Oncotarget

Research Papers:

A multifunctional lipid nanoparticle for co-delivery of paclitaxel and curcumin for targeted delivery and enhanced cytotoxicity in multidrug resistant breast cancer cells

Jong-Suep Baek and Cheong-Weon Cho _

PDF  |  HTML  |  How to cite  |  Order a Reprint

Oncotarget. 2017; 8:30369-30382. https://doi.org/10.18632/oncotarget.16153

Metrics: PDF 945 views  |   HTML 1503 views  |   ?  


Abstract

Jong-Suep Baek1, Cheong-Weon Cho1

1College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, Yuseong-gu, Daejeon 34134, South Korea

Correspondence to:

Cheong-Weon Cho, email: chocw@cnu.ac.kr

Keywords: solid lipid nanoparticle, multidrug resistance, p-glycoprotein, targeting delivery system, folate-mediated

Received: January 20, 2017     Accepted: February 08, 2017     Published: March 13, 2017

ABSTRACT

The objective of the work was to develop a multifunctional nanomedicine based on a folate-conjugated lipid nanoparticles loaded with paclitaxel and curcumin. The novel system combines therapeutic advantageous of efficient targeted delivery via folate and timed-release of curcumin and paclitaxel via 2-hydroxypropyl-ß-cyclodextrin, thereby overcoming multidrug resistance in breast cancer cells (MCF-7/ADR). The faster release of curcumin from the folate-conjugated curcumin and paclitaxel-loaded lipid nanoparticles enables sufficient p-glycoprotein inhibition, which allows increased cellular uptake and cytotoxicity of paclitaxel. In western blot assay, curcumin can efficiently inhibit the expression of p-glycoprotein, conformed the enhancement of cytotoxicity by paclitaxel. Furthermore, folate-conjugated curcumin and paclitaxel-loaded lipid nanoparticles exhibited increased uptake of paclitaxel and curcumin into MCF-7/ADR cells through the folate receptor-mediated internalization. Taken together, these results indicate that folate-conjugated curcumin and paclitaxel-loaded lipid nanoparticles enables the enhanced, folate-targeted delivery of multiple anticancer drugs by inhibiting the multi-drug resistance efficiently, which may also serve as a useful nano-system for co-delivery of other anticancer drugs.


Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.
PII: 16153