Oncotarget

Research Papers:

Prognostic significance of PLIN1 expression in human breast cancer

Cefan Zhou, Ming Wang, Li Zhou, Yi Zhang, Weiyong Liu, Wenying Qin, Rong He, Yang Lu, Yefu Wang, Xing-Zhen Chen and Jingfeng Tang _

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Oncotarget. 2016; 7:54488-54502. https://doi.org/10.18632/oncotarget.10239

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Abstract

Cefan Zhou1,2, Ming Wang3, Li Zhou4, Yi Zhang1, Weiyong Liu5, Wenying Qin1, Rong He1, Yang Lu1, Yefu Wang2, Xing-Zhen Chen1,6, Jingfeng Tang1

1Institute of Biomedical and Pharmaceutical Sciences, and Provincial Cooperative Innovation Center, College of Bioengineering, Hubei University of Technology, Wuhan, Hubei, China

2The State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei, China

3Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei, China

4Animal Biosafety Level III Laboratory at the Center for Animal Experiment, Wuhan University, Wuhan, China

5Department of Clinical Laboratory, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China

6Membrane Protein Disease Research Group, Department of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada

Correspondence to:

Jingfeng Tang, email: Jingfeng_HUT@163.com

Keywords: perilipin-1, Kaplan-Meier analysis, meta analysis, tumor suppressor, biomarker

Received: March 13, 2016     Accepted: May 13, 2016     Published: June 23, 2016

ABSTRACT

Breast cancer is a heterogeneous disease associated with diverse clinical, biological and molecular features, presenting huge challenges for prognosis and treatment. Here we found that perilipin-1 (PLIN1) mRNA expression is significantly downregulated in human breast cancer. Kaplan-Meier analysis indicated that patients presenting with reduced PLIN1 expression exhibited poorer overall metastatic relapse-free survival (p = 0.03). Further Cox proportional hazard models analysis revealed that the reduced expression of PLIN1 is an independent predictor of overall survival in estrogen receptor positive (p < 0.0001, HR = 0.87, 95% CI = 0.81–0.92, N = 3,600) and luminal A-subtype (p = 0.02, HR = 0.88, 95% CI = 0.78–0.98, N = 1,469) breast cancer patients. We also demonstrated that the exogenous expression of PLIN1 in human breast cancer MCF-7 and MDA-MB-231 cells significantly inhibits cell proliferation, migration, invasion and in vivo tumorigenesis in mice. Together, these data provide novel insights into a prognostic significance of PLIN1 in human breast cancer and reveal a potentially new gene therapy target for breast cancer.


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