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Treatment with L-asparaginase (Asp) inhibits proliferation and induces apoptosis across different glioblastoma cells. See Karpel-Massler et al.

Table of Contents

Priority Research Papers

LTR12 promoter activation in a broad range of human tumor cells by HDAC inhibition

https://doi.org/10.18632/oncotarget.9255

Sonja K. Krönung, Ulrike Beyer, Maria Luisa Chiaramonte, Diletta Dolfini, Roberto Mantovani, and Matthias Dobbelstein
33484-33497
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Enhanced killing of chordoma cells by antibodydependent cellmediated cytotoxicity employing the novel antiPDL1 antibody avelumab

https://doi.org/10.18632/oncotarget.9256

Rika Fujii, Eitan R. Friedman, Jacob Richards, Kwong Y. Tsang, Christopher R. Heery, Jeffrey Schlom, and James W. Hodge
33498-33511
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Metabolic reprogramming of glioblastoma cells by Lasparaginase sensitizes for apoptosis in vitro and in vivo

https://doi.org/10.18632/oncotarget.9257

Georg Karpel-Massler, Doruntina Ramani, Chang Shu, Marc-Eric Halatsch, Mike-Andrew Westhoff, Jeffrey N. Bruce, Peter Canoll, and Markus D. Siegelin
33512-33528
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite  |  Press Release

Conjugation to the sigma2 ligand SV119 overcomes uptake blockade and converts dmErastin into a potent pancreatic cancer therapeutic

https://doi.org/10.18632/oncotarget.9551

Kerri A. Ohman, Yassar M. Hashim, Suwanna Vangveravong, Timothy M. Nywening, Darren R. Cullinan, S. Peter Goedegebuure, Jingxia Liu, Brian A. Van Tine, Herve Tiriac, David A. Tuveson, David G. DeNardo, Dirk Spitzer, Robert H. Mach, and William G. Hawkins
33529-33541
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Dual inhibition of protein kinase C and p53MDM2 or PKC and mTORC1 are novel efficient therapeutic approaches for uveal melanoma

https://doi.org/10.18632/oncotarget.9552

Guillaume Carita, Estelle Frisch-Dit-Leitz, Ahmed Dahmani, Chloé Raymondie, Nathalie Cassoux, Sophie Piperno-Neumann, Fariba Némati, Cécile Laurent, Leanne De Koning, Ensar Halilovic, Sebastien Jeay, Andrew Wylie, Caroline Emery, Sergio Roman-Roman, Marie Schoumacher, and Didier Decaudin
33542-33556
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

β2spectrin depletion impairs DNA damage repair

https://doi.org/10.18632/oncotarget.9677

Nobuo Horikoshi, Raj K. Pandita, Kalpana Mujoo, Shashank Hambarde, Dharmendra Sharma, Abid R. Mattoo, Sharmistha Chakraborty, Vijaya Charaka, Clayton R. Hunt, and Tej K. Pandita
33557-33570
Abstract  |  PDF  |  Full Text  |  How to cite

Targeting hypoxic microenvironment of pancreatic xenografts with the hypoxiaactivated prodrug TH302

https://doi.org/10.18632/oncotarget.9654

Ines Lohse, Joanna Rasowski, Pinjiang Cao, Melania Pintilie, Trevor Do, Ming-Sound Tsao, Richard P. Hill, and David W. Hedley
33571-33580
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Research Papers: Gerotarget (Focus on Aging)

Vaccine efficacy and T helper cell differentiation change with aging

https://doi.org/10.18632/oncotarget.9254

Julie S. Lefebvre, Erica C. Lorenzo, April R. Masters, Jacob W. Hopkins, Sheri M. Eaton, Stephen T. Smiley, and Laura Haynes
33581-33594
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Thigh muscle size and vascular function after blood flowrestricted elastic band training in older women

https://doi.org/10.18632/oncotarget.9564

Tomohiro Yasuda, Kazuya Fukumura, Takanobu Tomaru, and Toshiaki Nakajima
33595-33607
Abstract  |  PDF  |  Full Text  |  How to cite

Research Papers: Pathology

Risk prediction for earlyonset gastric carcinoma: a casecontrol study of polygenic gastric cancer in Han Chinese with hereditary background

https://doi.org/10.18632/oncotarget.9025

Jiajia Yuan, Yanyan Li, Tiantian Tian, Na Li, Yan Zhu, Jianling Zou, Jing Gao, and Lin Shen
33608-33615
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Functional networks of aging markers in the glomeruli of IgA nephropathy: a new therapeutic opportunity

https://doi.org/10.18632/oncotarget.9033

Hong Jiang, Ludan Liang, Jing Qin, Yingying Lu, Bingjue Li, Yucheng Wang, Chuan Lin, Qin Zhou, Shi Feng, Shun H. Yip, Feng Xu, EnYin Lai, Junwen Wang, and Jianghua Chen
33616-33626
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

An integrated proteomics approach shows synaptic plasticity changes in an APP/PS1 Alzheimer's mouse model

https://doi.org/10.18632/oncotarget.9092

Stefan J. Kempf, Athanasios Metaxas, María Ibáñez-Vea, Sultan Darvesh, Bente Finsen, and Martin R. Larsen
33627-33648
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

IL33 treatment attenuated dietinduced hepatic steatosis but aggravated hepatic fibrosis

https://doi.org/10.18632/oncotarget.9259

Yinjie Gao, Yuan Liu, Mei Yang, Xiaodong Guo, Min Zhang, Hanwei Li, Jin Li, and Jingmin Zhao
33649-33661
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

NPRC gene polymorphism is associated with increased susceptibility to coronary artery disease in Chinese Han population: a multicenter study

https://doi.org/10.18632/oncotarget.9358

Qin Hu, Qiji Liu, Shasha Wang, Xi Zhen, Zhimian Zhang, Ruijuan Lv, Guihua Jiang, Zhiyong Ma, Hong He, Daqing Li, Xiaoling Liu, Fei Gao, Jifu Li, Li Li, Mei Zhang, Xiaoping Ji, Yuguo Chen, Daowen Wang, Dejia Huang, Aiqun Ma, Wei Huang, Yuxia Zhao, Yaoqin Gong, Cheng Zhang, and Yun Zhang
33662-33674
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Distinctive expression patterns of hypoxiainducible factor1α and endothelial nitric oxide synthase following hypergravity exposure

https://doi.org/10.18632/oncotarget.9372

Gun Yoon, Choong Sik Oh, and Hyun-Soo Kim
33675-33688
Abstract  |  PDF  |  Full Text  |  How to cite

Organochloride pesticides induced hepatic ABCG5/G8 expression and lipogenesis in Chinese patients with gallstone disease

https://doi.org/10.18632/oncotarget.9399

Guixiang Ji, Cheng Xu, Haidong Sun, Qian Liu, Hai Hu, Aihua Gu, and Zhao-Yan Jiang
33689-33702
Abstract  |  PDF  |  Full Text  |  How to cite

Pulmonary fibrosis in a mouse model of sarcoid granulomatosis induced by booster challenge with Propionibacterium acnes

https://doi.org/10.18632/oncotarget.9397

Dingyuan Jiang, Xiaoxi Huang, Jing Geng, Run Dong, Shuhong Li, Zheng Liu, Chen Wang, and Huaping Dai
33703-33714
Abstract  |  PDF  |  Full Text  |  How to cite

Polycystic ovary syndrome PCOS and the risk of coronary heart disease CHD: a metaanalysis

https://doi.org/10.18632/oncotarget.9553

Luqian Zhao, Zhigang Zhu, Huiling Lou, Guodong Zhu, Weimin Huang, Shaogang Zhang, and Feng Liu
33715-33721
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Use of estetrol with other steroids for attenuation of neonatal hypoxicIschemic brain injury: to combine or not to combine

https://doi.org/10.18632/oncotarget.9591

Ekaterine Tskitishvili, Christel Pequeux, Carine Munaut, Renaud Viellevoye, Michelle Nisolle, Agnes Noël, and Jean-Michel Foidart
33722-33743
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Research Papers: Immunology

