Oncotarget

Research Papers:

[11C]Choline PET/CT in therapy response assessment of a neoadjuvant therapy in locally advanced and high risk prostate cancer before radical prostatectomy

Sarah M. Schwarzenböck _, Anna Knieling, Michael Souvatzoglou, Jens Kurth, Katja Steiger, Matthias Eiber, Irene Esposito, Margitta Retz, Hubert Kübler, Jürgen E. Gschwend, Markus Schwaiger, Bernd J. Krause and Mark Thalgott

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Oncotarget. 2016; 7:63747-63757. https://doi.org/10.18632/oncotarget.11653

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Abstract

Sarah M. Schwarzenböck1,2, Anna Knieling2,*, Michael Souvatzoglou1,3, Jens Kurth2, Katja Steiger4, Matthias Eiber1, Irene Esposito4,5, Margitta Retz6, Hubert Kübler6, Jürgen E. Gschwend6, Markus Schwaiger1, Bernd J. Krause1,2, Mark Thalgott6

1Department of Nuclear Medicine, Klinikum Rechts der Isar, Technische Universität München, 81675 Munich, Germany

2Department of Nuclear Medicine, Rostock University Medical Centre, 18057 Rostock, Germany

3Department of Nuclear Medicine, Ulm University, 89081 Ulm, Germany

4Institute of Pathology, Klinikum Rechts der Isar, Technische Universität München, 81675 Munich, Germany

5Institute of Pathology, Heinrich-Heine University of Düsseldorf, 40225 Düsseldorf, Germany

6Department of Urology, Klinikum Rechts der Isar, Technische Universität München, 81675 Munich, Germany

*Second author

Correspondence to:

Sarah M. Schwarzenböck, email: [email protected]

Keywords: prostate cancer, therapy response assessment, neoadjuvant therapy, choline, PET/CT

Received: March 08, 2016     Accepted: August 24, 2016     Published: August 27, 2016

ABSTRACT

Purpose: Recent studies have shown promising results of neoadjuvant therapy in prostate cancer (PC). The aim of this study was to evaluate the potential of [11C]Choline PET/CT in therapy response monitoring after combined neoadjuvant docetaxel chemotherapy and complete androgen blockade in locally advanced and high risk PC patients.

Results: In [11C]Choline PET/CT there was a significant decrease of SUVmax and SUVmean (p = 0.004, each), prostate volume (p = 0.005) and PSA value (p = 0.003) after combined neoadjuvant therapy. MRI showed a significant prostate and tumor volume reduction (p = 0.003 and 0.005, respectively). Number of apoptotic cells was significantly higher in prostatectomy specimens of the therapy group compared to pretherapeutic biopsies and the control group (p = 0.02 and 0.003, respectively).

Methods: 11 patients received two [11C]Choline PET/CT and MRI scans before and after combined neoadjuvant therapy followed by radical prostatectomy and pelvic lymph node dissection. [11C]Choline uptake, prostate and tumor volume, PSA value (before/after neoadjuvant therapy) and apoptosis (of pretherapeutic biopsy/posttherapeutic prostatectomy specimens of the therapy group and prostatectomy specimens of a matched control group without neoadjuvant therapy) were assessed and tested for differences and correlation using SPSS.

Conclusions: The results showing a decrease in choline uptake after combined neoadjuvant therapy (paralleled by regressive and apoptotic changes in histopathology) confirm the potential of [11C]Choline PET/CT to monitor effects of neoadjuvant therapy in locally advanced and high risk PC patients. Further studies are recommended to evaluate its use during the course of neoadjuvant therapy for early response assessment.


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