VOLUME 8 (2017)
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About The Cover
The cover for issue 18 of Oncotarget features the handprint of the epigenomic master regulator KDM3A and its genome-wideimpact on a transcriptional network in cancer discovered by Wilson et al. The editorial on precision epigenomics discusses hopes and challenges for cancer treatments. Image by Systems Biology and Cancer Metabolism Laboratory, Fabian V. Filipp, University of California, Merced.
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Table of Contents
News
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| MiRsigning gastrointestinal contract cancer |
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https://doi.org/10.18632/oncotarget.15701
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| 29536-29537 |
Editorial
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| An epigenetic master regulator teams up to become an epioncogene |
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https://doi.org/10.18632/oncotarget.16484
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| 29538-29539 |
Priority Research Papers
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| MiR204 downregulation elicited perturbation of a gene target signature common to human cholangiocarcinoma and gastric cancer |
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https://doi.org/10.18632/oncotarget.15290
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| 29540-29557 |
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| BH3mimetics and BETinhibitors elicit enhanced lethality in malignant glioma |
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https://doi.org/10.18632/oncotarget.16365
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| 29558-29573 |
Research Papers: Gerotarget (Focus on Aging)
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| Rapamycin promotes differentiation increasing βIIItubulin NeuN and NeuroD while suppressing nestin expression in glioblastoma cells |
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https://doi.org/10.18632/oncotarget.15906
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| 29574-29599 |
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| Chicoric acid is a potent antiatherosclerotic ingredient by antioxidant action and antiinflammation capacity |
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https://doi.org/10.18632/oncotarget.16768
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| 29600-29612 |
Research Papers: Pathology
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| Chronic intratracheal application of the soluble guanylyl cyclase stimulator BAY 418543 ameliorates experimental pulmonary hypertension |
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https://doi.org/10.18632/oncotarget.16769
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| 29613-29624 |
Research Papers: Immunology
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| Interleukin2regulatory T cell axis critically regulates maintenance of hematopoietic stem cells |
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https://doi.org/10.18632/oncotarget.16377
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| 29625-29642 |
Research Papers: Cardiology
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| Plateletderived growth factor receptoralpha positive cardiac progenitor cells derived from multipotent germline stem cells are capable of cardiomyogenesis in vitro and in vivo |
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https://doi.org/10.18632/oncotarget.16772
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| 29643-29656 |
Research Papers
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| A signaling visualization toolkit to support rational design of combination therapies and biomarker discovery: SiViT |
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https://doi.org/10.18632/oncotarget.8747
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| 29657-29667 |
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| Novel role of cannabinoid receptor 2 in inhibiting EGF/EGFR and IGFI/IGFIR pathways in breast cancer |
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https://doi.org/10.18632/oncotarget.9408
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| 29668-29678 |
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| CM363 a novel naphthoquinone derivative which acts as multikinase modulator and overcomes imatinib resistance in chronic myelogenous leukemia |
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https://doi.org/10.18632/oncotarget.11425
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| 29679-29698 |
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| CTMP a predictive biomarker for trastuzumab resistance in HER2enriched breast cancer patient |
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https://doi.org/10.18632/oncotarget.10719
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| 29699-29710 |
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| Inhaled corticosteroids have a protective effect against lung cancer in female patients with chronic obstructive pulmonary disease: a nationwide populationbased cohort study |
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https://doi.org/10.18632/oncotarget.15386
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| 29711-29721 |
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| Development of comprehensive nomograms for evaluating overall and cancerspecific survival of laryngeal squamous cell carcinoma patients treated with neck dissection |
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https://doi.org/10.18632/oncotarget.15414
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| 29722-29740 |
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| Contrastenhanced computed tomography plus gadoliniumethoxybenzyl diethylenetriamine pentaacetic acidenhanced magnetic resonance imaging for gross classification of hepatocellular carcinoma |
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https://doi.org/10.18632/oncotarget.15712
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| 29741-29750 |
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| Genetic profiling of a rare condition: cooccurrence of albinism and multiple primary melanoma in a caucasian family |
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https://doi.org/10.18632/oncotarget.12777
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| 29751-29759 |
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| Effect of Y6 an epigallocatechin gallate derivative on reversing doxorubicin drug resistance in human hepatocellular carcinoma cells |
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https://doi.org/10.18632/oncotarget.15964
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| 29760-29770 |
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| Inhibition of the prolyl isomerase Pin1 enhances the ability of sorafenib to induce cell death and inhibit tumor growth in hepatocellular carcinoma |
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https://doi.org/10.18632/oncotarget.15967
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| 29771-29784 |
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| Transforming growth factorbeta1 suppresses hepatocellular carcinoma proliferation via activation of Hippo signaling |
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https://doi.org/10.18632/oncotarget.14523
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| 29785-29794 |