Unexpected positive control of NFκB and miR155 by DGKα and ζ ensures effector and memory CD8+ T cell differentiation

https://doi.org/10.18632/oncotarget.8164

Jialong Yang, Ping Zhang, Sruti Krishna, Jinli Wang, Xingguang Lin, Hongxiang Huang, Danli Xie, Balachandra Gorentla, Rick Huang, Jimin Gao, Qi-Jing Li, and Xiao-Ping Zhong
33744-33764
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Cisplatin induces tolerogenic dendritic cells in response to TLR agonists via the abundant production of IL10 thereby promoting Th2 and Tr1biased Tcell immunity

https://doi.org/10.18632/oncotarget.9260

Woo Sik Kim, Hongmin Kim, Kee Woong Kwon, Sin-Hyeog Im, Bo Ryeong Lee, Sang-Jun Ha, and Sung Jae Shin
33765-33782
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

AMPKdependent and independent effects of AICAR and compound C on Tcell responses

https://doi.org/10.18632/oncotarget.9277

Enyu Rao, Yuwen Zhang, Qiang Li, Jiaqing Hao, Nejat K. Egilmez, Jill Suttles, and Bing Li
33783-33795
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

HCV core protein binds to gC1qR to induce A20 expression and inhibit cytokine production through MAPKs and NFκB signaling pathways

https://doi.org/10.18632/oncotarget.9304

Xiaotian Song, Zhiyan Yao, Jianling Yang, Zhengzheng Zhang, Yuqing Deng, Miao Li, Cuiqing Ma, Lijuan Yang, Xue Gao, Wenjian Li, Jianguo Liu, and Lin Wei
33796-33808
Abstract  |  PDF  |  Full Text  |  How to cite

Research Papers: Chromosome

Translin and Trax differentially regulate telomereassociated transcript homeostasis

https://doi.org/10.18632/oncotarget.9278

Natalia Gomez-Escobar, Nasser Almobadel, Othman Alzahrani, Julia Feichtinger, Vicente Planells-Palop, Zafer Alshehri, Gerhard G. Thallinger, Jane A. Wakeman, and Ramsay J. McFarlane
33809-33820
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Research Papers

Rheb may complex with RASSF1A to coordinate Hippo and TOR signaling

https://doi.org/10.18632/oncotarget.8447

Nicholas Nelson, and Geoffrey J. Clark
33821-33831
Abstract  |  PDF  |  Full Text  |  How to cite

Loss of adipose triglyceride lipase is associated with human cancer and induces mouse pulmonary neoplasia

https://doi.org/10.18632/oncotarget.9418

Wael Al-Zoughbi, Martin Pichler, Gregor Gorkiewicz, Barbara Guertl-Lackner, Johannes Haybaeck, Stephan W. Jahn, Carolin Lackner, Bernadette Liegl-Atzwanger, Helmut Popper, Silvia Schauer, Elisa Nusshold, Alida S. D. Kindt, Zlatko Trajanoski, Michael R. Speicher, Guenther Haemmerle, Robert Zimmermann, Rudolf Zechner, Paul W. Vesely, and Gerald Hoefler
33832-33840
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Preventive and therapeutic effects of thymosin β4 Nterminal fragment AcSDKP in the bleomycin model of pulmonary fibrosis

https://doi.org/10.18632/oncotarget.8409

Enrico Conte, Evelina Fagone, Elisa Gili, Mary Fruciano, Maria Iemmolo, Maria Provvidenza Pistorio, Daniela Impellizzeri, Marika Cordaro, Salvatore Cuzzocrea, and Carlo Vancheri
33841-33854
Abstract  |  PDF  |  Full Text  |  How to cite

Gene expression in normalappearing tissue adjacent to prostate cancers are predictive of clinical outcome: evidence for a biologically meaningful field effect

https://doi.org/10.18632/oncotarget.8944

Cristina Magi-Galluzzi, Tara Maddala, Sara Moscovita Falzarano, Diana B. Cherbavaz, Nan Zhang, Dejan Knezevic, Phillip G. Febbo, Mark Lee, Hugh Jeffrey Lawrence, and Eric A. Klein
33855-33865
Abstract  |  PDF  |  Full Text  |  How to cite

IAP antagonists sensitize murine osteosarcoma cells to killing by TNFα

https://doi.org/10.18632/oncotarget.8980

Tanmay M. Shekhar, Mark A. Miles, Ankita Gupte, Scott Taylor, Brianna Tascone, Carl R. Walkley, and Christine J. Hawkins
33866-33886
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Dysregulation of junctional adhesion moleculeA via p63/GATA3 in head and neck squamous cell carcinoma

https://doi.org/10.18632/oncotarget.8432

Takuya Kakuki, Makoto Kurose, Ken-ichi Takano, Atsushi Kondoh, Kazufumi Obata, Kazuaki Nomura, Ryo Miyata, Yakuto Kaneko, Takumi Konno, Syunta Takahashi, Tsubasa Hatakeyama, Takayuki Kohno, Tetsuo Himi, and Takashi Kojima
33887-33900
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Neoadjuvant tamoxifen synchronizes ERα binding and gene expression profiles related to outcome and proliferation

https://doi.org/10.18632/oncotarget.8983

Tesa M. Severson, Ekaterina Nevedomskaya, Justine Peeters, Thomas Kuilman, Oscar Krijgsman, Annelot van Rossum, Marjolein Droog, Yongsoo Kim, Rutger Koornstra, Inès Beumer, Annuska M. Glas, Daniel Peeper, Jelle Wesseling, Iris M. Simon, Lodewyk Wessels, Sabine C. Linn, and Wilbert Zwart
33901-33918
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Repurposing cephalosporin antibiotics as prosenescent radiosensitizers

https://doi.org/10.18632/oncotarget.8984

Edwardine Labay, Helena J. Mauceri, Elena V. Efimova, Amy C. Flor, Harold G. Sutton, Stephen J. Kron, and Ralph R. Weichselbaum
33919-33933
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

The long noncoding RNA PARROT is an upstream regulator of cMyc and affects proliferation and translation

https://doi.org/10.18632/oncotarget.8985

Dubravka Vučićević, Maja Gehre, Sonam Dhamija, Lennart Friis-Hansen, David Meierhofer, Sascha Sauer, and Ulf Andersson Ørom
33934-33947
Abstract  |  PDF  |  Full Text  |  How to cite

Ergosterol peroxide activates Foxo3mediated cell death signaling by inhibiting AKT and cMyc in human hepatocellular carcinoma cells

https://doi.org/10.18632/oncotarget.8608

Xiangmin Li, Qingping Wu, Ming Bu, Liming Hu, William W. Du, Chunwei Jiao, Honghui Pan, Mouna Sdiri, Nan Wu, Yizhen Xie, and Burton B. Yang
33948-33959
Abstract  |  PDF  |  Full Text  |  How to cite

­­­­Cyclic AMP efflux inhibitors as potential therapeutic agents for leukemia

https://doi.org/10.18632/oncotarget.8986

Dominique R. Perez, Yelena Smagley, Matthew Garcia, Mark B. Carter, Annette Evangelisti, Ksenia Matlawska-Wasowska, Stuart S. Winter, Larry A. Sklar, and Alexandre Chigaev
33960-33982
Abstract  |  PDF  |  Full Text  |  How to cite

