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About The Cover

The cover for issue 11 of Oncotarget features Figure 6C, "Higher Hsp90α expression correlates with increase in tumor grade (p < 0.00001)," from Vartholomaiou, et al.

Table of Contents

News

RUNX1 a new regulator of EMT in breast cancer

https://doi.org/10.18632/oncotarget.15623

Saleh Khawaled, and Rami I. Aqeilan
17407-17408
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Editorial

Oleuropein unexpected benefits

https://doi.org/10.18632/oncotarget.15538

Wenyan Sun, Bess Frost, and Jiankang Liu
17409-17409
Abstract  |  PDF  |  How to cite

Reinnervated muscle fiber typegroupinginevitable

https://doi.org/10.18632/oncotarget.15757

Tessa Gordon
17410-17411
Abstract  |  PDF  |  How to cite

Priority Research Papers

Aurora A kinase inhibition enhances oncolytic herpes virotherapy through cytotoxic synergy and innate cellular immune modulation

https://doi.org/10.18632/oncotarget.14885

Mark A. Currier, Les Sprague, Tilat A. Rizvi, Brooke Nartker, Chun-Yu Chen, Pin-Yi Wang, Brian J. Hutzen, Meghan R. Franczek, Ami V. Patel, Katherine E. Chaney, Keri A. Streby, Jeffrey A. Ecsedy, Joe Conner, Nancy Ratner, and Timothy P. Cripe
17412-17427
Abstract  |  PDF  |  Full Text  |  How to cite

Cytosolic Hsp90α and its mitochondrial isoform Trap1 are differentially required in a breast cancer model

https://doi.org/10.18632/oncotarget.15659

Evangelia Vartholomaiou, Marta Madon-Simon, Stéphane Hagmann, Guillaume Mühlebach, Wolfgang Wurst, Thomas Floss, and Didier Picard
17428-17442
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Research Papers: Gerotarget (Focus on Aging)

Transplantation of mesenchymal stem cells reverses behavioural deficits and impaired neurogenesis caused by prenatal exposure to valproic acid

https://doi.org/10.18632/oncotarget.15245

Nikolai Gobshtis, Matanel Tfilin, Marina Wolfson, Vadim E. Fraifeld, and Gadi Turgeman
17443-17452
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The effects of graded levels of calorie restriction: VIII Impact of short term calorie and protein restriction on basal metabolic rate in the C57BL/6 mouse

https://doi.org/10.18632/oncotarget.15294

Sharon E. Mitchell, ZhanHui Tang, Celine Kerbois, Camille Delville, Davina Derous, Cara L. Green, Yingchun Wang, Jackie J.D. Han, Luonan Chen, Alex Douglas, David Lusseau, Daniel E.L. Promislow, and John R. Speakman
17453-17474
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Spermidine coupled with exercise rescues skeletal muscle atrophy from Dgalinduced aging rats through enhanced autophagy and reduced apoptosis via AMPKFOXO3a signal pathway

https://doi.org/10.18632/oncotarget.15728

Jingjing Fan, Xiaoqi Yang, Jie Li, Ziyang Shu, Jun Dai, Xingran Liu, Biao Li, Shaohui Jia, Xianjuan Kou, Yi Yang, and Ning Chen
17475-17490
Abstract  |  PDF  |  Full Text  |  How to cite

Research Papers: Pathology

Cytoskeletonassociated protein 5 and clathrin heavy chain binding regulates spindle assembly in mouse oocytes­­

https://doi.org/10.18632/oncotarget.15097

Angeleem Lu, Cheng-Jie Zhou, Dong-Hui Wang, Zhe Han, Xiang-Wei Kong, Yu-Zhen Ma, Zhi-Zhong Yun, and Cheng-Guang Liang
17491-17503
Abstract  |  PDF  |  Full Text  |  How to cite

CaMKII inhibition reduces isoproterenolinduced ischemia and arrhythmias in hypertrophic mice

https://doi.org/10.18632/oncotarget.15099

Ying Feng, Jun Cheng, Baozhu Wei, and Yanggan Wang
17504-17509
Abstract  |  PDF  |  Full Text  |  How to cite

Increased circulating fulllength betatrophin levels in drugnaïve metabolic syndrome

https://doi.org/10.18632/oncotarget.15102

Dan Liu, Sheyu Li, He He, Chuan Yu, Xiaodan Li, Libo Liang, Yi Chen, Jianwei Li, Jianshu Li, Xin Sun, Haoming Tian, and Zhenmei An
17510-17517
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

The effects of high glucose on tendonderived stem cells: implications of the pathogenesis of diabetic tendon disorders

https://doi.org/10.18632/oncotarget.15418

Yu-Cheng Lin, Ying-Juan Li, Yun-Feng Rui, Guang-Chun Dai, Liu Shi, Hong-Liang Xu, Ming Ni, Song Zhao, Hui Chen, Chen Wang, Gang Li, and Gao-Jun Teng
17518-17528
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Atorvastatin inhibits the immediateearly response gene EGR1 and improves the functional profile of CD4+Tlymphocytes in acute coronary syndromes

https://doi.org/10.18632/oncotarget.15420

Anna Severino, Chiara Zara, Mara Campioni, Davide Flego, Giulia Angelini, Daniela Pedicino, Ada Francesca Giglio, Francesco Trotta, Simona Giubilato, Vincenzo Pazzano, Claudia Lucci, Antonio Iaconelli, Aureliano Ruggio, Luigi Marzio Biasucci, Filippo Crea, and Giovanna Liuzzo
17529-17550
Abstract  |  PDF  |  Full Text  |  How to cite

