miR-497 expression, function and clinical application in cancer
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Gang Yang1,*, Guangbing Xiong1,*, Zhe Cao1,*, Suli Zheng1, Lei You1, Taiping Zhang1 and Yupei Zhao1
1 Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
* These authors contributed equally to this work
Taiping Zhang, email:
Yupei Zhao, email:
Keywords: miR-497; carcinogenesis; biomarker; clinical application
Received: April 01, 2016 Accepted: June 06, 2016 Published: June 17, 2016
MicroRNAs (miRNAs) are small non-coding RNAs that inhibit gene expression by binding to the 3’ untranslated region (3’-UTR) of their target mRNAs. Recent studies show that miR-497 plays an important role in various cancers. Here, we summarize the existing studies of miR-497 as following: (1) miR-497 expression in cancer; (2) regulation mechanisms of miR-497 expression; (3) function of miR-497 in cancer; (4) direct targets of miR-497; (5) Clinical applications of miR-497. Recent analyses verify that miR-497 mainly suppresses tumors; however, it also acts as an oncogene in several cancers. Increasing evidence indicates that miR-497 can serve as a diagnostic and prognostic biomarker and is a promising therapeutic target for future clinical applications.
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