Acquisition of an oncogenic fusion protein serves as an initial driving mutation by inducing aneuploidy and overriding proliferative defects

Blunted dynamics of adenosine A_2A receptors is associated with increased susceptibility to Candida albicans infection in the elderly

Transfection of the IHH gene into rabbit BMSCs in a simulated microgravity environment promotes chondrogenic differentiation and inhibits cartilage aging

Systematic analysis of tumour cell-extracellular matrix adhesion identifies independent prognostic factors in breast cancer

Two common functional catalase gene polymorphisms (rs1001179 and rs794316) and cancer susceptibility: evidence from 14,942 cancer cases and 43,285 controls

Clinicopathological and prognostic significance of metastasis-associated in colon cancer-1 (MACC1) overexpression in colorectal cancer: a meta-analysis

The effect of epigenetic silencing and TP53 mutation on the expression of DLL4 in human cancer stem disorder

Molecular dissection of the valproic acid effects on glioma cells

Gene expression signature based screening identifies ribonucleotide reductase as a candidate therapeutic target in Ewing sarcoma

Reversibility of glioma stem cells’ phenotypes explains their complex in vitro and in vivo behavior: Discovery of a novel neurosphere-specific enzyme, cGMP-dependent protein kinase 1, using the genomic landscape of human glioma stem cells as a discovery tool

Prognostic impact of the expression of Wnt-signaling proteins in cervical carcinoma FIGO stage I-IV treated with radiotherapy or chemoradiotherapy

Effect of epidermal growth factor receptor gene polymorphisms on prognosis in glioma patients

Targeted suppression of AR-V7 using PIP5K1α inhibitor overcomes enzalutamide resistance in prostate cancer cells

Clues toward precision medicine in oral squamous cell carcinoma: utility of next-generation sequencing for the prognostic stratification of high-risk patients harboring neck lymph node extracapsular extension

Visceral fat adipocytes from obese and colorectal cancer subjects exhibit distinct secretory and ω6 polyunsaturated fatty acid profiles and deliver immunosuppressive signals to innate immunity cells

Phosphatidylinositide 3-kinase (PI3K) and PI3K-related kinase (PIKK) activity contributes to radioresistance in thyroid carcinomas

DDA suppresses angiogenesis and tumor growth of colorectal cancer in vivo through decreasing VEGFR2 signaling

Hypoxia enhances the malignant nature of bladder cancer cells and concomitantly antagonizes protein O-glycosylation extension

Altered phosphatidylcholines expression in sputum for diagnosis of non-small cell lung cancer

Landscape of RNAs in human lumbar disc degeneration

Distinct mutation profile and prognostic relevance in patients with hypoplastic myelodysplastic syndromes (h-MDS)

Validation of a network-based strategy for the optimization of combinatorial target selection in breast cancer therapy: siRNA knockdown of network targets in MDA-MB-231 cells as an in vitro model for inhibition of tumor development

Immunosuppressive effect of bladder cancer on function of dendritic cells involving of Jak2/STAT3 pathway

FAM65B controls the proliferation of transformed and primary T cells

Therapeutic dosages of aspirin counteract the IL-6 induced pro-tumorigenic effects by slowing down the ribosome biogenesis rate

The double benefit of Spalax p53: surviving underground hypoxia while defying lung cancer cells in vitro via autophagy and caspase-dependent cell death

Target sequencing and CRISPR/Cas editing reveal simultaneous loss of UTX and UTY in urothelial bladder cancer

RORα and RORγ expression inversely correlates with human melanoma progression

The accuracy of microRNA-210 in diagnosing lung cancer: a systematic review and meta-analysis

Decreased TSPAN1 promotes prostate cancer progression and is a marker for early biochemical recurrence after radical prostatectomy

MetAP1 and MetAP2 drive cell selectivity for a potent anti-cancer agent in synergy, by controlling glutathione redox state

Sphingosine-1-phosphate induced epithelial-mesenchymal transition of hepatocellular carcinoma via an MMP-7/ syndecan-1/TGF-β autocrine loop

Correlation between body mass index (BMI) and the Gleason score of prostate biopsies in Chinese population

Rab27A mediated by NF-κB promotes the stemness of colon cancer cells via up-regulation of cytokine secretion

Mel-18 negatively regulates stem cell-like properties through downregulation of miR-21 in gastric cancer

Control of translational activation by PIM kinase in activated B-cell diffuse large B-cell lymphoma confers sensitivity to inhibition by PIM447

Adrenomedullin blockade suppresses sunitinib-resistant renal cell carcinoma growth by targeting the ERK/MAPK pathway

Identification of tumorigenesis-related mRNAs associated with RNA-binding protein HuR in thyroid cancer cells

Altered pH gradient at the plasma membrane of osteosarcoma cells is a key mechanism of drug resistance

