Vol 7, No 34

Effective combination therapies in preclinical endocrine resistant breast cancer models harboring ER mutations

EGFR-targeted therapy results in dramatic early lung tumor regression accompanied by imaging response and immune infiltration in EGFR mutant transgenic mouse models

ΔNp63 drives metastasis in breast cancer cells via PI3K/CD44v6 axis

Upregulation of long noncoding RNA MIAT in aggressive form of chronic lymphocytic leukemias

Age is associated with time in therapeutic range for warfarin therapy in patients with atrial fibrillation

Dose-dependent genotype effects of BDNF Val66Met polymorphism on default mode network in early stage Alzheimer’s disease

Increased Rab35 expression is a potential biomarker and implicated in the pathogenesis of Parkinson’s disease

Interferon gamma peptidomimetic targeted to interstitial myofibroblasts attenuates renal fibrosis after unilateral ureteral obstruction in mice

Tumor specific mutations in TERT promoter and CTNNB1 gene in hepatitis B and hepatitis C related hepatocellular carcinoma

Inhibition of heat shock protein 90 improves pulmonary arteriole remodeling in pulmonary arterial hypertension

Cardiac fibrosis in mouse expressing DsRed tetramers involves chronic autophagy and proteasome degradation insufficiency

NLRP3 inflammasome activation is involved in Ang II-induced kidney damage via mitochondrial dysfunction

Binge ethanol exposure causes endoplasmic reticulum stress, oxidative stress and tissue injury in the pancreas

Prolyl hydroxylase 2 (PHD2) inhibition protects human renal epithelial cells and mice kidney from hypoxia injury

Towards a multi protein and mRNA expression of biological predictive and distinguish model for post stroke depression

Combination of specific allergen and probiotics induces specific regulatory B cells and enhances specific immunotherapy effect on allergic rhinitis

ADAR1 is vital for B cell lineage development in the mouse bone marrow

Systematic identification of immunodominant CD4⁺ T cell responses to HpaA in Helicobacter pylori infected individuals

Myeloid cell expressed proprotein convertase FURIN attenuates inflammation

Downregulation of the neonatal Fc receptor expression in non-small cell lung cancer tissue is associated with a poor prognosis

Scaffold attachment factor A (SAF-A) and Ku temporally regulate repair of radiation-induced clustered genome lesions

Importance of the type I insulin-like growth factor receptor in HER2, FGFR2 and MET-unamplified gastric cancer with and without Ras pathway activation

Polypeptide N-acetylgalactosaminyltransferase-6 expression independently predicts poor overall survival in patients with lung adenocarcinoma after curative resection

The urokinase receptor-derived cyclic peptide [SRSRY] suppresses neovascularization and intravasation of osteosarcoma and chondrosarcoma cells

Prognostic significance of PLIN1 expression in human breast cancer

miRNA-193a-5p repression of p73 controls Cisplatin chemoresistance in primary bone tumors

Crizotinib inhibits NF2-associated schwannoma through inhibition of focal adhesion kinase 1

Targeted next generation sequencing of endoscopic ultrasound acquired cytology from ampullary and pancreatic adenocarcinoma has the potential to aid patient stratification for optimal therapy selection

Induction of apoptosis and autophagy via mitochondria- and PI3K/Akt/mTOR-mediated pathways by E. adenophorum in hepatocytes of saanen goat

Artificial small RNA for sequence specific cleavage of target RNA through RNase III endonuclease Dicer

Independent evaluation of a FOXM1-based quantitative malignancy diagnostic system (qMIDS) on head and neck squamous cell carcinomas

Systemic immune-inflammation index predicts the clinical outcome in patients with metastatic renal cell cancer treated with sunitinib

Post-transcriptional knowledge in pathway analysis increases the accuracy of phenotypes classification

Preclinical evaluation of potential therapeutic targets in dedifferentiated liposarcoma

The down-regulated ING5 expression in lung cancer: A potential target of gene therapy

Identification and validation of regulatory SNPs that modulate transcription factor chromatin binding and gene expression in prostate cancer

MET amplification in metastatic colorectal cancer: an acquired response to EGFR inhibition, not a de novo phenomenon

Annexin 2A sustains glioblastoma cell dissemination and proliferation

Specific patterns of PIWI-interacting small noncoding RNA expression in dysplastic liver nodules and hepatocellular carcinoma

Surgical resection and radiofrequency ablation initiate cancer in cytokeratin-19⁺- liver cells deficient for p53 and Rb

Circulating exosomes potentiate tumor malignant properties in a mouse model of chronic sleep fragmentation

Glutamine deprivation plus BPTES alters etoposide- and cisplatin-induced apoptosis in triple negative breast cancer cells

Gallic acid inhibition of Src-Stat3 signaling overcomes acquired resistance to EGF receptor tyrosine kinase inhibitors in advanced non-small cell lung cancer

