Interacting partners of FEN1 and its role in the development of anticancer therapeutics

Chandrasekhar Kathera, Jing Zhang, Avilala Janardhan, Hongfang Sun, Wajid Ali, Xiaolong Zhou, Lingfeng He and Zhigang Guo _

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Oncotarget. 2017; 8:27593-27602. https://doi.org/10.18632/oncotarget.15176

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Chandrasekhar Kathera1,*, Jing Zhang1,*, Avilala Janardhan1, Hongfang Sun1, Wajid Ali1, Xiaolong Zhou2, Lingfeng He1 and Zhigang Guo1

1 Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, China

2 The Laboratory of Animal Genetics, Breeding, and Reproduction, College of Animal Science and Technology, Zhejiang Agriculture and Forestry University, Hangzhou, China

* As co-first authors

Correspondence to:

Zhigang Guo, email:

Keywords: protein-protein interaction, small molecular inhibitors, FEN1, posttranslational, modifications

Received: December 14, 2016 Accepted: January 24, 2017 Published: February 07, 2017


Protein-protein interaction (PPI) plays a key role in cellular communication, Protein-protein interaction connected with each other with hubs and nods involved in signaling pathways. These interactions used to develop network based biomarkers for early diagnosis of cancer. FEN1(Flap endonuclease 1) is a central component in cellular metabolism, over expression and decrease of FEN1 levels may cause cancer, these regulation changes of Flap endonuclease 1reported in many cancer cells, to consider this data may needs to develop a network based biomarker. The current review focused on types of PPI, based on nature, detection methods and its role in cancer. Interacting partners of Flap endonuclease 1 role in DNA replication repair and development of anticancer therapeutics based on Protein-protein interaction data.

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PII: 15176