Epigenetic changes in localized gastric cancer: the role of RUNX3 in tumor progression and the immune microenvironment

Non-targeted and targeted metabolomics approaches to diagnosing lung cancer and predicting patient prognosis

Silencing of cZNF292 circular RNA suppresses human glioma tube formation via the Wnt/β-catenin signaling pathway

Subclones in B-lymphoma cell lines: isogenic models for the study of gene regulation

Integrin β1, myosin light chain kinase and myosin IIA are required for activation of PI3K-AKT signaling following MEK inhibition in metastatic triple negative breast cancer

Construction and immunological characterization of CD40L or GM-CSF incorporated Hantaan virus like particle

Differential IgM expression distinguishes two types of pediatric Burkitt lymphoma in mouse and human

Peptidome analysis of human milk from women delivering macrosomic fetuses reveals multiple means of protection for infants

A novel molecular and clinical staging model to predict survival for patients with esophageal squamous cell carcinoma

Secretome proteomics reveals candidate non-invasive biomarkers of BRCA1 deficiency in breast cancer

Novel synthetic cyclic integrin αvβ3 binding peptide ALOS4: antitumor activity in mouse melanoma models

Long non-coding RNA HoxA-AS3 interacts with EZH2 to regulate lineage commitment of mesenchymal stem cells

HER2 amplification level is not a prognostic factor for HER2-positive breast cancer with trastuzumab-based adjuvant treatment: a systematic review and meta-analysis

The ω-3 polyunsaturated fatty acids prevented colitis-associated carcinogenesis through blocking dissociation of β-catenin complex, inhibiting COX-2 through repressing NF-κB, and inducing 15-prostaglandin dehydrogenase

ERMP1, a novel potential oncogene involved in UPR and oxidative stress defense, is highly expressed in human cancer

Numb-like (NumbL) downregulation increases tumorigenicity, cancer stem cell-like properties and resistance to chemotherapy

Protein arginine methyltransferase 1 is a novel regulator of MYCN in neuroblastoma

Common genetic variations in cell cycle and DNA repair pathways associated with pediatric brain tumor susceptibility

NOD2 up-regulates TLR2-mediated IL-23p19 expression via NF-κB subunit c-Rel in Paneth cell-like cells

High CLEC-2 expression associates with unfavorable postoperative prognosis of patients with clear cell renal cell carcinoma

Expression of immune checkpoints in T cells of esophageal cancer patients

Leucine deprivation inhibits proliferation and induces apoptosis of human breast cancer cells via fatty acid synthase

Hypoxia inducible factor-1 mediates the expression of the immune checkpoint HLA-G in glioma cells through hypoxia response element located in exon 2

New role of osteopontin in DNA repair and impact on human glioblastoma radiosensitivity

Effectiveness of capecitabine with or without docetaxel therapy for the treatment of patients with advanced urothelial carcinoma: a single-institution experience

CEACAM1 controls the EMT switch in murine mammary carcinoma in vitro and in vivo

[¹¹C]Choline PET/CT in therapy response assessment of a neoadjuvant therapy in locally advanced and high risk prostate cancer before radical prostatectomy

Gene status and clinicopathologic characteristics of lung adenocarcinomas with mediastinal lymph node metastasis

RSPOs facilitated HSC activation and promoted hepatic fibrogenesis

RSL3 and Erastin differentially regulate redox signaling to promote Smac mimetic-induced cell death

NKAIN2 functions as a novel tumor suppressor in prostate cancer

Mycobacterium tuberculosis multistage antigens confer comprehensive protection against pre- and post-exposure infections by driving Th1-type T cell immunity

Essential role of Na⁺/Ca2⁺ exchanger 1 in smoking-induced growth and migration of esophageal squamous cell carcinoma

Differential effects of histone deacetylase inhibitors on cellular drug transporters and their implications for using epigenetic modifiers in combination chemotherapy

Induction of VEGFA and Snail-1 by meningitic Escherichia coli mediates disruption of the blood-brain barrier

Lipid rafts promote liver cancer cell proliferation and migration by up-regulation of TLR7 expression

Curcumin potentiates antitumor activity of cisplatin in bladder cancer cell lines via ROS-mediated activation of ERK1/2

FAM122A, a new endogenous inhibitor of protein phosphatase 2A

Long non-coding RNA MALAT1 acts as a competing endogenous RNA to promote malignant melanoma growth and metastasis by sponging miR-22

Autophagy regulates the survival of cells with chromosomal instability

A novel application of E1A in combination therapy with EGFR-TKI treatment in breast cancer

Comparative profiling between primary colorectal carcinomas and metastases identifies heterogeneity on drug resistance

Transcriptomic and functional pathways analysis of ascorbate-induced cytotoxicity and resistance of Burkitt lymphoma

The LSP1 rs3817198 T > C polymorphism contributes to increased breast cancer risk: a meta-analysis of twelve studies

