Research Papers:

TT genotype of rs2941484 in the human HNF4G gene is associated with hyperuricemia in Chinese Han men

Bang-Dang Chen, Xiao-Cui Chen, Shuo Pan, Yi-Ning Yang, Chun-Hui He, Fen Liu, Xiang Ma, Min-Tao Gai and Yi-Tong Ma _

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Oncotarget. 2017; 8:26918-26926. https://doi.org/10.18632/oncotarget.15851

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Bang-Dang Chen1,2,*, Xiao-Cui Chen1,2,*, Shuo Pan3,*, Yi-Ning Yang1,2, Chun-Hui He2, Fen Liu1,2, Xiang Ma1,2, Min-Tao Gai1,2, Yi-Tong Ma1,2

1Xinjiang Key Laboratory of Cardiovascular Disease, Clinical Medical Research Institute of First Affiliated Hospital of Xinjiang Medical University, Urumqi, China

2Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China

3First Department of Cardiology, People’s Hospital of Shaanxi Province, Xi’an, China

*These authors contributed equally to this work

Correspondence to:

Yi-Tong Ma, email: [email protected]

Keywords: hyperuricemia, HNF4G, single nucleotide polymorphism, genetic, case-control association study

Received: January 23, 2017     Accepted: February 20, 2017     Published: March 02, 2017


The aim of the study is to investigate the association between the human hepatocyte nuclear factor 4 gamma (HNF4G) gene and hyperuricemia in Chinese Han population. A total of 414 hyperuricemia patients and 406 gender and age-matched normouricemic controls were enrolled. Four single nucleotide polymorphisms were genotyped as genetic markers for the human HNF4G gene (rs2977939, rs1805098, rs2941484, rs4735692). Data were analyzed for two separate groups: men and women. For rs2941484, the genotype distribution frequency in hyperuricemic subjects and was significantly different from that in normouricemic controls in men (P = 0.038). Meanwhile, in recessive model of rs2941484, the distribution frequency of TT genotype and CC+CT genotypes also differed significantly between the hyperuricemia men and normouricemic men (P = 0.011). For the other 3 SNPs in both men and women, there was no difference in the genotype and allele and distribution frequency between the hyperuricemia patients and normouricemic controls. In men, after adjustments for BMI, SBP, DBP, fasting glucose, total cholesterol, triglycerides, low density lipoprotein cholesterol and creatinine, the men with the TT genotype of rs2941484 were found to have significantly higher probability of suffering from hyperuricemia than the ones with CT and CC genotypes (OR = 2.170, P < 0.001). Therefore, TT genotype of rs2941484 in the human HNF4G gene might be a gender-specific genetic marker for hyperuricemia in Chinese Han men.

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