GCGene: a gene resource for gastric cancer with literature evidence

https://doi.org/10.18632/oncotarget.9030

Min Zhao, Luming Chen, Yining Liu, and Hong Qu
33983-33993
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Extracellular miRNA21 as a novel biomarker in glioma: evidence from metaanalysis clinical validation and experimental investigations

https://doi.org/10.18632/oncotarget.9188

Kai Qu, Ting Lin, Qing Pang, Tian Liu, Zhixin Wang, Minghui Tai, Fandi Meng, Jingyao Zhang, Yong Wan, Ping Mao, Xiaoqun Dong, Chang Liu, Wenquan Niu, and Shunbin Dong
33994-34010
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Direct repression of the oncogene CDK4 by the tumor suppressor miR4865p in nonsmall cell lung cancer

https://doi.org/10.18632/oncotarget.8514

Yang Shao, Yu-Qing Shen, Yan-Li Li, Chen Liang, Bing-Jie Zhang, Sheng-Di Lu, Yan-Yun He, Ping Wang, Qiang-Ling Sun, You-Xin Jin, and Zhong-Liang Ma
34011-34021
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Identification of nasopharyngeal carcinoma metastasisrelated biomarkers by iTRAQ combined with 2DLCMS/MS

https://doi.org/10.18632/oncotarget.9067

Zhen Chen, Lu Long, Kun Wang, Facai Cui, Lepan Zhu, Ya Tao, Qiong Wu, Manlin Xiang, Yunlai Liang, Shiyang Qiu, Zhiqiang Xiao, and Bin Yi
34022-34037
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Lapatinibloaded human serum albumin nanoparticles for the prevention and treatment of triplenegative breast cancer metastasis to the brain

https://doi.org/10.18632/oncotarget.8697

Xu Wan, Xiaoyao Zheng, Xiaoyin Pang, Zhiqing Pang, Jingjing Zhao, Zheming Zhang, Tao Jiang, Wei Xu, Qizhi Zhang, and Xinguo Jiang
34038-34051
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

HIF1alpha links mitochondrial perturbation to the dynamic acquisition of breast cancer tumorigenicity

https://doi.org/10.18632/oncotarget.8570

Ching-Ying Kuo, Chun-Ting Cheng, Peifeng Hou, Yi-Pei Lin, Huimin Ma, Yiyin Chung, Kevin Chi, Yuan Chen, Wei Li, Hsing-Jien Kung, and David K. Ann
34052-34069
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Novel CD7specific nanobodybased immunotoxins potently enhanced apoptosis of CD7positive malignant cells

https://doi.org/10.18632/oncotarget.8710

Jinle Tang, Jialu Li, Xuejun Zhu, Yuan Yu, Dan Chen, Lei Yuan, Zhenyang Gu, Xingding Zhang, Lin Qi, Zhishu Gong, Pengjun Jiang, Juhua Yu, Huimin Meng, Gangli An, Huyong Zheng, and Lin Yang
34070-34083
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Repurposing atovaquone: Targeting mitochondrial complex III and OXPHOS to eradicate cancer stem cells

https://doi.org/10.18632/oncotarget.9122

Marco Fiorillo, Rebecca Lamb, Herbert B. Tanowitz, Luciano Mutti, Marija Krstic-Demonacos, Anna Rita Cappello, Ubaldo E. Martinez-Outschoorn, Federica Sotgia, and Michael P. Lisanti
34084-34099
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Radiosynthesis and preliminary biological evaluation of N2[18F]fluoropropionylLglutamine as a PET tracer for tumor imaging

https://doi.org/10.18632/oncotarget.9115

Caihua Tang, Ganghua Tang, Siyuan Gao, Shaoyu Liu, Fuhua Wen, Baoguo Yao, and Dahong Nie
34100-34111
Abstract  |  PDF  |  Full Text  |  How to cite

Inhibition of PHLPP2/cyclin D1 protein translation contributes to the tumor suppressive effect of NFκB2 p100

https://doi.org/10.18632/oncotarget.8746

Jiawei Xu, Yulei Wang, Xiaohui Hua, Jiheng Xu, Zhongxian Tian, Honglei Jin, Jingxia Li, Xue-Ru Wu, and Chuanshu Huang
34112-34130
Abstract  |  PDF  |  Full Text  |  How to cite

Antitumor effect of estrogenrelated receptor alpha knockdown on uterine endometrial cancer

https://doi.org/10.18632/oncotarget.9151

Hiroshi Matsushima, Taisuke Mori, Fumitake Ito, Takuro Yamamoto, Makoto Akiyama, Tetsuya Kokabu, Kaori Yoriki, Shiori Umemura, Kyoko Akashi, and Jo Kitawaki
34131-34148
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Can an IL13 1112 C/T rs1800925 polymorphism predict responsiveness to neoadjuvant chemoradiotherapy and survival of Chinese Han patients with locally advanced rectal cancer

https://doi.org/10.18632/oncotarget.9178

Lin Xiao, Xin Yu, Rong Zhang, Hui Chang, Shaoyan Xi, Weiwei Xiao, Zhifan Zeng, Huizhong Zhang, Ruihua Xu, and Yuanhong Gao
34149-34157
Abstract  |  PDF  |  Full Text  |  How to cite

Hyaluronic acidconjugated liposome nanoparticles for targeted delivery to CD44 overexpressing glioblastoma cells

https://doi.org/10.18632/oncotarget.8926

Stephen L. Hayward, Christina L. Wilson, and Srivatsan Kidambi
34158-34171
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Human umbilical cord matrixderived stem cells expressing interferonβ gene inhibit breast cancer cells via apoptosis

https://doi.org/10.18632/oncotarget.8997

Ching-Ju Shen, Te-Fu Chan, Chien-Chung Chen, Yi-Chiang Hsu, Cheng-Yu Long, and Chung-Sheng Lai
34172-34179
Abstract  |  PDF  |  Full Text  |  How to cite

iROSgPseKNC: Predicting replication origin sites in DNA by incorporating dinucleotide positionspecific propensity into general pseudo nucleotide composition

https://doi.org/10.18632/oncotarget.9057

Xuan Xiao, Han-Xiao Ye, Zi Liu, Jian-Hua Jia, and Kuo-Chen Chou
34180-34189
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

PKG II reverses HGFtriggered cellular activities by phosphorylating serine 985 of cMet in gastric cancer cells

https://doi.org/10.18632/oncotarget.9074

Yan Wu, Xiaoyuan Yao, Miaolin Zhu, Hai Qian, Lu Jiang, Ting Lan, Min Wu, Ji Pang, and Yongchang Chen
34190-34200
Abstract  |  PDF  |  Full Text  |  How to cite

Th17 cytokine differentiation and loss of plasticity after SOCS1 inactivation in a cutaneous Tcell lymphoma

https://doi.org/10.18632/oncotarget.9077

Stefan Ehrentraut, Björn Schneider, Stefan Nagel, Claudia Pommerenke, Hilmar Quentmeier, Robert Geffers, Maren Feist, Maren Kaufmann, Corinna Meyer, Marshall E. Kadin, Hans G. Drexler, and Roderick A. F. MacLeod
34201-34216
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Prognostic impact of tumorassociated macrophage infiltration in nonsmall cell lung cancer: A systemic review and metaanalysis

https://doi.org/10.18632/oncotarget.9079

Jiandong Mei, Zhilan Xiao, Chenglin Guo, Qiang Pu, Lin Ma, Chengwu Liu, Feng Lin, Hu Liao, Zongbing You, and Lunxu Liu
34217-34228
Abstract  |  PDF  |  Full Text  |  How to cite

XAF1 promotes neuroblastoma tumor suppression and is required for KIF1Bβmediated apoptosis

https://doi.org/10.18632/oncotarget.8748

Zhang'e Choo, Rachel Yu Lin Koh, Karin Wallis, Timothy Jia Wei Koh, Chik Hong Kuick, Veronica Sobrado, Rajappa S. Kenchappa, Amos Hong Pheng Loh, Shui Yen Soh, Susanne Schlisio, Kenneth Tou En Chang, and Zhi Xiong Chen
34229-34239
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Genetic alterations and protein expression in combined small cell lung cancers and small cell lung cancers arising from lung adenocarcinomas after therapy with tyrosine kinase inhibitors

https://doi.org/10.18632/oncotarget.9083

Xiaohua Shi, Huanli Duan, Xuguang Liu, Liangrui Zhou, and Zhiyong Liang
34240-34249
Abstract  |  PDF  |  Full Text  |  How to cite

