A potential molecular model for studying apoptosis enhanced by the interaction of BCL-G with JAB1 in swine

Pengfei Jiang; Xingye Wang; Xiaolin Chen; Yaping Wang; Zhanzhan Kang; Jingna Wang; Deli Zhang

doi:10.18632/oncotarget.11230

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Research Papers: Autophagy and Cell Death:

A potential molecular model for studying apoptosis enhanced by the interaction of BCL-G with JAB1 in swine

Pengfei Jiang, Xingye Wang, Xiaolin Chen, Yaping Wang, Zhanzhan Kang, Jingna Wang and Deli Zhang _

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Oncotarget. 2016; 7:62912-62924. https://doi.org/10.18632/oncotarget.11230

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Abstract

Pengfei Jiang1,2,*, Xingye Wang2,*, Xiaolin Chen2, Yaping Wang2, Zhanzhan Kang2, Jingna Wang2 and Deli Zhang2

1 Department of Microbiology & Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, P. R. China

2 College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, P. R. China

* These authors have contributed equally to this work

Correspondence to:

Deli Zhang, email:

Pengfei Jiang, email:

Keywords: porcine BCL-G; spatial expression; subcellular localization; interaction with porcine JAB1; enhancement to apoptosis; Autophagy

Received: December 13, 2015 Accepted: July 14, 2016 Published: August 11, 2016

Abstract

BCL-G, an apoptotic factor in Bcl-2 family, is involved in several kinds of diseases by interacting with several proteins. Although many studies on mouse and human BCL-G have been reported, porcine BCL-G (pBCL-G) has been little investigated. In this study, our results showed that pBCL-G was universally expressed in porcine tissues. The BH2 domain affected the subcellular distribution of pBCL-G protein. pBCL-G could interact with porcine JAB1 (pJAB1), by which its subcellular distribution was affected. pBCL-G promoted staurosporine-induced apoptosis that was significantly enhanced by interaction of pBCL-G with pJAB1. The apoptosis at least partially depended on the activated caspase-8, -9 and -3. Owing to the close phylogenetic distance between pigs and humans and their many physiological similarities, our findings may provide a potential molecular model to study human BCL-G and also may have implications in the treatment of diseases relevant with BCL-G.

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Research Papers: Autophagy and Cell Death:

A potential molecular model for studying apoptosis enhanced by the interaction of BCL-G with JAB1 in swine

Abstract