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| Role of interleukin12 gene polymorphisms in the onset risk of cancer: a metaanalysis |
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https://doi.org/10.18632/oncotarget.16080
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| 29795-29807 |
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| Nanocrystals of a new camptothecin derivative WCN21 enhance its solubility and efficacy |
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https://doi.org/10.18632/oncotarget.16159
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| 29808-29822 |
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| Salicylate •Phenanthroline copper II complex induces apoptosis in triplenegative breast cancer cells |
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https://doi.org/10.18632/oncotarget.16161
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| 29823-29832 |
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| Peroxynitrite dominates sodium nitroprussideinduced apoptosis in human hepatocellular carcinoma cells |
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https://doi.org/10.18632/oncotarget.16164
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| 29833-29845 |
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| Tyrosine kinase inhibitor induced growth factor receptor upregulation enhances the efficacy of nearinfrared targeted photodynamic therapy in esophageal adenocarcinoma cell lines |
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https://doi.org/10.18632/oncotarget.16165
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| 29846-29856 |
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| Development and validation of nomograms for predicting survival in patients with nonmetastatic colorectal cancer |
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https://doi.org/10.18632/oncotarget.16167
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| 29857-29864 |
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| Enhancement of radiosensitivity by the novel anticancer quinolone derivative vosaroxin in preclinical glioblastoma models |
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https://doi.org/10.18632/oncotarget.16168
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| 29865-29886 |
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| PIGN gene expression aberration is associated with genomic instability and leukemic progression in acute myeloid leukemia with myelodysplastic features |
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https://doi.org/10.18632/oncotarget.15136
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| 29887-29905 |
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| Cryptic BCRABL fusion gene as variant rearrangement in chronic myeloid leukemia: molecular cytogenetic characterization and influence on TKIs therapy |
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https://doi.org/10.18632/oncotarget.15369
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| 29906-29913 |
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| MiR766 induces p53 accumulation and G2/M arrest by directly targeting MDM4 |
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https://doi.org/10.18632/oncotarget.15530
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| 29914-29924 |
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| A varyingcoefficient cox model for the effect of CA199 kinetics on overall survival in patients with advanced pancreatic cancer |
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https://doi.org/10.18632/oncotarget.15557
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| 29925-29934 |
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| NUSAP1 promotes invasion and metastasis of prostate cancer |
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https://doi.org/10.18632/oncotarget.15604
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| 29935-29950 |
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| Mass spectral analysis of the multikinase inhibitor BZG and its metabolites and analysis of their binding to vascular endothelial growth factor receptor2 |
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https://doi.org/10.18632/oncotarget.16264
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| 29951-29962 |
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| Misregulation of DNA damage repair pathways in HPVpositive head and neck squamous cell carcinoma contributes to cellular radiosensitivity |
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https://doi.org/10.18632/oncotarget.16265
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| 29963-29975 |
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| The role of nitric oxide pathway in arginine transport and growth of IPEC1 cells |
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https://doi.org/10.18632/oncotarget.16267
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| 29976-29983 |
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| Arterial stiffness and blood pressure improvement in aldosteroneproducing adenoma harboring KCNJ5 mutations after adrenalectomy |
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https://doi.org/10.18632/oncotarget.16269
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| 29984-29995 |
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| λCarrageenan improves the antitumor effect of dendritic cellbased vaccine |
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https://doi.org/10.18632/oncotarget.15610
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| 29996-30007 |
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| OSR1 is a novel epigenetic silenced tumor suppressor regulating invasion and proliferation in renal cell carcinoma |
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https://doi.org/10.18632/oncotarget.15611
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| 30008-30018 |
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| Hmga2 translocation induced in skin tumorigenesis |
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https://doi.org/10.18632/oncotarget.16272
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| 30019-30029 |
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| Hyperglycemia via activation of thromboxane A2 receptor impairs the integrity and function of bloodbrain barrier in microvascular endothelial cells |
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https://doi.org/10.18632/oncotarget.16273
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| 30030-30038 |
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| Investigation of three potential autoantibodies in Sjogren’s syndrome and associated MALT lymphoma |
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https://doi.org/10.18632/oncotarget.15613
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| 30039-30049 |
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| Evaluation of the circulating level of fibroblast activation protein α for diagnosis of esophageal squamous cell carcinoma |
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https://doi.org/10.18632/oncotarget.16274
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| 30050-30062 |
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| A CD44specific peptide RP1 exhibits capacities of assisting diagnosis and predicting prognosis of gastric cancer |
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https://doi.org/10.18632/oncotarget.16275
