Oncotarget

Research Papers:

Association between single nucleotide polymorphisms in the TSPYL6 gene and breast cancer susceptibility in the Han Chinese population

Ming Liu, Bin Li, Wen Guo, Xiyang Zhang, Zhengshuai Chen, Jingjie Li, Mengdan Yan, Chao Chen and Tianbo Jin _

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Oncotarget. 2016; 7:54771-54781. https://doi.org/10.18632/oncotarget.10754

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Abstract

Ming Liu1,2,3,*, Bin Li1,2,*, Wen Guo4, Xiyang Zhang1,2, Zhengshuai Chen1,2, Jingjie Li1,2, Mengdan Yan1,2, Chao Chen1,2, Tianbo Jin1,2

1School of Life Sciences, Northwest University, Xi’an 710069, China

2National Engineering Research Center for Miniaturized Detection Systems, Xi’an 710069, China

3Department of Obstetrics and Gynecology, Second Affiliated Hospital, Xi’an Jiaotong University, Xi’an 710004, China

4Inner Mongolia Medical University, Inner Mongolia, Hohhot 010050, China

*These authors contributed equally to this work

Correspondence to:

Tianbo Jin, email: jintianbo@gmail.com

Chao Chen, email: cchen898@nwu.edu.cn

Keywords: association study, breast cancer, TSPYL6, single nucleotide polymorphism

Received: April 22, 2016     Accepted: July 10, 2016     Published: July 21, 2016

ABSTRACT

We investigated the associations between single nucleotide polymorphisms (SNPs) in the testis-specific Y-encoded-like protein 6 (TSPYL6) gene and breast cancer (BC) susceptibility in the Han Chinese population. A total of 183 BC patients and 195 healthy women were included in the study. Six SNPs in TSPYL6 were genotyped and the association with BC risk analyzed. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using unconditional logistic regression analysis. Multivariate logistic regression analysis was used to identify SNPs that correlated with BC susceptibility. Rs11896604 was associated with a decreased risk of BC based on dominant and genotype models. Rs843706 was associated with an increased risk of BC based on a recessive model. Rs11125529 was associated with decreased BC susceptibility based on a genotype model. Finally, rs843711 inversely correlated with clinical stage III/IV BC. Our findings reveal a significant association between SNPs in the TSPYL6 gene and BC risk in a Han Chinese population.


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