Research Papers: Immunology

Altered bone marrow lymphopoiesis and interleukin6dependent inhibition of thymocyte differentiation contribute to thymic atrophy during Trypanosoma cruzi infection

https://doi.org/10.18632/oncotarget.14886

Sofía Carbajosa, Susana Gea, Carlos Chillón-Marinas, Cristina Poveda, María del Carmen Maza, Manuel Fresno, and Núria Gironès
17551-17561
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

HDAC4 is expressed on multiple T cell lineages but dispensable for their development and function

https://doi.org/10.18632/oncotarget.15077

Queping Liu, Xilin Zhang, Congcong Yin, Xaing Chen, Zhenggang Zhang, Stephen Brown, Hongfu Xie, Li Zhou, and Qing-Sheng Mi
17562-17572
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Research Papers

ActivatedPAK4 predicts worse prognosis in breast cancer and promotes tumorigenesis through activation of PI3K/AKT signaling

https://doi.org/10.18632/oncotarget.7466

Li-Fang He, Hong-Wu Xu, Min Chen, Zhi-Rong Xian, Xiao-Fen Wen, Min-Na Chen, Cai-Wen Du, Wen-He Huang, Jun-Dong Wu, and Guo-Jun Zhang
17573-17585
Abstract  |  PDF  |  Full Text  |  How to cite

Twostage genomewide association study identifies a novel susceptibility locus associated with melanoma

https://doi.org/10.18632/oncotarget.15230

Katherine J. Ransohoff, Wenting Wu, Hyunje G. Cho, Harvind C. Chahal, Yuan Lin, Hong-Ji Dai, Christopher I. Amos, Jeffrey E. Lee, Jean Y. Tang, David A. Hinds, Jiali Han, Qingyi Wei, and Kavita Y. Sarin
17586-17592
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

The neuroleptic drug pimozide inhibits stemlike cell maintenance and tumorigenicity in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.4307

Jia-Jie Chen, Nan Cai, Guan-Zhong Chen, Chang-Chang Jia, Dong-Bo Qiu, Cong Du, Wei Liu, Yang Yang, Zi-Jie Long, and Qi Zhang
17593-17609
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Runx1 stabilizes the mammary epithelial cell phenotype and prevents epithelial to mesenchymal transition

https://doi.org/10.18632/oncotarget.15381

Deli Hong, Terri L. Messier, Coralee E. Tye, Jason R. Dobson, Andrew J. Fritz, Kenneth R. Sikora, Gillian Browne, Janet L. Stein, Jane B. Lian, and Gary S. Stein
17610-17627
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Haploinsufficiency in tumor predisposition syndromes: altered genomic transcription in morphologically normal cells heterozygous for VHL or TSC mutation

https://doi.org/10.18632/oncotarget.12192

Suraj Peri, Elena Caretti, Rossella Tricarico, Karthik Devarajan, Mitchell Cheung, Eleonora Sementino, Craig W. Menges, Emmanuelle Nicolas, Lisa A. Vanderveer, Sharon Howard, Peggy Conrad, James A. Crowell, Kerry S. Campbell, Eric A. Ross, Andrew K. Godwin, Anthony T. Yeung, Margie L. Clapper, Robert G. Uzzo, Elizabeth P. Henske, Christopher J. Ricketts, Cathy D. Vocke, W. Marston Linehan, Joseph R. Testa, Alfonso Bellacosa, Levy Kopelovich, and Alfred G. Knudson
17628-17642
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

The influence of PSA autoantibodies in prostate cancer patients: a prospective clinical studyII

https://doi.org/10.18632/oncotarget.12620

Kosei Nakajima, Lance K. Heilbrun, Daryn Smith, Victor Hogan, Avraham Raz, and Elisabeth Heath
17643-17650
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

SENP1 regulates PTEN stability to dictate prostate cancer development

https://doi.org/10.18632/oncotarget.13283

Tasneem Bawa-Khalfe, Feng-Ming Yang, Joan Ritho, Hui-Kuan Lin, Jinke Cheng, and Edward T.H. Yeh
17651-17664
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

The clinical value of lncRNA NEAT1 in digestive system malignancies: A comprehensive investigation based on 57 microarray and RNAseq datasets

https://doi.org/10.18632/oncotarget.14756

Dan-Dan Xiong, Zhen-Bo Feng, Wei-Luan Cen, Jing-Jing Zeng, Lu Liang, Rui-Xue Tang, Xiao-Ning Gan, Hai-Wei Liang, Zu-Yun Li, Gang Chen, and Dian-Zhong Luo
17665-17683
Abstract  |  PDF  |  Full Text  |  How to cite

Analysis of The Cancer Genome Atlas sequencing data reveals novel properties of the human papillomavirus 16 genome in head and neck squamous cell carcinoma

https://doi.org/10.18632/oncotarget.15179

Tara J. Nulton, Amy L. Olex, Mikhail Dozmorov, Iain M. Morgan, and Brad Windle
17684-17699
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Capsazepine inhibits JAK/STAT3 signaling tumor growth and cell survival in prostate cancer

https://doi.org/10.18632/oncotarget.10775

Jong Hyun Lee, Chulwon Kim, Seung Ho Baek, Jeong-Hyeon Ko, Seok Geun Lee, Woong Mo Yang, Jae-Young Um, Gautam Sethi, and Kwang Seok Ahn
17700-17711
Abstract  |  PDF  |  Full Text  |  How to cite

KDM4Bmediated epigenetic silencing of miRNA6155p augments RAB24 to facilitate malignancy of hepatoma cells

https://doi.org/10.18632/oncotarget.10832

Zheng Chen, Xiangling Wang, Ruiyan Liu, Lin Chen, Jianying Yi, Bing Qi, Zeyu Shuang, Min Liu, Xin Li, Shengping Li, and Hua Tang
17712-17725
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Suberoylanilide hydroxamic acid increases anticancer effect of tumor necrosis factorα through upregulation of TNF receptor 1 in lung cancer cells

https://doi.org/10.18632/oncotarget.14628

Bo Ra You, Bo Ram Han, and Woo Hyun Park
17726-17737
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