Exogenous carbon monoxide inhibits neutrophil infiltration in LPSinduced sepsis by interfering with FPR1 via p38 MAPK but not GRK2

https://doi.org/10.18632/oncotarget.9084

Xu Wang, Weiting Qin, Mingming Song, Yisen Zhang, and Bingwei Sun
34250-34265
Abstract  |  PDF  |  Full Text  |  How to cite

Quinazoline derivative QPB15e stabilizes the cmyc promoter Gquadruplex and inhibits tumor growth in vivo

https://doi.org/10.18632/oncotarget.9088

Zeng Li, Chen Liu, Cheng Huang, Xiaoming Meng, Lei Zhang, Jinhui He, and Jun Li
34266-34276
Abstract  |  PDF  |  Full Text  |  How to cite

A functional single nucleotide polymorphism of SET8 is prognostic for breast cancer

https://doi.org/10.18632/oncotarget.9099

Ben Liu, Xining Zhang, Fengju Song, Qun Liu, Hongji Dai, Hong Zheng, Ping Cui, Lina Zhang, Wei Zhang, and Kexin Chen
34277-34287
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Identification of miR34atarget interactions by a combined network based and experimental approach

https://doi.org/10.18632/oncotarget.9103

Martin Hart, Stefanie Rheinheimer, Petra Leidinger, Christina Backes, Jennifer Menegatti, Tobias Fehlmann, Friedrich Grässer, Andreas Keller, and Eckart Meese
34288-34299
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Wogonoside prevents colitisassociated colorectal carcinogenesis and colon cancer progression in inflammationrelated microenvironment via inhibiting NFκB activation through PI3K/Akt pathway

https://doi.org/10.18632/oncotarget.8815

Yang Sun, Yue Zhao, Xiaoping Wang, Li Zhao, Wenjun Li, Youxiang Ding, Lingyi Kong, Qinglong Guo, and Na Lu
34300-34315
Abstract  |  PDF  |  Full Text  |  How to cite

Genetic variant of miR146a rs2910164 C>G and gastric cancer susceptibility

https://doi.org/10.18632/oncotarget.8814

Zu-Guang Xia, Hua-Fang Yin, Ying Long, Lei Cheng, Ling-Jun Yu, Wei-Jian Guo, Xiao-Dong Zhu, Jin Li, Ya-Nong Wang, Ya-Jun Yang, Jiu-Cun Wang, Li Jin, Li-Xin Qiu, and Yongyue Wei
34316-34321
Abstract  |  PDF  |  Full Text  |  How to cite

MEK5/ERK5 signaling inhibition increases colon cancer cell sensitivity to 5fluorouracil through a p53dependent mechanism

https://doi.org/10.18632/oncotarget.9107

Diane M. Pereira, André E. S. Simões, Sofia E. Gomes, Rui E. Castro, Tânia Carvalho, Cecília M. P. Rodrigues, and Pedro M. Borralho
34322-34340
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Chimeric antigen receptor T cells secreting antiPDL1 antibodies more effectively regress renal cell carcinoma in a humanized mouse model

https://doi.org/10.18632/oncotarget.9114

Eloah Rabello Suarez, De-Kuan Chang, Jiusong Sun, Jianhua Sui, Gordon J. Freeman, Sabina Signoretti, Quan Zhu, and Wayne A. Marasco
34341-34355
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Asparaginyl endopeptidase promotes the invasion and metastasis of gastric cancer through modulating epithelialtomesenchymal transition

https://doi.org/10.18632/oncotarget.8879

Yuehong Cui, Yan Wang, Hong Li, Qian Li, Yiyi Yu, Xiaojing Xu, Bei Xu, and Tianshu Liu
34356-34370
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

FRA1 promotes squamous cell carcinoma growth and metastasis through distinct AKT and cJun dependent mechanisms

https://doi.org/10.18632/oncotarget.9110

Xiaoling Zhang, Joseph Wu, Suju Luo, Terry Lechler, and Jennifer Y. Zhang
34371-34383
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Identification of cytotoxic agents disrupting synovial sarcoma oncoprotein interactions by proximity ligation assay

https://doi.org/10.18632/oncotarget.8882

Aimée N. Laporte, Jennifer X. Ji, Limin Ma, Torsten O. Nielsen, and Bertha A. Brodin
34384-34394
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Multiplicity of acquired crossresistance in paclitaxelresistant cancer cells is associated with feedback control of TUBB3 via FOXO3amediated ABCB1 regulation

https://doi.org/10.18632/oncotarget.9118

Mark Borris D. Aldonza, Ji-Young Hong, Malona V. Alinsug, Jayoung Song, and Sang Kook Lee
34395-34419
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Autophagy suppresses cell migration by degrading GEFH1 a RhoA GEF

https://doi.org/10.18632/oncotarget.8883

Tatsushi Yoshida, Masatsune Tsujioka, Shinya Honda, Masato Tanaka, and Shigeomi Shimizu
34420-34429
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

AT101 exerts a synergetic efficacy in gastric cancer patients with 5FU based treatment through promoting apoptosis and autophagy

https://doi.org/10.18632/oncotarget.9119

Xi Wei, Wei Duan, Ying Li, Sheng Zhang, Xiaojie Xin, Lei Sun, Ming Gao, Qing Li, and Dong Wang
34430-34441
Abstract  |  PDF  |  Full Text  |  How to cite

Metformin restores crizotinib sensitivity in crizotinibresistant human lung cancer cells through inhibition of IGF1R signaling pathway

https://doi.org/10.18632/oncotarget.9120

Li Li, Yubo Wang, Tao Peng, Kejun Zhang, Caiyu Lin, Rui Han, Conghua Lu, and Yong He
34442-34452
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Obatoclax kills anaplastic thyroid cancer cells by inducing lysosome neutralization and necrosis

https://doi.org/10.18632/oncotarget.9121

Devora Champa, Arturo Orlacchio, Bindi Patel, Michela Ranieri, Anton A Shemetov, Vladislav V Verkhusha, Ana Maria Cuervo, and Antonio Di Cristofano
34453-34471
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

A functional variant at miRNA122 binding site in IL1α 3’ UTR predicts risk of recurrence in patients with oropharyngeal cancer

https://doi.org/10.18632/oncotarget.8908

Chengyuan Wang, Erich M. Sturgis, Xingming Chen, Qingyi Wei, and Guojun Li
34472-34479
Abstract  |  PDF  |  Full Text  |  How to cite

p75 neurotrophin receptor and proBDNF promote cell survival and migration in clear cell renal cell carcinoma

https://doi.org/10.18632/oncotarget.8911

Miguel A. De la Cruz-Morcillo, Julien Berger, Ricardo Sánchez-Prieto, Sofiane Saada, Thomas Naves, Angélique Guillaudeau, Aurélie Perraud, Philippe Sindou, Aurélie Lacroix, Aurélien Descazeaud, Fabrice Lalloué, and Marie-Odile Jauberteau
34480-34497
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

MicroRNA21 as a potential diagnostic biomarker for breast cancer patients: a pooled analysis of individual studies

https://doi.org/10.18632/oncotarget.9142

Ying Gao, Qiliang Cai, Yubei Huang, Shu Li, Hongxi Yang, Li Sun, Kexin Chen, and Yaogang Wang
34498-34506
Abstract  |  PDF  |  Full Text  |  How to cite

Stromaderived but not tumor ADAMTS1 is a main driver of tumor growth and metastasis

https://doi.org/10.18632/oncotarget.8922

Rubén Fernández-Rodríguez, Francisco Javier Rodríguez-Baena, Estefanía Martino-Echarri, Carlos Peris-Torres, María del Carmen Plaza-Calonge, and Juan Carlos Rodríguez-Manzaneque
34507-34519
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Association of SOX2 and Nestin DNA amplification and protein expression with clinical features and overall survival in nonsmall cell lung cancer: A systematic review and metaanalysis

https://doi.org/10.18632/oncotarget.9145

Qingbao Li, Fang Liu, Yuan Zhang, Lei Fu, Cong Wang, Xuan Chen, Shanghui Guan, and Xiangjiao Meng
34520-34531
Abstract  |  PDF  |  Full Text  |  How to cite