Prognostic value of metabolic parameters on preoperative 18F-Fluorodeoxyglucose positron emission tomography/ computed tomography in patients with stage III gastric cancer

LL202 protects against dextran sulfate sodium-induced experimental colitis in mice by inhibiting MAPK/AP-1 signaling

Modeling of signaling crosstalk-mediated drug resistance and its implications on drug combination

Gata3 restrains B cell proliferation and cooperates with p18^INK4c to repress B cell lymphomagenesis

Leptin induces osteocalcin expression in ATDC5 cells through activation of the MAPK-ERK1/2 signaling pathway

Defective CFTR- β-catenin interaction promotes NF-κB nuclear translocation and intestinal inflammation in cystic fibrosis

Methylation and expression of PTPN22 in esophageal squamous cell carcinoma

Simple and robust diagnosis of early, small and AFP-negative primary hepatic carcinomas: an integrative approach of serum fluorescence and conventional blood tests

Deep targeted sequencing in pediatric acute lymphoblastic leukemia unveils distinct mutational patterns between genetic subtypes and novel relapse-associated genes

Phase Ib/II randomized, open-label study of doxorubicin and cyclophosphamide with or without low-dose, short-course sunitinib in the pre-operative treatment of breast cancer

MiR-19b suppresses PTPRG to promote breast tumorigenesis

PARP3 controls TGFβ and ROS driven epithelial-to-mesenchymal transition and stemness by stimulating a TG2-Snail-E-cadherin axis

Dual role of the integrated stress response in medulloblastoma tumorigenesis

Regorafenib (Stivarga) pharmacologically targets epithelial-mesenchymal transition in colorectal cancer

Comprehensive characterization of lncRNA-mRNA related ceRNA network across 12 major cancers

Coupling CDH17 and CLDN18 markers for comprehensive membrane-targeted detection of human gastric cancer

Biologic behavior and long-term outcomes of breast ductal carcinoma in situ with microinvasion

DNA methylation array analysis identifies breast cancer associated RPTOR, MGRN1 and RAPSN hypomethylation in peripheral blood DNA

F5-peptide induces aspermatogenesis by disrupting organization of actin- and microtubule-based cytoskeletons in the testis

AAA-ATPase p97 suppresses apoptotic and autophagy-associated cell death in rheumatoid arthritis synovial fibroblasts

Circulating serum microRNA-345 correlates with unfavorable pathological response to preoperative chemoradiotherapy in locally advanced rectal cancer

Regulation of matrix metalloproteinases (MMPs) expression and secretion in MDA-MB-231 breast cancer cells by LIM and SH3 protein 1 (LASP1)

Loss of Par3 promotes lung adenocarcinoma metastasis through 14-3-3ζ protein

Activation of the A2B adenosine receptor in B16 melanomas induces CXCL12 expression in FAP-positive tumor stromal cells, enhancing tumor progression

DMBA induced mouse mammary tumors display high incidence of activating Pik3ca^H1047 and loss of function Pten mutations

Characterizing the immune microenvironment of malignant peripheral nerve sheath tumor by PD-L1 expression and presence of CD8+ tumor infiltrating lymphocytes

Lipocalin 2 over-expression facilitates progress of castration-resistant prostate cancer via improving androgen receptor transcriptional activity

Expressions of CD8+TILs, PD-L1 and Foxp3+TILs in stage I NSCLC guiding adjuvant chemotherapy decisions

The iron chelator deferasirox induces apoptosis by targeting oncogenic Pyk2/β-catenin signaling in human multiple myeloma

The TAT-RasGAP_317-326 anti-cancer peptide can kill in a caspase-, apoptosis-, and necroptosis-independent manner

Overexpression of PHRF1 attenuates the proliferation and tumorigenicity of non-small cell lung cancer cells

Circulating levels of C-reactive protein, interleukin-6 and tumor necrosis factor-α and risk of colorectal adenomas: a meta-analysis

A phase I study of intratumoral ipilimumab and interleukin-2 in patients with advanced melanoma

Alternative treatments in advanced hepatocellular carcinoma patients with progressive disease after sorafenib treatment: a prospective multicenter cohort study

Responses to crizotinib in patients with ALK-positive lung adenocarcinoma who tested immunohistochemistry (IHC)-positive and fluorescence in situ hybridization (FISH)-negative

Validation of prognostic scoring and assessment of clinical benefit for patients with bone sarcomas enrolled in phase I clinical trials

Molecular mechanisms underlying resistance to androgen deprivation therapy in prostate cancer

Ubc13: the Lys63 ubiquitin chain building machine

Suppressive role of myeloid-derived suppressor cells (MDSCs) in the microenvironment of breast cancer and targeted immunotherapies

The emerging insights into catalytic or non-catalytic roles of TET proteins in tumors and neural development