Research Papers:

Association between echocardiographic structural parameters and body weight in Wistar rats

Silvio A. Oliveira-Junior, Paula F. Martinez, William Y.C. Fan, Bruno T. Nakatani, Luana U. Pagan, Carlos R. Padovani, Antonio C. Cicogna, Marina P. Okoshi and Katashi Okoshi _

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Oncotarget. 2017; 8:26100-26105. https://doi.org/10.18632/oncotarget.15320

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Silvio A. Oliveira-Junior1,*, Paula F. Martinez1,*, William Y.C. Fan2,*, Bruno T. Nakatani2,*, Luana U. Pagan2,*, Carlos R. Padovani3,*, Antonio C. Cicogna2,*, Marina P. Okoshi2,*, Katashi Okoshi2,*

1School of Physical Therapy, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil

2Botucatu Medical School, Sao Paulo State University, UNESP, Botucatu, SP, Brazil

3Botucatu Biosciences Institute, Sao Paulo State University, UNESP, Botucatu, SP, Brazil

*These authors take responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation

Correspondence to:

Katashi Okoshi, email: [email protected]

Keywords: development, physiological cardiac remodeling, rat, echocardiogram, cardiac structures

Received: November 16, 2016     Accepted: January 26, 2017     Published: February 13, 2017


Background: The association between echocardiographic structural parameters and body weight (BW) during rat development has been poorly addressed. We evaluated echocardiographic variables: left ventricular (LV) end-diastolic (LVDD) and end-systolic (LVSD) diameters, LV diastolic posterior wall thickness (PWT), left atrial diameter (LA), and aortic diameter (AO) in function of BW during development.

Results/Materials and Methods: Male Wistar rats (n = 328, BW: 302–702 g) were retrospectively used to construct regression models and 95% confidence intervals relating to cardiac structural parameters and BW. Adjusted indexes were significant to all relationships; the regression model for predicting LVDD (R2 = 0.678; p < 0.001) and AO (R2 = 0.567; p < 0.001) had the highest prediction coefficients and LA function the lowest prediction coefficient (R2 = 0.274; p < 0.01). These relationships underwent validation by performing echocardiograms on additional rats (n = 43, BW: 300–600 g) and testing whether results were within confidence intervals of our regressions. Prediction models for AO and LA correctly allocated 38 (88.4%) and 39 rats (90.7%), respectively, within the 95% confidence intervals. Regression models for LVDD, LVSD, and PWT included 27 (62.7%), 30 (69.8%), and 19 (44.2%) animals, respectively, within the 95% confidence intervals.

Conclusions: Increase in cardiac structures is associated with BW gain during rat growth. LA and AO can be correctly predicted using regression models; prediction of PWT and LV diameters is not accurate.

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