Genetic variant of miR-146a rs2910164 C>G and gastric cancer susceptibility
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Zu-Guang Xia1,*, Hua-Fang Yin2,*, Ying Long3,*, Lei Cheng1, Ling-Jun Yu4, Wei-Jian Guo1, Xiao-Dong Zhu1, Jin Li1, Ya-Nong Wang5, Ya-Jun Yang6,7, Jiu-Cun Wang6,7, Li Jin6,7, Li-Xin Qiu1, Yongyue Wei8
1Department of Medical Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
2Department of Medical Oncology, The Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangsu, China
3Department of Medical Oncology, Wanzai City Hospital, Jiangxi, China
4Department of Informatics, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China
5Department of Gastric Cancer & Soft Tissue Sarcoma Surgery, Fudan University Shanghai Cancer Center, Shanghai, China
6Ministry of Education Key Laboratory of Contemporary Anthropology and State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China
7Fudan-Taizhou Institute of Health Sciences, Taizhou, Jiangsu, China
8Department of Biostatistics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center For Cancer Personalized Medicine, The Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China
*These authors have contributed equally to this work
Li-Xin Qiu, email: [email protected]
Yongyue Wei, email: [email protected]
Keywords: gastric cancer, genetic susceptibility, miR-146a, polymorphism
Received: January 30, 2016 Accepted: March 31, 2016 Published: April 18, 2016
The single nucleotide polymorphism (SNP) rs2910164 G>C within miR-146a has been reported that is associated with the increased risk of gastric cancer (GCa). However, the results are inconclusive, espicially among Asian populations, which probably due to small sample size in each single study. To validate this association and get a more precise estimation, we conducted a large GCa study including 1,125 cases and 1,196 controls in an eastern Chinese population. Our results showed that this SNP was not associated with GCa risk in either of the three genetic models [co-dominant model: CG vs. CC, odds ratio (OR) = 0.99, 95% confidence interval (95%CI): 0.83-1.19; GG vs. CC, OR = 1.03, 95%CI: 0.81-1.32; dominant model: (CG+GG) vs. CC, OR = 1.00, 95%CI = 0.84-1.19; recessive model: GG vs. (CG+CC), OR = 1.04, 95%CI = 0.83-1.29]. Stratified analysis by age, gender, smoking status, drinking status, or tumor location confirmed this non-significant association. In summary, these results suggest that the miR-146a SNP rs2910164 may not be a risk factor for GCa in this Chinese population. Larger and well-designed, preferably prospective studies are needed to further confirm our findings.
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