lindqvist, Anders Lundmark, Jessica Nordlund, Eva Freyhult, Diana Ekman, Jonas Carlsson Almlöf, Amanda Raine, Elin Övernäs, Jonas Abrahamsson, Britt-Marie Frost, Dan Grandér, Mats Heyman, Josefine Palle, Erik Forestier, Gudmar Lönnerholm, Eva C. Berglund, and Ann-Christine Syvänen
64071-64088

Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Phase Ib/II randomized openlabel study of doxorubicin and cyclophosphamide with or without lowdose shortcourse sunitinib in the preoperative treatment of breast cancer	Phase Ib/II randomized openlabel study of doxorubicin and cyclophosphamide with or without lowdose shortcourse sunitinib in the preoperative treatment of breast cancer
https://doi.org/10.18632/oncotarget.11596 Andrea L.A. Wong, Raghav Sundar, Ting-Ting Wang, Thian-C Ng, Bo Zhang, Sing-Huang Tan, Thomas I.P. Soh, Angela S.L. Pang, Chee-Seng Tan, Samuel G.W. Ow, Lingzhi Wang, Jannet Mogro, Jingshan Ho, Anand D. Jeyasekharan, Yiqing Huang, Choon-Hua Thng, Ching-Wan Chan, Mikael Hartman, Philip Iau, Shaik A. Buhari, Boon-Cher Goh, and Soo-Chin Lee
64089-64099

Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

MiR19b suppresses PTPRG to promote breast tumorigenesis	MiR19b suppresses PTPRG to promote breast tumorigenesis
https://doi.org/10.18632/oncotarget.11799 Minghui Liu, Rong Yang, Uzair Urrehman, Chao Ye, Xin Yan, Shufang Cui, Yeting Hong, Yuanyuan Gu, Yanqing Liu, Chihao Zhao, Liang Yan, Chen-Yu Zhang, Hongwei Liang, and Xi Chen
64100-64108

Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

PARP3 controls TGFβ and ROS driven epithelialtomesenchymal transition and stemness by stimulating a TG2SnailEcadherin axis	PARP3 controls TGFβ and ROS driven epithelialtomesenchymal transition and stemness by stimulating a TG2SnailEcadherin axis
https://doi.org/10.18632/oncotarget.11627 Olga Karicheva, José Manuel Rodriguez-Vargas, Nadège Wadier, Kathline Martin-Hernandez, Romain Vauchelles, Najat Magroun, Agnès Tissier, Valérie Schreiber, and Françoise Dantzer
64109-64123

Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Dual role of the integrated stress response in medulloblastoma tumorigenesis	Dual role of the integrated stress response in medulloblastoma tumorigenesis
https://doi.org/10.18632/oncotarget.11873 Sarrabeth Stone, Yeung Ho, Xiting Li, Stephanie Jamison, Heather P. Harding, David Ron, and Wensheng Lin
64124-64135

Abstract  |  PDF  |  Full Text  |  How to cite

Regorafenib Stivarga pharmacologically targets epithelialmesenchymal transition in colorectal cancer	Regorafenib Stivarga pharmacologically targets epithelialmesenchymal transition in colorectal cancer
https://doi.org/10.18632/oncotarget.11636 Li-Ching Fan, Hao-Wei Teng, Chung-Wai Shiau, Wei-Tien Tai, Man-Hsin Hung, Shung-Haur Yang, Jeng-Kai Jiang, and Kuen-Feng Chen
64136-64147

Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Comprehensive characterization of lncRNAmRNA related ceRNA network across 12 major cancers	Comprehensive characterization of lncRNAmRNA related ceRNA network across 12 major cancers
https://doi.org/10.18632/oncotarget.11637 Yunpeng Zhang, Yanjun Xu, Li Feng, Feng Li, Zeguo Sun, Tan Wu, Xinrui Shi, Jing Li, and Xia Li
64148-64167

Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Coupling CDH17 and CLDN18 markers for comprehensive membranetargeted detection of human gastric cancer	Coupling CDH17 and CLDN18 markers for comprehensive membranetargeted detection of human gastric cancer
https://doi.org/10.18632/oncotarget.11638 Keisuke Matsusaka, Tetsuo Ushiku, Masayuki Urabe, Masaki Fukuyo, Hiroyuki Abe, Shumpei Ishikawa, Yasuyuki Seto, Hiroyuki Aburatani, Takao Hamakubo, Atsushi Kaneda, and Masashi Fukayama
64168-64181

Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Biologic behavior and longterm outcomes of breast ductal carcinoma in situ with microinvasion	Biologic behavior and longterm outcomes of breast ductal carcinoma in situ with microinvasion
https://doi.org/10.18632/oncotarget.11639 Yan Fang, Jiayi Wu, Wei Wang, Xiaochun Fei, Yu Zong, Xiaosong Chen, Ou Huang, Jianrong He, Weiguo Chen, Yafen Li, Kunwei Shen, and Li Zhu
64182-64190

