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Role of the PEBP4 protein in the development and metastasis of gastric cancer

Zijian Wu _, Bin Liu, Xuemin Zheng, Huijing Hou and Ying Li

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Oncotarget. 2017; 8:18177-18184. https://doi.org/10.18632/oncotarget.15255

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Zijian Wu1,*, Bin Liu1,*, Xuemin Zheng2, Huijing Hou1, Ying Li3

1Tianjin Key Laboratory of Food Biotechnology, College of Biotechnology and Food Science, Tianjin University of Commerce, China

2Tianjin Institute of Pharmaceutical Research, China

3Tianjin Neurological Institute, Tianjin Medical University General Hospital, China

*These authors have contributed equally to this work

Correspondence to:

Zijian Wu, email: [email protected]

Ying Li, email: [email protected]

Keywords: gastric cancer, PEBP4, cancer immigration, cancer invasion

Received: November 02, 2016     Accepted: December 28, 2016     Published: February 10, 2017


Phosphatidylethanolamine-binding protein 4 (PEBP4) has previously been reported to be upregulated in various cancers. However, the physiological functions of PEBP4 in gastric cancer are still unknown. Aiming to clarify the properties and role of PEBP4 in the development and invasion of gastric cancer, we performed several biological assays and a knockdown assay. The expression level of PEBP4 was shown to be significantly upregulated in gastric cancer tissue samples, and knockdown of the expression of PEBP4 induced significant inhibitory effects on cell proliferation, migration and invasiveness. In addition, it was demonstrated that PEBP4 was associated with the development and invasion of gastric cancer cells through activation of the PI3K/Akt signaling pathway. Our findings supported the hypothesis that PEBP4 might be a novel potential drug target for the treatment of gastric cancer.

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