MnTnBuOE2PyP protects normal colorectal fibroblasts from radiation damage and simultaneously enhances radio/chemotherapeutic killing of colorectal cancer cells

https://doi.org/10.18632/oncotarget.8923

Elizabeth A. Kosmacek, Arpita Chatterjee, Qiang Tong, Chi Lin, and Rebecca E. Oberley-Deegan
34532-34545
Abstract  |  PDF  |  Full Text  |  How to cite

A metaanalysis of MSI frequency and race in colorectal cancer

https://doi.org/10.18632/oncotarget.8945

Hassan Ashktorab, Sadhna Ahuja, Lakshmi Kannan, Xavier Llor, Nathan A. Ellis, Rosa M. Xicola, Adeyinka O. Laiyemo, John M. Carethers, Hassan Brim, and Mehdi Nouraie
34546-34557
Abstract  |  PDF  |  Full Text  |  How to cite

iCarPseCp: identify carbonylation sites in proteins by Monte Carlo sampling and incorporating sequence coupled effects into general PseAAC

https://doi.org/10.18632/oncotarget.9148

Jianhua Jia, Zi Liu, Xuan Xiao, Bingxiang Liu, and Kuo-Chen Chou
34558-34570
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Downregulation and proapoptotic effect of hypoxiainducible factor 2 alpha in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.8952

Sheng-li Yang, Li-ping Liu, Leilei Niu, Yun-fan Sun, Xing-rong Yang, Jia Fan, Jian-wei Ren, George G. Chen, and Paul B.S. Lai
34571-34581
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

A role for multiple chimeric antigen receptorexpressing leukocytes in antigenspecific responses to cancer

https://doi.org/10.18632/oncotarget.9149

Carmen S.M. Yong, Liza B. John, Christel Devaud, Miles H. Prince, Ricky W. Johnstone, Joseph A. Trapani, Phillip K. Darcy, and Michael H. Kershaw
34582-34598
Abstract  |  PDF  |  Full Text  |  How to cite

Synonymous mutations in oncogenesis and apoptosis versus survival unveiled by network modeling

https://doi.org/10.18632/oncotarget.8963

Xiang Li, Yuan Chen, Hong Qi, Liyu Liu, and Jianwei Shuai
34599-34616
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

FXR agonists enhance the sensitivity of biliary tract cancer cells to cisplatin via SHP dependent inhibition of BclxL expression

https://doi.org/10.18632/oncotarget.8964

Wei Wang, Ming Zhan, Qi Li, Wei Chen, Huiling Chu, Qihong Huang, Zhaoyuan Hou, Mohan Man, and Jian Wang
34617-34629
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

S100A4 drives nonsmall cell lung cancer invasion associates with poor prognosis and is effectively targeted by the FDAapproved antihelminthic agent niclosamide

https://doi.org/10.18632/oncotarget.8969

Rachel L. Stewart, Brittany L. Carpenter, Dava S. West, Teresa Knifley, Lili Liu, Chi Wang, Heidi L. Weiss, Tamas S. Gal, Eric B. Durbin, Susanne M. Arnold, Kathleen L. O'Connor, and Min Chen
34630-34642
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Impact of suppression of tumorigenicity 14 ST14/serine protease 14 Prss14 expression analysis on the prognosis and management of estrogen receptor negative breast cancer

https://doi.org/10.18632/oncotarget.9155

Sauryang Kim, Jae Woong Yang, Chungho Kim, and Moon Gyo Kim
34643-34663
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Characterization of preneoplastic and neoplastic rat mesothelial cell lines: the involvement of TETs DNMTs and 5hydroxymethylcytosine

https://doi.org/10.18632/oncotarget.8970

David Roulois, Sophie Deshayes, Marie-Noëlle Guilly, Joëlle S. Nader, Charly Liddell, Myriam Robard, Philippe Hulin, Amal Ouacher, Vanessa Le Martelot, Jean-François Fonteneau, Marc Grégoire, Christophe Blanquart, and Daniel L. Pouliquen
34664-34687
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Targeting radioresistant breast cancer cells by single agent CHK1 inhibitor via enhancing replication stress

https://doi.org/10.18632/oncotarget.9156

Yao Zhang, Jinzhi Lai, Zhanwen Du, Jinnan Gao, Shuming Yang, Shashank Gorityala, Xiahui Xiong, Ou Deng, Zhefu Ma, Chunhong Yan, Gonzalo Susana, Yan Xu, and Junran Zhang
34688-34702
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Management of hepatocellular carcinoma: an overview of major findings from metaanalyses

https://doi.org/10.18632/oncotarget.9157

Xingshun Qi, Yan Zhao, Hongyu Li, Xiaozhong Guo, and Guohong Han
34703-34751
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Coexistence of YWHAZ amplification predicts better prognosis in muscleinvasive bladder cancer with CDKN2A or TP53 loss

https://doi.org/10.18632/oncotarget.9158

Shenghua Liu, Yishuo Wu, Tian Yang, Chenchen Feng, and Haowen Jiang
34752-34758
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Ubiquitin specific protease 19 involved in transcriptional repression of retinoic acid receptor by stabilizing CORO2A

https://doi.org/10.18632/oncotarget.8976

Key-Hwan Lim, Jong-Ho Choi, Jung-Hyun Park, Hyeon-Ju Cho, Jang-Joon Park, Eung-Ji Lee, Lan Li, Young-Kil Choi, and Kwang-Hyun Baek
34759-34772
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

FOXO3a promotes gastric cancer cell migration and invasion through the induction of cathepsin L

https://doi.org/10.18632/oncotarget.8977

Shan Yu, Yiyi Yu, Wen Zhang, Wei Yuan, Naiqing Zhao, Qian Li, Yuehong Cui, Yan Wang, Wei Li, Yihong Sun, and Tianshu Liu
34773-34784
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Inhibition of CHK1 enhances cell death induced by the Bcl2selective inhibitor ABT199 in acute myeloid leukemia cells

https://doi.org/10.18632/oncotarget.9185

Jianyun Zhao, Xiaojia Niu, Xinyu Li, Holly Edwards, Guan Wang, Yue Wang, Jeffrey W Taub, Hai Lin, and Yubin Ge
34785-34799
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Nnbutyl haloperidol iodide ameliorates hypoxia/reoxygenation injury through modulating the LKB1/AMPK/ROS pathway in cardiac microvascular endothelial cells

https://doi.org/10.18632/oncotarget.9186

Binger Lu, Bin Wang, Shuping Zhong, Yanmei Zhang, Fenfei Gao, Yicun Chen, Fuchun Zheng, and Ganggang Shi
34800-34810
Abstract  |  PDF  |  Full Text  |  How to cite

Serum VEGFA and CCL5 levels as candidate biomarkers for efficacy and toxicity of regorafenib in patients with metastatic colorectal cancer

https://doi.org/10.18632/oncotarget.9187

Mitsukuni Suenaga, Tetsuo Mashima, Naomi Kawata, Takeru Wakatsuki, Yuki Horiike, Satoshi Matsusaka, Shingo Dan, Eiji Shinozaki, Hiroyuki Seimiya, Nobuyuki Mizunuma, Kensei Yamaguchi, and Toshiharu Yamaguchi
34811-34823
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Comparative effectiveness and safety between oxaliplatinbased and cisplatinbased therapy in advanced gastric cancer: A metaanalysis of randomized controlled trials

https://doi.org/10.18632/oncotarget.9189

Jun Huang, Yongzhao Zhao, Yong Xu, Yanjie Zhu, Jiale Huang, Yanna Liu, Liying Zhao, Zhijia Li, Hao Liu, Qi-long Wang, and Xiaolong Qi
34824-34831
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Metformin blocks progression of obesityactivated thyroid cancer in a mouse model

https://doi.org/10.18632/oncotarget.8989

Jeongwon Park, Won Gu Kim, Li Zhao, Keisuke Enomoto, Mark Willingham, and Sheue-Yann Cheng
34832-34844
Abstract  |  PDF  |  Full Text  |  How to cite

