Vol 8, No 16

Realistic modeling of tumor cells

A target of potential RELAvance in inflammatory breast cancer

Inflammatory breast cancer tumor emboli express high levels of anti-apoptotic proteins: use of a quantitative high content and high-throughput 3D IBC spheroid assay to identify targeting strategies

Ginsenoside-Rb1 targets chemotherapy-resistant ovarian cancer stem cells via simultaneous inhibition of Wnt/β-catenin signaling and epithelial-to-mesenchymal transition

Tissue Factor promotes breast cancer stem cell activity in vitro

Metabolic heterogeneity signature of primary treatment-naïve prostate cancer

The long noncoding RNA, treRNA, decreases DNA damage and is associated with poor response to chemotherapy in chronic lymphocytic leukemia

Prevention of tumor seeding during needle biopsy by chemotherapeutic-releasing gelatin sticks

MicroRNA regulation of progesterone receptor in breast cancer

Over-expression of ASIC1a promotes proliferation via activation of the β-catenin/LEF-TCF axis and is associated with disease outcome in liver cancer

CMV70-3P miRNA contributes to the CMV mediated glioma stemness and represents a target for glioma experimental therapy

Stathmin overexpression is associated with growth, invasion and metastasis of lung adenocarcinoma

C/EBPβ-1 promotes transformation and chemoresistance in Ewing sarcoma cells

The CRISPR/Cas9 system efficiently reverts the tumorigenic ability of BCR/ABL in vitro and in a xenograft model of chronic myeloid leukemia

Proteomic analysis of laser capture microdissected focal lesions in a rat model of progenitor marker-positive hepatocellular carcinoma

Incorporation of the number of positive lymph nodes leads to better prognostic discrimination of node-positive early stage cervical cancer

Pre-clinical evaluation of small molecule LOXL2 inhibitors in breast cancer

Long non-coding RNA PTENP1 functions as a ceRNA to modulate PTEN level by decoying miR-106b and miR-93 in gastric cancer

Upregulation of long non-coding RNA PlncRNA-1 promotes proliferation and induces epithelial-mesenchymal transition in prostate cancer

Association between echocardiographic structural parameters and body weight in Wistar rats

Fluorescence in situ hybridization status of voided urine predicts invasive and high-grade upper tract urothelial carcinoma

Expression of MET in circulating tumor cells correlates with expression in tumor tissue from advanced-stage lung cancer patients

Immunohistochemical Ki67 after short-term hormone therapy identifies low-risk breast cancers as reliably as genomic markers

ZNF521 sustains the differentiation block in MLL-rearranged acute myeloid leukemia

Increased reactive oxygen species levels cause ER stress and cytotoxicity in andrographolide treated colon cancer cells

C-terminal binding protein-2 promotes cell proliferation and migration in breast cancer via suppression of p16^INK4A

Small molecule inhibitor screening identifified HSP90 inhibitor 17-AAG as potential therapeutic agent for gallbladder cancer

Whole genome sequencing of matched tumor, adjacent non-tumor tissues and corresponding normal blood samples of hepatocellular carcinoma patients revealed dynamic changes of the mutations profiles during hepatocarcinogenesis

Glucose deprivation elicits phenotypic plasticity via ZEB1-mediated expression of NNMT

Tumor biology, clinicopathological characteristics and prognosis of screen detected T1 invasive non-palpable breast cancer in asymptomatic Chinese women (2001–2014)

Reduced NOV expression correlates with disease progression in colorectal cancer and is associated with survival, invasion and chemoresistance of cancer cells

Retinoic acid receptor alpha drives cell cycle progression and is associated with increased sensitivity to retinoids in T-cell lymphoma

Combination epidermal growth factor receptor variant III peptide-pulsed dendritic cell vaccine with miR-326 results in enhanced killing on EGFRvIII-positive cells

Opposite effects of GCN5 and PCAF knockdowns on the alternative mechanism of telomere maintenance

Circulating tumor DNA profiling by next generation sequencing reveals heterogeneity of crizotinib resistance mechanisms in a gastric cancer patient with MET amplification