HDAC6 inhibition prevents TNF-α-induced caspase 3 activation in lung endothelial cell and maintains cell-cell junctions

Inhibition of primary breast tumor growth and metastasis using a neuropilin-1 transmembrane domain interfering peptide

MALAT1 promotes osteosarcoma development by targeting TGFA via MIR376A

PAX3 is a novel tumor suppressor by regulating the activities of major signaling pathways and transcription factor FOXO3a in thyroid cancer

Comprehensive assessment of the expression of the SWI/SNF complex defines two distinct prognostic subtypes of ovarian clear cell carcinoma

Association between single nucleotide polymorphisms in the TSPYL6 gene and breast cancer susceptibility in the Han Chinese population

Cooperation between AlphavBeta3 integrin and the fibroblast growth factor receptor enhances proliferation of Hox-overexpressing acute myeloid leukemia cells

Hypoxia-targeted ¹³¹I therapy of hepatocellular cancer after systemic mesenchymal stem cell-mediated sodium iodide symporter gene delivery

Regression of experimental NIS-expressing breast cancer brain metastases in response to radioiodide/gemcitabine dual therapy

Mutation profiling of 19 candidate genes in acute myeloid leukemia suggests significance of DNMT3A mutations

MiR-34b-3 and miR-449a inhibit malignant progression of nasopharyngeal carcinoma by targeting lactate dehydrogenase A

Lung cancer exosomes as drivers of epithelial mesenchymal transition

Genomic similarity between gastroesophageal junction and esophageal Barrett’s adenocarcinomas

FoxO proteins or loss of functional p53 maintain stemness of glioblastoma stem cells and survival after ionizing radiation plus PI3K/mTOR inhibition

PIM kinases as therapeutic targets against advanced melanoma

MIEN1 drives breast tumor cell migration by regulating cytoskeletal-focal adhesion dynamics

Photoimmunotheranostic agents for triple-negative breast cancer diagnosis and therapy that can be activated on demand

MYCN promotes neuroblastoma malignancy by establishing a regulatory circuit with transcription factor AP4

Tumor growth accelerated by chemotherapy-induced senescent cells is suppressed by treatment with IL-12 producing cellular vaccines

Plasma MiRNA alterations between NSCLC patients harboring Del19 and L858R EGFR mutations

Expression of CDX2 in gastric cardia adenocarcinoma and its correlation with H. pylori and cell proliferation

NHERF1, a novel GPER associated protein, increases stability and activation of GPER in ER-positive breast cancer

MiR-328 targeting PIM-1 inhibits proliferation and migration of pulmonary arterial smooth muscle cells in PDGFBB signaling pathway

MiRSEA: Discovering the pathways regulated by dysfunctional MicroRNAs

CNS germinomas are characterized by global demethylation, chromosomal instability and mutational activation of the Kit-, Ras/Raf/Erk- and Akt-pathways

Adrenomedullin promotes the growth of pancreatic ductal adenocarcinoma through recruitment of myelomonocytic cells

Metformin increases PDH and suppresses HIF-1α under hypoxic conditions and induces cell death in oral squamous cell carcinoma

Phenotypic and genetic heterogeneity of tumor tissue and circulating tumor cells in patients with metastatic castration-resistant prostate cancer: a report from the PETRUS prospective study

MLN0128, a novel mTOR kinase inhibitor, disrupts survival signaling and triggers apoptosis in AML and AML stem/ progenitor cells

Tumor LINE-1 methylation level and colorectal cancer location in relation to patient survival

Carboxyl-terminal truncated HBx contributes to invasion and metastasis via deregulating metastasis suppressors in hepatocellular carcinoma

MITF depletion elevates expression levels of ERBB3 receptor and its cognate ligand NRG1-beta in melanoma

Targeting αvβ3 and αvβ5 integrins inhibits pulmonary metastasis in an intratibial xenograft osteosarcoma mouse model

High expression of intratumoral stromal proteins is associated with chemotherapy resistance in breast cancer

Sex-specific clinicopathological significance of novel (Frizzled-7) and established (MGMT, IDH1) biomarkers in glioblastoma

Serum neuron-specific enolase levels are upregulated in patients with acute lymphoblastic leukemia and are predictive of prognosis

14-3-3ζ and aPKC-ι synergistically facilitate epithelial-mesenchymal transition of cholangiocarcinoma via GSK-3β/Snail signaling pathway

Nomogram and recursive partitioning analysis to predict overall survival in patients with stage IIB-III thoracic esophageal squamous cell carcinoma after esophagectomy

Altered phenotypic and functional characteristics of CD3⁺CD56⁺ NKT-like cells in human gastric cancer

Identification of a circulating microRNA signature to distinguish recurrence in breast cancer patients

Meta-dimensional data integration identifies critical pathways for susceptibility, tumorigenesis and progression of endometrial cancer

Somatic mutations predict outcomes of hypomethylating therapy in patients with myelodysplastic syndrome