MECP2 promotes the growth of gastric cancer cells by suppressing miR338mediated antiproliferative effect

https://doi.org/10.18632/oncotarget.9197

Dongdong Tong, Lingyu Zhao, Kang He, Hongfei Sun, Donghui Cai, Lei Ni, Ruifang Sun, Su’e Chang, Tusheng Song, and Chen Huang
34845-34859
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Trk inhibition reduces cell proliferation and potentiates the effects of chemotherapeutic agents in Ewing sarcoma

https://doi.org/10.18632/oncotarget.8992

Tiago Elias Heinen, Rafael Pereira dos Santos, Amanda da Rocha, Michel Pinheiro do Santos, Patrícia Luciana da Costa Lopez, Marco Aurélio Silva Filho, Bárbara Kunzler Souza, Luís Fernando da Rosa Rivero, Ricardo Gehrke Becker, Lauro José Gregianin, Algemir Lunardi Brunetto, André Tesainer Brunetto, Caroline Brunetto de Farias, and Rafael Roesler
34860-34880
Abstract  |  PDF  |  Full Text  |  How to cite

The prognostic and predictive value of the lymphocyte to monocyte ratio in luminaltype breast cancer patients treated with CEF chemotherapy

https://doi.org/10.18632/oncotarget.8993

Hongfei Ji, Qijia Xuan, Caichuan Yan, Tao Liu, Abiyasi Nanding, and Qingyuan Zhang
34881-34889
Abstract  |  PDF  |  Full Text  |  How to cite

SOX2 functions as a molecular rheostat to control the growth tumorigenicity and drug responses of pancreatic ductal adenocarcinoma cells

https://doi.org/10.18632/oncotarget.8994

Erin L. Wuebben, Phillip J. Wilder, Jesse L. Cox, James A. Grunkemeyer, Thomas Caffrey, Michael A. Hollingsworth, and Angie Rizzino
34890-34906
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Systemic release of osteoprotegerin during oxaliplatincontaining induction chemotherapy and favorable systemic outcome of sequential radiotherapy in rectal cancer

https://doi.org/10.18632/oncotarget.8995

Sebastian Meltzer, Erta Kalanxhi, Helga Helseth Hektoen, Svein Dueland, Kjersti Flatmark, Kathrine Røe Redalen, and Anne Hansen Ree
34907-34917
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Quantitative assessment of preoperative serum thyrotropin level and thyroid cancer

https://doi.org/10.18632/oncotarget.9201

Jiaojiao Zheng, Chen Li, Weihui Lu, Cong Wang, and Zhilong Ai
34918-34929
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Heterogeneous PSMA expression on circulating tumor cells a potential basis for stratification and monitoring of PSMAdirected therapies in prostate cancer

https://doi.org/10.18632/oncotarget.9004

Tobias M. Gorges, Sabine Riethdorf, Oliver von Ahsen, Paulina Nastały, Katharina Röck, Marcel Boede, Sven Peine, Andra Kuske, Elke Schmid, Christoph Kneip, Frank König, Marion Rudolph, and Klaus Pantel
34930-34941
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Mutant IDH1 expression is associated with downregulation of monocarboxylate transporters

https://doi.org/10.18632/oncotarget.9006

Pavithra Viswanath, Chloe Najac, Jose L. Izquierdo-Garcia, Aleksandr Pankov, Chibo Hong, Pia Eriksson, Joseph F. Costello, Russell O. Pieper, and Sabrina M. Ronen
34942-34955
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Identification of genes that are essential to restrict genome duplication to once per cell division

https://doi.org/10.18632/oncotarget.9008

Alex Vassilev, Chrissie Y. Lee, Boris Vassilev, Wenge Zhu, Pinar Ormanoglu, Scott E. Martin, and Melvin L. DePamphilis
34956-34976
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Overexpression of ankyrin1 promotes pancreatic cancer cell growth

https://doi.org/10.18632/oncotarget.9009

Noriyuki Omura, Masamichi Mizuma, Anne MacGregor, Seung-Mo Hong, Michael Ayars, Jose Alejandro Almario, Michael Borges, Mitsuro Kanda, Ang Li, Audrey Vincent, Anirban Maitra, and Michael Goggins
34977-34987
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Nextgeneration proteasome inhibitor oprozomib synergizes with modulators of the unfolded protein response to suppress hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.9222

Yves-Paul Vandewynckel, Céline Coucke, Debby Laukens, Lindsey Devisscher, Annelies Paridaens, Eliene Bogaerts, Astrid Vandierendonck, Sarah Raevens, Xavier Verhelst, Christophe Van Steenkiste, Louis Libbrecht, Anja Geerts, and Hans Van Vlierberghe
34988-35000
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

A natural small molecule catechol induces cMyc degradation by directly targeting ERK2 in lung cancer

https://doi.org/10.18632/oncotarget.9223

Do Young Lim, Seung Ho Shin, Mee-Hyun Lee, Margarita Malakhova, Igor Kurinov, Qiong Wu, Jinglong Xu, Yanan Jiang, Ziming Dong, Kangdong Liu, Kun Yeong Lee, Ki Beom Bae, Bu Young Choi, Yibin Deng, Ann Bode, and Zigang Dong
35001-35014
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Significance of microRNArelated variants in susceptibility to recurrence of oropharyngeal cancer patients after definitive radiotherapy

https://doi.org/10.18632/oncotarget.9014

Xingming Chen, Erich M. Sturgis, Chengyuan Wang, Xiaoli Cao, Yuncheng Li, Qingyi Wei, and Guojun Li
35015-35025
Abstract  |  PDF  |  Full Text  |  How to cite

microRNA802/Rnd3 pathway imposes on carcinogenesis and metastasis of fine particulate matter exposure

https://doi.org/10.18632/oncotarget.9019

Xiaobo Li, Yang Lv, Na Gao, Hao Sun, Runze Lu, Hongbao Yang, Chengcheng Zhang, Qingtao Meng, Shenshen Wu, Ai-Qun Li, Yankai Xia, and Rui Chen
35026-35043
Abstract  |  PDF  |  Full Text  |  How to cite

Integrative analysis reveals clinical phenotypes and oncogenic potentials of long noncoding RNAs across 15 cancer types

https://doi.org/10.18632/oncotarget.9037

Ze-Lin Wang, Bin Li, Stephen R. Piccolo, Xiao-Qin Zhang, Jun-Hao Li, Hui Zhou, Jian-Hua Yang, and Liang-Hu Qu
35044-35055
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

BISmediated STAT3 stabilization regulates glioblastoma stem celllike phenotypes

https://doi.org/10.18632/oncotarget.9039

Chang-Nim Im, Hye Hyeon Yun, Byunghoo Song, Dong-Ye Youn, Mei Nu Cui, Hong Sug Kim, Gyeong Sin Park, and Jeong-Hwa Lee
35056-35070
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Prognostic factors in patients with recurrent hepatocellular carcinoma treated with salvage liver transplantation: a singlecenter study

https://doi.org/10.18632/oncotarget.9040

Pusen Wang, Hao Li, Baojie Shi, Weitao Que, Chunguang Wang, Junwei Fan, Zhihai Peng, and Lin Zhong
35071-35083
Abstract  |  PDF  |  Full Text  |  How to cite