Promoter mutations and cellular distribution of telomerase in non-clear cell and clear cell hepatocellular carcinoma

Krüppel-like factor 4 (KLF4) regulates the miR-183~96~182 cluster under physiologic and pathologic conditions

Selenomethionine and methyl selenocysteine: multiple-dose pharmacokinetics in selenium-replete men

Tumor necrosis factor receptor 2/AKT and ERK signaling pathways contribute to the switch from fibroblasts to CAFs by progranulin in microenvironment of colorectal cancer

microRNA-302c-3p inhibits renal cell carcinoma cell proliferation by targeting Grb2-associated binding 2 (Gab2)

Poly (ADP-ribose) polymerase inhibitor, an effective radiosensitizer in lung and pancreatic cancers

Clinicopathologic implications of immune classification by PD-L1 expression and CD8-positive tumor-infiltrating lymphocytes in stage II and III gastric cancer patients

The prognosis analysis of different metastasis pattern in patients with different breast cancer subtypes: a SEER based study

Minichromosome maintenance protein 2 and 3 promote osteosarcoma progression via DHX9 and predict poor patient prognosis

Identification of microRNAs associated with glioma diagnosis and prognosis

Effect of marital status on the survival of patients with gallbladder cancer treated with surgical resection: a population-based study

Genomic mutation-driven metastatic breast cancer therapy: a single center experience

microRNA-135b expression silences Ppm1e to provoke AMPK activation and inhibit osteoblastoma cell proliferation

RAB10 overexpression promotes tumor growth and indicates poor prognosis of hepatocellular carcinoma

Prognostic role of metformin intake in diabetic patients with colorectal cancer: An updated qualitative evidence of cohort studies

Trichosanthin increases Granzyme B penetration into tumor cells by upregulation of CI-MPR on the cell surface

Histamine therapeutic efficacy in metastatic melanoma: Role of histamine H₄ receptor agonists and opportunity for combination with radiation

Expression and functional regulation of stemness gene Lgr5 in esophageal squamous cell carcinoma

Autoimmune hematological diseases following haploidentical donor hematopoietic stem cell Transplant compared with matched sibling and unrelated donor

The cell polarity protein Scrib functions as a tumor suppressor in liver cancer

Sodium butyrate improves porcine host defense peptide expression and relieves the inflammatory response upon toll-like receptor 2 activation and histone deacetylase inhibition in porcine kidney cells

Anti-MDA5 antibody as a potential diagnostic and prognostic biomarker in patients with dermatomyositis

Laparoscopic versus open radical cystectomy for patients with bladder cancer over 75-year-old: a prospective randomized controlled trial

Systematic identification and comparison of expressed profiles of lncRNAs and circRNAs with associated co-expression and ceRNA networks in mouse germline stem cells

Genome-wide analysis of long noncoding RNA and mRNA co-expression profile in intrahepatic cholangiocarcinoma tissue by RNA sequencing

Epigenetically altered miR-1247 functions as a tumor suppressor in pancreatic cancer

Synergistic killing of FLT3ITD-positive AML cells by combined inhibition of tyrosine-kinase activity and N-glycosylation

Value of circulating cell-free DNA analysis as a diagnostic tool for breast cancer: a meta-analysis

CBX7 is a glioma prognostic marker and induces G₁/S arrest via the silencing of CCNE1

Inhibition of epidermal growth factor receptor attenuates LPS-induced inflammation and acute lung injury in rats

CCDC106 promotes non-small cell lung cancer cell proliferation

Postoperative adjuvant TACE for patients of hepatocellular carcinoma in AJCC stage I: friend or foe? a propensity score analysis

Role of CD152 genetic polymorphisms in the susceptibility to breast cancer

The vitamin D receptor is involved in the regulation of human breast cancer cell growth via a ligand-independent function in cytoplasm

Inactivation of p38 MAPK contributes to stem cell-like properties of non-small cell lung cancer

TRIP13 impairs mitotic checkpoint surveillance and is associated with poor prognosis in multiple myeloma