Expression of neural cell adhesion molecule L1 (CD171) in neuroectodermal and other tumors: An immunohistochemical study of 5155 tumors and critical evaluation of CD171 prognostic value in gastrointestinal stromal tumors

CEACAM6 is upregulated by Helicobacter pylori CagA and is a biomarker for early gastric cancer

Nucleophosmin leukemogenic mutant activates Wnt signaling during zebrafish development

The human Smoothened inhibitor PF-04449913 induces exit from quiescence and loss of multipotent Drosophila hematopoietic progenitor cells

CD109 is identified as a potential nasopharyngeal carcinoma biomarker using aptamer selected by cell-SELEX

A novel gene expression-based prognostic scoring system to predict survival in gastric cancer

Ranking novel cancer driving synthetic lethal gene pairs using TCGA data

Incidence and origin of histologically confirmed liver metastases: an explorative case-study of 23,154 patients

Identification of biomarkers for pseudo and true progression of GBM based on radiogenomics study

MicroRNA fingerprints in juvenile myelomonocytic leukemia (JMML) identified miR-150-5p as a tumor suppressor and potential target for treatment

CD44v6-competent tumor exosomes promote motility, invasion and cancer-initiating cell marker expression in pancreatic and colorectal cancer cells

Prorenin receptor acts as a potential molecular target for pancreatic ductal adenocarcinoma diagnosis

ABCC2-24C > T polymorphism is associated with the response to platinum/5-Fu-based neoadjuvant chemotherapy and better clinical outcomes in advanced gastric cancer patients

Thromboxane A2 receptor (TBXA2R) is a potent survival factor for triple negative breast cancers (TNBCs)

Monocyte-derived factors including PLA2G7 induced by macrophage-nasopharyngeal carcinoma cell interaction promote tumor cell invasiveness

Insulin-like growth factor binding protein-3 links obesity and breast cancer progression

Upregulation of brain-derived neurotrophic factor in advanced gastric cancer contributes to bone metastatic osteolysis by inducing long pentraxin 3

Downregulated pseudogene CTNNAP1 promote tumor growth in human cancer by downregulating its cognate gene CTNNA1 expression

The application of mRNA-based gene transfer in mesenchymal stem cell-mediated cytotoxicity of glioma cells

A FASN-TGF-β1-FASN regulatory loop contributes to high EMT/metastatic potential of cisplatin-resistant non-small cell lung cancer

Targeting hyperactivated DNA-PKcs by KU0060648 inhibits glioma progression and enhances temozolomide therapy via suppression of AKT signaling

Integrin β3 and CD44 levels determine the effects of the OPN-a splicing variant on lung cancer cell growth

YMO1 suppresses invasion and metastasis by inhibiting RhoC signaling and predicts favorable prognosis in hepatocellular carcinoma

Decreased expression of FOXF2 as new predictor of poor prognosis in stage I non-small cell lung cancer

The associations between MDM4 gene polymorphisms and cancer risk

Hypoxia-NOTCH1-SOX2 signaling is important for maintaining cancer stem cells in ovarian cancer

Constitutive gp130 activation rapidly accelerates the transformation of human hepatocytes via an impaired oxidative stress response

S18 family of mitochondrial ribosomal proteins: evolutionary history and Gly132 polymorphism in colon carcinoma

CD24 promoted cancer cell angiogenesis via Hsp90-mediated STAT3/VEGF signaling pathway in colorectal cancer

Epigenetic activation of LY6K predicts the presence of metastasis and poor prognosis in breast carcinoma

Healthy CD4⁺ T lymphocytes are not affected by targeted therapies against the PI3K/Akt/mTOR pathway in T-cell acute lymphoblastic leukemia

The trans-membrane domain of Bcl-2α, but not its hydrophobic cleft, is a critical determinant for efficient IP₃ receptor inhibition

Chemotherapy plus targeted drugs in conversion therapy for potentially resectable colorectal liver metastases: a meta-analysis

Pharmacogenomics of platinum-based chemotherapy response in NSCLC: a genotyping study and a pooled analysis

TCF21 genetic polymorphisms and breast cancer risk in Chinese women

Elevated serum C-reactive protein level predicts a poor prognosis for recurrent gastric cancer

The multifaceted role of lysine acetylation in cancer: prognostic biomarker and therapeutic target

Sulfonation, an underexploited area: from skeletal development to infectious diseases and cancer

Positive and negative functions of B lymphocytes in tumors

Endocannabinoid control of glutamate NMDA receptors: the therapeutic potential and consequences of dysfunction

Cytoplasmic vacuolization in cell death and survival

Prognostic value of amphiregulin and epiregulin mRNA expression in metastatic colorectal cancer patients

miR-497 expression, function and clinical application in cancer

A meta-analysis of alcohol consumption and thyroid cancer risk

FGFR3-TACC3 fusion in solid tumors: mini review