NUSAP1 promotes invasion and metastasis of prostate cancer
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Catherine A. Gordon1, Xue Gong1,2, Durga Ganesh1, James D. Brooks1,3
1Department of Urology, Stanford University School of Medicine, Stanford, CA, 94305, USA
2Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA
3Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, 94305, USA
James D. Brooks, email: [email protected]
Keywords: NUSAP1, invasion, migration, metastasis, prostate cancer
Received: September 18, 2016 Accepted: January 25, 2017 Published: February 22, 2017
We have previously identified nucleolar and spindle associated protein 1 (NUSAP1) as a prognostic biomarker in early stage prostate cancer. To better understand the role of NUSAP1 in prostate cancer progression, we tested the effects of increased and decreased NUSAP1 expression in cell lines, in vivo models, and patient samples. NUSAP1 promotes invasion, migration, and metastasis, possibly by modulating family with sequence similarity 101 member B (FAM101B), a transforming growth factor beta 1 (TGFβ1) signaling effector involved in the epithelial to mesenchymal transition. Our findings provide insights into the importance of NUSAP1 in prostate cancer progression and provide a rationale for further study of NUSAP1 function, regulation, and clinical utility.
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