POLE and POLD1 screening in 155 patients with multiple polyps and early-onset colorectal cancer

Comprehensive immunohistochemical study of mesothelin (MSLN) using different monoclonal antibodies 5B2 and MN-1 in 1562 tumors with evaluation of its prognostic value in malignant pleural mesothelioma

Clinical relevance of the transcriptional signature regulated by CDC42 in colorectal cancer

Tumor regression is mediated via the induction of HER2_63-71- specific CD8+ CTL activity in a 4T1.2/HER2 tumor model: no involvement of CD80 in tumor control

The prognostic role of immune checkpoint markers programmed cell death protein 1 (PD-1) and programmed death ligand 1 (PD-L1) in a large, multicenter prostate cancer cohort

SET oncoprotein accumulation regulates transcription through DNA demethylation and histone hypoacetylation

PPARγ activation by troglitazone enhances human lung cancer cells to TRAIL-induced apoptosis via autophagy flux

Functional characterisation of a novel ovarian cancer cell line, NUOC-1

PD-L1 expression and its relationship with oncogenic drivers in non-small cell lung cancer (NSCLC)

Identification of microRNA 885-5p as a novel regulator of tumor metastasis by targeting CPEB2 in colorectal cancer

A novel oncolytic adenovirus based on simian adenovirus serotype 24

NCTD promotes Birinapant-mediated anticancer activity in breast cancer cells by downregulation of c-FLIP

Fungal lectin MpL enables entry of protein drugs into cancer cells and their subcellular targeting

miR-29a-deficiency does not modify the course of murine pancreatic acinar carcinoma

TT genotype of rs2941484 in the human HNF4G gene is associated with hyperuricemia in Chinese Han men

Triptolide suppresses the in vitro and in vivo growth of lung cancer cells by targeting hyaluronan-CD44/RHAMM signaling

Astragalin-induced cell death is caspase-dependent and enhances the susceptibility of lung cancer cells to tumor necrosis factor by inhibiting the NF-кB pathway

The relative efficacy and safety of targeted agents used in combination with chemotherapy in treating patients with untreated advanced gastric cancer: a network meta-analysis

hTERT promotes gastric intestinal metaplasia by upregulating CDX2 via NF-κB signaling pathway

Protein phosphatase 2A regulatory subunit B55α functions in mouse oocyte maturation and early embryonic development

Hispidin induces autophagic and necrotic death in SGC-7901 gastric cancer cells through lysosomal membrane permeabilization by inhibiting tubulin polymerization

Network pharmacology-based and clinically relevant prediction of the active ingredients and potential targets of Chinese herbs in metastatic breast cancer patients

Skip lateral lymph node metastasis leaping over the central neck compartment in papillary thyroid carcinoma

The extracellular matrix protein EMILIN1 silences the RAS-ERK pathway via α4β1 integrin and decreases tumor cell growth

Small RNA sequencing reveals metastasis-related microRNAs in lung adenocarcinoma

Influence of ipilimumab on expanded tumour derived T cells from patients with metastatic melanoma

Human α-L-fucosidase-1 attenuates the invasive properties of thyroid cancer

Paeonol suppresses solar ultraviolet-induced skin inflammation by targeting T-LAK cell-originated protein kinase

Noncanonical Wnt signaling plays an important role in modulating canonical Wnt-regulated stemness, proliferation and terminal differentiation of hepatic progenitors

Gambogic acid suppresses cancer invasion and migration by inhibiting TGFβ1-induced epithelial-to-mesenchymal transition

Prognostic role of B7-H4 in patients with non-small cell lung cancer: A meta-analysis

Experience with precision genomics and tumor board, indicates frequent target identification, but barriers to delivery

EGFR mediates activation of RET in lung adenocarcinoma with neuroendocrine differentiation characterized by ASCL1 expression

Sphingosine-1-phosphate promotes ovarian cancer cell proliferation by disrupting Hippo signaling

Simultaneous sentinel lymph node computed tomography and locoregional chemotherapy for lymph node metastasis in rabbit using an iodine-docetaxel emulsion