MTDH promotes glioma invasion through regulating miR130bceRNAs

https://doi.org/10.18632/oncotarget.14717

Liping Tong, Ming Chu, Bingqing Yan, Weiyi Zhao, Shuang Liu, Wei Wei, Huihuang Lou, Shengkun Zhang, Shuai Ma, Juan Xu, and Lanlan Wei
17738-17749
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Investigated the safety of intrarenal arterial transfusion of autologous CD34+ cells and time courses of creatinine levels endothelial dysfunction biomarkers and microRNAs in chronic kidney disease patientsphase I clinical trial

https://doi.org/10.18632/oncotarget.14831

Mel S. Lee, Fan-Yen Lee, Yung-Lung Chen, Pei-Hsun Sung, Hsin-Ju Chiang, Kuan-Hung Chen, Tien-Hung Huang, Yi-Ling Chen, John Y. Chiang, Tsung-Cheng Yin, Hsueh-Wen Chang, and Hon-Kan Yip
17750-17762
Abstract  |  PDF  |  Full Text  |  How to cite

Angioimmunoblastic T cell lymphoma: novel molecular insights by mutation profiling

https://doi.org/10.18632/oncotarget.14846

Ming Wang, Shaowei Zhang, Shih-Sung Chuang, Margaret Ashton-Key, Eguzkine Ochoa, Niccolo Bolli, George Vassiliou, Zifen Gao, and Ming-Qing Du
17763-17770
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

SATB1 plays an oncogenic role in esophageal cancer by upregulation of FN1 and PDGFRB

https://doi.org/10.18632/oncotarget.14849

Guiqin Song, Kang Liu, Xiaolin Yang, Bo Mu, Junbao Yang, Lang He, Xin Hu, Qiujiang Li, Yunxia Zhao, Xiaoming Cai, and Gang Feng
17771-17784
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Upregulated lncRNA SNHG1 contributes to progression of nonsmall cell lung cancer through inhibition of miR1013p and activation of Wnt/βcatenin signaling pathway

https://doi.org/10.18632/oncotarget.14854

Yun Cui, Fuming Zhang, Chunkai Zhu, Liang Geng, Tongde Tian, and Huaimin Liu
17785-17794
Abstract  |  PDF  |  Full Text  |  How to cite

MAPK pathway inhibition induces MET and GAB1 levels priming BRAF mutant melanoma for rescue by hepatocyte growth factor

https://doi.org/10.18632/oncotarget.14855

Sean Caenepeel, Keegan Cooke, Sarah Wadsworth, Guo Huang, Lidia Robert, Blanca Homet Moreno, Giulia Parisi, Elaina Cajulis, Richard Kendall, Pedro Beltran, Antoni Ribas, Angela Coxon, and Paul E. Hughes
17795-17809
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

EZH2 expression is a prognostic biomarker in patients with colorectal cancer treated with antiEGFR therapeutics

https://doi.org/10.18632/oncotarget.14863

Itaru Yamamoto, Katsuhiko Nosho, Shinichi Kanno, Hisayoshi Igarashi, Hiroyoshi Kurihara, Keisuke Ishigami, Kazuya Ishiguro, Kei Mitsuhashi, Reo Maruyama, Hideyuki Koide, Hiroyuki Okuda, Tadashi Hasegawa, Yasutaka Sukawa, Kenji Okita, Ichiro Takemasa, Hiroyuki Yamamoto, Yasuhisa Shinomura, and Hiroshi Nakase
17810-17818
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Keratin 5 overexpression is associated with serous ovarian cancer recurrence and chemotherapy resistance

https://doi.org/10.18632/oncotarget.14867

Carmela Ricciardelli, Noor A. Lokman, Carmen E. Pyragius, Miranda P. Ween, Anne M. Macpherson, Andrew Ruszkiewicz, Peter Hoffmann, and Martin K. Oehler
17819-17832
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Mevastatin blockade of autolysosome maturation stimulates LBH589induced cell death in triplenegative breast cancer cells

https://doi.org/10.18632/oncotarget.14868

Zhaohu Lin, Zhuqing Zhang, Xiaoxiao Jiang, Xinhui Kou, Yong Bao, Huijuan Liu, Fanghui Sun, Shuang Ling, Ning Qin, Lan Jiang, and Yonghua Yang
17833-17848
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

VEGF promotes cartilage angiogenesis by phosphoERK1/2 activation of Dll4 signaling in temporomandibular joint osteoarthritis caused by chronic sleep disturbance in Wistar rats

https://doi.org/10.18632/oncotarget.14874

Yabing Dong, Gaoyi Wu, Ting Zhu, Hongyu Chen, Yong Zhu, Guoxiong Zhu, Fabin Han, and Huaqiang Zhao
17849-17861
Abstract  |  PDF  |  Full Text  |  How to cite

Serum ferritin in combination with prostatespecific antigen improves predictive accuracy for prostate cancer

https://doi.org/10.18632/oncotarget.14977

Xijuan Wang, Peng An, Jiling Zeng, Xiaoyan Liu, Bo Wang, Xuexian Fang, Fudi Wang, Guoping Ren, and Junxia Min
17862-17872
Abstract  |  PDF  |  Full Text  |  How to cite

