Effect of epidermal growth factor receptor gene polymorphisms on prognosis in glioma patients
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Bin Li1,2,*, Wenhui Zhao3,*, Jingjie Li1,2, Mengdan Yan1,2, Zhilan Xie2, Yuanyuan Zhu2, Chao Chen1,2, Tianbo Jin1,2,4
1School of Life Sciences, Northwest University, Xi’an, Shaanxi, 710069, China
2National Engineering Research Center for Miniaturized Detection Systems, Xi’an, Shaanxi, 710069, China
3Department of Anesthesiology, Shaanxi Provincial Tumor Hospital, Xi’an, Shaanxi, 710061, China
4Xi’an Tiangen Precision Medical Institute, Xi’an, Shaanxi 710075, China
*These authors have contributed equally to this work
Tianbo Jin, email: [email protected]
Chao Chen, email: [email protected]
Keywords: EGFR, glioma, polymorphism, prognosis
Received: March 17, 2016 Accepted: May 29, 2016 Published: July 18, 2016
Previous studies suggested that single nucleotide polymorphisms (SNPs) in epidermal growth factor receptor (EGFR) are associated with risk of glioma. However, the associations between these SNPs and glioma patient prognosis have not yet been fully investigated. Therefore, the present study was aimed to evaluate the effects of EGFR polymorphisms on the glioma patient prognosis. We retrospectively evaluated 269 glioma patients and investigated associations between EGFR SNPs and patient prognosis using Cox proportional hazard models and Kaplan-Meier curves. Univariate analysis revealed that age, gross-total resection and chemotherapy were associated with the prognosis of glioma patients (p < 0.05). In addition, four EGFR SNPs (rs11506105, rs3752651, rs1468727 and rs845552) correlated with overall survival (OS) (Log-rank p = 0.011, 0.020, 0.008, and 0.009, respectively) and progression-free survival PFS (Log-rank p = 0.026, 0.024, 0.019 and 0.009, respectively). Multivariate analysis indicated that the rs11506105 G/G genotype, the rs3752651 and rs1468727 C/C genotype and the rs845552 A/A genotype correlated inversely with OS and PFS. In addition, OS among patients with the rs730437 C/C genotype (p = 0.030) was significantly lower OS than among patients with A/A genotype. These data suggest that five EGFR SNPs (rs11506105, rs3752651, rs1468727, rs845552 and rs730437) correlated with glioma patient prognosis, and should be furthered validated in studies of ethnically diverse patients.
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