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| 30063-30076 |
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| Thalidezine a novel AMPK activator eliminates apoptosisresistant cancer cells through energymediated autophagic cell death |
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https://doi.org/10.18632/oncotarget.15616
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| 30077-30091 |
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| Flattened microvessel independently predicts poor prognosis of patients with nonsmall cell lung cancer |
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https://doi.org/10.18632/oncotarget.15617
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| 30092-30099 |
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| Macrophagestimulated microRNA expression in mural cells promotes transplantationinduced neointima formation |
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https://doi.org/10.18632/oncotarget.16279
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| 30100-30111 |
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| Expression of Rho GTPases family in melanoma cells and its influence on cytoskeleton and migration |
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https://doi.org/10.18632/oncotarget.15618
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| 30112-30122 |
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| Rab7 GTPase controls lipid metabolic signaling in myeloidderived suppressor cells |
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https://doi.org/10.18632/oncotarget.16280
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| 30123-30137 |
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| A novel role of CKIP1 in promoting megakaryocytic differentiation |
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https://doi.org/10.18632/oncotarget.15619
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| 30138-30150 |
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| The preclinical assessment of XL388 a mTOR kinase inhibitor as a promising antirenal cell carcinoma agent |
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https://doi.org/10.18632/oncotarget.15620
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| 30151-30161 |
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| The pancreas responds to remote damage and systemic stress by secretion of the pancreatic secretory proteins PSP/regI and PAP/regIII |
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https://doi.org/10.18632/oncotarget.16282
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| 30162-30174 |
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| Prognostic significance of tumorinfiltrating immune cells and PDL1 expression in esophageal squamous cell carcinoma |
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https://doi.org/10.18632/oncotarget.15621
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| 30175-30189 |
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| BIRADS 35 microcalcifications: prediction of lymph node metastasis of breast cancer |
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https://doi.org/10.18632/oncotarget.16318
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| 30190-30198 |
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| Targeting the PIM protein kinases for the treatment of a Tcell acute lymphoblastic leukemia subset |
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https://doi.org/10.18632/oncotarget.16320
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| 30199-30216 |
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| Mechanistic characterization of a copper containing thiosemicarbazone with potent antitumor activity |
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https://doi.org/10.18632/oncotarget.16324
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| 30217-30234 |
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| The amelioration of cartilage degeneration by photocrosslinked GelHA hydrogel and crizotinib encapsulated chitosan microspheres |
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https://doi.org/10.18632/oncotarget.15750
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| 30235-30251 |
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| Aspirin regulation of cmyc and cyclinD1 proteins to overcome tamoxifen resistance in estrogen receptorpositive breast cancer cells |
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https://doi.org/10.18632/oncotarget.16325
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| 30252-30264 |
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| Circumvent the uncertainty in the applications of transcriptional signatures to tumor tissues sampled from different tumor sites |
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https://doi.org/10.18632/oncotarget.15754
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| 30265-30275 |
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| Targeting programmed cell death ligand 1 by CRISPR/Cas9 in osteosarcoma cells |
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https://doi.org/10.18632/oncotarget.16326
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| 30276-30287 |
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| Deep sequencingbased microRNA expression signatures in head and neck squamous cell carcinoma: dual strands of premiR150 as antitumor miRNAs |
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https://doi.org/10.18632/oncotarget.16327
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| 30288-30304 |
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| Interaction between granulin A and enolase 1 attenuates the migration and invasion of human hepatoma cells |
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https://doi.org/10.18632/oncotarget.16328
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| 30305-30316 |
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| Recombinant human erythropoietin stimulates melanoma tumor growth through activation of initiation factor eIF4E |
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https://doi.org/10.18632/oncotarget.16331
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| 30317-30327 |
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| The histone demethylase KDM3A regulates the transcriptional program of the androgen receptor in prostate cancer cells |
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https://doi.org/10.18632/oncotarget.15681
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| 30328-30343 |
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| Isoform expression patterns of EPHA10 protein mediate breast cancer progression by regulating the ECadherin and βcatenin complex |
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https://doi.org/10.18632/oncotarget.15910
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| 30344-30356 |
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| A single center clinical analysis of children with highrisk neuroblastoma |
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https://doi.org/10.18632/oncotarget.15996
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| 30357-30368 |
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| A multifunctional lipid nanoparticle for codelivery of paclitaxel and curcumin for targeted delivery and enhanced cytotoxicity in multidrug resistant breast cancer cells |
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https://doi.org/10.18632/oncotarget.16153