The interference of Notch1 target Hes1 affects cell growth differentiation and invasiveness of glioblastoma stem cells through modulation of multiple oncogenic targets

https://doi.org/10.18632/oncotarget.15013

Carlo Cenciarelli, Hany E. Marei, Manuela Zonfrillo, Patrizia Casalbore, Armando Felsani, Stefano Giannetti, Gianluca Trevisi, Asma Althani, and Annunziato Mangiola
17873-17886
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

The natural compound fucoidan from New Zealand Undaria pinnatifida synergizes with the ERBB inhibitor lapatinib enhancing melanoma growth inhibition

https://doi.org/10.18632/oncotarget.14437

Varsha Thakur, Jun Lu, Giuseppe Roscilli, Luigi Aurisicchio, Manuela Cappelletti, Emiliano Pavoni, William Lindsey White, and Barbara Bedogni
17887-17896
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

A tree shrew glioblastoma model recapitulates features of human glioblastoma

https://doi.org/10.18632/oncotarget.15225

Yaohui Tong, Junjun Hao, Qiu Tu, Hualin Yu, Lanzhen Yan, Yuan Li, Longbao Lv, Fei Wang, Antonio Iavarone, and Xudong Zhao
17897-17907
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Docosahexaenoic acid and disulfiram act in concert to kill cancer cells: a mutual enhancement of their anticancer actions

https://doi.org/10.18632/oncotarget.14702

Yang Jiao, Bethany N. Hannafon, Roy R. Zhang, Kar-Ming Fung, and Wei-Qun Ding
17908-17920
Abstract  |  PDF  |  Full Text  |  How to cite

Expression and role of anion exchanger 1 in esophageal squamous cell carcinoma

https://doi.org/10.18632/oncotarget.14900

Atsushi Shiozaki, Michihiro Kudou, Daisuke Ichikawa, Hiroki Shimizu, Tomohiro Arita, Toshiyuki Kosuga, Hirotaka Konishi, Shuhei Komatsu, Hitoshi Fujiwara, Kazuma Okamoto, Mitsuo Kishimoto, Yoshinori Marunaka, and Eigo Otsuji
17921-17935
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Using highsensitivity sequencing for the detection of mutations in BTK and PLCγ2 genes in cellular and cellfree DNA and correlation with progression in patients treated with BTK inhibitors

https://doi.org/10.18632/oncotarget.15316

Adam Albitar, Wanlong Ma, Ivan DeDios, Jeffrey Estella, Inhye Ahn, Mohammed Farooqui, Adrian Wiestner, and Maher Albitar
17936-17944
Abstract  |  PDF  |  Full Text  |  How to cite

The DPC4/SMAD4 genetic status determines recurrence patterns and treatment outcomes in resected pancreatic ductal adenocarcinoma: A prospective cohort study

https://doi.org/10.18632/oncotarget.14901

Sang Hyun Shin, Hwa Jung Kim, Dae Wook Hwang, Jae Hoon Lee, Ki Byung Song, Eunsung Jun, In Kyong Shim, Seung-Mo Hong, Hyoung Jung Kim, Kwang-Min Park, Young-Joo Lee, and Song Cheol Kim
17945-17959
Abstract  |  PDF  |  Full Text  |  How to cite

Loss of PFKFB4 induces cell death in mitotically arrested ovarian cancer cells

https://doi.org/10.18632/oncotarget.14910

Charlotte Taylor, David Mannion, Fabrizio Miranda, Mohammad Karaminejadranjbar, Sandra Herrero-Gonzalez, Karin Hellner, Yiyan Zheng, Geoffrey Bartholomeusz, Robert C. Bast Jr, and Ahmed Ashour Ahmed
17960-17980
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Breast cancer cell cyclooxygenase2 expression alters extracellular matrix structure and function and numbers of cancer associated fibroblasts

https://doi.org/10.18632/oncotarget.14912

Balaji Krishnamachary, Ioannis Stasinopoulos, Samata Kakkad, Marie-France Penet, Desmond Jacob, Flonne Wildes, Yelena Mironchik, Arvind P. Pathak, Meiyappan Solaiyappan, and Zaver M. Bhujwalla
17981-17994
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

KRASdependent suppression of MYC enhances the sensitivity of cancer cells to cytotoxic agents

https://doi.org/10.18632/oncotarget.14929

Irene Ischenko, Jizu Zhi, Michael J. Hayman, and Oleksi Petrenko
17995-18009
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Akt/mTOR mediated induction of bystander effect signaling in a nucleus independent manner in irradiated human lung adenocarcinoma epithelial cells

https://doi.org/10.18632/oncotarget.14931

Lu Li, Lu Wang, Kevin M. Prise, K.N. Yu, Guodong Chen, Lianyun Chen, Yide Mei, and Wei Han
18010-18020
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

High PDL1 expression is associated with stage IV disease and poorer overall survival in 186 cases of small cell lung cancers

https://doi.org/10.18632/oncotarget.14935

Yih-Leong Chang, Ching-Yao Yang, Yen-Lin Huang, Chen-Tu Wu, and Pan-Chyr Yang
18021-18030
Abstract  |  PDF  |  Full Text  |  How to cite

Small G protein Rac GTPases regulate the maintenance of glioblastoma stemlike cells in vitro and in vivo

https://doi.org/10.18632/oncotarget.14949

Yun-Ju Lai, Jui-Cheng Tsai, Ying-Ting Tseng, Meng-Shih Wu, Wen-Shan Liu, Hoi-Ian Lam, Jei-Hwa Yu, Susan E. Nozell, and Etty N. Benveniste
18031-18049
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Pharmacogenetics of dipeptidyl peptidase 4 inhibitors in a Taiwanese population with type 2 diabetes

https://doi.org/10.18632/oncotarget.14951

Wen-Ling Liao, Wen-Jane Lee, Ching-Chu Chen, Chieh Hsiang Lu, Chien-Hsiun Chen, Yi-Chun Chou, I-Te Lee, Wayne H-H Sheu, Jer-Yuarn Wu, Chi-Fan Yang, Chung-Hsing Wang, and Fuu-Jen Tsai
18050-18058
Abstract  |  PDF  |  Full Text  |  How to cite

