Research Papers: Immunology:
HDAC4 is expressed on multiple T cell lineages but dispensable for their development and function
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Queping Liu1,2,3, Xilin Zhang2,3, Congcong Yin2,3, Xiang Chen1, Zhenggang Zhang4, Stephen Brown5, Hongfu Xie1, Li Zhou2,3,6 and Qing-Sheng Mi2,3,6
1 Department of Dermatology, Xiang-Ya Hospital of Central South University, Changsha, Hunan, China
2 Henry Ford Immunology Program, Henry Ford Health System, Detroit, MI, USA
3 Department of Dermatology, Henry Ford Health System, Detroit, MI, USA
4 Department of Neurology, Henry Ford Health System, Detroit, MI, USA
5 Department of Radiation Oncology, Henry Ford Health System, Detroit, MI, USA
6 Department of Internal Medicine, Henry Ford Health System, Detroit, MI, USA
Qing-Sheng Mi, email:
Hongfu Xie, email:
Li Zhou, email:
Keywords: HDAC4, conventional T cells, invariant NKT cells, development, polarization, Immunology and Microbiology Section, Immune response, Immunity
Received: November 18, 2016 Accepted: January 11, 2017 Published: February 03, 2017
Histone deacetylation, reciprocally mediated by histone deacetylases (HDAC) and acetyltransferases, represents one major form of post-translational modification. Previous research indicates that HDACs play an essential regulatory role in the development of various immune cells. However, the specific function of individual HDACs remains largely unexplored. HDAC4, a member of class II HDACs, profoundly investigated in the nervous system, while the expression profile and function of HDAC4 in T cells are barely known. For the first time, we report here that HDAC4 is expressed in the multiple T cell lineages. Using T-cell-specific HDAC4-deficient mice, we discovered that lack of HDAC4 did not alter the frequencies of conventional T cells, invariant NKT (iNKT) cells or regulatory T cells within both the thymus and secondary lymphoid organs. Moreover, conventional T cells and iNKT cells from wild-type and HDAC4-deficient mice displayed no significant difference in cytokine production. In conclusion, our results imply that under steady stage, HDAC4 is not required for the development and function of multiple T cell lineages, including conventional T cells and iNKT cells.
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