Differential IgM expression distinguishes two types of pediatric Burkitt lymphoma in mouse and human
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Anthony B. Eason1,2, Sang-Hoon Sin1,2, Carolina Lin1,2, Blossom Damania1,2, Steven Park1,3, Yuri Fedoriw1,4, Carlos E. Bacchi5, Dirk P. Dittmer1,2
1Lineberger Comprehensive Cancer Center, the University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA
2Department of Microbiology and Immunology, the University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA
3Department of Medicine, the University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA
4Department of Pathology and Laboratory Medicine, the University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA
5Pathology Reference Laboratory, Botucatu, São Paulo, Brazil
Dirk P. Dittmer, email: [email protected]
Keywords: Burkitt lymphoma, Epstein-Barr virus, IgM, Myc, ibrutinib
Received: May 23, 2016 Accepted: August 13, 2016 Published: August 23, 2016
Endemic Burkitt lymphoma (eBL) is primarily a childhood cancer in parts of Africa and Brazil. Classic studies describe eBL as a homogeneous entity based on t(8;14) IgH-Myc translocation and clinical response to cytotoxic therapy. By contrast, sporadic BL (sBL) in Western countries is considered more heterogeneous, and affects both children and adults. It is overrepresented in AIDS patients. Unlike diffuse large B cell lymphoma (DLBCL), molecular subtypes within BL have not been well defined. We find that differential IgM positivity can be used to describe two subtypes of pediatric Burkitt lymphoma both in a high incidence region (Brazil), as well as in a sporadic region (US), suggesting the phenotype is not necessarily geographically isolated. Moreover, we find that IgM positivity also distinguishes between early and late onset BL in the standard Eμ-Myc mouse model of BL. This suggests that the t(8;14) translocation not only can take place before, but also after isotype switch recombination, and that IgM-negative, t(8;14) positive lymphomas in children should nevertheless be considered BL.
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