Radioiodinated indomethacin amide for molecular imaging of cyclooxygenase2 expressing tumors

https://doi.org/10.18632/oncotarget.15437

Agnieszka Morgenroth, Andreas T.J. Vogg, Bernd Neumaier, Felix M. Mottaghy, and Boris D. Zlatopolskiy
18059-18069
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Exosome secretome and mediated signaling in breast cancer patients with nontuberculous mycobacterial disease

https://doi.org/10.18632/oncotarget.14964

Julie V. Philley, Anbarasu Kannan, David E. Griffith, Megan S. Devine, Jeana L. Benwill, Richard J. WallaceJr, Barbara A. Brown-Elliott, Foram Thakkar, Varsha Taskar, James G. Fox, Ammar Alqaid, Hernaina Bains, Sudeep Gupta, and Santanu Dasgupta
18070-18081
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Menin mediates Tatinduced neuronal apoptosis in brain frontal cortex of SIVinfected macaques and in Tattreated cells

https://doi.org/10.18632/oncotarget.14993

Jun Wang, Yu Zhang, Qiping Xu, Jinhua Qiu, Honghua Zheng, Xiang Ye, Yuhua Xue, Yongmei Yin, Zhou Zhang, Ying Liu, Yanling Hao, Qiang Wei, Wei Wang, Kazuyasu Mori, Shuji Izumo, Ryuji Kubota, Yiming Shao, and Hui Qin Xing
18082-18094
Abstract  |  PDF  |  Full Text  |  How to cite

Enhancement of TRAILinduced apoptosis by 5fluorouracil requires activating Bax and p53 pathways in TRAILresistant lung cancers

https://doi.org/10.18632/oncotarget.14994

Uddin MD. Nazim, Mohammad Rasheduzzaman, You-Jin Lee, Dai-Wu Seol, and Sang-Youel Park
18095-18105
Abstract  |  PDF  |  Full Text  |  How to cite

3'hydroxy4'methoxyβmethylβnitrostyrene inhibits tumorigenesis in colorectal cancer cells through ROSmediated DNA damage and mitochondrial dysfunction

https://doi.org/10.18632/oncotarget.14996

Chun-Hao Tsai, Amos C. Hung, Yuan-Yin Chen, Ya-Wen Chiu, Pei-Wen Hsieh, Yi-Chen Lee, Yu-Han Su, Po-Chih Chang, Stephen Chu-Sung Hu, and Shyng-Shiou F. Yuan
18106-18117
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Designing of dual inhibitors for GSK3β and CDK5: Virtual screening and in vitro biological activities study

https://doi.org/10.18632/oncotarget.15085

Hongbo Xie, Haixia Wen, Denan Zhang, Lei Liu, Bo Liu, Qiuqi Liu, Qing Jin, Kehui Ke, Ming Hu, and Xiujie Chen
18118-18128
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

OIP5 a target of miR15b5p regulates hepatocellular carcinoma growth and metastasis through the AKT/mTORC1 and βcatenin signaling pathways

https://doi.org/10.18632/oncotarget.15185

Hua Li, Jun Zhang, Mi-Jin Lee, Goung-Ran Yu, Xueji Han, and Dae-Ghon Kim
18129-18144
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Downregulation of lncRNA CASC2 promotes cell proliferation and metastasis of bladder cancer by activation of the Wnt/βcatenin signaling pathway

https://doi.org/10.18632/oncotarget.15210

Zhijun Pei, Xian Du, Yafeng Song, Lin Fan, Fuyan Li, Yan Gao, Ruimin Wu, Yijia Chen, Wei Li, Hong Zhou, Yi Yang, and Jing Zeng
18145-18153
Abstract  |  PDF  |  Full Text  |  How to cite

Metabolic interrogation as a tool to optimize chemotherapeutic regimens

https://doi.org/10.18632/oncotarget.15186

Vlad C. Sandulache, Yunyun Chen, Lei Feng, William N. William, Heath D. Skinner, Jeffrey N. Myers, Raymond E. Meyn, Jinzhong Li, Ainiwaer Mijiti, James A. Bankson, Clifton D. Fuller, Marina Y. Konopleva, and Stephen Y. Lai
18154-18165
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Presence of cancerassociated mutations in exhaled breath condensates of healthy individuals by next generation sequencing

https://doi.org/10.18632/oncotarget.15233

Omar Youssef, Aija Knuuttila, Päivi Piirilä, Tom Böhling, Virinder Sarhadi, and Sakari Knuutila
18166-18176
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Role of the PEBP4 protein in the development and metastasis of gastric cancer

https://doi.org/10.18632/oncotarget.15255

Zijian Wu, Bin Liu, Xuemin Zheng, Huijing Hou, and Ying Li
18177-18184
Abstract  |  PDF  |  Full Text  |  How to cite

The prevalence and clinicopathological features of breast cancer patients with hepatitis B virus infection in China

https://doi.org/10.18632/oncotarget.15305

He Wu, Chunxia Zhao, Vishnu Prasad Adhikari, Linjie Lu, Jianbo Huang, Yuxian Wei, Qingqing Luo, Wei Dai, Yutuan Wu, Xin Li, Kainan Wu, and Ling-Quan Kong
18185-18190
Abstract  |  PDF  |  Full Text  |  How to cite