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| 30369-30382 |
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| Neoplastic plasma cells generate an inflammatory environment within bone marrow and markedly alter the distribution of T cells between lymphoid compartments |
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https://doi.org/10.18632/oncotarget.16628
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| 30383-30394 |
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| Novel impact of the DNMT3A R882H mutation on GSH metabolism in a K562 cell model established by TALENs |
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https://doi.org/10.18632/oncotarget.16449
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| 30395-30409 |
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| Novel potential predictive markers of sunitinib outcomes in longterm responders versus primary refractory patients with metastatic clearcell renal cell carcinoma |
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https://doi.org/10.18632/oncotarget.16494
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| 30410-30421 |
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| The innate immunity of guinea pigs against highly pathogenic avian influenza virus infection |
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https://doi.org/10.18632/oncotarget.16503
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| 30422-30437 |
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| Inhibition of p70 S6 kinase S6K1 activity by A77 1726 the active metabolite of leflunomide induces autophagy through TAK1mediated AMPK and JNK activation |
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https://doi.org/10.18632/oncotarget.16737
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| 30438-30454 |
Clinical Research Papers
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| Efficacy and safety of proprotein convertase subtilisin/kexin type 9 monoclonal antibody in adults with familial hypercholesterolemia |
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https://doi.org/10.18632/oncotarget.10762
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| 30455-30463 |
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| Hepatocellular carcinoma and antidepressants: a nationwide populationbased study |
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https://doi.org/10.18632/oncotarget.12826
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| 30464-30470 |
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| Jiedu granule preparation for the treatment of advanced hepatocellular carcinoma: a retrospective cohort study of 177 patients |
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https://doi.org/10.18632/oncotarget.12887
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| 30471-30476 |
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| Approaches and genetic determinants in predicting response to neoadjuvant chemotherapy in locally advanced gastric cancer |
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https://doi.org/10.18632/oncotarget.12955
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| 30477-30494 |
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| Paclitaxel/oxaliplatin/fluorouracil TOF regimen versus S1/oxaliplatin SOX regimen for metastatic gastric cancer patients |
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https://doi.org/10.18632/oncotarget.13721
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| 30495-30501 |
Reviews
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| Epithelialtoendothelial transition and cancer stem cells: two cornerstones of vasculogenic mimicry in malignant tumors |
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https://doi.org/10.18632/oncotarget.8461
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| 30502-30510 |
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| Serious adverse events of cell therapy for respiratory diseases: a systematic review and metaanalysis |
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https://doi.org/10.18632/oncotarget.15426
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| 30511-30523 |
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| Photosensitizers in prostate cancer therapy |
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https://doi.org/10.18632/oncotarget.15496
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| 30524-30538 |
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| Vascular endothelial growth factor A polymorphisms are associated with increased risk of coronary heart disease: a metaanalysis |
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https://doi.org/10.18632/oncotarget.15546
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| 30539-30551 |
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| Estrogen and androgenconverting enzymes 17βhydroxysteroid dehydrogenase and their involvement in cancer: with a special focus on 17βhydroxysteroid dehydrogenase type 1 2 and breast cancer |
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https://doi.org/10.18632/oncotarget.15547
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| 30552-30562 |
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| Red and processed meat consumption and gastric cancer risk: a systematic review and metaanalysis |
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https://doi.org/10.18632/oncotarget.15699
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| 30563-30575 |
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| Prognostic significance of tumorassociated macrophages in breast cancer: a metaanalysis of the literature |
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https://doi.org/10.18632/oncotarget.15736
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| 30576-30586 |
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| Association between BRCA1 P871L polymorphism and cancer risk: evidence from a metaanalysis |
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https://doi.org/10.18632/oncotarget.15739
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| 30587-30594 |
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| Therapeutic role of glutamine in management of radiation enteritis: a metaanalysis of 13 randomized controlled trials |
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https://doi.org/10.18632/oncotarget.15741
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| 30595-30605 |
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| Metabolic syndrome endocrine disruptors and prostate cancer associations: biochemical and pathophysiological evidences |
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https://doi.org/10.18632/oncotarget.16725
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| 30606-30616 |
Corrections
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| Correction: PRSS8 methylation and its significance in esophageal squamous cell carcinoma |
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https://doi.org/10.18632/oncotarget.17541
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| 30617-30618 |
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| Correction: HDAC5 a potential therapeutic target and prognostic biomarker promotes proliferation invasion and migration in human breast cancer |
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https://doi.org/10.18632/oncotarget.17542
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| 30619-30620 |
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