Lung cancer and chronic obstructive pulmonary disease: From a clinical perspective

Jie Dai, Ping Yang, Angela Cox and Gening Jiang _

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Oncotarget. 2017; 8:18513-18524. https://doi.org/10.18632/oncotarget.14505

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Jie Dai1, Ping Yang2, Angela Cox3 and Gening Jiang1

1 Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China

2 Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Minnesota, United States of America

3 Department of Oncology, University of Sheffield Medical School, Sheffield, United Kingdom

Correspondence to:

Gening Jiang, email:

Jie Dai, email:

Keywords: chronic obstructive pulmonary disease; lung cancer; association

Received: October 04, 2016 Accepted: December 27, 2016 Published: January 04, 2017


Chronic obstructive pulmonary disease (COPD) and lung cancer are devastating pulmonary diseases that commonly coexist and present a number of clinical challenges. COPD confers a higher risk for lung cancer development, but available chemopreventive measures remain rudimentary. Current studies have shown a marked benefit of cancer screening in the COPD population, although challenges remain, including the common underdiagnosis of COPD. COPD-associated lung cancer presents distinct clinical features. Treatment for lung cancer coexisting with COPD is challenging as COPD may increase postoperative morbidities and decrease survival. In this review, we outline current progress in the understanding of the clinical association between COPD and lung cancer, and suggest possible cancer prevention strategies in this patient population.

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