Oncotarget

Research Papers:

The LSP1 rs3817198 T > C polymorphism contributes to increased breast cancer risk: a meta-analysis of twelve studies

Jianzhou Tang _, Hui Li, Jiashun Luo, Hua Mei, Liang Peng and Xiaojie Li

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Oncotarget. 2016; 7:63960-63967. https://doi.org/10.18632/oncotarget.11741

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Abstract

Jianzhou Tang1,5,*, Hui Li2,*, Jiashun Luo3, Hua Mei4, Liang Peng1, Xiaojie Li5

1Department of Biological and Environmental Engineering, Changsha University, Changsha 410003, Hunan, China

2Department of Microbiology and Immunology, Medical School of Jishou University, Jishou 416000, Hunan, China

3Institute of Medical Sciences, Medical School of Jishou University, Jishou 416000, Hunan, China

4Hunan Guangxiu Hospital, Changsha 410002, Hunan, China

5College of Animal Science and Technology of Hunan Agriculture University, Changsha 410128, Hunan, China

*These authors contributed equally to this work and should be considered as co-first authors

Correspondence to:

Jianzhou Tang, email: [email protected]

Keywords: LSP1, breast cancer, risk, meta-analysis

Received: June 06, 2016     Accepted: August 26, 2016     Published: August 31, 2016

ABSTRACT

The association between the LSP1 rs3817198 T > C polymorphism and breast cancer risk has been widely investigated, but remains controversial. We therefore undertook a comprehensive meta-analysis to provide a high-quality evaluation of this association. A literature search was performed among Pubmed, EMBASE and Chinese National Knowledge Infrastructure (CNKI) databases prior to July 31, 2016, and the strength of the association between the LSP1 rs3817198 T > C polymorphism and breast cancer risk was assessed based on odds ratio (OR) and 95% confidence interval (95% CI). In total, 12 studies with 50,525 cases and 54,302 controls were included. Pooled risk estimates indicated a significant association between the LSP1 rs3817198 T > C polymorphism and breast cancer risk. Analysis of cases stratified based on ethnicity suggested that the association was significant in both Caucasian and Asian populations. Stratification based on source of controls revealed an association only in population-based studies. These findings indicate the LSP1 rs3817198 T > C polymorphism is associated with increased risk of breast cancer, especially in Caucasian and Asian populations. Large, well-designed studies with different ethnicities are still needed to verify our findings.


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