The antitumor activity and preliminary modeling on the potential mechanism of action of human peroxiredoxin-5

Model-based unsupervised learning informs metformin-induced cell-migration inhibition through an AMPK-independent mechanism in breast cancer

Systematic analysis of gene expression alterations and clinical outcomes of adenylate cyclase-associated protein in cancer

Inhibition of lysophosphatidic acid receptor ameliorates Sjögren’s syndrome in NOD mice

Combination therapy with dendritic cells and lenalidomide is an effective approach to enhance antitumor immunity in a mouse colon cancer model

SHP2 is induced by the HBx-NF-κB pathway and contributes to fibrosis during human early hepatocellular carcinoma development

Gene-based comparative analysis of tools for estimating copy number alterations using whole-exome sequencing data

A bispecific enediyne-energized fusion protein targeting both epidermal growth factor receptor and insulin-like growth factor 1 receptor showing enhanced antitumor efficacy against non-small cell lung cancer

The β-catenin/CBP-antagonist ICG-001 inhibits pediatric glioma tumorigenicity in a Wnt-independent manner

HMGB1 promotes differentiation syndrome by inducing hyperinflammation via MEK/ERK signaling in acute promyelocytic leukemia cells

Epstein-Barr virus (EBV)-encoded small RNAs (EBERs) associated with poor prognosis of head and neck carcinomas

Improvement of dexamethasone sensitivity by chelation of intracellular Ca2+ in pediatric acute lymphoblastic leukemia cells through the prosurvival kinase ERK1/2 deactivation

Essential role of endogenous prolactin and CDK7 in estrogen-induced upregulation of the prolactin receptor in breast cancer cells

Identification of Ras suppressor-1 (RSU-1) as a potential breast cancer metastasis biomarker using a three-dimensional in vitro approach

Targeting the centriolar replication factor STIL synergizes with DNA damaging agents for treatment of ovarian cancer

Identification of serum miR-139-3p as a non-invasive biomarker for colorectal cancer

Impact of statins therapy on morphological changes in lipid-rich plaques stratified by 10-Year framingham risk score: A serial optical coherence tomography study

GLI1-mediated regulation of side population is responsible for drug resistance in gastric cancer

Development of a radiosensitivity gene signature for patients with soft tissue sarcoma

Decreased ATF4 expression as a mechanism of acquired resistance to long-term amino acid limitation in cancer cells

Multi-factorial modulation of colorectal carcinoma cells motility – partial coordination by the tetraspanin Co-029/tspan8

Luteolin inhibits cell proliferation and induces cell apoptosis via down-regulation of mitochondrial membrane potential in esophageal carcinoma cells EC1 and KYSE450

Single nucleotide polymorphisms in CIDEC gene are associated with metabolic syndrome components risks and antihypertensive drug efficacy

Randomized clinical trial comparing the effects of sevoflurane and propofol on carbon dioxide embolism during pneumoperitoneum in laparoscopic hepatectomy

Early outcome of early-goal directed therapy for patients with sepsis or septic shock: a systematic review and meta-analysis of randomized controlled trials

Ultrasonographic characteristics of medullary thyroid carcinoma: a comparison with papillary thyroid carcinoma

Clinical study of the time of repeated computed tomography and replanning for patients with nasopharyngeal carcinoma

Dysregulation of miRNAs in bladder cancer: altered expression with aberrant biogenesis procedure

Tat is a multifunctional viral protein that modulates cellular gene expression and functions

Long non-coding RNA in glioma: signaling pathways

Interacting partners of FEN1 and its role in the development of anticancer therapeutics

The association between nuclear receptors and ocular diseases

Tumor necrosis factor alpha is a promising circulating biomarker for the development of obstructive sleep apnea syndrome: a meta-analysis

Association of polymorphisms rs1800012 in COL1A1 with sports-related tendon and ligament injuries: a meta-analysis

Laparoscopic cryoablation vs. percutaneous cryoablation for treatment of small renal masses: a systematic review and meta-analysis

Clinical implications of HLA locus mismatching in unrelated donor hematopoietic cell transplantation: a meta-analysis