Branchedchain amino acids prevent hepatic fibrosis and development of hepatocellular carcinoma in a nonalcoholic steatohepatitis mouse model

https://doi.org/10.18632/oncotarget.15304

Kai Takegoshi, Masao Honda, Hikari Okada, Riuta Takabatake, Naoto Matsuzawa-Nagata, Jean S. Campbell, Masashi Nishikawa, Tetsuro Shimakami, Takayoshi Shirasaki, Yoshio Sakai, Taro Yamashita, Toshinari Takamura, Takuji Tanaka, and Shuichi Kaneko
18191-18205
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Association between single nucleotide polymorphisms in ADRB2 GNB3 and GSTP1 genes and highaltitude pulmonary edema HAPE in the Chinese Han population

https://doi.org/10.18632/oncotarget.15309

Yongjun He, Lijun Liu, Pengcheng Xu, Na He, Dongya Yuan, Longli Kang, and Tianbo Jin
18206-18212
Abstract  |  PDF  |  Full Text  |  How to cite

AFB1 hepatocarcinogenesis is via lipid peroxidation that inhibits DNA repair sensitizes mutation susceptibility and induces aldehydeDNA adducts at p53 mutational hotspot codon 249

https://doi.org/10.18632/oncotarget.15313

Mao-Wen Weng, Hyun-Wook Lee, Bongkun Choi, Hsiang-Tsui Wang, Yu Hu, Manju Mehta, Dhimant Desai, Shantu Amin, Yi Zheng, and Moon-Shong Tang
18213-18226
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Construction of a pathological risk model of occult lymph node metastases for prognostication by semiautomated image analysis of tumor budding in earlystage oral squamous cell carcinoma

https://doi.org/10.18632/oncotarget.15314

Nicklas Juel Pedersen, David Hebbelstrup Jensen, Giedrius Lelkaitis, Katalin Kiss, Birgitte Charabi, Lena Specht, and Christian von Buchwald
18227-18237
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Urinary cell microRNAbased prognostic classifier for nonmuscle invasive bladder cancer

https://doi.org/10.18632/oncotarget.15315

Mercedes Ingelmo-Torres, Juan Jose Lozano, Laura Izquierdo, Albert Carrion, Meritxell Costa, Lidia Gomez, María José Ribal, Antonio Alcaraz, and Lourdes Mengual
18238-18247
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Ataxin1 regulates epithelial–mesenchymal transition of cervical cancer cells

https://doi.org/10.18632/oncotarget.15319

A-ram Kang, Hyoung-Tae An, Jesang Ko, and Seongman Kang
18248-18259
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Artesunate suppresses the viability and mobility of prostate cancer cells through UCA1 the sponge of miR184

https://doi.org/10.18632/oncotarget.15353

Yan Zhou, Xiuju Wang, Jianjun Zhang, Aina He, Ya Ling Wang, Kun Han, Yang Su, Junyi Yin, Xiaobin Lv, and Haiyan Hu
18260-18270
Abstract  |  PDF  |  Full Text  |  How to cite

Genetic characterization and antiretroviral resistance mutations among treatmentnaive HIVinfected individuals in Jiaxing China

https://doi.org/10.18632/oncotarget.15382

Jinlei Guo, Yong Yan, Jiafeng Zhang, Jimei Ji, Zhijian Ge, Rui Ge, Xiaofei Zhang, Henghui Wang, Zhongwen Chen, and Jianyong Luo
18271-18279
Abstract  |  PDF  |  Full Text  |  How to cite

Extrapancreatic invasion induces lipolytic and fibrotic changes in the adipose microenvironment with released fatty acids enhancing the invasiveness of pancreatic cancer cells

https://doi.org/10.18632/oncotarget.15430

Takashi Okumura, Kenoki Ohuchida, Masafumi Sada, Toshiya Abe, Sho Endo, Kazuhiro Koikawa, Chika Iwamoto, Daisuke Miura, Yusuke Mizuuchi, Taiki Moriyama, Kohei Nakata, Yoshihiro Miyasaka, Tatsuya Manabe, Takao Ohtsuka, Eishi Nagai, Kazuhiro Mizumoto, Yoshinao Oda, Makoto Hashizume, and Masafumi Nakamura
18280-18295
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Tumor stage and primary treatment of hepatocellular carcinoma at a large tertiary hospital in China: A realworld study

https://doi.org/10.18632/oncotarget.15433

Jian-Hong Zhong, Ning-Fu Peng, Xue-Mei You, Liang Ma, Xiao Xiang, Yan-Yan Wang, Wen-Feng Gong, Fei-Xiang Wu, Bang-De Xiang, and Le-Qun Li
18296-18302
Abstract  |  PDF  |  Full Text  |  How to cite

Cytokeratin 19 promoter directs the expression of Cre recombinase in various epithelia of transgenic mice

https://doi.org/10.18632/oncotarget.15435

Gui-Feng Zhao, Shuang Zhao, Jia-Jie Liu, Ji-Cheng Wu, Hao-Yu He, Xiao-Qing Ding, Xue-Wen Yu, Ke-Qiang Huang, Zhi-Jie Li, and Hua-Chuan Zheng
18303-18311
Abstract  |  PDF  |  Full Text  |  How to cite

NPC26 kills human colorectal cancer cells via activating AMPK signaling

https://doi.org/10.18632/oncotarget.15436

Zhen Zhao, Li Feng, Jiqin Wang, Deshan Cheng, Mei Liu, Meirong Ling, Weiping Xu, and Keyu Sun
18312-18321
Abstract  |  PDF  |  Full Text  |  How to cite