Increased number of negative lymph nodes is associated with improved survival outcome in node positive gastric cancer following radical gastrectomy

https://doi.org/10.18632/oncotarget.9041

Rong-liang Shi, Qian Chen, Jun Bing Ding, Zhen Yang, Gaofeng Pan, Daowen Jiang, and Weiyan Liu
35084-35091
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Downregulation of miR199b is associated with distant metastasis in colorectal cancer via activation of SIRT1 and inhibition of CREB/KISS1 signaling

https://doi.org/10.18632/oncotarget.9042

Zhan-long Shen, Bo Wang, Ke-wei Jiang, Chun-xiang Ye, Cheng Cheng, Yi-chao Yan, Ji-zhun Zhang, Yang Yang, Zhi-dong Gao, Ying-jiang Ye, and Shan Wang
35092-35105
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Assessment of epigenetic alterations in early colorectal lesions containing BRAF mutations

https://doi.org/10.18632/oncotarget.9044

Takeshi Sawada, Eiichiro Yamamoto, Hiro-o Yamano, Masanori Nojima, Taku Harada, Reo Maruyama, Masami Ashida, Hironori Aoki, Hiro-o Matsushita, Kenjiro Yoshikawa, Eiji Harada, Yoshihito Tanaka, Shigenori Wakita, Takeshi Niinuma, Masahiro Kai, Makoto Eizuka, Tamotsu Sugai, and Hiromu Suzuki
35106-35118
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

JNK2 downregulation promotes tumorigenesis and chemoresistance by decreasing p53 stability in bladder cancer

https://doi.org/10.18632/oncotarget.9046

Chun-Wu Pan, Hailong Liu, Yu Zhao, Chenchen Qian, Liguo Wang, and Jun Qi
35119-35131
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Continuous antiangiogenic therapy after tumor progression in patients with recurrent highgrade epithelial ovarian cancer: phase I trial experience

https://doi.org/10.18632/oncotarget.9048

Ming-Mo Hou, Zhijie Wang, Filip Janku, Sarina Piha-Paul, Aung Naing, David Hong, Shannon Westin, Robert L. Coleman, Anil K. Sood, Apostolia M. Tsimberidou, Vivek Subbiah, Jennifer Wheler, Ralph Zinner, Karen Lu, Funda Meric-Bernstam, and Siqing Fu
35132-35143
Abstract  |  PDF  |  Full Text  |  How to cite

Prevention effect of rare ginsenosides against stresshormone induced MTOC amplification

https://doi.org/10.18632/oncotarget.9059

Jung-Hyun Cho, Ho-Young Chun, Jung Suk Lee, Jee-Hyun Lee, Kyu Jin Cheong, Youn-Sang Jung, Tae-Gyun Woo, Min-Ho Yoon, Ah-Young Oh, So-Mi Kang, Chunghui Lee, Hokeun Sun, Jihwan Hwang, Gyu-Yong Song, and Bum-Joon Park
35144-35158
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

ERCC1 expression affects outcome in metastatic pancreatic carcinoma treated with FOLFIRINOX: A single institution analysis

https://doi.org/10.18632/oncotarget.9063

Antonia Strippoli, Sabrina Rossi, Maurizio Martini, Michele Basso, Ettore D'Argento, Giovanni Schinzari, Rosalba Barile, Alessandra Cassano, and Carlo Barone
35159-35168
Abstract  |  PDF  |  Full Text  |  How to cite

Solid tumors provide nichespecific conditions that lead to preferential growth of Salmonella

https://doi.org/10.18632/oncotarget.9071

Cecilia A. Silva-Valenzuela, Prerak T. Desai, Roberto C. Molina-Quiroz, David Pezoa, Yong Zhang, Steffen Porwollik, Ming Zhao, Robert M. Hoffman, Inés Contreras, Carlos A. Santiviago, and Michael McClelland
35169-35180
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Metastatic renal cell carcinoma: the first report of unilateral fundus hemorrhage induced by sorafenib

https://doi.org/10.18632/oncotarget.9285

Zhi Yong Li, Xin Xiang Fan, Yan Jun Wang, Kai Yao, Zhuo Wei Liu, Wen Tao Pan, Yun Lin Ye, Ping Yang, Yi Chuan Huang, Zhi Ming Wu, and Fang Jian Zhou
35181-35187
Abstract  |  PDF  |  Full Text  |  How to cite

mir1013p is a key regulator of tumor metabolism in triple negative breast cancer targeting AMPK

https://doi.org/10.18632/oncotarget.9072

Peng Liu, Feng Ye, Xinhua Xie, Xing Li, Hailin Tang, Shuaijie Li, Xiaojia Huang, Cailu Song, Weidong Wei, and Xiaoming Xie
35188-35198
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Identification of a functional variant for colorectal cancer risk mapping to chromosome 5q311

https://doi.org/10.18632/oncotarget.9298

Juntao Ke, Jiao Lou, Xueqin Chen, Jiaoyuan Li, Cheng Liu, Yajie Gong, Yang Yang, Ying Zhu, Yi Zhang, Jianbo Tian, Jiang Chang, Rong Zhong, Jing Gong, and Xiaoping Miao
35199-35207
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Nobiletin inhibits human osteosarcoma cells metastasis by blocking ERK and JNKmediated MMPs expression

https://doi.org/10.18632/oncotarget.9106

Hsin-Lin Cheng, Ming-Ju Hsieh, Jia-Sin Yang, Chiao-Wen Lin, Ko-Haung Lue, Ko-Hsiu Lu, and Shun-Fa Yang
35208-35223
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Androgen suppresses testicular cancer cell growth in vitro and in vivo

https://doi.org/10.18632/oncotarget.9109

Hideo Nakagawa, Takashi Ueda, Saya Ito, Takumi Shiraishi, Hidefumi Taniguchi, Naruhiro Kayukawa, Hiroyuki Nakanishi, So Ushijima, Motohiro Kanazawa, Terukazu Nakamura, Yoshio Naya, Fumiya Hongo, Kazumi Kamoi, Koji Okihara, and Osamu Ukimura
35224-35232
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Predictive value of APAF1 and COX2 expression in pathologic complete response to neoadjuvant chemoradiotherapy for patients with locally advanced rectal adenocarcinoma

https://doi.org/10.18632/oncotarget.9125

Haihua Peng, Kaiyun You, Rong Zhang, Shaoyan Xi, Tian Zhang, Jun Dong, Muyan Cai, Chengtao Wang, Huizhong Zhang, Tongchong Zhou, Yuanhong Gao, and Bixiu Wen
35233-35240
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Cell cycle progression score is a marker for fiveyear lung cancerspecific mortality risk in patients with resected stage I lung adenocarcinoma

https://doi.org/10.18632/oncotarget.9129

Takashi Eguchi, Kyuichi Kadota, Jamie Chaft, Brent Evans, John Kidd, Kay See Tan, Joe Dycoco, Kathryn Kolquist, Thaylon Davis, Stephanie A. Hamilton, Kraig Yager, Joshua T. Jones, William D. Travis, David R. Jones, Anne-Renee Hartman, and Prasad S. Adusumilli
35241-35256
Abstract  |  PDF  |  Full Text  |  How to cite

miR592/WSB1/HIF1α axis inhibits glycolytic metabolism to decrease hepatocellular carcinoma growth

https://doi.org/10.18632/oncotarget.9135

Yan-Yan Jia, Jin-Yi Zhao, Bing-Ling Li, Kai Gao, Ying Song, Mei-You Liu, Xiao-Juan Yang, Yan Xue, Ai-Dong Wen, and Lei Shi
35257-35269
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Upregulation of lactate dehydrogenase a by 1433ζ leads to increased glycolysis critical for breast cancer initiation and progression

https://doi.org/10.18632/oncotarget.9136

Chia-Chi Chang, Chenyu Zhang, Qingling Zhang, Ozgur Sahin, Hai Wang, Jia Xu, Yi Xiao, Jian Zhang, Sumaiyah K. Rehman, Ping Li, Mien-Chie Hung, Fariba Behbod, and Dihua Yu
35270-35283
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

miR363 promotes proliferation and chemoresistance of human gastric cancer via targeting of FBW7 ubiquitin ligase expression

https://doi.org/10.18632/oncotarget.9169

Peng-Fei Zhang, Lu-Lu Sheng, Ge Wang, Mi Tian, Ling-Yin Zhu, Rui Zhang, Jing Zhang, and Jin-Shui Zhu
35284-35292
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Leukemic stem cell persistence in chronic myeloid leukemia patients in deep molecular response induced by tyrosine kinase inhibitors and the impact of therapy discontinuation

https://doi.org/10.18632/oncotarget.9182

Jean Claude Chomel, Marie Laure Bonnet, Nathalie Sorel, Ivan Sloma, Annelise Bennaceur-Griscelli, Delphine Rea, Laurence Legros, Anne Marfaing-Koka, Jean-Henri Bourhis, Shanti Ame, Agnès Guerci-Bresler, Philippe Rousselot, and Ali G. Turhan
35293-35301
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

