Oncotarget

Research Papers:

Long non-coding RNA MALAT1 acts as a competing endogenous RNA to promote malignant melanoma growth and metastasis by sponging miR-22

Wenkang Luan _, Lubo Li, Yan Shi, Xuefeng Bu, Yun Xia, Jinlong Wang, Henry Siaw Djangmah, Xiaohui Liu, Yongping You and Bin Xu

PDF  |  HTML  |  How to cite

Oncotarget. 2016; 7:63901-63912. https://doi.org/10.18632/oncotarget.11564

Metrics: PDF 2635 views  |   HTML 2696 views  |   ?  


Abstract

Wenkang Luan1,*, Lubo Li2,*, Yan Shi4,*, Xuefeng Bu3, Yun Xia1, Jinlong Wang1, Henry Siaw Djangmah1, Xiaohui Liu1, Yongping You5, Bin Xu1

1Department of Plastic Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu, China

2Department of Neurosurgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu, China

3Department of General Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu, China

4Department of Neurosurgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China

5Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

*These authors have contributed equally to this work

Correspondence to:

Wenkang Luan, email: [email protected]

Bin Xu, email: [email protected]

Keywords: MALAT1, miR-22, MMP14 and Snail, ceRNA, melanoma

Received: June 03, 2016     Accepted: August 13, 2016     Published: August 24, 2016

ABSTRACT

Long non-coding RNAs (lncRNAs) are involved in tumorigenesis. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), an lncRNAs, is associated with the growth and metastasis of many human tumors, but its biological roles in malignant melanoma remain unclear. In this study, the aberrant up-regulation of MALAT1 was detected in melanoma. We determined that MALAT1 promotes melanoma cells proliferation, invasion and migration by sponging miR-22. MiR-22 was decreased and acted as a tumor suppressor in melanoma, and MMP14 and Snail were the functional targets of miR-22. Furthermore, MALAT1 could modulate MMP14 and Snail by operating as a competing endogenous RNA (ceRNA) for miR-22. The effects of MALAT1 in malignant melanoma is verified using a xenograft model. This finding elucidates a new mechanism for MALAT1 in melanoma development and provides a potential target for melanoma therapeutic intervention.


Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.
PII: 11564