The suppressing effects of BTG3 expression on aggressive behaviors and phenotypes of colorectal cancer: An in vitro and vivo study

https://doi.org/10.18632/oncotarget.15438

Hua-Chuan Zheng, Hao-Yu He, Ji-Cheng Wu, Jing Li, Shuang Zhao, Gui-Feng Zhao, Hua-Mao Jiang, Xue-Wen Yu, and Zhi-Jie Li
18322-18336
Abstract  |  PDF  |  Full Text  |  How to cite

TET2 and MEG3 promoter methylation is associated with acute myeloid leukemia in a Hainan population

https://doi.org/10.18632/oncotarget.15440

Hongxia Yao, Mengling Duan, Lie Lin, Congming Wu, Xiangjun Fu, Hua Wang, Li Guo, Wenting Chen, Li Huang, Dan Liu, Ruo Rao, Shuwen Wang, and Yipeng Ding
18337-18347
Abstract  |  PDF  |  Full Text  |  How to cite

MicroRNA137 inhibits BMP7 to enhance the epithelialmesenchymal transition of breast cancer cells

https://doi.org/10.18632/oncotarget.15442

Xuexiang Ying, Yunpo Sun, and Pingqing He
18348-18358
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Discovery and characterization of a novel irreversible EGFR mutants selective and potent kinase inhibitor CHMFLEGFR26 with a distinct binding mode

https://doi.org/10.18632/oncotarget.15443

Chen Hu, Aoli Wang, Hong Wu, Ziping Qi, Xixiang Li, Xiao-E Yan, Cheng Chen, Kailin Yu, Fengming Zou, Wenchao Wang, Wei Wang, Jiaxin Wu, Juan Liu, Beilei Wang, Li Wang, Tao Ren, Shanchun Zhang, Cai-Hong Yun, Jing Liu, and Qingsong Liu
18359-18372
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Molecular mechanisms of activating cMET in KSHV+ primary effusion lymphoma

https://doi.org/10.18632/oncotarget.15444

Bao Quoc Lam, Lu Dai, Li Li, Jing Qiao, Zhen Lin, and Zhiqiang Qin
18373-18380
Abstract  |  PDF  |  Full Text  |  How to cite

TP53based interaction analysis identifies ciseQTL variants for TP53BP2 FBXO28 and FAM53A that associate with survival and treatment outcome in breast cancer

https://doi.org/10.18632/oncotarget.15110

Rainer Fagerholm, Sofia Khan, Marjanka K. Schmidt, Montserrat García-Closas, Päivi Heikkilä, Jani Saarela, Jonathan Beesley, Maral Jamshidi, Kristiina Aittomäki, Jianjun Liu, H. Raza Ali, Irene L. Andrulis, Matthias W. Beckmann, Sabine Behrens, Fiona M. Blows, Hermann Brenner, Jenny Chang-Claude, Fergus J. Couch, Kamila Czene, Peter A. Fasching, Jonine Figueroa, Giuseppe Floris, Gord Glendon, Qi Guo, Per Hall, Emily Hallberg, Ute Hamann, Bernd Holleczek, Maartje J. Hooning, John L. Hopper, Agnes Jager, Maria Kabisch, kConFab/AOCS Investigators, Renske Keeman, Veli-Matti Kosma, Diether Lambrechts, Annika Lindblom, Arto Mannermaa, Sara Margolin, Elena Provenzano, Mitul Shah, Melissa C. Southey, Joe Dennis, Michael Lush, Kyriaki Michailidou, Qin Wang, Manjeet K. Bolla, Alison M. Dunning, Douglas F. Easton, Paul D.P. Pharoah, Georgia Chenevix-Trench, Carl Blomqvist, and Heli Nevanlinna
18381-18398
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Clinical Research Papers

Pathological complete response as a surrogate for relapsefree survival in patients with triple negative breast cancer after neoadjuvant chemotherapy

https://doi.org/10.18632/oncotarget.9369

JunJie Li, Sheng Chen, CanMing Chen, GenHong Di, GuangYu Liu, Jiong Wu, and ZhiMin Shao
18399-18408
Abstract  |  PDF  |  Full Text  |  How to cite

Effect of parental physiological conditions and assisted reproductive technologies on the pregnancy and birth outcomes in infertile patients

https://doi.org/10.18632/oncotarget.12553

Xinqi Zhong, Jianqiao Liu, Qiliang Cui, Shaozhen Liang, Yuanqing Lin, Haiying Liu, and Qiyi Zeng
18409-18416
Abstract  |  PDF  |  Full Text  |  How to cite

Incidence and physiological mechanism of carboplatininduced electrolyte abnormality among patients with nonsmall cell lung cancer

https://doi.org/10.18632/oncotarget.12813

Yushui Ma, Likun Hou, Fei Yu, Gaixia Lu, Shanshan Qin, Ruting Xie, Huiqiong Yang, Tingmiao Wu, Pei Luo, Li Chai, Zhongwei Lv, Xiaodong Peng, Da Fu, and Da Fu
18417-18423
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Low serum total testosterone level as a predictor of upstaging and upgrading in lowrisk prostate cancer patients meeting the inclusion criteria for active surveillance

https://doi.org/10.18632/oncotarget.12906

Matteo Ferro, Giuseppe Lucarelli, Dario Bruzzese, Giuseppe Di Lorenzo, Sisto Perdonà, Riccardo Autorino​‌, Francesco Cantiello, Roberto La Rocca, Gian Maria Busetto, Amelia Cimmino, Carlo Buonerba, Michele Battaglia, Rocco Damiano, Ottavio De Cobelli, Vincenzo Mirone, and Daniela Terracciano
18424-18434
Abstract  |  PDF  |  Full Text  |  How to cite