RNA sequencingbased analysis of gallbladder cancer reveals the importance of the liver X receptor and lipid metabolism in gallbladder cancer

https://doi.org/10.18632/oncotarget.9181

Mingxin Zuo, Asif Rashid, Ying Wang, Apurva Jain, Donghui Li, Anu Behari, Vinay Kumar Kapoor, Eugene J. Koay, Ping Chang, Jean Nicholas Vauthey, Yanan Li, Jaime A. Espinoza, Juan Carlos Roa, and Milind Javle
35302-35312
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Reduction in promotor methylation utilizing EGCG epigallocatechin3gallate restores RXRα expression in human colon cancer cells

https://doi.org/10.18632/oncotarget.9204

Jay Morris, Vondina R. Moseley, April B. Cabang, Katie Coleman, Wei Wei, Elizabeth Garrett-Mayer, and Michael J. Wargovich
35313-35326
Abstract  |  PDF  |  Full Text  |  How to cite

Zinc and bicarbonatedependent ZIP8 transporter mediates selenite uptake

https://doi.org/10.18632/oncotarget.9205

Joseph R. McDermott, Xiangrong Geng, Lan Jiang, Marina Gálvez-Peralta, Fei Chen, Daniel W. Nebert, and Zijuan Liu
35327-35340
Abstract  |  PDF  |  Full Text  |  How to cite

The IRX1/HOXA connection: insights into a novel t4;11 specific cancer mechanism

https://doi.org/10.18632/oncotarget.9241

Alessa Kühn, Denise Löscher, and Rolf Marschalek
35341-35352
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Monomeric gremlin is a novel vascular endothelial growth factor receptor2 antagonist

https://doi.org/10.18632/oncotarget.9286

Elisabetta Grillo, Cosetta Ravelli, Michela Corsini, Kurt Ballmer-Hofer, Luca Zammataro, Pasqua Oreste, Giorgio Zoppetti, Chiara Tobia, Roberto Ronca, Marco Presta, and Stefania Mitola
35353-35368
Abstract  |  PDF  |  Full Text  |  How to cite

Prognostic value of microRNAs in cervical carcinoma: a systematic review and metaanalysis

https://doi.org/10.18632/oncotarget.9294

Shengkang Dai, Yan Lu, Ying Long, Yuehua Lai, Ping Du, Nan Ding, and Desheng Yao
35369-35378
Abstract  |  PDF  |  Full Text  |  How to cite

Characterization of the novel indolylmaleimides’ PDA66 and PDA377 effect on canine lymphoma cells

https://doi.org/10.18632/oncotarget.9297

Wen Liu, Julia Beck, Laura C. Schmidt, Catrin Roolf, Anahit Pews-Davtyan, Barbara C. Rütgen, Sabine Hammer, Saskia Willenbrock, Anett Sekora, Arndt Rolfs, Matthias Beller, Bertram Brenig, Ingo Nolte, Christian Junghanss, Ekkehard Schütz, and Hugo Murua Escobar
35379-35389
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Ginsenoside Rg1 and plateletrich fibrin enhance human breast adiposederived stem cells function for soft tissue regeneration

https://doi.org/10.18632/oncotarget.9360

Fang-Tian Xu, Zhi-Jie Liang, Hong-Mian Li, Qi-Liu Peng, Min-Hong Huang, De-Quan Li, Yi-Dan Liang, Gang-Yi Chi, De-Hui Li, Bing-Chao Yu, and Ji-Rong Huang
35390-35403
Abstract  |  PDF  |  Full Text  |  How to cite

Clinical Research Papers

High risk of deep vein thrombosis associated with peripherally inserted central catheters in lymphoma

https://doi.org/10.18632/oncotarget.8639

Xi Zhang, Jia-Jia Huang, Yi Xia, Chao-Feng Li, Yu Wang, Pan-Pan Liu, Xi-Wen Bi, Peng Sun, Tong-Yu Lin, Wen-Qi Jiang, and Zhi-Ming Li
35404-35411
Abstract  |  PDF  |  Full Text  |  How to cite

Analysis of the efficacy and safety of a combined gemcitabine oxaliplatin and pegaspargase regimen for NK/Tcell lymphoma

https://doi.org/10.18632/oncotarget.8643

Jing-hua Wang, Hua Wang, Yan-jun Wang, Zhong-jun Xia, Hui-qiang Huang, Wen-qi Jiang, and Yue Lu
35412-35422
Abstract  |  PDF  |  Full Text  |  How to cite

Prognostic significance of preoperative serum CA125 CA199 and CEA in gastric carcinoma

https://doi.org/10.18632/oncotarget.8770

Wei Wang, Xiao-Long Chen, Shen-Yu Zhao, Yu-Hui Xu, Wei-Han Zhang, Kai Liu, Xin-Zu Chen, Kun Yang, Bo Zhang, Zhi-Xin Chen, Jia-Ping Chen, Zong-Guang Zhou, and Jian-Kun Hu
35423-35436
Abstract  |  PDF  |  Full Text  |  How to cite

Metformin therapy associated with survival benefit in lung cancer patients with diabetes

https://doi.org/10.18632/oncotarget.8881

Guoxing Wan, Xiongjie Yu, Ping Chen, Xianhe Wang, Dongfeng Pan, Xuanbin Wang, Linjun Li, Xiaojun Cai, and Fengjun Cao
35437-35445
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Combined preoperative concentrations of CEA CA 199 and 724 for predicting outcomes in patients with gastric cancer after curative resection

https://doi.org/10.18632/oncotarget.9060

Xuechao Liu, Haibo Qiu, Jianjun Liu, Shangxiang Chen, Dazhi Xu, Wei Li, Youqing Zhan, Yuanfang Li, Yingbo Chen, Zhiwei Zhou, and Xiaowei Sun
35446-35453
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Reviews

Control of CREB expression in tumors: from molecular mechanisms and signal transduction pathways to therapeutic target

https://doi.org/10.18632/oncotarget.7721

André Steven, and Barbara Seliger
35454-35465
Abstract  |  PDF  |  Full Text  |  How to cite

Multiple myeloma cancer stem cells

https://doi.org/10.18632/oncotarget.8154

Minjie Gao, Yuanyuan Kong, Guang Yang, Lu Gao, and Jumei Shi
35466-35477
Abstract  |  PDF  |  Full Text  |  How to cite

Hallmarks of glycosylation in cancer

https://doi.org/10.18632/oncotarget.8155

Jennifer Munkley, and David J. Elliott
35478-35489
Abstract  |  PDF  |  Full Text  |  How to cite

Interplay between myeloidderived suppressor cells MDSCs and Th17 cells: foe or friend

https://doi.org/10.18632/oncotarget.8204

Liang Wen, Ping Gong, Chao Liang, Dawei Shou, Baoqing Liu, Yiwen Chen, Changqian Bao, Li Chen, Xiaowei Liu, Tingbo Liang, and Weihua Gong
35490-35496
Abstract  |  PDF  |  Full Text  |  How to cite

Corrections

Correction: Molecular profiling of cetuximab and bevacizumab treatment of colorectal tumours reveals perturbations in metabolic and hypoxic response pathways

https://doi.org/10.18632/oncotarget.9855

David W. Greening, Sze Ting Lee, Hong Ji, Richard J. Simpson, Angela Rigopoulos, Carmel Murone, Catherine Fang, Sylvia Gong, Graeme O’Keefe, and Andrew M. Scott
35497
Correction  |  PDF  |  How to cite


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