Ubiquitin specific protease 19 involved in transcriptional repression of retinoic acid receptor by stabilizing CORO2A
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Key-Hwan Lim1, Jong-Ho Choi2, Jung-Hyun Park1, Hyeon-Ju Cho1, Jang-Joon Park1, Eung-Ji Lee1, Lan Li1, Young-Kil Choi2,3, Kwang-Hyun Baek1,2
1Department of Biomedical Science, Bundang CHA Hospital, Bundang-Gu, Seongnam-Si, Gyeonggi-Do 463-400, Republic of Korea
2Department of Internal Medicine, College of Medicine, Bundang CHA Hospital, Bundang-Gu, Seongnam-Si, Gyeonggi-Do 463-400, Republic of Korea
3Department of Internal Medicine, CHA University, CHA General Hospital, Nonhyon-ro, Grangnam-Gu, Seoul 135-081, Republic of Korea
Kwang-Hyun Baek, e-mail: [email protected]
Keywords: adipogenesis, CORO2A, deubiquitinating enzyme, USP19
Received: November 09, 2015 Accepted: March 28, 2016 Published: April 25, 2016
Deubiquitination via deubiquitinating enzymes (DUBs) has been emerged as one of the important post-translational modifications, resulting in the regulation of numerous target proteins. In this study, we screened new protein biomarkers for adipogenesis, and related studies showed that ubiquitin specific protease 19 (USP19) as a DUB is gradually decreased during adipogenesis and it regulates coronin 2A (CORO2A) as one of the components for the nuclear receptor co-repressor (NCoR) complex in some studies. The regulation of CORO2A through the deubiquitinating activity of USP19 affected the transcriptional repression activity of the retinoic acid receptor (RAR), suggesting that USP19 may be involved in the regulation of RAR-mediated adipogenesis.
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