Is there a dosedependent effect of genetic susceptibility loci for gastric cancer on prognosis of the patients

https://doi.org/10.18632/oncotarget.13123

Lei Cheng, Li-Xin Qiu, Ming Jia, Fei Zhou, Meng-Yun Wang, Ruo-Xin Zhang, Yajun Yang, Xiaofeng Wang, Jiucun Wang, Li Jin, and Qing-Yi Wei
18435-18443
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Reviews

Research progress of neuroblastoma related gene variations

https://doi.org/10.18632/oncotarget.14408

Yanna Cao, Yan Jin, Jinpu Yu, Jingfu Wang, Jie Yan, and Qiang Zhao
18444-18455
Abstract  |  PDF  |  Full Text  |  How to cite

2017 update on the relationship between diabetes and colorectal cancer: epidemiology potential molecular mechanisms and therapeutic implications

https://doi.org/10.18632/oncotarget.14472

Nieves González, Isabel Prieto, Laura del Puerto-Nevado, Sergio Portal-Nuñez, Juan Antonio Ardura, Marta Corton, Beatriz Fernández-Fernández, Oscar Aguilera, Carmen Gomez-Guerrero, Sebastián Mas, Juan Antonio Moreno, Marta Ruiz-Ortega, Ana Belen Sanz, Maria Dolores Sanchez-Niño, Federico Rojo, Fernando Vivanco, Pedro Esbrit, Carmen Ayuso, Gloria Alvarez-Llamas, Jesús Egido, Jesús García-Foncillas, Alberto Ortiz, and Diabetes Cancer Connect Consortium
18456-18485
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Targeting macrophage antitumor activity to suppress melanoma progression

https://doi.org/10.18632/oncotarget.14474

Huafeng Wang, Lijuan Zhang, Luhong Yang, Chengfang Liu, Qi Zhang, and Linjing Zhang
18486-18496
Abstract  |  PDF  |  Full Text  |  How to cite

Prostate cancer proteomics: Current trends and future perspectives for biomarker discovery

https://doi.org/10.18632/oncotarget.14501

Cristiana Pistol Tanase, Elena Codrici, Ionela Daniela Popescu, Simona Mihai, Ana-Maria Enciu, Laura Georgiana Necula, Adrian Preda, Gener Ismail, and Radu Albulescu
18497-18512
Abstract  |  PDF  |  Full Text  |  How to cite

Lung cancer and chronic obstructive pulmonary disease: From a clinical perspective

https://doi.org/10.18632/oncotarget.14505

Jie Dai, Ping Yang, Angela Cox, and Gening Jiang
18513-18524
Abstract  |  PDF  |  Full Text  |  How to cite
Special Collection ToC

The heterogeneous landscape of ALK negative ALCL

https://doi.org/10.18632/oncotarget.14503

Elisabetta Mereu, Elisa Pellegrino, Irene Scarfò, Giorgio Inghirami, and Roberto Piva
18525-18536
Abstract  |  PDF  |  Full Text  |  How to cite

Harms and benefits of adoptive immunotherapy for postoperative hepatocellular carcinoma: an updated review

https://doi.org/10.18632/oncotarget.14507

Bao-Hong Yuan, Ru-Hong Li, Wei-Ping Yuan, Tian Yang, Tie-Jun Tong, Ning-Fu Peng, Le-Qun Li, and Jian-Hong Zhong
18537-18549
Abstract  |  PDF  |  Full Text  |  How to cite

Androgen receptor splice variants and prostate cancer: From bench to bedside

https://doi.org/10.18632/oncotarget.14537

Kristine M. Wadosky, and Shahriar Koochekpour
18550-18576
Abstract  |  PDF  |  Full Text  |  How to cite

Advances in epigenetic glioblastoma therapy

https://doi.org/10.18632/oncotarget.14612

Dong Hoon Lee, Hyun-Wook Ryu, Hye-Rim Won, and So Hee Kwon
18577-18589
Abstract  |  PDF  |  Full Text  |  How to cite

Liquid biopsy genotyping in lung cancer: ready for clinical utility

https://doi.org/10.18632/oncotarget.14613

Wei-Lun Huang, Yi-Lin Chen, Szu-Chun Yang, Chung-Liang Ho, Fang Wei, David T. Wong, Wu-Chou Su, and Chien-Chung Lin
18590-18608
Abstract  |  PDF  |  Full Text  |  How to cite

Case Reports

Transformation to smallcell carcinoma as an acquired resistance mechanism to AZD9291: A case report

https://doi.org/10.18632/oncotarget.14506

Lin Li, Hui Wang, Chao Li, Zheng Wang, Ping Zhang, and Xu Yan
18609-18614
Abstract  |  PDF  |  Full Text  |  How to cite

Corrections

Correction: DAPK loss in colon cancer tumor buds: implications for migration capacity of disseminating tumor cells

https://doi.org/10.18632/oncotarget.16154

Jelena Ivanovska, Inti Zlobec, Stefan Forster, Eva Karamitopoulou, Heather Dawson, Viktor Hendrik Koelzer, Abbas Agaimy, Fabian Garreis, Stephan Söder, William Laqua, Alessandro Lugli, Arndt Hartmann, Tilman T. Rau, and Regine Schneider-Stock
18615-18616
Correction  |  PDF  |  How to cite

Correction: A new immunohistochemistry prognostic score IPS for recurrence and survival in resected pancreatic neuroendocrine tumors PanNET

https://doi.org/10.18632/oncotarget.16155

Antonio Viúdez, Filipe L.F. Carvalho, Zahra Maleki, Marianna Zahurak, Daniel Laheru, Alejandro Stark, Nilofer S. Azad, Christopher L. Wolfgang, Stephen Baylin, James G. Herman, and Ana De Jesus-Acosta
18617-18617
Correction  |  PDF  |  How to cite


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