Abstract  |  PDF  |  Full Text  |  How to cite

DNA methylation array analysis identifies breast cancer associated RPTOR MGRN1 and RAPSN hypomethylation in peripheral blood DNA	DNA methylation array analysis identifies breast cancer associated RPTOR MGRN1 and RAPSN hypomethylation in peripheral blood DNA
https://doi.org/10.18632/oncotarget.11640 Qiuqiong Tang, Tim Holland-Letz, Alla Slynko, Katarina Cuk, Frederik Marme, Sarah Schott, Jörg Heil, Bin Qu, Michael Golatta, Melanie Bewerunge-Hudler, Christian Sutter, Harald Surowy, Barbara Wappenschmidt, Rita Schmutzler, Markus Hoth, Peter Bugert, Claus R. Bartram, Christof Sohn, Andreas Schneeweiss, Rongxi Yang, and Barbara Burwinkel
64191-64202

Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

F5peptide induces aspermatogenesis by disrupting organization of actin and microtubulebased cytoskeletons in the testis	F5peptide induces aspermatogenesis by disrupting organization of actin and microtubulebased cytoskeletons in the testis
https://doi.org/10.18632/oncotarget.11887 Ying Gao, Dolores D. Mruk, Wing-yee Lui, Will M. Lee, and C. Yan Cheng
64203-64220

Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

AAAATPase p97 suppresses apoptotic and autophagyassociated cell death in rheumatoid arthritis synovial fibroblasts	AAAATPase p97 suppresses apoptotic and autophagyassociated cell death in rheumatoid arthritis synovial fibroblasts
https://doi.org/10.18632/oncotarget.11890 Masaru Kato, Caroline Ospelt, Christoph Kolling, Tomohiro Shimizu, Michihito Kono, Shinsuke Yasuda, Beat A. Michel, Renate E. Gay, Steffen Gay, Kerstin Klein, and Tatsuya Atsumi
64221-64232

Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Circulating serum microRNA345 correlates with unfavorable pathological response to preoperative chemoradiotherapy in locally advanced rectal cancer	Circulating serum microRNA345 correlates with unfavorable pathological response to preoperative chemoradiotherapy in locally advanced rectal cancer
https://doi.org/10.18632/oncotarget.11649 Jing Yu, Ning Li, Xin Wang, Hua Ren, Weihu Wang, Shulian Wang, Yongwen Song, Yueping Liu, Yexiong Li, Xuantong Zhou, Aiping Luo, Zhihua Liu, and Jing Jin
64233-64243

Abstract  |  PDF  |  Full Text  |  How to cite

Regulation of matrix metalloproteinases MMPs expression and secretion in MDAMB231 breast cancer cells by LIM and SH3 protein 1 LASP1	Regulation of matrix metalloproteinases MMPs expression and secretion in MDAMB231 breast cancer cells by LIM and SH3 protein 1 LASP1
https://doi.org/10.18632/oncotarget.11720 Marcel Endres, Susanne Kneitz, Martin F. Orth, Ruwan K. Perera, Alma Zernecke, and Elke Butt
64244-64259

Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Loss of Par3 promotes lung adenocarcinoma metastasis through 1433ζ protein	Loss of Par3 promotes lung adenocarcinoma metastasis through 1433ζ protein
https://doi.org/10.18632/oncotarget.11728 Song Tong, Tian Xia, Kai Fan, Ke Jiang, Wei Zhai, Jing-Song Li, Si-Hua Wang, and Jian-Jun Wang
64260-64273

Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Activation of the A2B adenosine receptor in B16 melanomas induces CXCL12 expression in FAPpositive tumor stromal cells enhancing tumor progression	Activation of the A2B adenosine receptor in B16 melanomas induces CXCL12 expression in FAPpositive tumor stromal cells enhancing tumor progression
https://doi.org/10.18632/oncotarget.11729 Claudia Sorrentino, Lucio Miele, Amalia Porta, Aldo Pinto, and Silvana Morello
64274-64288

Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

DMBA induced mouse mammary tumors display high incidence of activating Pik3caH1047 and loss of function Pten mutations	DMBA induced mouse mammary tumors display high incidence of activating Pik3caH1047 and loss of function Pten mutations
https://doi.org/10.18632/oncotarget.11733 Martín C. Abba, Yi Zhong, Jaeho Lee, Hyunsuk Kil, Yue Lu, Yoko Takata, Melissa S. Simper, Sally Gaddis, Jianjun Shen, and C. Marcelo Aldaz
64289-64299

Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Characterizing the immune microenvironment of malignant peripheral nerve sheath tumor by PDL1 expression and presence of CD8+ tumor infiltrating lymphocytes	Characterizing the immune microenvironment of malignant peripheral nerve sheath tumor by PDL1 expression and presence of CD8+ tumor infiltrating lymphocytes
https://doi.org/10.18632/oncotarget.11734 Elizabeth Shurell, Arun S. Singh, Joseph G. Crompton, Sarah Jensen, Yunfeng Li, Sarah Dry, Scott Nelson, Bartosz Chmielowski, Nicholas Bernthal, Noah Federman, Paul Tumeh, and Fritz C. Eilber
64300-64308

Abstract  |  PDF  |  Full Text  |  How to cite

Lipocalin 2 overexpression facilitates progress of castrationresistant prostate cancer via improving androgen receptor transcriptional activity	Lipocalin 2 overexpression facilitates progress of castrationresistant prostate cancer via improving androgen receptor transcriptional activity
https://doi.org/10.18632/oncotarget.11790 Guanxiong Ding, Jianqing Wang, Chenchen Feng, Haowen Jiang, Jianfeng Xu, and Qiang Ding
64309-64317

Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Expressions of CD8+TILs PDL1 and Foxp3+TILs in stage I NSCLC guiding adjuvant chemotherapy decisions	Expressions of CD8+TILs PDL1 and Foxp3+TILs in stage I NSCLC guiding adjuvant chemotherapy decisions
https://doi.org/10.18632/oncotarget.11793 Feifei Teng, Xiangjiao Meng, Xin Wang, Jupeng Yuan, Sujing Liu, Dianbin Mu, Hui Zhu, Li Kong, and Jinming Yu
64318-64329

Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

The iron chelator deferasirox induces apoptosis by targeting oncogenic Pyk2/βcatenin signaling in human multiple myeloma	The iron chelator deferasirox induces apoptosis by targeting oncogenic Pyk2/βcatenin signaling in human multiple myeloma
https://doi.org/10.18632/oncotarget.11830 Yusuke Kamihara, Kohichi Takada, Tsutomu Sato, Yutaka Kawano, Kazuyuki Murase, Yohei Arihara, Shohei Kikuchi, Naotaka Hayasaka, Makoto Usami, Satoshi Iyama, Koji Miyanishi, Yasushi Sato, Masayoshi Kobune, and Junji Kato
64330-64341

Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

The TATRasGAP317326 anticancer peptide can kill in a caspase apoptosis and necroptosisindependent manner	The TATRasGAP317326 anticancer peptide can kill in a caspase apoptosis and necroptosisindependent manner
https://doi.org/10.18632/oncotarget.11841 Mathieu Heulot, Nadja Chevalier, Julien Puyal, Christiane Margue, Sébastien Michel, Stephanie Kreis, Dagmar Kulms, David Barras, Aimable Nahimana, and Christian Widmann
64342-64359

Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Overexpression of PHRF1 attenuates the proliferation and tumorigenicity of nonsmall cell lung cancer cells	Overexpression of PHRF1 attenuates the proliferation and tumorigenicity of nonsmall cell lung cancer cells
https://doi.org/10.18632/oncotarget.11842 Yadong Wang, Haiyu Wang, Teng Pan, Li Li, Jiangmin Li, and Haiyan Yang
64360-64370

Abstract  |  PDF  |  Full Text  |  How to cite

Circulating levels of Creactive protein interleukin6 and tumor necrosis factorα and risk of colorectal adenomas: a metaanalysis	Circulating levels of Creactive protein interleukin6 and tumor necrosis factorα and risk of colorectal adenomas: a metaanalysis
https://doi.org/10.18632/oncotarget.11853 Xiaoqian Zhang, Shanglong Liu, and Yanbing Zhou
64371-64379

Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Clinical Research Papers

Association between gallbladder stone disease and prostate cancer: A nationwide populationbased study	Association between gallbladder stone disease and prostate cancer: A nationwide populationbased study
https://doi.org/10.18632/oncotarget.9062 Chien-Hua Chen, Cheng-Li Lin, and Chia-Hung Kao
64380-64389

Abstract  |  PDF  |  Full Text  |  How to cite

A phase I study of intratumoral ipilimumab and interleukin2 in patients with advanced melanoma	A phase I study of intratumoral ipilimumab and interleukin2 in patients with advanced melanoma
https://doi.org/10.18632/oncotarget.10453 Abhijit Ray, Matthew A. Williams, Stephanie M. Meek, Randy C. Bowen, Kenneth F. Grossmann, Robert H.I. Andtbacka, Tawnya L. Bowles, John R. Hyngstrom, Sancy A. Leachman, Douglas Grossman, Glen M. Bowen, Sheri L. Holmen, Matthew W. VanBrocklin, Gita Suneja, and Hung T. Khong
64390-64399

Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Alternative treatments in advanced hepatocellular carcinoma patients with progressive disease after sorafenib treatment: a prospective multicenter cohort study	Alternative treatments in advanced hepatocellular carcinoma patients with progressive disease after sorafenib treatment: a prospective multicenter cohort study
https://doi.org/10.18632/oncotarget.10794 Masahito Nakano, Masatoshi Tanaka, Ryoko Kuromatsu, Hiroaki Nagamatsu, Manabu Satani, Takashi Niizeki, Shusuke Okamura, Hideki Iwamoto, Shigeo Shimose, Tomotake Shirono, Yu Noda, Hironori Koga, Takuji Torimura, and Kurume Liver Cancer Study Group of Japan
64400-64409

Abstract  |  PDF  |  Full Text  |  How to cite

Responses to crizotinib in patients with ALKpositive lung adenocarcinoma who tested immunohistochemistry IHCpositive and fluorescence in situ hybridization FISHnegative	Responses to crizotinib in patients with ALKpositive lung adenocarcinoma who tested immunohistochemistry IHCpositive and fluorescence in situ hybridization FISHnegative
https://doi.org/10.18632/oncotarget.10560 Di Ma, Zheng Wang, Lin Yang, Xinlin Mu, Yan Wang, Xinming Zhao, Junling Li, and Dongmei Lin
64410-64420

Abstract  |  PDF  |  Full Text  |  How to cite

Validation of prognostic scoring and assessment of clinical benefit for patients with bone sarcomas enrolled in phase I clinical trials	Validation of prognostic scoring and assessment of clinical benefit for patients with bone sarcomas enrolled in phase I clinical trials
https://doi.org/10.18632/oncotarget.10910 J. Andrew Livingston, Kenneth R. Hess, Aung Naing, David S. Hong, Shreyaskumar Patel, Robert S. Benjamin, Joseph A. Ludwig, Anthony Conley, Cynthia E. Herzog, Pete Anderson, Funda Meric-Bernstam, Razelle Kurzrock, and Vivek Subbiah
64421-64430

Abstract  |  PDF  |  Full Text  |  How to cite

Reviews

Mechanisms of resistance and sensitivity to antiHER2 therapies in HER2+ breast cancer	Mechanisms of resistance and sensitivity to antiHER2 therapies in HER2+ breast cancer
https://doi.org/10.18632/oncotarget.7043 Debora de Melo Gagliato, Denis Leonardo Fontes Jardim, Mario Sergio Pereira Marchesi, and Gabriel N. Hortobagyi
64431-64446

Abstract  |  PDF  |  Full Text  |  How to cite

Molecular mechanisms underlying resistance to androgen deprivation therapy in prostate cancer	Molecular mechanisms underlying resistance to androgen deprivation therapy in prostate cancer
https://doi.org/10.18632/oncotarget.10901 Kristine M. Wadosky, and Shahriar Koochekpour
64447-64470

Abstract  |  PDF  |  Full Text  |  How to cite

Ubc13: the Lys63 ubiquitin chain building machine	Ubc13: the Lys63 ubiquitin chain building machine
https://doi.org/10.18632/oncotarget.10948 Curtis D. Hodge, Leo Spyracopoulos, and J. N. Mark Glove
64471-64504

Abstract  |  PDF  |  Full Text  |  How to cite

Suppressive role of myeloidderived suppressor cells MDSCs in the microenvironment of breast cancer and targeted immunotherapies	Suppressive role of myeloidderived suppressor cells MDSCs in the microenvironment of breast cancer and targeted immunotherapies
https://doi.org/10.18632/oncotarget.11352 Dawei Shou, Liang Wen, Zhenya Song, Jian Yin, Qiming Sun, and Weihua Gong
64505-64511

Abstract  |  PDF  |  Full Text  |  How to cite

The emerging insights into catalytic or noncatalytic roles of TET proteins in tumors and neural development	The emerging insights into catalytic or noncatalytic roles of TET proteins in tumors and neural development
https://doi.org/10.18632/oncotarget.11412 Hao Lian, Wen-Bin Li, and Wei-Lin Jin
64512-64525

Abstract  |  PDF  |  Full Text  |  How to cite

Corrections

Correction: Cyclin D1 silencing suppresses tumorigenicity impairs DNA double strand break repair and thus radiosensitizes androgenindependent prostate cancer cells to DNA damage	Correction: Cyclin D1 silencing suppresses tumorigenicity impairs DNA double strand break repair and thus radiosensitizes androgenindependent prostate cancer cells to DNA damage
https://doi.org/10.18632/oncotarget.12267 Francesco Marampon, Giovanni Luca Gravina, Xiaoming Ju, Antonella Vetuschi, Roberta Sferra, Mathew C. Casimiro, Simona Pompili, Claudio Festuccia, Alessandro Colapietro, Eugenio Gaudio, Ernesto Di Cesare, Vincenzo Tombolini, and Richard G. Pestell
64526-64526

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